def add_5HTreceptors(self, compartment, x, time, g):
'''
Adds 5HT receptors
Parameters
----------
compartment: section of NEURON cell
part of neuron
x: int
x - coordinate of serotonin application
time: int (ms)
time of serotonin application
g: float
receptor conductance
'''
if self.fast_diff:
diff = h.diff_5HT(compartment(0.5))
diff.h = math.sqrt((x-self.coordinates.get(compartment).get('x'))**2 + (0-self.coordinates.get(compartment).get('y'))**2 + (0.001-self.coordinates.get(compartment).get('z'))**2)
diff.tx1 = time
#diff.a = 1000
#diff.Deff = 0.0004
#diff.c0cleft = 2
else:
diff = h.slow_5HT(compartment(0.5))
diff.h = math.sqrt((x-self.coordinates.get(compartment).get('x'))**2 + (0-self.coordinates.get(compartment).get('y'))**2 + (0.001-self.coordinates.get(compartment).get('z'))**2)
diff.tx1 = time + 0 + (diff.h/1250)*1000
diff.c0cleft = 100
rec = h.r5ht3a(compartment(0.5))
rec.gmax = g
h.setpointer(diff._ref_serotonin, 'serotonin', rec)
self.diffs.append(diff)
self.recs.append(rec)
def add_5HTreceptors(self, compartment, time, g):
'''
Adds 5HT receptors
Parameters
----------
compartment: section of NEURON cell
part of neuron
x: int
x - coordinate of serotonin application
time: int (ms)
time of serotonin application
g: float
receptor conductance
'''
if self.fast_diff:
diff = h.diff_5HT(compartment(0.5))
diff.h = self.distances.get(compartment)
diff.tx1 = time
if self.numofmodel == 14:
diff.a = 100
else:
diff.a = 0
diff.Deff = 0.004
diff.c0cleft = 3
else:
diff = h.slow_5HT(compartment(0.5))
diff.h = self.distances.get(compartment)
diff.tx1 = time + 0 + (diff.h/50)*1000
diff.c0cleft = 3
rec = h.r5ht3a(compartment(0.5))
rec.gmax = g
h.setpointer(diff._ref_serotonin, 'serotonin', rec)
self.diffs.append(diff)
self.recs.append(rec)
def add_5HTreceptors(self, compartment, time, g):
'''
Adds 5HT receptors
Parameters
----------
compartment: section of NEURON cell
part of neuron
x: int
x - coordinate of serotonin application
time: int (ms)
time of serotonin application
g: float
receptor conductance
'''
x = [8300, 13485, 13485]
y = [0, 1800, -1800]
z = [0, 0, 0]
if self.fast_diff:
for i in range(len(x)):
diff = h.diff_5HT(compartment(0.5))
diff.h = self.distance(compartment, x[i], y[i], z[i])
print(compartment)
print(diff.h)
diff.tx1 = time + i * self.dt
diff.a = 0.25
diff.Deff = 0.4
diff.c0cleft = 2
rec = h.r5ht3a(compartment(0.5))
rec.gmax = g
h.setpointer(diff._ref_serotonin, 'serotonin', rec)
self.recs.append(rec)
self.diffs.append(diff)
else:
diff = h.slow_5HT(compartment(0.5))
diff.h = self.distance(compartment, x[0], y[0], z[0])
diff.tx1 = time + 0 + (diff.h / 50) * 10 #00
diff.c0cleft = 3
rec = h.r5ht3a(compartment(0.5))
rec.gmax = g
h.setpointer(diff._ref_serotonin, 'serotonin', rec)
self.diffs.append(diff)
self.recs.append(rec)
def add_5HTreceptors(self, compartment, time, g):
'''
Adds 5HT receptors
Parameters
----------
compartment: section of NEURON cell
part of neuron
x: int
x - coordinate of serotonin application
time: int (ms)
time of serotonin application
g: float
receptor conductance
'''
diff = h.slow_5HT(compartment(0.5))
diff.h = random.uniform(10, 2500)
diff.tx1 = time + 0 + (diff.h / 50) * 10 #00
diff.c0cleft = 3
diff.a = 0.1
rec = h.r5ht3a(compartment(0.5))
rec.gmax = g
h.setpointer(diff._ref_serotonin, 'serotonin', rec)
self.diffs.append(diff)
self.recs.append(rec)