kineticsTools

Note this repo only includes models for RSII chemistries, recent Sequel / Sequel II data should be analyzed with a recent version of SMRT Analysis https://www.pacb.com/support/software-downloads/

Tools for detecting DNA modifications from single molecule, real-time (SMRT®) sequencing data. This tool implements the P_ModificationDetection module in SMRT® Portal, used by the RS_Modification_Detection and RS_Modifications_and_Motif_Detection protocol. Researchers interested in understanding or extending the modification detection algorthims can use these tools as a starting point.

Academic Publications:

• Characterization of DNA methyltransferase specificities using single-molecule, real-time DNA sequencing
• The methylomes of six bacteria

Documentation:

• Tool documentation
• Methods description

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