Extremely small bindings to libykpers for communicating with a YubiKey over USB. The features are currently "whatever I need at the time." Feel free to make suggestions about what to do next. Here's approximately what it can do at the moment:
from ykpers import YubiKey
yk = YubiKey.open_first_key()
print 'yubikey {0.versionMajor}.{0.versionMinor}'.format(yk.get_status())
print 'slot 1:', yk.hmac_challenge_response('hi').encode('hex')
print 'slot 2:', yk.hmac_challenge_response('hi', slot=2).encode('hex')
Why not python-yubico?
It only runs on linux and reimplements what libykpers already does.