High-resolution analysis of temporal dynamics of genetic effects on gene expression throughout cardiomyocyte differentiation.
Contact Ben Strober (bstrober3@gmail.com) with any questions.
The analysis/code is divided into three sections (each of which is a subdirectory):
- 'preprocess_expression': Aligns reads and performs expression quantification.
- 'standard_eqtl_calling': Runs the WASP Combined Haplotype Test (CHT) in each time step, independently.
- 'dynamic_eqtl_calling': Identifies linear and non-linear dynamic eQTLs.
Each section depends on the previous, and therefore must be run sequentially, in series.
This pipeline was designed to run on midway2 rcc.
- Ben Strober -- BennyStrobes