def test_filters_no_filter(self, case_obj): plugin = VcfPlugin() plugin.add_case(case_obj) case_id = case_obj.case_id filters = {} result = plugin.variants(case_id, filters=filters, count=1000) assert result.nr_of_variants == 108
def test_filters_no_filter(self, case_obj): plugin = VcfPlugin() plugin.add_case(case_obj) case_id = case_obj.case_id filters = {} result = plugin.variants(case_id, filters=filters, count=1000) assert result.nr_of_variants == 108
def test_variants_case_with_ped(): vcf_plugin = VcfPlugin(root_path=vcf, case_lines=individuals, case_type='ped') variants = vcf_plugin.variants(case_id='636808') variant = next(variants) assert variant['CHROM'] == 'X' assert int(variant['POS']) == 84563218 assert variant['index'] == 1 variant = next(variants) assert variant['CHROM'] == '2' assert int(variant['POS']) == 233349186 assert variant['index'] == 2
def test_variants_case_no_ped(): vcf_plugin = VcfPlugin(root_path=vcf) variants = vcf_plugin.variants(case_id='hapmap.vcf') variant = next(variants) assert variant['CHROM'] == 'X' assert int(variant['POS']) == 84563218 assert variant['index'] == 1 variant = next(variants) assert variant['CHROM'] == '2' assert int(variant['POS']) == 233349186 assert variant['index'] == 2
def test_filters_frequency(self, case_obj): plugin = VcfPlugin() plugin.add_case(case_obj) case_id = case_obj.case_id filters = {'frequency':'0.001'} result = plugin.variants(case_id, filters=filters, count=1000) variants = result.variants nr_of_variants = result.nr_of_variants for variant_obj in variants: assert variant_obj.max_freq <= 0.001 assert nr_of_variants == 73
def test_filters_frequency(self, case_obj): plugin = VcfPlugin() plugin.add_case(case_obj) case_id = case_obj.case_id filters = {'frequency':'0.001'} result = plugin.variants(case_id, filters=filters, count=1000) variants = result.variants nr_of_variants = result.nr_of_variants for variant_obj in variants: assert variant_obj.max_freq <= 0.001 assert nr_of_variants == 88
def test_filters_gene_ids(self, case_obj): plugin = VcfPlugin() plugin.add_case(case_obj) case_id = case_obj.case_id filters = {'gene_ids':['POF1B']} result = plugin.variants(case_id, filters=filters, count=1000) variants = result.variants nr_of_variants = result.nr_of_variants for variant_obj in variants: assert 'POF1B' in variant_obj.gene_symbols assert nr_of_variants == 1
def test_filters_cadd(self, case_obj): plugin = VcfPlugin() plugin.add_case(case_obj) case_id = case_obj.case_id filters = {'cadd':'20'} result = plugin.variants(case_id, filters=filters, count=1000) variants = result.variants nr_of_variants = result.nr_of_variants for variant_obj in variants: variant_obj.cadd_score >= 20 assert nr_of_variants == 50
def test_filters_consequence(self, case_obj): plugin = VcfPlugin() plugin.add_case(case_obj) case_id = case_obj.case_id filters = {'consequence':['frameshift_variant']} result = plugin.variants(case_id, filters=filters, count=1000) variants = result.variants nr_of_variants = result.nr_of_variants for variant_obj in variants: assert 'frameshift_variant' in variant_obj.consequences assert nr_of_variants == 4
def test_filters_gene_ids(self, case_obj): plugin = VcfPlugin() plugin.add_case(case_obj) case_id = case_obj.case_id filters = {'gene_ids':['POF1B']} result = plugin.variants(case_id, filters=filters, count=1000) variants = result.variants nr_of_variants = result.nr_of_variants for variant_obj in variants: assert 'POF1B' in variant_obj.gene_symbols assert nr_of_variants == 1
def test_filters_consequence(self, case_obj): plugin = VcfPlugin() plugin.add_case(case_obj) case_id = case_obj.case_id filters = {'consequence':['frameshift_variant']} result = plugin.variants(case_id, filters=filters, count=1000) variants = result.variants nr_of_variants = result.nr_of_variants for variant_obj in variants: assert 'frameshift_variant' in variant_obj.consequences assert nr_of_variants == 4
def test_filters_impact_severities_high(self, case_obj): plugin = VcfPlugin() plugin.add_case(case_obj) case_id = case_obj.case_id filters = {'impact_severities':['HIGH']} result = plugin.variants(case_id, filters=filters, count=1000) variants = result.variants nr_of_variants = result.nr_of_variants for variant_obj in variants: assert variant_obj.impact_severity == 'HIGH' assert nr_of_variants == 7
def test_filters_impact_severities_high(self, case_obj): plugin = VcfPlugin() plugin.add_case(case_obj) case_id = case_obj.case_id filters = {'impact_severities':['HIGH']} result = plugin.variants(case_id, filters=filters, count=1000) variants = result.variants nr_of_variants = result.nr_of_variants for variant_obj in variants: assert variant_obj.impact_severity == 'HIGH' assert nr_of_variants == 7
def test_filters_cadd(self, case_obj): plugin = VcfPlugin() plugin.add_case(case_obj) case_id = case_obj.case_id filters = {'cadd':'20'} result = plugin.variants(case_id, filters=filters, count=1000) variants = result.variants nr_of_variants = result.nr_of_variants for variant_obj in variants: variant_obj.cadd_score >= 20 assert nr_of_variants == 50
def test_variants_case(case_obj): vcf_plugin = VcfPlugin() vcf_plugin.add_case(case_obj) #case_id is 'hapmap.vcf' since no ped file is given result = vcf_plugin.variants(case_id=case_obj.case_id) variants = result.variants variant = variants[0] assert variant['CHROM'] == 'X' assert int(variant['POS']) == 84563218 assert variant['index'] == 1 variant = variants[1] assert variant['CHROM'] == '2' assert int(variant['POS']) == 233349186 assert variant['index'] == 2
def test_variants_case(case_obj): vcf_plugin = VcfPlugin() vcf_plugin.add_case(case_obj) #case_id is 'hapmap.vcf' since no ped file is given result = vcf_plugin.variants(case_id=case_obj.case_id) variants = result.variants variant = variants[0] assert variant['CHROM'] == 'X' assert int(variant['POS']) == 84563218 assert variant['index'] == 1 variant = variants[1] assert variant['CHROM'] == '2' assert int(variant['POS']) == 233349186 assert variant['index'] == 2
def test_filters_range(self, case_obj, indexed_vcf_file): plugin = VcfPlugin() case_obj.variant_source = indexed_vcf_file case_obj.compressed = True case_obj.tabix_index = True plugin.add_case(case_obj) case_id = case_obj.case_id start = 1771120 end = 1771130 filters = {'range':{'chromosome':'1', 'start':start, 'end':end}} result = plugin.variants(case_id, filters=filters, count=1000) variants = result.variants nr_of_variants = result.nr_of_variants for variant_obj in variants: assert variant_obj.start >= start assert variant_obj.stop <= end assert nr_of_variants == 1
def test_filters_range(self, case_obj, indexed_vcf_file): plugin = VcfPlugin() case_obj.variant_source = indexed_vcf_file case_obj.compressed = True case_obj.tabix_index = True plugin.add_case(case_obj) case_id = case_obj.case_id start = 1771120 end = 1771130 filters = {'range':{'chromosome':'1', 'start':start, 'end':end}} result = plugin.variants(case_id, filters=filters, count=1000) variants = result.variants nr_of_variants = result.nr_of_variants for variant_obj in variants: assert variant_obj.start >= start assert variant_obj.stop <= end assert nr_of_variants == 1