pyelasticsearch is a clean, future-proof, high-scale API to elasticsearch. It provides features like...

• Transparent conversion of Python data types to and from JSON
• Translating HTTP status codes representing failure into exceptions
• Connection pooling
• Load-balancing of requests across nodes in a cluster
• Failed-node marking to avoid downed nodes for a period
• Optional automatic retrying of failed requests

Full documentation: http://pyelasticsearch.readthedocs.org/