pip install tli
You will also need to create yourself some Twitter API keys that will be used by TLI. Head over to https://apps.twitter.com/app/new and create an application. Click the button to create access tokens and have them ready for the TLI setup.
Once the installation is complete, run TLI with tli. On first run, a configuratin file will be created to store the twitter authentication. I suggest you encrypt the config if at all possible.
$ tli timeline
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Twitter Line Interface
[*] Config file /home/bob/.tli.conf does not exist!
[*] Entering first time setup.
[*] TLI supports encryption configuration objects.
[*] If you *enable* encryption, you will have to type a password everytime you lauch TIL.
[*] Do you want to encrypt your config file? [y/N]: y
[q] Enter a passphrase:
[q] Confirm the passphrase:
[*] Ok, we need 5 things to get going.
[*] Make sure you have setup an app at https://apps.twitter.com/ first!tli timeline - Stream the users timeline
tli watch -t security,exploit - Stream tweets with specific words