TADbit is a computational package that precesses and analyze Hi-C data to detect Topologically Associating Domain (TAD) borders. The TAD analysis performed in TADbit allows to:

1. identify conserved TAD borders
2. define sets of TADs sharing structural features
3. model the three-dimensional structures of selected TADs

Hi-C experiments generate genomic interaction between loci located in the same or in different chromosomes. TADbit is built around the concept of a chromosome, and uses it as a central item to store and compare different Hi-C experiments. The library has been designed to be used by researchers with no expertise in computer science. All-in-one scripts provided in TADbit allow to run the full analysis using one single command line; advanced users may produce their own programs using TADbit as a complementary library.

Current version: 0.1_alpha.114

• TADbit documentation
• Summary of TADbit classes and functions

Next TADbit training, CSDM14 Chromosome structure determination using modelling and Hi-C data, will take place at the Instituto Gulbenkian de Ciencia in Oeiras (Portugal) at the GTPB training programme from the Nov 25th to Nov 28th.

• September 6th 2014: TADbit: Automated Analysis and Three-Dimensional Modeling of Genomic Domains at ECCB14 Strasbourg (France)
• November 27th to November 29th 2013: CSDM 2013 at the GTPB training programme Oeiras (Portugal)