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Expectation maximisation for concomitant variable NB models in python

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scde-scratch

Expectation maximisation for concomitant variable NB models in python

This python script implements a simplified version of 'Bayesian approach to single-cell differential expression analysis' (Nature Methods 2014), but from scratch (rather than using the FlexMix R package) and in python.

It essentially performs EM inference on a poisson-negative binomial model where the mixing distribution is dependent on each genes average expression (known as concomitant variable model or mixture of experts regression).

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Expectation maximisation for concomitant variable NB models in python

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