MRTool (Meta-Regression Tool) package is designed to solve general meta-regression problem. The most common features include,

• linear and log prediction function,
• spline extension for covariates,
• direct Gaussian, Uniform and Laplace prior on fixed and random effects,
• shape constraints (monotonicity and convexity) for spline.

Advanced features include,

• spline knots ensemble,
• automatic covariate selection.

Required packages include,

• basic scientific computing suite, Numpy, Scipy and Pandas,
• main optimization engine, IPOPT,
• customized packages, LimeTr and XSpline,
• testing tool, Pytest.

After install the required packages, clone the repository and install MRTool.

git clone https://github.com/ihmeuw-msca/MRTool.git
cd MRTool && python setup.py install

For more information please check the documentation.