def get_snp_mask(self):
# keep sites that pass the snp prevalence threshold
# Together with self.general_mask, this filter should produce exactly the
# same sites as parse_midas_data.parse_snps
# Need to use the alt and depth arr again
alt_arr = da.from_zarr('{}/full_alt.zarr'.format(self.data_dir))
depth_arr = da.from_zarr('{}/full_depth.zarr'.format(self.data_dir))
# increase chunk size to reduce overhead
rechunked_alt_arr = alt_arr.rechunk((1000000, 10))
rechunked_depth_arr = depth_arr.rechunk((1000000, 10))
filtered_depth = rechunked_depth_arr[:, self.sample_mask]
filtered_alt = rechunked_alt_arr[:, self.sample_mask]
# Some snps need to be polarized according to pop_freqs
from plos_bio_scripts import calculate_snp_prevalences
population_freqs = calculate_snp_prevalences.parse_population_freqs(
self.species_name, polarize_by_consensus=False)
all_pop_freqs = np.array(
map(lambda x: population_freqs.get(x, 0),
zip(self.chromosomes, self.locations)))
sites_to_flip = all_pop_freqs > 0.5
# take care of sites need not polarize
round_1_mask = self.general_mask & np.invert(sites_to_flip)
alt_threshold = da.ceil(
filtered_depth[round_1_mask, :] * config.parse_snps_min_freq) + 0.5
passed_snp_mask1 = da.sum(
filtered_alt[round_1_mask, :] > alt_threshold, axis=1) > 0
# then flip alt
round_2_mask = self.general_mask & sites_to_flip
alt_threshold2 = da.ceil(
filtered_depth[round_2_mask, :] * config.parse_snps_min_freq) + 0.5
polarized_alts = filtered_depth[round_2_mask, :] - filtered_alt[
round_2_mask, :]
passed_snp_mask2 = da.sum(polarized_alts > alt_threshold2, axis=1) > 0
# perform dask computation
passed_snp_mask1 = passed_snp_mask1.compute()
passed_snp_mask2 = passed_snp_mask2.compute()
final_mask = self.general_mask.copy()
final_mask[self.general_mask
& np.invert(sites_to_flip)] = passed_snp_mask1
final_mask[self.general_mask & sites_to_flip] = passed_snp_mask2
print("%d sites left after applying snp filter" % np.sum(final_mask))
return final_mask[self.general_mask]
def searchdaskuniform(a0, step, n_a, v, how=None, atol=None):
index = (v - a0) / step
if how == 'nearest':
indexer = da.maximum(da.minimum(da.around(index), n_a - 1), 0)
elif how == 'bfill':
indexer = da.maximum(da.ceil(index), 0)
elif how == 'ffill':
indexer = da.minimum(da.floor(index), n_a - 1)
elif how is None:
indexer = da.ceil(index)
indexer = da.where(indexer != index, n_a, indexer)
if atol is not None:
indexer = da.where((da.absolute(indexer - index) * step > atol) |
(indexer < 0) | (indexer >= n_a), n_a, indexer)
else:
indexer = da.where((indexer < 0) | (indexer >= n_a), n_a, indexer)
return indexer.astype(int)
def test_arithmetic():
x = np.arange(5).astype('f4') + 2
y = np.arange(5).astype('i8') + 2
z = np.arange(5).astype('i4') + 2
a = da.from_array(x, chunks=(2,))
b = da.from_array(y, chunks=(2,))
c = da.from_array(z, chunks=(2,))
assert eq(a + b, x + y)
assert eq(a * b, x * y)
assert eq(a - b, x - y)
assert eq(a / b, x / y)
assert eq(b & b, y & y)
assert eq(b | b, y | y)
assert eq(b ^ b, y ^ y)
assert eq(a // b, x // y)
assert eq(a ** b, x ** y)
assert eq(a % b, x % y)
assert eq(a > b, x > y)
assert eq(a < b, x < y)
assert eq(a >= b, x >= y)
assert eq(a <= b, x <= y)
assert eq(a == b, x == y)
assert eq(a != b, x != y)
assert eq(a + 2, x + 2)
assert eq(a * 2, x * 2)
assert eq(a - 2, x - 2)
assert eq(a / 2, x / 2)
assert eq(b & True, y & True)
assert eq(b | True, y | True)
assert eq(b ^ True, y ^ True)
assert eq(a // 2, x // 2)
assert eq(a ** 2, x ** 2)
assert eq(a % 2, x % 2)
assert eq(a > 2, x > 2)
assert eq(a < 2, x < 2)
assert eq(a >= 2, x >= 2)
assert eq(a <= 2, x <= 2)
assert eq(a == 2, x == 2)
assert eq(a != 2, x != 2)
assert eq(2 + b, 2 + y)
assert eq(2 * b, 2 * y)
assert eq(2 - b, 2 - y)
assert eq(2 / b, 2 / y)
assert eq(True & b, True & y)
assert eq(True | b, True | y)
assert eq(True ^ b, True ^ y)
assert eq(2 // b, 2 // y)
assert eq(2 ** b, 2 ** y)
assert eq(2 % b, 2 % y)
assert eq(2 > b, 2 > y)
assert eq(2 < b, 2 < y)
assert eq(2 >= b, 2 >= y)
assert eq(2 <= b, 2 <= y)
assert eq(2 == b, 2 == y)
assert eq(2 != b, 2 != y)
assert eq(-a, -x)
assert eq(abs(a), abs(x))
assert eq(~(a == b), ~(x == y))
assert eq(~(a == b), ~(x == y))
assert eq(da.logaddexp(a, b), np.logaddexp(x, y))
assert eq(da.logaddexp2(a, b), np.logaddexp2(x, y))
assert eq(da.exp(b), np.exp(y))
assert eq(da.log(a), np.log(x))
assert eq(da.log10(a), np.log10(x))
assert eq(da.log1p(a), np.log1p(x))
assert eq(da.expm1(b), np.expm1(y))
assert eq(da.sqrt(a), np.sqrt(x))
assert eq(da.square(a), np.square(x))
assert eq(da.sin(a), np.sin(x))
assert eq(da.cos(b), np.cos(y))
assert eq(da.tan(a), np.tan(x))
assert eq(da.arcsin(b/10), np.arcsin(y/10))
assert eq(da.arccos(b/10), np.arccos(y/10))
assert eq(da.arctan(b/10), np.arctan(y/10))
assert eq(da.arctan2(b*10, a), np.arctan2(y*10, x))
assert eq(da.hypot(b, a), np.hypot(y, x))
assert eq(da.sinh(a), np.sinh(x))
assert eq(da.cosh(b), np.cosh(y))
assert eq(da.tanh(a), np.tanh(x))
assert eq(da.arcsinh(b*10), np.arcsinh(y*10))
assert eq(da.arccosh(b*10), np.arccosh(y*10))
assert eq(da.arctanh(b/10), np.arctanh(y/10))
assert eq(da.deg2rad(a), np.deg2rad(x))
assert eq(da.rad2deg(a), np.rad2deg(x))
assert eq(da.logical_and(a < 1, b < 4), np.logical_and(x < 1, y < 4))
assert eq(da.logical_or(a < 1, b < 4), np.logical_or(x < 1, y < 4))
assert eq(da.logical_xor(a < 1, b < 4), np.logical_xor(x < 1, y < 4))
assert eq(da.logical_not(a < 1), np.logical_not(x < 1))
assert eq(da.maximum(a, 5 - a), np.maximum(a, 5 - a))
assert eq(da.minimum(a, 5 - a), np.minimum(a, 5 - a))
assert eq(da.fmax(a, 5 - a), np.fmax(a, 5 - a))
assert eq(da.fmin(a, 5 - a), np.fmin(a, 5 - a))
assert eq(da.isreal(a + 1j * b), np.isreal(x + 1j * y))
assert eq(da.iscomplex(a + 1j * b), np.iscomplex(x + 1j * y))
assert eq(da.isfinite(a), np.isfinite(x))
assert eq(da.isinf(a), np.isinf(x))
assert eq(da.isnan(a), np.isnan(x))
assert eq(da.signbit(a - 3), np.signbit(x - 3))
assert eq(da.copysign(a - 3, b), np.copysign(x - 3, y))
assert eq(da.nextafter(a - 3, b), np.nextafter(x - 3, y))
assert eq(da.ldexp(c, c), np.ldexp(z, z))
assert eq(da.fmod(a * 12, b), np.fmod(x * 12, y))
assert eq(da.floor(a * 0.5), np.floor(x * 0.5))
assert eq(da.ceil(a), np.ceil(x))
assert eq(da.trunc(a / 2), np.trunc(x / 2))
assert eq(da.degrees(b), np.degrees(y))
assert eq(da.radians(a), np.radians(x))
assert eq(da.rint(a + 0.3), np.rint(x + 0.3))
assert eq(da.fix(a - 2.5), np.fix(x - 2.5))
assert eq(da.angle(a + 1j), np.angle(x + 1j))
assert eq(da.real(a + 1j), np.real(x + 1j))
assert eq((a + 1j).real, np.real(x + 1j))
assert eq(da.imag(a + 1j), np.imag(x + 1j))
assert eq((a + 1j).imag, np.imag(x + 1j))
assert eq(da.conj(a + 1j * b), np.conj(x + 1j * y))
assert eq((a + 1j * b).conj(), (x + 1j * y).conj())
assert eq(da.clip(b, 1, 4), np.clip(y, 1, 4))
assert eq(da.fabs(b), np.fabs(y))
assert eq(da.sign(b - 2), np.sign(y - 2))
l1, l2 = da.frexp(a)
r1, r2 = np.frexp(x)
assert eq(l1, r1)
assert eq(l2, r2)
l1, l2 = da.modf(a)
r1, r2 = np.modf(x)
assert eq(l1, r1)
assert eq(l2, r2)
assert eq(da.around(a, -1), np.around(x, -1))
def test_arithmetic():
x = np.arange(5).astype('f4') + 2
y = np.arange(5).astype('i8') + 2
z = np.arange(5).astype('i4') + 2
a = da.from_array(x, chunks=(2, ))
b = da.from_array(y, chunks=(2, ))
c = da.from_array(z, chunks=(2, ))
assert eq(a + b, x + y)
assert eq(a * b, x * y)
assert eq(a - b, x - y)
assert eq(a / b, x / y)
assert eq(b & b, y & y)
assert eq(b | b, y | y)
assert eq(b ^ b, y ^ y)
assert eq(a // b, x // y)
assert eq(a**b, x**y)
assert eq(a % b, x % y)
assert eq(a > b, x > y)
assert eq(a < b, x < y)
assert eq(a >= b, x >= y)
assert eq(a <= b, x <= y)
assert eq(a == b, x == y)
assert eq(a != b, x != y)
assert eq(a + 2, x + 2)
assert eq(a * 2, x * 2)
assert eq(a - 2, x - 2)
assert eq(a / 2, x / 2)
assert eq(b & True, y & True)
assert eq(b | True, y | True)
assert eq(b ^ True, y ^ True)
assert eq(a // 2, x // 2)
assert eq(a**2, x**2)
assert eq(a % 2, x % 2)
assert eq(a > 2, x > 2)
assert eq(a < 2, x < 2)
assert eq(a >= 2, x >= 2)
assert eq(a <= 2, x <= 2)
assert eq(a == 2, x == 2)
assert eq(a != 2, x != 2)
assert eq(2 + b, 2 + y)
assert eq(2 * b, 2 * y)
assert eq(2 - b, 2 - y)
assert eq(2 / b, 2 / y)
assert eq(True & b, True & y)
assert eq(True | b, True | y)
assert eq(True ^ b, True ^ y)
assert eq(2 // b, 2 // y)
assert eq(2**b, 2**y)
assert eq(2 % b, 2 % y)
assert eq(2 > b, 2 > y)
assert eq(2 < b, 2 < y)
assert eq(2 >= b, 2 >= y)
assert eq(2 <= b, 2 <= y)
assert eq(2 == b, 2 == y)
assert eq(2 != b, 2 != y)
assert eq(-a, -x)
assert eq(abs(a), abs(x))
assert eq(~(a == b), ~(x == y))
assert eq(~(a == b), ~(x == y))
assert eq(da.logaddexp(a, b), np.logaddexp(x, y))
assert eq(da.logaddexp2(a, b), np.logaddexp2(x, y))
assert eq(da.exp(b), np.exp(y))
assert eq(da.log(a), np.log(x))
assert eq(da.log10(a), np.log10(x))
assert eq(da.log1p(a), np.log1p(x))
assert eq(da.expm1(b), np.expm1(y))
assert eq(da.sqrt(a), np.sqrt(x))
assert eq(da.square(a), np.square(x))
assert eq(da.sin(a), np.sin(x))
assert eq(da.cos(b), np.cos(y))
assert eq(da.tan(a), np.tan(x))
assert eq(da.arcsin(b / 10), np.arcsin(y / 10))
assert eq(da.arccos(b / 10), np.arccos(y / 10))
assert eq(da.arctan(b / 10), np.arctan(y / 10))
assert eq(da.arctan2(b * 10, a), np.arctan2(y * 10, x))
assert eq(da.hypot(b, a), np.hypot(y, x))
assert eq(da.sinh(a), np.sinh(x))
assert eq(da.cosh(b), np.cosh(y))
assert eq(da.tanh(a), np.tanh(x))
assert eq(da.arcsinh(b * 10), np.arcsinh(y * 10))
assert eq(da.arccosh(b * 10), np.arccosh(y * 10))
assert eq(da.arctanh(b / 10), np.arctanh(y / 10))
assert eq(da.deg2rad(a), np.deg2rad(x))
assert eq(da.rad2deg(a), np.rad2deg(x))
assert eq(da.logical_and(a < 1, b < 4), np.logical_and(x < 1, y < 4))
assert eq(da.logical_or(a < 1, b < 4), np.logical_or(x < 1, y < 4))
assert eq(da.logical_xor(a < 1, b < 4), np.logical_xor(x < 1, y < 4))
assert eq(da.logical_not(a < 1), np.logical_not(x < 1))
assert eq(da.maximum(a, 5 - a), np.maximum(a, 5 - a))
assert eq(da.minimum(a, 5 - a), np.minimum(a, 5 - a))
assert eq(da.fmax(a, 5 - a), np.fmax(a, 5 - a))
assert eq(da.fmin(a, 5 - a), np.fmin(a, 5 - a))
assert eq(da.isreal(a + 1j * b), np.isreal(x + 1j * y))
assert eq(da.iscomplex(a + 1j * b), np.iscomplex(x + 1j * y))
assert eq(da.isfinite(a), np.isfinite(x))
assert eq(da.isinf(a), np.isinf(x))
assert eq(da.isnan(a), np.isnan(x))
assert eq(da.signbit(a - 3), np.signbit(x - 3))
assert eq(da.copysign(a - 3, b), np.copysign(x - 3, y))
assert eq(da.nextafter(a - 3, b), np.nextafter(x - 3, y))
assert eq(da.ldexp(c, c), np.ldexp(z, z))
assert eq(da.fmod(a * 12, b), np.fmod(x * 12, y))
assert eq(da.floor(a * 0.5), np.floor(x * 0.5))
assert eq(da.ceil(a), np.ceil(x))
assert eq(da.trunc(a / 2), np.trunc(x / 2))
assert eq(da.degrees(b), np.degrees(y))
assert eq(da.radians(a), np.radians(x))
assert eq(da.rint(a + 0.3), np.rint(x + 0.3))
assert eq(da.fix(a - 2.5), np.fix(x - 2.5))
assert eq(da.angle(a + 1j), np.angle(x + 1j))
assert eq(da.real(a + 1j), np.real(x + 1j))
assert eq((a + 1j).real, np.real(x + 1j))
assert eq(da.imag(a + 1j), np.imag(x + 1j))
assert eq((a + 1j).imag, np.imag(x + 1j))
assert eq(da.conj(a + 1j * b), np.conj(x + 1j * y))
assert eq((a + 1j * b).conj(), (x + 1j * y).conj())
assert eq(da.clip(b, 1, 4), np.clip(y, 1, 4))
assert eq(da.fabs(b), np.fabs(y))
assert eq(da.sign(b - 2), np.sign(y - 2))
l1, l2 = da.frexp(a)
r1, r2 = np.frexp(x)
assert eq(l1, r1)
assert eq(l2, r2)
l1, l2 = da.modf(a)
r1, r2 = np.modf(x)
assert eq(l1, r1)
assert eq(l2, r2)
assert eq(da.around(a, -1), np.around(x, -1))