def glif_api():
endpoint = None
if 'TEST_API_ENDPOINT' in os.environ:
endpoint = os.environ['TEST_API_ENDPOINT']
return GlifApi(endpoint)
else:
return GlifApi()
def model_ids_for_cell_type(cells_df, cell_type_tag):
model_ids = []
type_cells = cells_df[cells_df.transgenic_line.str.contains(cell_type_tag)]
glif_api = GlifApi()
for neuron_id in type_cells.index.values:
if glif_api.get_neuronal_models([neuron_id]):
models_metadata = glif_api.get_neuronal_models([neuron_id])[0]
for model in models_metadata['neuronal_models']:
model_ids.append(model['id'])
return np.array(model_ids)
def generate_train_from_model_id(model_id,
stimulus_amplitude=1e-8,
duration=1e6,
noise_exponent=0):
glif_api = GlifApi()
neuron_config = glif_api.get_neuron_configs([model_id])
neuron = GlifNeuron.from_dict(neuron_config[model_id])
stimulus = stimulus_amplitude * colorednoise(exponent=noise_exponent,
size=int(duration))
neuron.dt = 5e-6
output = neuron.run(stimulus)
spike_times = output['interpolated_spike_times']
return spike_times
def main():
args = parse_arguments()
logging.getLogger().setLevel(args.log_level)
glif_api = None
if (args.neuron_config_file is None or args.sweeps_file is None
or args.ephys_file is None):
assert args.neuronal_model_id is not None, Exception(
"A neuronal model id is required if no neuron config file, sweeps file, or ephys data file is provided."
)
glif_api = GlifApi()
glif_api.get_neuronal_model(args.neuronal_model_id)
if args.neuron_config_file:
neuron_config = json_utilities.read(args.neuron_config_file)
else:
neuron_config = glif_api.get_neuron_config()
if args.sweeps_file:
sweeps = json_utilities.read(args.sweeps_file)
else:
sweeps = glif_api.get_ephys_sweeps()
if args.ephys_file:
ephys_file = args.ephys_file
else:
ephys_file = 'stimulus_%d.nwb' % args.neuronal_model_id
if not os.path.exists(ephys_file):
logging.info("Downloading stimulus to %s." % ephys_file)
glif_api.cache_stimulus_file(ephys_file)
else:
logging.warning("Reusing %s because it already exists." %
ephys_file)
if args.output_ephys_file:
output_ephys_file = args.output_ephys_file
else:
logging.warning(
"Overwriting input file data with simulated data in place.")
output_ephys_file = ephys_file
neuron = GlifNeuron.from_dict(neuron_config)
# filter out test sweeps
sweep_numbers = [
s['sweep_number'] for s in sweeps if s['stimulus_name'] != 'Test'
]
simulate_neuron(neuron, sweep_numbers, ephys_file, output_ephys_file,
args.spike_cut_value)
def __init__(self, allen_id=None):
self = self
if allen_id == None:
self.allen_id = 566302806
glif_api = GlifApi()
self.nc = glif_api.get_neuron_configs([self.allen_id
])[self.allen_id]
self.glif = GlifNeuron.from_dict(self.nc)
self.metad = glif_api.get_neuronal_models_by_id([self.allen_id])[0]
else:
glif_api = GlifApi()
self.allen_id = allen_id
self.glif = glif_api.get_neuronal_models_by_id([allen_id])[0]
self.nc = glif_api.get_neuron_configs([allen_id])[allen_id]
self.glif = GlifNeuron.from_dict(self.nc)
self.metad = glif_api.get_neuronal_models_by_id([self.allen_id])[0]
def init_backend(self,
attrs=None,
cell_name='alice',
current_src_name='hannah',
DTC=None):
backend = 'GLIF'
super(GLIFBackend, self).init_backend()
self.model._backend.use_memory_cache = False
self.current_src_name = current_src_name
self.cell_name = cell_name
self.vM = None
self.allen_id = None
self.attrs = attrs
self.nc = None
self.temp_attrs = None
if self.allen_id == None:
try:
self.nc = pickle.load(open(str('allen_id.p'), 'rb'))
except:
self.allen_id = 566302806
glif_api = GlifApi()
self.nc = glif_api.get_neuron_configs([self.allen_id
])[self.allen_id]
pickle.dump(copy.copy(self.nc), open(str('allen_id.p'), 'wb'))
else:
try:
self.nc = pickle.load(open(str('allen_id.p'), 'rb'))
except:
glif_api = GlifApi()
self.allen_id = allen_id
self.glif = glif_api.get_neuronal_models_by_id([allen_id])[0]
self.nc = glif_api.get_neuron_configs([self.allen_id
])[self.allen_id]
pickle.dump(self.nc, open(str('allen_id.p'), 'wb'))
self.glif = GlifNeuron.from_dict(self.nc)
if type(attrs) is not type(None):
self.set_attrs(**attrs)
self.sim_attrs = attrs
if type(DTC) is not type(None):
if type(DTC.attrs) is not type(None):
self.set_attrs(**DTC.attrs)
if hasattr(DTC, 'current_src_name'):
self._current_src_name = DTC.current_src_name
if hasattr(DTC, 'cell_name'):
self.cell_name = DTC.cell_name
def test_download():
if os.path.exists(OUTPUT_DIR):
shutil.rmtree(OUTPUT_DIR)
os.makedirs(OUTPUT_DIR)
glif_api = GlifApi()
glif_api.get_neuronal_model(NEURONAL_MODEL_ID)
glif_api.cache_stimulus_file(os.path.join(OUTPUT_DIR, '%d.nwb' % NEURONAL_MODEL_ID))
neuron_config = glif_api.get_neuron_config()
json_utilities.write(os.path.join(OUTPUT_DIR, '%d_neuron_config.json' % NEURONAL_MODEL_ID), neuron_config)
ephys_sweeps = glif_api.get_ephys_sweeps()
json_utilities.write(os.path.join(OUTPUT_DIR, 'ephys_sweeps.json'), ephys_sweeps)
def __init__(self):
self = self
import allensdk.core.json_utilities as json_utilities
from allensdk.model.glif.glif_neuron import GlifNeuron
try:
from allensdk.api.queries.glif_api import GlifApi
from allensdk.core.cell_types_cache import CellTypesCache
import allensdk.core.json_utilities as json_utilities
import sciunit
except:
import os
os.system('pip install allensdk')
from allensdk.api.queries.glif_api import GlifApi
from allensdk.core.cell_types_cache import CellTypesCache
import allensdk.core.json_utilities as json_utilities
os.system('pip install git+https://github.com/scidash/sciunit@dev')
neuronal_model_id = 566302806
glif_api = GlifApi()
nc = glif_api.get_neuron_configs([neuronal_model_id])[neuronal_model_id]
self.nm = GlifNeuron.from_dict(nc)
def main():
args = parse_arguments()
logging.getLogger().setLevel(args.log_level)
glif_api = None
if (args.neuron_config_file is None or
args.sweeps_file is None or
args.ephys_file is None):
assert args.neuronal_model_id is not None, Exception("A neuronal model id is required if no neuron config file, sweeps file, or ephys data file is provided.")
glif_api = GlifApi()
glif_api.get_neuronal_model(args.neuronal_model_id)
if args.neuron_config_file:
neuron_config = json_utilities.read(args.neuron_config_file)
else:
neuron_config = glif_api.get_neuron_config()
if args.sweeps_file:
sweeps = json_utilities.read(args.sweeps_file)
else:
sweeps = glif_api.get_ephys_sweeps()
if args.ephys_file:
ephys_file = args.ephys_file
else:
ephys_file = 'stimulus_%d.nwb' % args.neuronal_model_id
if not os.path.exists(ephys_file):
logging.info("Downloading stimulus to %s." % ephys_file)
glif_api.cache_stimulus_file(ephys_file)
else:
logging.warning("Reusing %s because it already exists." % ephys_file)
if args.output_ephys_file:
output_ephys_file = args.output_ephys_file
else:
logging.warning("Overwriting input file data with simulated data in place.")
output_ephys_file = ephys_file
neuron = GlifNeuron.from_dict(neuron_config)
# filter out test sweeps
sweep_numbers = [ s['sweep_number'] for s in sweeps if s['stimulus_name'] != 'Test' ]
simulate_neuron(neuron, sweep_numbers, ephys_file, output_ephys_file, args.spike_cut_value)
def download_glif_models(cell_ids,
base_dir,
incl_ephys=True,
force_overwrite=False):
"""Goes through the list of cell_ids and downloads cell config and ephys data in base_dir/cell_<ID>. Then looks up
all possible models and downloads model files int base_dir/cell_<ID>/<MODEL_TYPE>_<MODEL_ID>/
"""
# Determine the best url for connecting to cell-types db
try:
# see if we can connect to interal cell-types db
request = requests.get('http://icelltypes/')
if request.status_code == 200:
base_uri = 'http://icelltypes/'
else:
base_uri = None
except Exception:
base_uri = None # use the default url
base_dir = base_dir if base_dir.endswith('/') else base_dir + '/'
valid_cells = []
ct_api = CellTypesApi(base_uri)
for cell in ct_api.list_cells():
if cell['id'] in cell_ids:
# create directory for cell
cell_home = '{}cell_{}/'.format(base_dir, cell['id'])
if not os.path.exists(cell_home):
os.makedirs(cell_home)
# save metadata
cell_metadata_file = cell_home + 'cell_metadata.json'
if force_overwrite or not os.path.exists(cell_metadata_file):
print('Saving metadata for cell {} in {}'.format(
cell['id'], cell_metadata_file))
json_utilities.write(cell_metadata_file, cell)
else:
print('File {} already exists. Skipping'.format(
cell_metadata_file))
# save ephys data
if incl_ephys:
cell_ephys_file = cell_home + 'ephys_data.nwb'
if force_overwrite or not os.path.exists(cell_ephys_file):
print('Saving ephys data for cell {} in {}'.format(
cell['id'], cell_ephys_file))
ct_api.save_ephys_data(cell['id'], cell_ephys_file)
else:
print('File {} already exists. Skipping'.format(
cell_ephys_file))
# save sweeps file
sweeps_file = cell_home + 'ephys_sweeps.json'
if force_overwrite or not os.path.exists(sweeps_file):
print('- Saving sweeps file to {}'.format(sweeps_file))
ephys_sweeps = ct_api.get_ephys_sweeps(cell['id'])
json_utilities.write(sweeps_file, ephys_sweeps)
else:
print('- File {} already exits. Skipping.'.format(sweeps_file))
# keep track of valid ids
valid_cells.append(cell['id'])
cell_ids.remove(cell['id'])
for cid in cell_ids:
print('Warning: cell #{} was not found in cell-types database'.format(
cid))
# Iterate through each all available models and find ones correspoding to cell list
glif_models = {} # map model-id to their directory
glif_api = GlifApi(base_uri=base_uri)
for model in glif_api.list_neuronal_models():
if model['specimen_id'] in valid_cells:
# save model files <BASE_DIR>/cell_<CELL_ID>/<MODEL_TYPE>_<MODEL_ID>/
cell_id = model['specimen_id']
model_id = model['id']
model_type = model[
'neuronal_model_template_id'] #['id'] # type of model, GLIF-LIF, GLIF-ASC, etc
type_name = model_id2name.get(model_type, None)
if type_name is None:
print(
'Warning: Unknown model type {} ({}) for cell/model {}/{}'.
format(model_type,
model['neuronal_model_template']['name'], cell_id,
model_id))
type_name = model_type
model_home_dir = '{}cell_{}/{}_{}/'.format(base_dir, cell_id,
type_name, model_id)
glif_models[model_id] = model_home_dir
# go through all the found models, download necessary files
n_models = len(glif_models)
for i, (gid, home_dir) in enumerate(glif_models.iteritems()):
print('Processing model {} ({} of {})'.format(gid, (i + 1), n_models))
model_metadata = glif_api.get_neuronal_model(gid)
if not os.path.exists(home_dir):
os.makedirs(home_dir)
# save model metadata
metadata_file = home_dir + 'metadata.json'
if force_overwrite or not os.path.exists(metadata_file):
print('- Saving metadata file to {}'.format(metadata_file))
#print type(metadata_file)
with open(metadata_file, 'wb') as fp:
json.dump(model_metadata, fp, indent=2)
else:
print('- File {} already exits. Skipping.'.format(metadata_file))
# get neuron configuration file
config_file = home_dir + 'config.json'
if force_overwrite or not os.path.exists(config_file):
print('- Saving configuration file to {}'.format(config_file))
neuron_config = glif_api.get_neuron_config()
json_utilities.write(config_file, neuron_config)
else:
print('- File {} already exits. Skipping.'.format(config_file))
from allensdk.api.queries.glif_api import GlifApi
import allensdk.core.json_utilities as json_utilities
neuronal_model_id = 472423251
glif_api = GlifApi()
glif_api.get_neuronal_model(neuronal_model_id)
glif_api.cache_stimulus_file('stimulus.nwb')
neuron_config = glif_api.get_neuron_config()
json_utilities.write('neuron_config.json', neuron_config)
ephys_sweeps = glif_api.get_ephys_sweeps()
json_utilities.write('ephys_sweeps.json', ephys_sweeps)
class glifBackend(Backend):
backend = 'glif'
try:
from allensdk.api.queries.glif_api import GlifApi
from allensdk.core.cell_types_cache import CellTypesCache
import allensdk.core.json_utilities as json_utilities
except:
import os
os.system('pip install allensdk')
from allensdk.api.queries.glif_api import GlifApi
from allensdk.core.cell_types_cache import CellTypesCache
import allensdk.core.json_utilities as json_utilities
neuronal_model_id = 566302806
# download model metadata
glif_api = GlifApi()
nm = glif_api.get_neuronal_models_by_id([neuronal_model_id])[0]
# download the model configuration file
nc = glif_api.get_neuron_configs([neuronal_model_id])[neuronal_model_id]
neuron_config = glif_api.get_neuron_configs([neuronal_model_id])
json_utilities.write('neuron_config.json', neuron_config)
# download information about the cell
ctc = CellTypesCache()
ctc.get_ephys_data(nm['specimen_id'], file_name='stimulus.nwb')
ctc.get_ephys_sweeps(nm['specimen_id'], file_name='ephys_sweeps.json')
import allensdk.core.json_utilities as json_utilities
from allensdk.model.glif.glif_neuron import GlifNeuron
# initialize the neuron
neuron_config = json_utilities.read('neuron_config.json')
neuron_config = neuron_config['566302806']
neuron = GlifNeuron.from_dict(neuron_config)
def init_backend(self, attrs=None, simulator='neuron', DTC=None):
from pyNN import neuron
self.neuron = neuron
from pyNN.neuron import simulator as sim
from pyNN.neuron import setup as setup
from pyNN.neuron import Izhikevich
from pyNN.neuron import Population
from pyNN.neuron import DCSource
self.Izhikevich = Izhikevich
self.Population = Population
self.DCSource = DCSource
self.setup = setup
self.model_path = None
self.related_data = {}
self.lookup = {}
self.attrs = {}
super(pyNNBackend, self).init_backend() #*args, **kwargs)
if DTC is not None:
self.set_attrs(**DTC.attrs)
backend = 'pyNN'
def get_membrane_potential(self):
"""Must return a neo.core.AnalogSignal.
And must destroy the hoc vectors that comprise it.
"""
dt = float(copy.copy(self.neuron.dt))
data = self.population.get_data().segments[0]
return data.filter(name="v")[0]
def _local_run(self):
'''
pyNN lazy array demands a minimum population size of 3. Why is that.
'''
import numpy as np
results = {}
#self.population.record('v')
#self.population.record('spikes')
# For ome reason you need to record from all three neurons in a population
# In order to get the membrane potential from only the stimulated neuron.
self.population[0:2].record(('v', 'spikes', 'u'))
'''
self.Iz.record('v')
self.Iz.record('spikes')
# For ome reason you need to record from all three neurons in a population
# In order to get the membrane potential from only the stimulated neuron.
self.Iz.record(('v', 'spikes','u'))
'''
#self.neuron.run(650.0)
DURATION = 1000.0
self.neuron.run(DURATION)
data = self.population.get_data().segments[0]
vm = data.filter(name="v")[0] #/10.0
results['vm'] = vm
#print(vm)
sample_freq = DURATION / len(vm)
results['t'] = np.arange(0, len(vm), DURATION / len(vm))
results['run_number'] = results.get('run_number', 0) + 1
return results
def load_model(self):
self.Iz = None
self.population = None
self.setup(timestep=0.01, min_delay=1.0)
import pyNN
#i_offset=[0.014, 0.0, 0.0]
pop = self.neuron.Population(
3,
pyNN.neuron.Izhikevich(a=0.02,
b=0.2,
c=-65,
d=6,
i_offset=[0.014, -65.0, 0.0])) #,v=-65))
self.population = pop
def set_attrs(self, **attrs):
#attrs = copy.copy(self.model.attrs)
self.init_backend()
#self.set_attrs(**attrs)
self.model.attrs.update(attrs)
assert type(self.model.attrs) is not type(None)
attrs['i_offset'] = None
attrs_ = {x: attrs[x] for x in ['a', 'b', 'c', 'd', 'i_offset']}
attrs_['i_offset'] = 0.014 #[0.014,-attrs_['v0'],0.0]
#self.population[0].initialize()
self.population[0].set_parameters(**attrs_)
print(self.population[0].get_parameters())
self.neuron.h.psection()
return self
def inject_square_current(self, current):
import copy
attrs = copy.copy(self.model.attrs)
self.init_backend()
self.set_attrs(**attrs)
c = copy.copy(current)
if 'injected_square_current' in c.keys():
c = current['injected_square_current']
c['delay'] = re.sub('\ ms$', '', str(c['delay'])) # take delay
c['duration'] = re.sub('\ ms$', '', str(c['duration']))
c['amplitude'] = re.sub('\ pA$', '', str(c['amplitude']))
stop = float(c['delay']) + float(c['duration'])
start = float(c['delay'])
amplitude = float(c['amplitude']) / 1000.0
#print('amplitude',amplitude)
electrode = self.neuron.DCSource(start=start,
stop=stop,
amplitude=amplitude)
print(self.population[0])
print(type(self.population[0]))
print(self.population[0].get_parameters())
electrode.inject_into(self.population[0:1])
exit(1)
# model name and model template id mapping
LIF = 'LIF'
LIF_R = 'LIF-R'
LIF_ASC = 'LIF-ASC'
LIF_R_ASC = 'LIF-R-ASC'
LIF_R_ASC_A = 'LIF-R-ASC-A'
model_id2name = {
395310469: LIF,
395310479: LIF_R,
395310475: LIF_ASC,
471355161: LIF_R_ASC,
395310498: LIF_R_ASC_A
}
glif_api = GlifApi()
for cell_result in glif_api.get_neuronal_models(cell_ids): #[325464516]
cell_id = cell_result['id']
for curr_model in cell_result['neuronal_models']:
if model_id2name[
curr_model['neuronal_model_template_id']] != options.model:
continue
model_id = curr_model['id']
neuron_config = glif_api.get_neuron_configs([model_id])[model_id]
for stim in options.stimulus.split(','):
simulate = stimulus[stim]
output = simulate(cell_id, options.model, neuron_config)
plt.figure('Cell ' + str(cell_id) + ' ' + options.model + ' ' +
stim)
plotter.plt_comparison_neurons(np.array(output['I']) * 1.0e12,
def glif_api():
glif_api = GlifApi()
return glif_api
# set matplotlib headless - this turns off the production of visible plots!
import matplotlib
matplotlib.use("Agg")
#===============================================================================
# example 1
#===============================================================================
from allensdk.api.queries.glif_api import GlifApi
from allensdk.core.cell_types_cache import CellTypesCache
import allensdk.core.json_utilities as json_utilities
neuronal_model_id = 566302806
# download model metadata
glif_api = GlifApi()
nm = glif_api.get_neuronal_models_by_id([neuronal_model_id])[0]
# download the model configuration file
nc = glif_api.get_neuron_configs([neuronal_model_id])[neuronal_model_id]
neuron_config = glif_api.get_neuron_configs([neuronal_model_id])
json_utilities.write('neuron_config.json', neuron_config)
# download information about the cell
ctc = CellTypesCache()
ctc.get_ephys_data(nm['specimen_id'], file_name='stimulus.nwb')
ctc.get_ephys_sweeps(nm['specimen_id'], file_name='ephys_sweeps.json')
#===============================================================================
# example 2
#===============================================================================
import time
import numpy as np
from allensdk.api.queries.glif_api import GlifApi
from allensdk.core.cell_types_cache import CellTypesCache
import allensdk.core.json_utilities as json_utilities
neuronal_model_id = 566302806
# download model metadata
glif_api = GlifApi()
nm = glif_api.get_neuronal_models_by_id([neuronal_model_id])[0]
# download the model configuration file
nc = glif_api.get_neuron_configs([neuronal_model_id])[neuronal_model_id]
neuron_config = glif_api.get_neuron_configs([neuronal_model_id])
json_utilities.write('neuron_config.json', neuron_config)
# download information about the cell
ctc = CellTypesCache()
ctc.get_ephys_data(nm['specimen_id'], file_name='stimulus.nwb')
ctc.get_ephys_sweeps(nm['specimen_id'], file_name='ephys_sweeps.json')
import allensdk.core.json_utilities as json_utilities
from allensdk.model.glif.glif_neuron import GlifNeuron
# initialize the neuron
neuron_config = json_utilities.read('neuron_config.json')['566302806']
neuron = GlifNeuron.from_dict(neuron_config)
# make a short square pulse. stimulus units should be in Amps.
stimulus = [0.0] * 100 + [10e-9] * 100 + [0.0] * 100
from allensdk.api.queries.glif_api import GlifApi
import random
import pprint
import os
pp = pprint.PrettyPrinter(indent=4)
api = GlifApi()
models = api.list_neuronal_models()
max = 5
def write_to_file(directory, file_name, jstring):
file_path = '%s/%s' % (directory, file_name)
print("Writing to: %s" % file_path)
if not os.path.isdir(directory):
os.mkdir(directory)
f = open(file_path, 'w')
#info = str(jstring)
pretty = pp.pformat(jstring)
pretty = pretty.replace('\'', '"')
pretty = pretty.replace('u"', '"')
pretty = pretty.replace('None', 'null')
pretty = pretty.replace('False', 'false')
pretty = pretty.replace('True', 'true')
f.write(pretty)
f.close()
'''Written by Corinne Teeter. Grab the explained variance for the published biophys models'''
import numpy as np
from allensdk.core.cell_types_cache import CellTypesCache
import allensdk.internal.core.lims_utilities as lu
import pandas as pd
from allensdk.api.queries.glif_api import GlifApi
import os
import sys
relative_path = os.path.dirname(os.getcwd())
sys.path.append(os.path.join(relative_path, 'libraries'))
# Find all mouse cells with models
glif_api = GlifApi()
ctc = CellTypesCache(
manifest_file=os.path.join(relative_path, 'cell_types_manifest.json'))
specimen_id_list = []
temp = ctc.get_cells()
for c in temp:
if c['species'] == 'Mus musculus':
specimen_id_list.append(c['id'])
print len(specimen_id_list), 'mouse specimens in public database'
def get_expVar(specimen_id_list, keyword):
'''Grab explained variance value of specimen id list in public database
Inputs:
specimen_id_list: list of integers
desired specimen ids of data in AIBS public database
def test_find_optimization_sweeps():
ga = GlifApi()
nm = ga.get_neuronal_model(473836744)
sweeps = ga.get_ephys_sweeps()
opt_sweeps, stim_index, errs = find_optimization_sweeps(sweeps)
def get_files_from_LIMS_public(output_path, glif_sp_ids=None, type='mouse'):
'''This will grab cre positive data config files from LIMS and sort them and put them in
the specified output folder.
input:
output_path: string
specifies path for files to be placed in
glif_sp_ids: list of strings or integers
specimen ids of cells specifically want to grab. If none it will get all available on the
Allen Institue Cell Types Database.
type: string
can be 'mouse' or 'human'. Note that if mouse is specified is will only grab cre positive mouse cells
(code can be altered to get cre negative cells).
output:
Does not return values but creates the specified 'output_path' folder.
Inside the folder a series of folders are created with the name format:
specimenid_cre. Inside those inner folders are the neuron configs of
the available GLIF models along with the preprocessor files.
'''
glif_api = GlifApi()
ctc = CellTypesCache(manifest_file=os.path.join(relative_path,'cell_types_manifest.json'))
# select the specimen ids to grab from the data base (cre positive or human which have at least 1 GLIF model)
if glif_sp_ids==None: #if no specimen id's are specified grab all data in the cell types manifest
specimen_id_list = []
if type=='mouse':
for c in ctc.get_cells():
if c['reporter_status']=='cre reporter positive':
specimen_id_list.append(c['id'])
elif type=='human':
print 'getting human'
for c in ctc.get_cells(species=['H**o Sapiens']):
#print c
specimen_id_list.append(c['id'])
print specimen_id_list
# reduce list to cells that have a GLIF model
glif_sp_ids=[]
for sp in specimen_id_list:
models=glif_api.get_neuronal_models(sp)[0]
for m in models['neuronal_models']:
if 'LIF' in m['name']:
glif_sp_ids.append(m['specimen_id'])
glif_sp_ids=list(set(glif_sp_ids))
print len(glif_sp_ids), 'cre positive specimens with at least 1 LIF model'
# create the overall output directory if it doesn't exist
try:
os.makedirs(output_path)
except:
pass
# go get the files corresponding to the specimen ids from the Allen Cell Types Database
# and put them into a specified output directory
for id in glif_sp_ids:
model_query=glif_api.get_neuronal_models(id)[0]['neuronal_models']
df=pd.DataFrame(model_query)
for mt_id, short_name in zip(model_template_ids, model_names):
dff=df[df['neuronal_model_template_id']==mt_id]
if len(dff)>=2:
print dff
raise Exception("This is public data, there should not be more than 1 model")
elif len(dff)==1:
use_me=dff
#go get the file
path=use_me['well_known_files'].iloc[0][0]['path']
if type=='mouse':
cre=(str(use_me['name'].values).split(')_'))[1].split(';')[0]
elif type=='human':
cre='human'
else:
raise Exception('specified species not known')
# convert old non complete cre names
if 'Ntsr1-Cre' in cre:
cre='Ntsr1-Cre_GN220'
if 'Chat-IRES-Cre' in cre:
cre='Chat-IRES-Cre-neo'
dir_name=os.path.join(output_path, str(id)+'_'+cre)
try:
os.makedirs(dir_name)
except:
pass
if path.endswith('_neuron_config.json'):
pass
else:
print path
raise Exception('the file doesnt end with _neuron_config.json')
try:
copyfile(path, os.path.join(dir_name, str(id)+'_'+cre+'_'+short_name+'_neuron_config.json'))
except:
print 'couldnt make ', os.path.join(dir_name, str(id)+'_'+cre+'_'+short_name+'_neuron_config.json')
if mt_id==model_template_ids[0]:
model_path=os.path.dirname(path)
pp_path=os.path.join(model_path,
os.listdir(model_path)[np.where([fname.endswith('_preprocessor_values.json') for fname in os.listdir(model_path)])[0][0]])
try:
copyfile(pp_path, os.path.join(dir_name, str(id)+'_'+cre+'_preprocessor_values.json'))
except:
print 'couldnt make ', os.path.join(dir_name, str(id)+'_'+cre+'_preprocessor_values.json')
raise Exception('there should be a preprocessed file')
elif len(dff)<1:
use_me=pd.DataFrame()
path=None
def test_find_optimization_sweeps():
ga = GlifApi()
nm = ga.get_neuronal_model(473836744)
sweeps = ga.get_ephys_sweeps()
opt_sweeps, stim_index, errs = find_optimization_sweeps(sweeps)
