txJSON-RPC allows you to create async Python JSON-RPC servers and clients either over HTTP or directly on TCP with the Netstring protocol. txJSON-RPC is written in Twisted.

• Asynchronous JSON-RPC server and client code.
• Support for HTTP and TCP (Netstring) JSON-RPC.
• A jsonrpclib similar to the one for XLM-RPC offered by the Python standard library.