#Erev, tau1, tau2 (SI units)
#C is concentration of Mg, A is 1/eta and B is 1/gamma,
#Rebekah's:
#These params are too insensitive to voltage
#mgparams={'A':(1/18.0), 'B':(1/99.0), 'C': 1.4}
#Classic (allows significant calcium at resting potential):
#mgparams={'A':(1/3.57), 'B':(1/62.0), 'C': 1.4}
#Intermediate
desenYN = 0
_NMDA_MgParams = MgParams(A=1 / 18.0, B=1 / 99.0, C=1.4)
#Sriram uses 0.109e-9 for AMPA and 0.9e-9 for Gaba
_SynGaba = SynChannelParams(Erev=-60e-3,
tau1=0.25e-3,
tau2=3.75e-3,
Gbar=0.2e-9,
nmdaCaFrac=0.0,
var=0.05)
SynGabaNPY = SynChannelParams(
Erev=-60e-3, #NPY
tau1=0.25e-3,
tau2=80.75e-3,
Gbar=0.5e-9,
nmdaCaFrac=0.0,
var=0.05)
_SynAMPA = SynChannelParams(Erev=5e-3,
tau1=1.1e-3,
tau2=2.0e-3,
Gbar=2e-9,
#Parameters for synpases (SI units):
#Erev (Volts), tau1 & tau2 (sec)
#Gbar units: Siemens/meter squared
#C is concentration of Mg in mM, A is 1/eta and B is 1/gamma,
#These params are too insensitive to voltage
#mgparams={'A':(1/18.0), 'B':(1/99.0), 'C': 1.4}
#Classic (allows significant calcium at resting potential):
#mgparams={'A':(1/3.57), 'B':(1/62.0), 'C': 1.4}
#Intermediate
_NMDA_MgParams = MgParams(A=1 / 6.0, B=1 / 80.0, C=1.4)
#Lavian Eur J Neurosci: Egaba=-75 mV, amp ~1mV at -60 mV
_SynGaba = SynChannelParams(Erev=-75e-3,
tau1=0.5e-3,
tau2=10e-3,
Gbar=0.25e-9,
var=0.05)
#may need two time constants of decay to match Lavian
#Use 1.5e-9 for str and 3e-9 for GPe?
_SynAMPA = SynChannelParams(Erev=0,
tau1=1e-3,
tau2=3e-3,
Gbar=0.15e-9,
var=0.05,
spinic=True)
_SynNMDA = SynChannelParams(Erev=0,
tau1=10e-3,
tau2=30e-3,
Gbar=0.252e-9,
var=0.05,
#Parameters for inhibitory synpases:
#Erev, tau1, tau2 (SI units)
#C is concentration of Mg, A is 1/eta and B is 1/gamma,
#Rebekah's:
#These params are too insensitive to voltage
#mgparams={'A':(1/18.0), 'B':(1/99.0), 'C': 1.4}
#Classic (allows significant calcium at resting potential):
#mgparams={'A':(1/3.57), 'B':(1/62.0), 'C': 1.4}
#Intermediate
_NMDA_MgParams = MgParams(A=1 / 6.0, B=1 / 80.0, C=1.4)
#Sriram uses 0.109e-9 for AMPA and 0.9e-9 for Gaba
_SynGaba = SynChannelParams(Erev=-60e-3,
tau1=0.25e-3,
tau2=3.75e-3,
Gbar=0.2e-9,
var=0.05)
_SynAMPA = SynChannelParams(Erev=5e-3,
tau1=1.1e-3,
tau2=5.75e-3,
Gbar=2e-9,
var=0.05,
spinic=True)
_SynNMDA = SynChannelParams(Erev=5e-3,
tau1=1.1e-3,
tau2=37.5e-3,
Gbar=2e-9,
var=0.05,
MgBlock=_NMDA_MgParams,
spinic=True,
#C is concentration of Mg, A is 1/eta and B is 1/gamma,
#Rebekah's:
#These params are too insensitive to voltage
#mgparams={'A':(1/18.0), 'B':(1/99.0), 'C': 1.4}
#Classic (allows significant calcium at resting potential):
#mgparams={'A':(1/3.57), 'B':(1/62.0), 'C': 1.4}
#Intermediate
desenYN = 0
_NMDA_MgParams = MgParams(A=1 / 18.0, B=1 / 99.0, C=1.4)
#Sriram uses 0.109e-9 for AMPA and 0.9e-9 for Gaba
#-70e-3 is 10 mV lower than measured, accounting for junction potential
_SynGaba = SynChannelParams(Erev=-70e-3,
tau1=0.25e-3,
tau2=3.75e-3,
Gbar=0.25e-9,
nmdaCaFrac=0.0,
var=0.05)
_SynGaba2 = SynChannelParams(Erev=-75e-3,
tau1=0.25e-3,
tau2=3.75e-3,
Gbar=0.25e-9,
nmdaCaFrac=0.0,
var=0.05)
_SynAMPA = SynChannelParams(Erev=0e-3,
tau1=1.1e-3,
tau2=2.0e-3,
Gbar=0.15e-9,
var=0.05,
#C is concentration of Mg, A is 1/eta and B is 1/gamma,
#Rebekah's:
#These params are too insensitive to voltage
#mgparams={'A':(1/18.0), 'B':(1/99.0), 'C': 1.4}
#Classic (allows significant calcium at resting potential):
#mgparams={'A':(1/3.57), 'B':(1/62.0), 'C': 1.4}
#Intermediate
desenYN = 0
__NMDA_MgParams = MgParams(A=1 / 18.0, B=1 / 99.0, C=1.4)
#Sriram uses 0.109e-9 for AMPA and 0.9e-9 for Gaba
#Dieter Jaeger uses 0.25e-9 for gaba
_SynGaba = SynChannelParams(Erev=-70e-3,
tau1=1.33e-3,
tau2=4e-3,
Gbar=0.25e-9,
var=0.05)
_SynAMPA = SynChannelParams(Erev=5e-3,
tau1=1e-3,
tau2=3e-3,
Gbar=0.15e-9,
var=0.05,
spinic=True)
#nmdaCaFra fraction of nmda current carried by calcium
#Note that since Ca reversal produces ~2x driving potential,
#need to make this half of typical value. Default is 0.02 in Moose
SYNAPSE_TYPES = NamedDict(
'SYNAPSE_TYPES',
#C is concentration of Mg, A is 1/eta and B is 1/gamma,
#Rebekah's:
#These params are too insensitive to voltage
#mgparams={'A':(1/18.0), 'B':(1/99.0), 'C': 1.4}
#Classic (allows significant calcium at resting potential):
#mgparams={'A':(1/3.57), 'B':(1/62.0), 'C': 1.4}
#Intermediate
desenYN = 0
_NMDA_MgParams = MgParams(A=1 / 18.0, B=1 / 99.0, C=1.4)
#Sriram uses 0.109e-9 for AMPA and 0.9e-9 for Gaba
_SynGaba = SynChannelParams(
Erev=-60e-3,
tau1=1.33e-3,
tau2=4e-3,
Gbar=0.5e-10, #or 1.2 (from p file)
nmdaCaFrac=0.0,
var=0.05)
_SynAMPA = SynChannelParams(
Erev=5e-3,
tau1=1e-3, #or 0.67e-3
tau2=3.0e-3, #or 2e-3
Gbar=2e-9, #or 0.8 (from p file)
var=0.05,
nmdaCaFrac=0.0)
#nmdaCaFra fraction of nmda current carried by calcium
#Note that since Ca reversal produces ~2x driving potential,
#need to make this half of typical value. Default is 0.02 in Moose