def __init__(self, schema, paths, key, intervals):
assert (key is None) == (intervals is None)
self.schema = schema
self.paths = paths
self.key = key
if intervals is not None:
t = hl.expr.impute_type(intervals)
if not isinstance(t, hl.tarray) and not isinstance(
t.element_type, hl.tinterval):
raise TypeError("'intervals' must be an array of tintervals")
pt = t.element_type.point_type
if isinstance(pt, hl.tstruct):
self._interval_type = t
else:
self._interval_type = hl.tarray(
hl.tinterval(hl.tstruct(__point=pt)))
if intervals is not None and t != self._interval_type:
self.intervals = [
hl.Interval(hl.Struct(__point=i.start),
hl.Struct(__point=i.end), i.includes_start,
i.includes_end) for i in intervals
]
else:
self.intervals = intervals
def generate_5_sample_vds():
paths = [
os.path.join(resource('gvcfs'), '1kg_chr22', path) for path in [
'HG00187.hg38.g.vcf.gz', 'HG00190.hg38.g.vcf.gz',
'HG00308.hg38.g.vcf.gz', 'HG00313.hg38.g.vcf.gz',
'HG00320.hg38.g.vcf.gz'
]
]
parts = [
hl.Interval(start=hl.Struct(
locus=hl.Locus('chr22', 1, reference_genome='GRCh38')),
end=hl.Struct(locus=hl.Locus(
'chr22',
hl.get_reference('GRCh38').contig_length('chr22') - 1,
reference_genome='GRCh38')),
includes_end=True)
]
vcfs = hl.import_gvcfs(paths,
parts,
reference_genome='GRCh38',
array_elements_required=False)
to_keep = defined_entry_fields(
vcfs[0].filter_rows(hl.is_defined(vcfs[0].info.END)), 100_000)
vds = hl.vds.combiner.combine_variant_datasets(
[hl.vds.combiner.transform_gvcf(mt, to_keep) for mt in vcfs])
vds.variant_data = vds.variant_data._key_rows_by_assert_sorted(
'locus', 'alleles')
vds.write(os.path.join(resource('vds'), '1kg_chr22_5_samples.vds'),
overwrite=True)
def test_aggregate(self):
vds = self.get_vds()
vds = vds.annotate_globals(foo=5)
vds = vds.annotate_rows(x1=agg.count())
vds = vds.annotate_cols(y1=agg.count())
vds = vds.annotate_entries(z1=vds.DP)
qv = vds.aggregate_rows(agg.count())
qs = vds.aggregate_cols(agg.count())
qg = vds.aggregate_entries(agg.count())
self.assertIsNotNone(vds.aggregate_entries(hl.agg.take(vds.s, 1)[0]))
self.assertEqual(qv, 346)
self.assertEqual(qs, 100)
self.assertEqual(qg, qv * qs)
qvs = vds.aggregate_rows(
hl.Struct(x=agg.collect(vds.locus.contig), y=agg.collect(vds.x1)))
qss = vds.aggregate_cols(
hl.Struct(x=agg.collect(vds.s), y=agg.collect(vds.y1)))
qgs = vds.aggregate_entries(
hl.Struct(x=agg.collect(agg.filter(False, vds.y1)),
y=agg.collect(agg.filter(hl.rand_bool(0.1), vds.GT))))
def test_annotate_globals(self):
mt = hl.utils.range_matrix_table(1, 1)
ht = hl.utils.range_table(1, 1)
data = [(5, hl.tint, operator.eq),
(float('nan'), hl.tfloat32, lambda x, y: str(x) == str(y)),
(float('inf'), hl.tfloat64, lambda x, y: str(x) == str(y)),
(float('-inf'), hl.tfloat64, lambda x, y: str(x) == str(y)),
(1.111, hl.tfloat64, operator.eq),
([
hl.Struct(**{
'a': None,
'b': 5
}),
hl.Struct(**{
'a': 'hello',
'b': 10
})
], hl.tarray(hl.tstruct(a=hl.tstr, b=hl.tint)), operator.eq)]
for x, t, f in data:
self.assertTrue(
f(mt.annotate_globals(foo=hl.literal(x, t)).foo.value, x),
f"{x}, {t}")
self.assertTrue(
f(ht.annotate_globals(foo=hl.literal(x, t)).foo.value, x),
f"{x}, {t}")
def collect_mappings_and_precomputed(selected):
mapping_per_geom = []
precomputes = {}
for geom_idx, geom in enumerate(self.geoms):
geom_label = make_geom_label(geom_idx)
combined_mapping = selected["figure_mapping"].annotate(
**selected[geom_label])
for key in combined_mapping:
if key in self.scales:
combined_mapping = combined_mapping.annotate(
**{
key:
self.scales[key].transform_data(
combined_mapping[key])
})
mapping_per_geom.append(combined_mapping)
precomputes[geom_label] = geom.get_stat().get_precomputes(
combined_mapping)
# Is there anything to precompute?
should_precompute = any(
[len(precompute) > 0 for precompute in precomputes.values()])
if should_precompute:
precomputed = selected.aggregate(hl.struct(**precomputes))
else:
precomputed = hl.Struct(
**{key: hl.Struct()
for key in precomputes.keys()})
return mapping_per_geom, precomputed
def test_maximal_independent_set_on_floats(self):
t = hl.utils.range_table(1).annotate(l=hl.struct(s="a", x=3.0),
r=hl.struct(s="b", x=2.82))
expected = [hl.Struct(node=hl.Struct(s="a", x=3.0))]
actual = hl.maximal_independent_set(
t.l, t.r, keep=False,
tie_breaker=lambda l, r: l.x - r.x).collect()
assert actual == expected
def test_filter_intervals_compound_partition_key(self):
ds = hl.import_vcf(resource('sample.vcf'), min_partitions=20)
ds = (ds.annotate_rows(variant=hl.struct(locus=ds.locus, alleles=ds.alleles))
.key_rows_by('locus', 'alleles'))
intervals = [hl.Interval(hl.Struct(locus=hl.Locus('20', 10639222), alleles=['A', 'T']),
hl.Struct(locus=hl.Locus('20', 10644700), alleles=['A', 'T']))]
self.assertEqual(hl.filter_intervals(ds, intervals).count_rows(), 3)
def read(fname: str) -> 'DNDArray':
# read without good partitioning, just to get the globals
a = DNDArray(hl.read_table(fname))
t = hl.read_table(fname, _intervals=[
hl.Interval(hl.Struct(r=i, c=j),
hl.Struct(r=i, c=j + 1))
for i in range(a.n_block_rows)
for j in range(a.n_block_cols)])
return DNDArray(t)
def test_aggregate_by_key_partitioning(self):
ht1 = hl.Table.parallelize([
{'k': 'foo', 'b': 1},
{'k': 'bar', 'b': 2},
{'k': 'bar', 'b': 2}],
hl.tstruct(k=hl.tstr, b=hl.tint32),
key='k')
self.assertEqual(
set(ht1.group_by('k').aggregate(mean_b = hl.agg.mean(ht1.b)).collect()),
{hl.Struct(k='foo', mean_b=1.0), hl.Struct(k='bar', mean_b=2.0)})
def test_row_joins_into_table(self):
rt = hl.utils.range_matrix_table(9, 13, 3)
mt1 = rt.key_rows_by(idx=rt.row_idx)
mt1 = mt1.select_rows(v=mt1.idx + 2)
mt2 = rt.key_rows_by(idx=rt.row_idx, idx2=rt.row_idx + 1)
mt2 = mt2.select_rows(v=mt2.idx + 2)
t1 = hl.utils.range_table(10, 3)
t2 = t1.key_by(t1.idx, idx2=t1.idx + 1)
t1 = t1.select(v=t1.idx + 2)
t2 = t2.select(v=t2.idx + 2)
tinterval1 = t1.key_by(k=hl.interval(t1.idx, t1.idx, True, True))
tinterval1 = tinterval1.select(v=tinterval1.idx + 2)
tinterval2 = t2.key_by(k=hl.interval(t2.key, t2.key, True, True))
tinterval2 = tinterval2.select(v=tinterval2.idx + 2)
values = [hl.Struct(v=i + 2) for i in range(9)]
# join on mt row key
self.assertEqual(t1.index(mt1.row_key).collect(), values)
self.assertEqual(t2.index(mt2.row_key).collect(), values)
self.assertEqual(t1.index(mt1.idx).collect(), values)
self.assertEqual(t2.index(mt2.idx, mt2.idx2).collect(), values)
self.assertEqual(t1.index(mt2.idx).collect(), values)
with self.assertRaises(hl.expr.ExpressionException):
t2.index(mt2.idx).collect()
with self.assertRaises(hl.expr.ExpressionException):
t2.index(mt1.row_key).collect()
# join on not mt row key
self.assertEqual(
t1.index(mt1.v).collect(),
[hl.Struct(v=i + 2) for i in range(2, 10)] + [None])
self.assertEqual(
t2.index(mt2.idx2, mt2.v).collect(),
[hl.Struct(v=i + 2) for i in range(1, 10)])
with self.assertRaises(hl.expr.ExpressionException):
t2.index(mt2.v).collect()
# join on interval of first field of mt row key
self.assertEqual(tinterval1.index(mt1.idx).collect(), values)
self.assertEqual(tinterval1.index(mt1.row_key).collect(), values)
self.assertEqual(tinterval1.index(mt2.idx).collect(), values)
with self.assertRaises(hl.expr.ExpressionException):
tinterval1.index(mt2.row_key).collect()
with self.assertRaises(hl.expr.ExpressionException):
tinterval2.index(mt2.idx).collect()
with self.assertRaises(hl.expr.ExpressionException):
tinterval2.index(mt2.row_key).collect()
with self.assertRaises(hl.expr.ExpressionException):
tinterval2.index(mt2.idx, mt2.idx2).collect()
def test(self):
schema = hl.tstruct(a=hl.tint32, b=hl.tint32, c=hl.tint32, d=hl.tint32, e=hl.tstr,
f=hl.tarray(hl.tint32),
g=hl.tarray(
hl.tstruct(x=hl.tint32, y=hl.tint32, z=hl.tstr)),
h=hl.tstruct(a=hl.tint32, b=hl.tint32, c=hl.tstr),
i=hl.tbool,
j=hl.tstruct(x=hl.tint32, y=hl.tint32, z=hl.tstr))
rows = [{'a': 4, 'b': 1, 'c': 3, 'd': 5,
'e': "hello", 'f': [1, 2, 3],
'g': [hl.Struct(x=1, y=5, z='banana')],
'h': hl.Struct(a=5, b=3, c='winter'),
'i': True,
'j': hl.Struct(x=3, y=2, z='summer')}]
kt = hl.Table.parallelize(rows, schema)
result = convert_struct_to_dict(kt.annotate(
chisq=hl.chisq(kt.a, kt.b, kt.c, kt.d),
ctt=hl.ctt(kt.a, kt.b, kt.c, kt.d, 5),
dict=hl.dict(hl.zip([kt.a, kt.b], [kt.c, kt.d])),
dpois=hl.dpois(4, kt.a),
drop=kt.h.drop('b', 'c'),
exp=hl.exp(kt.c),
fet=hl.fisher_exact_test(kt.a, kt.b, kt.c, kt.d),
hwe=hl.hardy_weinberg_p(1, 2, 1),
index=hl.index(kt.g, 'z'),
is_defined=hl.is_defined(kt.i),
is_missing=hl.is_missing(kt.i),
is_nan=hl.is_nan(hl.float64(kt.a)),
json=hl.json(kt.g),
log=hl.log(kt.a, kt.b),
log10=hl.log10(kt.c),
or_else=hl.or_else(kt.a, 5),
or_missing=hl.or_missing(kt.i, kt.j),
pchisqtail=hl.pchisqtail(kt.a, kt.b),
pcoin=hl.rand_bool(0.5),
pnorm=hl.pnorm(0.2),
pow=2.0 ** kt.b,
ppois=hl.ppois(kt.a, kt.b),
qchisqtail=hl.qchisqtail(kt.a, kt.b),
range=hl.range(0, 5, kt.b),
rnorm=hl.rand_norm(0.0, kt.b),
rpois=hl.rand_pois(kt.a),
runif=hl.rand_unif(kt.b, kt.a),
select=kt.h.select('c', 'b'),
sqrt=hl.sqrt(kt.a),
to_str=[hl.str(5), hl.str(kt.a), hl.str(kt.g)],
where=hl.cond(kt.i, 5, 10)
).take(1)[0])
def get_groupable_matrix():
rt = hl.utils.range_matrix_table(n_rows=100, n_cols=20)
rt = rt.annotate_globals(foo="foo")
rt = rt.annotate_rows(group1=rt['row_idx'] % 6,
group2=hl.Struct(a=rt['row_idx'] % 6, b="foo"))
rt = rt.annotate_cols(group3=rt['col_idx'] % 6,
group4=hl.Struct(a=rt['col_idx'] % 6, b="foo"))
return rt.annotate_entries(c=rt['row_idx'],
d=rt['col_idx'],
e="foo",
f=rt['group1'],
g=rt['group2']['a'],
h=rt['group3'],
i=rt['group4']['a'])
def test_sampleqc_gq_dp():
vds = hl.vds.read_vds(
os.path.join(resource('vds'), '1kg_chr22_5_samples.vds'))
sqc = hl.vds.sample_qc(vds)
assert hl.eval(sqc.index_globals()) == hl.Struct(gq_bins=(0, 20, 60),
dp_bins=(0, 1, 10, 20,
30))
hg00320 = sqc.filter(sqc.s == 'HG00320').select(
'bases_over_gq_threshold', 'bases_over_dp_threshold').collect()[0]
assert hg00320 == hl.Struct(s='HG00320',
bases_over_gq_threshold=(334822, 515, 82),
bases_over_dp_threshold=(334822, 10484, 388,
111, 52))
def test_concordance(self):
dataset = get_dataset()
glob_conc, cols_conc, rows_conc = hl.concordance(dataset, dataset)
self.assertEqual(sum([sum(glob_conc[i]) for i in range(5)]), dataset.count_rows() * dataset.count_cols())
counts = dataset.aggregate_entries(hl.Struct(n_het=agg.filter(dataset.GT.is_het(), agg.count()),
n_hom_ref=agg.filter(dataset.GT.is_hom_ref(),
agg.count()),
n_hom_var=agg.filter(dataset.GT.is_hom_var(),
agg.count()),
nNoCall=agg.filter(hl.is_missing(dataset.GT),
agg.count())))
self.assertEqual(glob_conc[0][0], 0)
self.assertEqual(glob_conc[1][1], counts.nNoCall)
self.assertEqual(glob_conc[2][2], counts.n_hom_ref)
self.assertEqual(glob_conc[3][3], counts.n_het)
self.assertEqual(glob_conc[4][4], counts.n_hom_var)
[self.assertEqual(glob_conc[i][j], 0) for i in range(5) for j in range(5) if i != j]
self.assertTrue(cols_conc.all(hl.sum(hl.flatten(cols_conc.concordance)) == dataset.count_rows()))
self.assertTrue(rows_conc.all(hl.sum(hl.flatten(rows_conc.concordance)) == dataset.count_cols()))
cols_conc.write('/tmp/foo.kt', overwrite=True)
rows_conc.write('/tmp/foo.kt', overwrite=True)
def annotate_gene_transcripts_with_refseq_id(table_path,
mane_select_transcripts_path):
mane_select_transcripts = hl.read_table(mane_select_transcripts_path)
ensembl_to_refseq_map = {}
for transcript in mane_select_transcripts.collect():
ensembl_to_refseq_map[transcript.ensembl_id] = {
transcript.ensembl_version:
hl.Struct(refseq_id=transcript.refseq_id,
refseq_version=transcript.refseq_version)
}
ensembl_to_refseq_map = hl.literal(ensembl_to_refseq_map)
genes = hl.read_table(table_path)
genes = genes.annotate(transcripts=genes.transcripts.map(
lambda transcript: transcript.annotate(**ensembl_to_refseq_map.get(
transcript.transcript_id,
hl.empty_dict(
hl.tstr, hl.tstruct(refseq_id=hl.tstr, refseq_version=hl.tstr)
),
).get(
transcript.transcript_version,
hl.struct(refseq_id=hl.null(hl.tstr),
refseq_version=hl.null(hl.tstr)),
))))
return genes
def process_joins(obj, exprs, broadcast_f):
all_uids = []
left = obj
used_joins = set()
broadcasts = []
for e in exprs:
joins = e._ast.search(lambda a: isinstance(a, hail.expr.expr_ast.Join))
for j in sorted(joins, key=lambda j: j.idx): # Make sure joins happen in order
if j not in used_joins:
left = j.join_func(left)
all_uids.extend(j.temp_vars)
used_joins.add(j)
broadcasts.extend(e._ast.search(lambda a: isinstance(a, hail.expr.expr_ast.Broadcast)))
if broadcasts:
t = hail.tstruct(**{b.uid: b.dtype for b in broadcasts})
all_uids.extend(list(t))
data = hail.Struct(**{b.uid: b.value for b in broadcasts})
data_json = t._to_json(data)
left = broadcast_f(left, data_json, t._jtype)
def cleanup(table):
remaining_uids = [uid for uid in all_uids if uid in table._fields]
return table.drop(*remaining_uids)
return left, cleanup
def test_aggregate2(self):
schema = hl.tstruct(status=hl.tint32, GT=hl.tcall, qPheno=hl.tint32)
rows = [{'status': 0, 'GT': hl.Call([0, 0]), 'qPheno': 3},
{'status': 0, 'GT': hl.Call([0, 1]), 'qPheno': 13}]
kt = hl.Table.parallelize(rows, schema)
result = convert_struct_to_dict(
kt.group_by(status=kt.status)
.aggregate(
x1=agg.collect(kt.qPheno * 2),
x2=agg.explode(lambda elt: agg.collect(elt), [kt.qPheno, kt.qPheno + 1]),
x3=agg.min(kt.qPheno),
x4=agg.max(kt.qPheno),
x5=agg.sum(kt.qPheno),
x6=agg.product(hl.int64(kt.qPheno)),
x7=agg.count(),
x8=agg.count_where(kt.qPheno == 3),
x9=agg.fraction(kt.qPheno == 1),
x10=agg.stats(hl.float64(kt.qPheno)),
x11=agg.hardy_weinberg_test(kt.GT),
x13=agg.inbreeding(kt.GT, 0.1),
x14=agg.call_stats(kt.GT, ["A", "T"]),
x15=agg.collect(hl.Struct(a=5, b="foo", c=hl.Struct(banana='apple')))[0],
x16=agg.collect(hl.Struct(a=5, b="foo", c=hl.Struct(banana='apple')).c.banana)[0],
x17=agg.explode(lambda elt: agg.collect(elt), hl.null(hl.tarray(hl.tint32))),
x18=agg.explode(lambda elt: agg.collect(elt), hl.null(hl.tset(hl.tint32))),
x19=agg.take(kt.GT, 1, ordering=-kt.qPheno)
).take(1)[0])
expected = {u'status': 0,
u'x13': {u'n_called': 2, u'expected_homs': 1.64, u'f_stat': -1.777777777777777,
u'observed_homs': 1},
u'x14': {u'AC': [3, 1], u'AF': [0.75, 0.25], u'AN': 4, u'homozygote_count': [1, 0]},
u'x15': {u'a': 5, u'c': {u'banana': u'apple'}, u'b': u'foo'},
u'x10': {u'min': 3.0, u'max': 13.0, u'sum': 16.0, u'stdev': 5.0, u'n': 2, u'mean': 8.0},
u'x8': 1, u'x9': 0.0, u'x16': u'apple',
u'x11': {u'het_freq_hwe': 0.5, u'p_value': 0.5},
u'x2': [3, 4, 13, 14], u'x3': 3, u'x1': [6, 26], u'x6': 39, u'x7': 2, u'x4': 13, u'x5': 16,
u'x17': [],
u'x18': [],
u'x19': [hl.Call([0, 1])]}
self.maxDiff = None
self.assertDictEqual(result, expected)
def test_DB(self):
mt = hl.balding_nichols_model(n_populations=3,
n_samples=50,
n_variants=10010)
db = hl.experimental.DB()
mt = db.annotate_rows_db(mt, "DANN")
actual = mt.filter_rows(hl.is_defined(mt.DANN)).DANN.collect()
expected = [
hl.Struct(score=0.3618202027281013),
hl.Struct(score=0.36516159615040267),
hl.Struct(score=0.3678246364006052),
hl.Struct(score=0.3697632743148331)
]
for i in range(len(array1)):
self.assertAlmostEqual(actual[i], expected[i])
def test_value_same_after_parsing(self):
for t, v in self.values():
row_v = ir.Literal(t, v)
map_globals_ir = ir.TableMapGlobals(
ir.TableRange(1, 1),
ir.InsertFields(ir.Ref("global"), [("foo", row_v)], None))
new_globals = hl.eval(hl.Table(map_globals_ir).index_globals())
self.assertEqual(new_globals, hl.Struct(foo=v))
def test_value_same_after_parsing(self):
for t, v in self.values():
row_v = ir.Literal(t, v)
map_globals_ir = ir.TableMapGlobals(
ir.TableRange(1, 1),
ir.InsertFields(ir.Ref("global", hl.tstruct()),
[("foo", row_v)]))
new_globals = hl.Table._from_ir(map_globals_ir).globals.value
self.assertEquals(new_globals, hl.Struct(foo=v))
def __init__(self, path, intervals, filter_intervals):
if intervals is not None:
t = hl.expr.impute_type(intervals)
if not isinstance(t, hl.tarray) and not isinstance(t.element_type, hl.tinterval):
raise TypeError("'intervals' must be an array of tintervals")
pt = t.element_type.point_type
if isinstance(pt, hl.tstruct):
self._interval_type = t
else:
self._interval_type = hl.tarray(hl.tinterval(hl.tstruct(__point=pt)))
self.path = path
self.filter_intervals = filter_intervals
if intervals is not None and t != self._interval_type:
self.intervals = [hl.Interval(hl.Struct(__point=i.start),
hl.Struct(__point=i.end),
i.includes_start,
i.includes_end) for i in intervals]
else:
self.intervals = intervals
def test_multiple_files_variant_filtering(self):
bgen_file = [
resource('random-b.bgen'),
resource('random-c.bgen'),
resource('random-a.bgen')
]
hl.index_bgen(bgen_file)
alleles = ['A', 'G']
desired_variants = [
hl.Struct(locus=hl.Locus('20', 11), alleles=alleles),
hl.Struct(locus=hl.Locus('20', 13), alleles=alleles),
hl.Struct(locus=hl.Locus('20', 29), alleles=alleles),
hl.Struct(locus=hl.Locus('20', 28), alleles=alleles),
hl.Struct(locus=hl.Locus('20', 1), alleles=alleles),
hl.Struct(locus=hl.Locus('20', 12), alleles=alleles),
]
actual = hl.import_bgen(bgen_file, ['GT'],
n_partitions=10,
variants=desired_variants)
self.assertEqual(actual.count_rows(), 6)
everything = hl.import_bgen(bgen_file, ['GT'])
self.assertEqual(everything.count(), (30, 10))
expected = everything.filter_rows(
hl.set(desired_variants).contains(everything.row_key))
self.assertTrue(expected._same(actual))
def test_pc_relate_simple_example():
gs = hl.literal(
[[0, 0, 0, 0, 1, 1, 1, 1],
[0, 0, 1, 1, 0, 0, 1, 1],
[0, 1, 0, 1, 0, 1, 0, 1],
[0, 0, 1, 1, 0, 0, 1, 1]])
scores = hl.literal([[0, 1], [1, 1], [1, 0], [0, 0]])
mt = hl.utils.range_matrix_table(n_rows=8, n_cols=4)
mt = mt.annotate_entries(GT=hl.unphased_diploid_gt_index_call(gs[mt.col_idx][mt.row_idx]))
mt = mt.annotate_cols(scores=scores[mt.col_idx])
pcr = hl.pc_relate(mt.GT, min_individual_maf=0, scores_expr=mt.scores)
expected = [
hl.Struct(i=0, j=1, kin=-0.14570713364640647,
ibd0=1.4823511628401964, ibd1=-0.38187379109476693, ibd2=-0.10047737174542953),
hl.Struct(i=0, j=2, kin=0.16530591922102378,
ibd0=0.5234783206257841, ibd1=0.2918196818643366, ibd2=0.18470199750987923),
hl.Struct(i=0, j=3, kin=-0.14570713364640647,
ibd0=1.4823511628401964, ibd1=-0.38187379109476693, ibd2=-0.10047737174542953),
hl.Struct(i=1, j=2, kin=-0.14570713364640647,
ibd0=1.4823511628401964, ibd1=-0.38187379109476693, ibd2=-0.10047737174542953),
hl.Struct(i=1, j=3, kin=0.14285714285714285,
ibd0=0.7027734170591313, ibd1=0.02302459445316596, ibd2=0.2742019884877027),
hl.Struct(i=2, j=3, kin=-0.14570713364640647,
ibd0=1.4823511628401964, ibd1=-0.38187379109476693, ibd2=-0.10047737174542953),
]
ht_expected = hl.Table.parallelize(expected)
ht_expected = ht_expected.key_by(i=hl.struct(col_idx=ht_expected.i),
j=hl.struct(col_idx=ht_expected.j))
assert ht_expected._same(pcr)
def test_combiner_works():
_paths = ['gvcfs/HG00096.g.vcf.gz', 'gvcfs/HG00268.g.vcf.gz']
paths = [resource(p) for p in _paths]
parts = [
hl.Interval(start=hl.Struct(locus=hl.Locus('chr20', 17821257, reference_genome='GRCh38')),
end=hl.Struct(locus=hl.Locus('chr20', 18708366, reference_genome='GRCh38')),
includes_end=True),
hl.Interval(start=hl.Struct(locus=hl.Locus('chr20', 18708367, reference_genome='GRCh38')),
end=hl.Struct(locus=hl.Locus('chr20', 19776611, reference_genome='GRCh38')),
includes_end=True),
hl.Interval(start=hl.Struct(locus=hl.Locus('chr20', 19776612, reference_genome='GRCh38')),
end=hl.Struct(locus=hl.Locus('chr20', 21144633, reference_genome='GRCh38')),
includes_end=True)
]
vcfs = hl.import_gvcfs(paths, parts, reference_genome='GRCh38', array_elements_required=False)
entry_to_keep = defined_entry_fields(vcfs[0].filter_rows(hl.is_defined(vcfs[0].info.END)), 100_000) - {'GT', 'PGT', 'PL'}
vcfs = [transform_gvcf(mt.annotate_rows(info=mt.info.annotate(
MQ_DP=hl.missing(hl.tint32),
VarDP=hl.missing(hl.tint32),
QUALapprox=hl.missing(hl.tint32))),
reference_entry_fields_to_keep=entry_to_keep)
for mt in vcfs]
comb = combine_variant_datasets(vcfs)
assert len(parts) == comb.variant_data.n_partitions()
comb.variant_data._force_count_rows()
comb.reference_data._force_count_rows()
def test_vcf_vds_combiner_equivalence():
import hail.experimental.vcf_combiner.vcf_combiner as vcf
import hail.vds.combiner as vds
_paths = ['gvcfs/HG00096.g.vcf.gz', 'gvcfs/HG00268.g.vcf.gz']
paths = [resource(p) for p in _paths]
parts = [
hl.Interval(start=hl.Struct(locus=hl.Locus('chr20', 17821257, reference_genome='GRCh38')),
end=hl.Struct(locus=hl.Locus('chr20', 18708366, reference_genome='GRCh38')),
includes_end=True),
hl.Interval(start=hl.Struct(locus=hl.Locus('chr20', 18708367, reference_genome='GRCh38')),
end=hl.Struct(locus=hl.Locus('chr20', 19776611, reference_genome='GRCh38')),
includes_end=True),
hl.Interval(start=hl.Struct(locus=hl.Locus('chr20', 19776612, reference_genome='GRCh38')),
end=hl.Struct(locus=hl.Locus('chr20', 21144633, reference_genome='GRCh38')),
includes_end=True)
]
vcfs = [mt.annotate_rows(info=mt.info.annotate(
MQ_DP=hl.missing(hl.tint32),
VarDP=hl.missing(hl.tint32),
QUALapprox=hl.missing(hl.tint32)))
for mt in hl.import_gvcfs(paths, parts, reference_genome='GRCh38',
array_elements_required=False)]
entry_to_keep = defined_entry_fields(vcfs[0].filter_rows(hl.is_defined(vcfs[0].info.END)), 100_000) - {'GT', 'PGT', 'PL'}
vds = vds.combine_variant_datasets([vds.transform_gvcf(mt, reference_entry_fields_to_keep=entry_to_keep) for mt in vcfs])
smt = vcf.combine_gvcfs([vcf.transform_gvcf(mt) for mt in vcfs])
smt_from_vds = hl.vds.to_merged_sparse_mt(vds).drop('RGQ')
smt = smt.select_entries(*smt_from_vds.entry) # harmonize fields and order
smt = smt.key_rows_by('locus', 'alleles')
assert smt._same(smt_from_vds)
def test_loop_with_struct_of_strings(self):
def loop_func(recur_f, my_struct):
return hl.if_else(
hl.len(my_struct.s1) > hl.len(my_struct.s2), my_struct,
recur_f(
hl.struct(s1=my_struct.s1 + my_struct.s2[-1],
s2=my_struct.s2[:-1])))
initial_struct = hl.struct(s1="a", s2="gfedcb")
assert hl.eval(
hl.experimental.loop(loop_func, hl.tstruct(s1=hl.tstr, s2=hl.tstr),
initial_struct)) == hl.Struct(s1="abcd",
s2="gfe")
def test_summarize_variants(self):
mt = hl.utils.range_matrix_table(3, 3)
variants = hl.literal({
0:
hl.Struct(locus=hl.Locus('1', 1), alleles=['A', 'T', 'C']),
1:
hl.Struct(locus=hl.Locus('2', 1), alleles=['A', 'AT', '@']),
2:
hl.Struct(locus=hl.Locus('2', 1), alleles=['AC', 'GT'])
})
mt = mt.annotate_rows(**variants[mt.row_idx]).key_rows_by(
'locus', 'alleles')
r = hl.summarize_variants(mt, show=False)
self.assertEqual(r.n_variants, 3)
self.assertEqual(r.contigs, {'1': 1, '2': 2})
self.assertEqual(r.allele_types, {
'SNP': 2,
'MNP': 1,
'Unknown': 1,
'Insertion': 1
})
self.assertEqual(r.allele_counts, {2: 1, 3: 2})
def test_transmute(self):
schema = hl.tstruct(a=hl.tint32, b=hl.tint32, c=hl.tint32, d=hl.tint32, e=hl.tstr, f=hl.tarray(hl.tint32),
g=hl.tstruct(x=hl.tbool, y=hl.tint32))
rows = [{'a': 4, 'b': 1, 'c': 3, 'd': 5, 'e': "hello", 'f': [1, 2, 3], 'g': {'x': True, 'y': 2}},
{'a': 0, 'b': 5, 'c': 13, 'd': -1, 'e': "cat", 'f': [], 'g': {'x': True, 'y': 2}},
{'a': 4, 'b': 2, 'c': 20, 'd': 3, 'e': "dog", 'f': [5, 6, 7], 'g': None}]
df = hl.Table.parallelize(rows, schema)
df = df.transmute(h=df.a + df.b + df.c + df.g.y)
r = df.select('h').collect()
self.assertEqual(list(df.row), ['d', 'e', 'f', 'h'])
self.assertEqual(r, [hl.Struct(h=x) for x in [10, 20, None]])
def values(self):
values = [(hl.tbool, True), (hl.tint32, 0), (hl.tint64, 0),
(hl.tfloat32, 0.5), (hl.tfloat64, 0.5), (hl.tstr, "foo"),
(hl.tstruct(x=hl.tint32), hl.Struct(x=0)),
(hl.tarray(hl.tint32), [0, 1, 4]),
(hl.tset(hl.tint32), {0, 1, 4}),
(hl.tdict(hl.tstr, hl.tint32), {
"a": 0,
"b": 1,
"c": 4
}), (hl.tinterval(hl.tint32), hl.Interval(0, 1, True,
False)),
(hl.tlocus(hl.default_reference()), hl.Locus("1", 1)),
(hl.tcall, hl.Call([0, 1]))]
return values
def test_table_head_returns_right_number(self):
rt = hl.utils.range_table(10, 11)
par = hl.Table.parallelize([hl.Struct(x=x) for x in range(10)], schema='struct{x: int32}', n_partitions=11)
# test TableRange and TableParallelize rewrite rules
tables = [rt, par, rt.cache()]
for table in tables:
self.assertEqual(table.head(10).count(), 10)
self.assertEqual(table.head(10)._force_count(), 10)
self.assertEqual(table.head(9).count(), 9)
self.assertEqual(table.head(9)._force_count(), 9)
self.assertEqual(table.head(11).count(), 10)
self.assertEqual(table.head(11)._force_count(), 10)
self.assertEqual(table.head(0).count(), 0)
self.assertEqual(table.head(0)._force_count(), 0)
