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Validation of Olfactory Bulb Mitral Cell models with data from NeuroElectro.org using NeuronUnit framework

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MitralSuite - Objective Validation of Computational Neuroscience Models

Validation of Olfactory Bulb Mitral Cell models with data from NeuroElectro.org and using NeuronUnit framework.

CNS2016 Conference Slides

The copy of the presentation can be found here: Presentation

Requirements

  1. Ensure you have Python >=2.7, numpy, and matplotlib
  2. Install NEURON with Python interface ("import neuron" statement works)
  3. Install SciUnit and NeuronUnit
  4. Install iPython and Jupyter

Simple Model Example

Once you have all the requirements installed, you should be able to run a example that subjects a simple HH cell to a suite of tests.

Download this repository and run the following notebook in iPython: SimpleNeuronCellTests

Pooled Data from NeuroElectro Example

Once the simple model example is working, you can see how to obtain pooled experimental results from the NeuroElectro database.

The notebook with the steps for pooling: PooledPropertyValuesTest

Mitral Cell Experimental Data

The results obtained from pooling the experimental data for the mitral cells can be found in the following notebook: ExperimentalObservations

Mitral Cell Model Results

The results of subjecting the mitral cell models to the 6 tests can be found here: GetResultsSummary

The NEURON code for the 8 models that were prepared for the tests (to isolate the cells and remove external inputs) can be found in the following folder: Models

The results of running individual models can be found in the notebooks that follow the "AuthorYYYY" format. For example the results for the Bhalla & Bower (1993) model can be found at this notebook: BhallaBower1993

Issues and Contact

If you run into problems or bugs, please report them as Issues.

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Validation of Olfactory Bulb Mitral Cell models with data from NeuroElectro.org using NeuronUnit framework

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