Propagation of Conformational Coordinates Across Angular Space.

We have used the Matlab version for this paper: Maji et al. 2020."Propagation of Conformational Coordinates Across Angular Space in Mapping the Continuum of States from Cryo-EM Data by Manifold Embedding". DOI: 10.1021/acs.jcim.9b01115. https://doi.org/10.1021/acs.jcim.9b01115

We are providing here with the python code which is part of the ManifoldEM python software, since it contains a cleaner and updated version of the original Matlab implementation.

Since the code is part of the ManifoldEM workflow, it takes intermediate output from ManifoldEM as input. Therefore to run the code independently we need the input files in a specific format. We will update the required file format and description soon.

The graph files are produced by FindCCGraph.py , FindCCGraphPruned.py (if required)

The main script is: FindConformationalCoord.py

Suvrajit Maji (Matlab and Python version)

Hstau Liao (Python version)

We are part of the "Propagation of Conformational Coordinates Across Angular Space ..." project and also part of the ManifoldEM python software team.

Also thanks to other ManifoldEM python team members Evan Seitz and Sonya Hanson.