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Sequential Importance Sampling (SIS) method

♢ Developed a sequential Monte Carlo sampling method for constructing 3D chromatin fiber conformations for studying of long range gene regulation

  • Discovered spatial confinement as a major determinant of folding landscape of human chromosomes and genetic programming of cell
  • Explored the biological function of α-globin gene domain

♢ Requirement

  • boost library
  • eigen3 library
  • biopython
  • cmake
  • doxygen (optional)

♢ Build

  • cd build
  • cmake ..
  • make

<!—Partial code released—>

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