Flask Flask-SQLAlchemy Flask-Misaka Flask-Migrate

Just run web.py runserver. This runs the server on localhost, port 5000. To interface with the database you can use the web.py app as a module, as per these instructions.

When you make changes to the database model you can save them as Alembic revisions with web.py db migrate -m "* Some message". This creates migrations under migrations/versions which then can be applied to the database with web.py db upgrade.