CoReCo is a computational method for reconstructing metabolic networks of multiple species from protein sequence and phylogenetic data.

1. Software requirements
2. Data requirements

1. Python
2. Perl
3. InterProScan
4. NCBI Blast+ toolkit
5. R
6. Python module newick
7. libsbml

1. UniProt (uniprot_sprot.fasta.gz, uniprot_sport.dat)
2. EC to GO mapping (ec2go)
3. KEGG
4. GTG nrdb40

See doc/CoReCoManual.pdf for installation and usage instructions.

• Pitkänen et al., Comparative Genome-Scale Reconstruction of Gapless Metabolic Networks for Present and Ancestral Species. PLOS Computational Biology 2014, doi:10.1371/journal.pcbi.1003465
• Castillo et al., Whole-genome metabolic model of Trichoderma reesei built by comparative reconstruction. Biotechnology for Biofuels 2016, doi:10.1186/s13068-016-0665-0