tgbotplug is meant to be an easy-to-extend telegram bot built around twx.botapi.

Plugin examples can be found in tgbotplug-plugins.

Using tgbotplug, after choosing/developing your plugins, is as simple as:

import tgbot
tgbot.TGBot(
  'YOUR_BOT_TOKEN',
  plugins=[
    Plugin1(),
    ...,
    PluginN(),
  ],
).run()

Plugins should inherit tgbot.TGPluginBaseand implement list_commands() (and the methods mapped in its result).