def divideData(filename, direct, num=5, mph=3, delet=True):
print "Estimating heritability using " + str(num) + " components"
[yFil, sFil] = getData(filename, mph=mph)
n = sFil.iid_count
reOrd = perm(n)
yFil = yFil[reOrd, :]
sFil = sFil[reOrd, :]
div = [int(math.ceil(i * n / float(num))) for i in range(0, num + 1)]
varEsts = []
for i in range(0, num):
print "For component " + str(i)
sFilTemp = sFil[div[i]:div[i + 1], :]
yFilTemp = yFil[div[i]:div[i + 1], :]
fileTemp = direct + "/tempFile_" + str(i)
Bed.write(fileTemp, sFilTemp.read())
Pheno.write(fileTemp + ".phen", yFilTemp.read())
varEsts.append(varRes(fileTemp, direct))
if delet:
os.system("rm " + direct + "/tempFile_" + str(i) + "*")
return varEsts
def test_c_reader_pheno(self):
snpdata1 = Pheno(self.currentFolder + "/examples/toydata.phe").read()
self.assertEqual(np.float64, snpdata1.val.dtype)
snpdata1.val[1,0] = np.NaN # Inject a missing value to test writing and reading missing values
output = "tempdir/snpreader/toydata.phe"
create_directory_if_necessary(output)
Pheno.write(output, snpdata1)
snpreader = Pheno(output)
_fortesting_JustCheckExists().input(snpreader)
s = str(snpreader)
snpdata2 = snpreader.read()
np.testing.assert_array_almost_equal(snpdata1.val, snpdata2.val, decimal=10)
snpdata1 = Pheno(self.currentFolder + "/examples/toydata.phe").read()
import pysnptools.util.pheno as pstpheno
dict = pstpheno.loadOnePhen(self.currentFolder + "/examples/toydata.phe",missing="")
snpdata3 = Pheno(dict).read()
np.testing.assert_array_almost_equal(snpdata1.val, snpdata3.val, decimal=10)
dict = pstpheno.loadOnePhen(self.currentFolder + "/examples/toydata.phe",missing="",vectorize=True)
assert len(dict['vals'].shape)==1, "test 1-d array of values"
snpdata3 = Pheno(dict).read()
np.testing.assert_array_almost_equal(snpdata1.val, snpdata3.val, decimal=10)
snpdata4 = Pheno(None,iid_if_none=snpdata1.iid)
assert (snpdata4.row == snpdata1.row).all() and snpdata4.col_count == 0
snpdata5 = Pheno(self.currentFolder + "/examples/toydata.id.phe").read()
np.testing.assert_array_almost_equal(snpdata1.val, snpdata5.val, decimal=10)
snpdata6 = Pheno(self.currentFolder + "/examples/toydata.fid.phe").read()
np.testing.assert_array_almost_equal(snpdata1.val, snpdata6.val, decimal=10)
def divideData(filename,direct,num=5,mph=3,delet=True):
print "Estimating heritability using "+str(num)+" components"
[yFil,sFil]=getData(filename,mph=mph);
n=sFil.iid_count
reOrd=perm(n);
yFil=yFil[reOrd,:];
sFil=sFil[reOrd,:];
div=[int(math.ceil( i*n/float(num) )) for i in range(0,num+1)];
varEsts=[];
for i in range(0,num):
print "For component "+str(i);
sFilTemp=sFil[div[i]:div[i+1],:];
yFilTemp=yFil[div[i]:div[i+1],:];
fileTemp=direct+"/tempFile_"+str(i);
Bed.write(fileTemp,sFilTemp.read());
Pheno.write(fileTemp+".phen",yFilTemp.read())
varEsts.append(varRes(fileTemp,direct));
if delet:
os.system("rm "+direct+"/tempFile_"+str(i)+"*");
return varEsts;
def _sel_plus_pc(self, h2, force_low_rank, force_full_rank, count_A1=None):
do_plot = False
use_cache = False
# define file names
bed_fn = self.pythonpath + "/tests/datasets/synth/all.bed"
phen_fn = self.pythonpath + "/tests/datasets/synth/pheno_10_causals.txt"
pcs_fn = os.path.join(self.tempout_dir, "sel_plus_pc.pcs.txt")
if not (use_cache and os.path.exists(pcs_fn)):
from fastlmm.util import compute_auto_pcs
covar = compute_auto_pcs(bed_fn, count_A1=count_A1)
logging.info("selected number of PCs: {0}".format(
covar["vals"].shape[1]))
Pheno.write(
pcs_fn,
SnpData(iid=covar['iid'],
sid=covar['header'],
val=covar['vals']))
else:
logging.info("Using top pcs's cache")
covar = Pheno(pcs_fn)
mf_name = "lmp" #"lmpl" "local", "coreP", "nodeP", "socketP", "nodeE", "lmp"
runner = mf_to_runner_function(mf_name)(20)
logging.info(
"Working on h2={0},force_low_rank={1},force_full_rank={2}".format(
h2, force_low_rank, force_full_rank))
result_file_name = "sel_plus_pc_{0}".format("h2IsHalf" if h2 ==
.5 else "h2Search")
output_file_name = os.path.join(self.tempout_dir,
result_file_name) + ".txt"
results = single_snp_select(test_snps=bed_fn,
G=bed_fn,
pheno=phen_fn,
k_list=[
0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 20,
30, 40, 50, 60, 70, 80, 90, 100, 125,
160, 200, 250, 320, 400, 500, 630, 800,
1000
],
h2=h2,
n_folds=self.pythonpath +
"/tests/datasets/synth/DebugEmitFolds.txt",
covar=covar,
output_file_name=output_file_name,
force_low_rank=force_low_rank,
force_full_rank=force_full_rank,
GB_goal=2,
count_A1=False
#runner = runner
)
logging.info(results.head())
self.compare_files(results, result_file_name)
def test_c_reader_pheno(self):
snpdata1 = Pheno(self.currentFolder + "/examples/toydata.phe").read()
self.assertEqual(np.float64, snpdata1.val.dtype)
snpdata1.val[
1,
0] = np.NaN # Inject a missing value to test writing and reading missing values
output = "tempdir/snpreader/toydata.phe"
create_directory_if_necessary(output)
Pheno.write(output, snpdata1)
snpreader = Pheno(output)
_fortesting_JustCheckExists().input(snpreader)
s = str(snpreader)
snpdata2 = snpreader.read()
np.testing.assert_array_almost_equal(snpdata1.val,
snpdata2.val,
decimal=10)
snpdata1 = Pheno(self.currentFolder + "/examples/toydata.phe").read()
import pysnptools.util.pheno as pstpheno
dict = pstpheno.loadOnePhen(self.currentFolder +
"/examples/toydata.phe",
missing="")
snpdata3 = Pheno(dict).read()
np.testing.assert_array_almost_equal(snpdata1.val,
snpdata3.val,
decimal=10)
dict = pstpheno.loadOnePhen(self.currentFolder +
"/examples/toydata.phe",
missing="",
vectorize=True)
assert len(dict['vals'].shape) == 1, "test 1-d array of values"
snpdata3 = Pheno(dict).read()
np.testing.assert_array_almost_equal(snpdata1.val,
snpdata3.val,
decimal=10)
snpdata4 = Pheno(None, iid_if_none=snpdata1.iid)
assert (snpdata4.row == snpdata1.row).all() and snpdata4.col_count == 0
snpdata5 = Pheno(self.currentFolder +
"/examples/toydata.id.phe").read()
np.testing.assert_array_almost_equal(snpdata1.val,
snpdata5.val,
decimal=10)
snpdata6 = Pheno(self.currentFolder +
"/examples/toydata.fid.phe").read()
np.testing.assert_array_almost_equal(snpdata1.val,
snpdata6.val,
decimal=10)
def _sel_plus_pc(self,h2,force_low_rank,force_full_rank,count_A1=None):
do_plot = False
use_cache = False
# define file names
bed_fn = self.pythonpath + "/tests/datasets/synth/all.bed"
phen_fn = self.pythonpath + "/tests/datasets/synth/pheno_10_causals.txt"
pcs_fn = os.path.join(self.tempout_dir,"sel_plus_pc.pcs.txt")
if not (use_cache and os.path.exists(pcs_fn)):
from fastlmm.util import compute_auto_pcs
covar = compute_auto_pcs(bed_fn,count_A1=count_A1)
logging.info("selected number of PCs: {0}".format(covar["vals"].shape[1]))
Pheno.write(pcs_fn,SnpData(iid=covar['iid'],sid=covar['header'],val=covar['vals']))
else:
logging.info("Using top pcs's cache")
covar=Pheno(pcs_fn)
mf_name = "lmp" #"lmpl" "local", "coreP", "nodeP", "socketP", "nodeE", "lmp"
runner = mf_to_runner_function(mf_name)(20)
logging.info("Working on h2={0},force_low_rank={1},force_full_rank={2}".format(h2,force_low_rank,force_full_rank))
result_file_name = "sel_plus_pc_{0}".format("h2IsHalf" if h2 == .5 else "h2Search")
output_file_name = os.path.join(self.tempout_dir,result_file_name)+".txt"
results = single_snp_select(test_snps=bed_fn, G=bed_fn, pheno=phen_fn,
k_list = [0,1,2,3,4,5,6,7,8,9,10,20,30,40,50,60,70,80,90,100,125,160,200,250,320,400,500,630,800,1000],
h2=h2,
n_folds = self.pythonpath + "/tests/datasets/synth/DebugEmitFolds.txt",
covar=covar,
output_file_name=output_file_name,
force_low_rank=force_low_rank,force_full_rank=force_full_rank,
GB_goal=2,
count_A1=False
#runner = runner
)
logging.info(results.head())
self.compare_files(results,result_file_name)
from pysnptools.snpreader import Pheno
phenoreader = Pheno("pheno_10_causals.txt")
print phenoreader, phenoreader.iid_count, phenoreader.sid_count, phenoreader.sid, phenoreader.pos
#Pheno('pheno_10_causals.txt') 500 1 ['pheno0'] [[ nan nan nan]]
phenodata = phenoreader.read()
print phenodata.val
#[[ 4.85339514e-01]
# [ -2.07698457e-01]
# [ 1.49090841e+00]
# [ -1.21289967e+00]
# ...
# Write 1st 10 iids and sids of Bed data into Pheno format
snpdata1010 = Bed("all.bed")[:10, :10].read()
Pheno.write("deleteme1010.txt", snpdata1010)
#Write it to Bed format
Bed.write("deleteme1010.bed", snpdata1010)
# Create a snpdata on the fly and write to Bed
snpdata1 = SnpData(iid=[['f1', 'c1'], ['f1', 'c2'], ['f2', 'c1']],
sid=['snp1', 'snp2'],
val=[[0, 1], [2, 1], [1, np.nan]])
Bed.write("deleteme1.bed", snpdata1)
#Pheno is slow because its txt. Bed format can only hold 0,1,2,missing.
# Use SnpNpz for fastest read/write times, smallest file size
from pysnptools.snpreader import SnpNpz
SnpNpz.write("deleteme1010.snp.npz", snpdata1010)
from pysnptools.snpreader import Pheno
phenoreader = Pheno("pheno_10_causals.txt")
print phenoreader, phenoreader.iid_count, phenoreader.sid_count, phenoreader.sid, phenoreader.pos
#Pheno('pheno_10_causals.txt') 500 1 ['pheno0'] [[ nan nan nan]]
phenodata = phenoreader.read()
print phenodata.val
#[[ 4.85339514e-01]
# [ -2.07698457e-01]
# [ 1.49090841e+00]
# [ -1.21289967e+00]
# ...
# Write 1st 10 iids and sids of Bed data into Pheno format
snpdata1010 = Bed("all.bed")[:10,:10].read()
Pheno.write("deleteme1010.txt",snpdata1010)
#Write it to Bed format
Bed.write("deleteme1010.bed",snpdata1010)
# Create a snpdata on the fly and write to Bed
snpdata1 = SnpData(iid=[['f1','c1'],['f1','c2'],['f2','c1']],sid=['snp1','snp2'],val=[[0,1],[2,1],[1,np.nan]])
Bed.write("deleteme1.bed",snpdata1)
#Pheno is slow because its txt. Bed format can only hold 0,1,2,missing.
# Use SnpNpz for fastest read/write times, smallest file size
from pysnptools.snpreader import SnpNpz
SnpNpz.write("deleteme1010.snp.npz", snpdata1010)
# Use SnpHdf5 for random-access reads, good speed and size, and compatiblity outside Python
