This is the readme file for my ACCN project. First objective:

• Verify Hay et al. and Larkum et al. neuron models:
  • Backpropagating APs
  • Firing response to current injection
  • Ca2+ spikes
  • Dendritic processing:
    • One NMDA spike in distal tuft branch can not reach treshold for Ca2+ spike in Ca2+ initiation zone, but two can (Larkum et al. 2009).
    • Small depolarizations near Ca2+ spike initiation zone enables NMDA spike in single tuft to evoke Ca2+ spikes (Larkum et al. 2009).

Second objective:

• How can effects of cannel blockers,
  • Fast Na+ blocker TTX
  • Calsium blocker Cadmium
  • Calsium blocker Nickel
  • I_h blocker ZD7288 and receptor blocker:
  • NMDA blocker AP5 best be introduced into the computational models.

Third objective:

• Can these effects be seen on any realistic/unrealistic MEA:
  • Backpropagating APs
  • Ca2+ spikes
  • Subtreshold current injection
  • Dendritic processing:
    • NMDA spikes in distal tuft
      • More than one at the time?
    • Depolarizations?
  • Changed channel densities
  • Other changed neuron parameters

Need to find/develop/adjust: - Find(/develop) good plotting tools for neural activity (Neuronvisio)