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time_evol.py
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time_evol.py
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#!/usr/bin/python
#bioinfo.py
__author__ = '''Hyunju Kim'''
import os
import sys
import numpy as np
import networkx as nx
import matplotlib.pyplot as plt
from collections import OrderedDict
import input_net as inet
import updating_rule as ur
################# BEGIN: decimal_to_binary(nodes_list, decState, Nbr_States=2) ########################
def decimal_to_binary(nodes_list, decState, Nbr_States=2): # more left in the nodes list means higher order of 2 in binary
biStates = {}
x = len(nodes_list) -1
for u in nodes_list:
biStates[u] = decState / np.power(Nbr_States, x)
decState = decState % np.power(Nbr_States, x)
x = x - 1
return biStates
################# END: decimal_to_binary(nodes_list, decState, Nbr_States=2) ########################
################# BEGIN: binary_to_decimal(nodes_list, biStates, Nbr_States=2) ########################
def binary_to_decimal(nodes_list, biStates, Nbr_States=2): # more left in the nodes list means higher order of 2 in binary
decState = 0
x = len(nodes_list) -1
for u in nodes_list:
decState = decState + biStates[u] * np.power(Nbr_States, x)
x = x - 1
return decState
################# END: binary_to_decimal(nodes_list, biStates, Nbr_States=2) ########################
'''
################# BEGIN: biological_sequence(net, nodes_list, Nbr_States=2) ########################
def biological_sequence(net, nodes_list, bio_initStates, fileName, Nbr_States=2):
bioSeq = []
currBiStates = bio_initStates
finished = False
while(not finished):
oneDiff = 0
prevBiStates = currBiStates.copy()
bioSeq.append(prevBiStates)
currBiStates = ur.sigmoid_updating(net, prevBiStates)
for u in nodes_list:
if abs(prevBiStates[u] - currBiStates[u]) > 0:
oneDiff = 1
break
finished = (oneDiff < 1)
OUTPUT_FILE = open(fileName, 'w')
OUTPUT_FILE.write('time step')
for u in nodes_list:
OUTPUT_FILE.write('\t%s'%(u))
OUTPUT_FILE.write('\n')
for i in range(len(bioSeq)):
OUTPUT_FILE.write('%d'%i)
for u in nodes_list:
OUTPUT_FILE.write('\t%d'%(bioSeq[i][u]))
OUTPUT_FILE.write('\n')
#return bioSeq
################# END: biological_sequence(net, nodes_list, Nbr_States=2) ########################
'''
################# BEGIN: time_series_en(net, nodes_list, Nbr_States=2, MAX_TimeStep=20, Transition_Step=0) ########################
def time_series_all(net, nodes_list, Nbr_Initial_States, Nbr_States, MAX_TimeStep=20):
'''
Description:
-- compute TE for every pair of nodes using distribution from all possible initial conditions or an arbitrary set of initial conditions
Arguments:
-- 1. net
-- 2. nodes_list
-- 3. Initial_States_List
-- 4. Nbr_States
-- 5. MAX_TimeStep
Return:
-- 1. timeSeriesData
'''
#Nbr_Nodes = len(net.nodes())
#Nbr_All_Initial_States = np.power(Nbr_States, Nbr_Nodes)
timeSeriesData = {}
for n in net.nodes():
timeSeriesData[n] = {}
for initState in range(Nbr_Initial_States):
timeSeriesData[n][initState] = []
for initDecState in range(Nbr_Initial_States):
currBiState = decimal_to_binary(nodes_list, initDecState, Nbr_States)
for step in range(MAX_TimeStep):
prevBiState = currBiState.copy()
for n in nodes_list:
timeSeriesData[n][initDecState].append(prevBiState[n])
currBiState = ur.sigmoid_updating(net, prevBiState)
return timeSeriesData
################# END: time_series_en(net, nodes_list, Nbr_States=2, MAX_TimeStep=20) ########################
################# BEGIN: net_state_transition_map(net, nodes_list, Nbr_States=2) ########################
def net_state_transition(net, nodes_list, Nbr_States=2):
'''
Arguments:
1. net
2. Nbr_States
Return:
1. decStateTransMap
'''
Nbr_Nodes = len(net.nodes())
Nbr_All_Initial_States = np.power(Nbr_States, Nbr_Nodes)
decStateTransMap = nx.DiGraph()
for prevDecState in range(Nbr_All_Initial_States):
prevBiState = decimal_to_binary(nodes_list, prevDecState, Nbr_States)
currBiState = ur.sigmoid_updating(net, prevBiState)
currDecState = binary_to_decimal(nodes_list, currBiState, Nbr_States)
decStateTransMap.add_edge(prevDecState, currDecState)
return decStateTransMap
################# END: net_state_transition_map(net, nodes_list, Nbr_States=2) ########################
################# BEGIN: find_attractor_old(decStateTransMap) ########################
def find_attractor_old(decStateTransMap):
'''
Arguments:
1. decStateTransMap
Return:
1. attractor
'''
attractor_list = nx.simple_cycles(decStateTransMap) #in case of deterministic system, any cycle without considering edge direction will be directed cycle.
attractors = {}
attractors['fixed'] = []
attractors['cycle'] = []
for u in attractor_list:
if len(u) == 1:
attractors['fixed'].append(u)
else:
attractors['cycle'].append(u)
return attractors
################# END: find_attractor_old(decStateTransMap) ########################
################# BEGIN: attractor_analysis(decStateTransMap) ########################
def find_attractor(decStateTransMap):
'''
Arguments:
-- 1. decStateTransMap
Return:
-- attractor
'''
attractor_list = nx.simple_cycles(decStateTransMap) #in case of deterministic system, any cycle without considering edge direction will be directed cycle.
attractors = {}
#attractors['fixed'] = []
#attractors['cycle'] = []
undirectedMap = nx.DiGraph.to_undirected(decStateTransMap)
for u in attractor_list:
attractors[u[0]] = {}
if len(u) == 1:
attractors[u[0]]['type'] = 'fixed'
else:
attractors[u[0]]['type'] = 'cycle'
for v in attractors.iterkeys():
basin = nx.node_connected_component(undirectedMap, v)
attractors[v]['basin'] = basin
attractors[v]['basin-size'] = len(basin)
sorted_attractors = OrderedDict(sorted(attractors.items(), key=lambda kv: kv[1]['basin-size'], reverse=True))
return sorted_attractors
################# END: attractor_analysis(decStateTransMap) ########################
################# BEGIN: time_series_pa(net, nodes_list, Initial_States_List, Nbr_States=2, MAX_TimeStep=20) ########################
def time_series_pa(net, nodes_list, Initial_States_List, Nbr_States, MAX_TimeStep=20):
'''
Description:
-- compute TE for every pair of nodes using distribution from all initial conditions that converge to the primary or biological attractor
Arguments:
-- 1. net
-- 2. nodes_list
-- 3. Initial_States_List
-- 4. Nbr_States
-- 5. MAX_TimeStep
Return:
-- 1. timeSeriesData (only for primary attractor)
'''
timeSeriesData = {}
for n in net.nodes():
timeSeriesData[n] = {}
for initState in range(len(Initial_States_List)):
timeSeriesData[n][initState] = []
for initState in range(len(Initial_States_List)):
initDecState = Initial_States_List[initState]
currBiState = decimal_to_binary(nodes_list, initDecState, Nbr_States)
for step in range(MAX_TimeStep):
prevBiState = currBiState.copy()
for n in nodes_list:
timeSeriesData[n][initState].append(prevBiState[n])
currBiState = ur.sigmoid_updating(net, prevBiState)
return timeSeriesData
################# END: time_series_pa(net, nodes_list, Nbr_States=2, MAX_TimeStep=20) ########################
################# BEGIN: time_series_one(net, nodes_list, Initial_State, Nbr_States=2, MAX_TimeStep=20) ########################
def time_series_one(net, nodes_list, Initial_State, Nbr_States, MAX_TimeStep=20):
'''
Description:
-- compute TE for every pair of nodes using distribution from all initial conditions that converge to the primary or biological attractor
Arguments:
-- 1. net
-- 2. nodes_list
-- 3. Initial_States_List
-- 4. Nbr_States
-- 5. MAX_TimeStep
Return:
-- 1. timeSeriesData (only for primary attractor)
'''
timeSeriesData = {}
for n in net.nodes():
timeSeriesData[n] = {}
timeSeriesData[n][0] = []
currBiState = Initial_State
for step in range(MAX_TimeStep):
prevBiState = currBiState.copy()
for n in nodes_list:
timeSeriesData[n][0].append(prevBiState[n])
currBiState = ur.sigmoid_updating(net, prevBiState)
return timeSeriesData
################# END: time_series_one(net, nodes_list, Initial_State, Nbr_States=2, MAX_TimeStep=20) ########################
def main():
print "time_evol module is the main code."
## to import a network of 3-node example
EDGE_FILE = 'C:\Boolean_Delay_in_Economics\Manny\EDGE_FILE.dat'
NODE_FILE = 'C:\Boolean_Delay_in_Economics\Manny\NODE_FILE.dat'
net = inet.read_network_from_file(EDGE_FILE, NODE_FILE)
nodes_list = inet.build_nodes_list(NODE_FILE)
'''
## to obtain time series data for all possible initial conditions for 3-node example network
timeSeriesData = ensemble_time_series(net, nodes_list, 2, 10)#, Nbr_States=2, MAX_TimeStep=20)
initState = 1
biStates = decimal_to_binary(nodes_list, initState)
print 'initial state', biStates
## to print time series data for each node: a, b, c starting particualr decimal inital condition 1
print 'a', timeSeriesData['a'][1]
print 'b', timeSeriesData['b'][1]
print 'c', timeSeriesData['c'][1]
'''
## to obtain and visulaize transition map in the network state space
decStateTransMap = net_state_transition(net, nodes_list)
nx.write_graphml(decStateTransMap,'C:\Boolean_Delay_in_Economics\Manny\Results\BDE.graphml')
'''
nx.draw(decStateTransMap)
plt.show()
## to find fixed point attractors and limited cycle attractors with given transition map.
attractors = find_attractor(decStateTransMap)
print attractors
'''
'''
## to obtain biological sequence for the Fission Yeast Cell-Cycle Net starting from biological inital state
EDGE_FILE = 'C:\Boolean_Delay_in_Economics\Manny\EDGE_FILE.dat'
NODE_FILE = 'C:\Boolean_Delay_in_Economics\Manny\NODE_FILE.dat'
#BIO_INIT_FILE = '../data/fission-net/fission-net-bioSeq-initial.txt'
net = inet.read_network_from_file(EDGE_FILE, NODE_FILE)
nodes_list = inet.build_nodes_list(NODE_FILE)
bio_initStates = inet.read_init_from_file(BIO_INIT_FILE)
outputFile = 'C:\Boolean_Delay_in_Economics\Manny\Results\BDE-bioSeq.txt'
bioSeq = biological_sequence(net, nodes_list, bio_initStates, outputFile)
'''
if __name__=='__main__':
main()