def interpolation_demo():
interpol = moose.Interpol2D('/interpol2D')
interpol.xmin = 0.0
interpol.xmax = 1.0
interpol.ymin = 0.0
interpol.ymax = 1.0
# Make a 50 element array with entries at equal distance from
# [0,1) and reshape it into a 10x5 matrix and assign to table.
matrix = np.linspace(0, 1.0, 50).reshape(10, 5)
print('Setting table to')
print(matrix)
interpol.tableVector2D = matrix
# interpolating beyond top left corner.
# value should be
pos = (0.8, 0.3)
print(('Interpolated value at', pos))
print((interpol.z[pos[0], pos[1]]))
print(('Point going out of bound on both x and y', interpol.z[1.1, 1.1]))
print(('Point going out of bound on both x and y', interpol.z[0.5, 1.1]))
def readChannelML(self, channelElement, params={}, units="SI units"):
"""Loads a single channel
"""
# I first calculate all functions assuming a consistent system of units.
# While filling in the A and B tables, I just convert to SI. Also
# convert gmax and Erev.
if 'Physiological Units' in units:
# see pg 219 (sec 13.2) of Book of Genesis
Vfactor = 1e-3 # V from mV
Tfactor = 1e-3 # s from ms
Gfactor = 1e1 # S/m^2 from mS/cm^2
concfactor = 1e6 # Mol = mol/m^-3 from mol/cm^-3
elif 'SI Units' in units:
Vfactor = 1.0
Tfactor = 1.0
Gfactor = 1.0
concfactor = 1.0
else:
debug.printDebug("ERR",
"wrong units %s. Existing... " % units,
frame=inspect.currentframe())
raise UserWarning, "Unknown units"
# creates /library in MOOSE tree; elif present, wraps
channel_name = channelElement.attrib['name']
if utils.neuroml_debug:
msg = "Loading channel {} into {} ".format(channel_name,
self.libraryPath)
debug.printDebug("INFO", msg)
IVrelation = channelElement.find('./{' + self.cml +
'}current_voltage_relation')
concdep = IVrelation.find('./{' + self.cml + '}conc_dependence')
cPath = os.path.join(self.libraryPath, channel_name)
if concdep is None:
channel = moose.HHChannel(cPath)
else:
channel = moose.HHChannel2D(cPath)
if IVrelation.attrib['cond_law'] == "ohmic":
channel.Gbar = float(IVrelation.attrib['default_gmax']) * Gfactor
channel.Ek = float(IVrelation.attrib['default_erev']) * Vfactor
channelIon = moose.Mstring(channel.path + '/ion')
channelIon.value = IVrelation.attrib['ion']
if concdep is not None:
channelIonDependency = moose.Mstring(channel.path +
'/ionDependency')
channelIonDependency.value = concdep.attrib['ion']
nernstnote = IVrelation.find('./{' + utils.meta_ns + '}notes')
if nernstnote is not None:
# the text in nernstnote is "Nernst,Cout=<float>,z=<int>"
nernst_params = string.split(nernstnote.text, ',')
if nernst_params[0] == 'Nernst':
nernstMstring = moose.Mstring(channel.path + '/nernst_str')
nernstMstring.value = str(
float(string.split(nernst_params[1], '=')[1]) *
concfactor) + ',' + str(
int(string.split(nernst_params[2], '=')[1]))
gates = IVrelation.findall('./{' + self.cml + '}gate')
if len(gates) > 3:
msg = "Sorry! Maximum x, y, and z (three) gates are possible in\
MOOSE/Genesis"
debug.printDebug("ERR", msg, frame=inspect.currentframe())
raise UserWarning, "Bad value or parameter"
# These are the names that MOOSE uses to create gates.
gate_full_name = ['gateX', 'gateY', 'gateZ']
# if impl_prefs tag is present change VMIN, VMAX and NDIVS
impl_prefs = channelElement.find('./{' + self.cml + '}impl_prefs')
if impl_prefs is not None:
table_settings = impl_prefs.find('./{' + self.cml +
'}table_settings')
# some problem here... disable
VMIN_here = float(table_settings.attrib['min_v'])
VMAX_here = float(table_settings.attrib['max_v'])
NDIVS_here = int(table_settings.attrib['table_divisions'])
dv_here = (VMAX_here - VMIN_here) / NDIVS_here
else:
# default VMIN, VMAX and dv are in SI convert them to current
# calculation units used by channel definition while loading into
# tables, convert them back to SI
VMIN_here = utils.VMIN / Vfactor
VMAX_here = utils.VMAX / Vfactor
NDIVS_here = utils.NDIVS
dv_here = utils.dv / Vfactor
offset = IVrelation.find('./{' + self.cml + '}offset')
if offset is None:
vNegOffset = 0.0
else:
vNegOffset = float(offset.attrib['value'])
self.parameters = []
for parameter in channelElement.findall('.//{' + self.cml +
'}parameter'):
self.parameters.append(
(parameter.attrib['name'], float(parameter.attrib['value'])))
for num, gate in enumerate(gates):
# if no q10settings tag, the q10factor remains 1.0 if present but no
# gate attribute, then set q10factor if there is a gate attribute,
# then set it only if gate attrib matches gate name
self.q10factor = 1.0
self.gate_name = gate.attrib['name']
q10sets = IVrelation.findall('./{' + self.cml + '}q10_settings')
for q10settings in q10sets:
# self.temperature from neuro.utils
if 'gate' in list(q10settings.attrib.keys()):
if q10settings.attrib['gate'] == self.gate_name:
self.setQ10(q10settings)
break
else:
self.setQ10(q10settings)
# HHChannel2D crashing on setting Xpower! temperamental! If you
# print something before, it gives cannot creategate from copied
# channel, else crashes Setting power first. This is necessary
# because it also initializes the gate's internal data structures as
# a side effect. Alternatively, gates can be initialized explicitly
# by calling HHChannel.createGate().
gate_power = float(gate.get('instances'))
if num == 0:
channel.Xpower = gate_power
if concdep is not None: channel.Xindex = "VOLT_C1_INDEX"
elif num == 1:
channel.Ypower = gate_power
if concdep is not None: channel.Yindex = "VOLT_C1_INDEX"
elif num == 2:
channel.Zpower = gate_power
if concdep is not None: channel.Zindex = "VOLT_C1_INDEX"
## Getting handle to gate using the gate's path.
gate_path = os.path.join(channel.path, gate_full_name[num])
if concdep is None:
moosegate = moose.HHGate(gate_path)
# set SI values inside MOOSE
moosegate.min = VMIN_here * Vfactor
moosegate.max = VMAX_here * Vfactor
moosegate.divs = NDIVS_here
## V.IMP to get smooth curves, else even with 3000 divisions
## there are sudden transitions.
moosegate.useInterpolation = True
else:
moosegate = moose.HHGate2D(gate_path)
# If alpha and beta functions exist, make them here
for transition in gate.findall('./{' + self.cml + '}transition'):
# make python functions with names of transitions...
fn_name = transition.attrib['name']
# I assume that transitions if present are called alpha and beta
# for forwand backward transitions...
if fn_name in ['alpha', 'beta']:
self.make_cml_function(transition, fn_name, concdep)
else:
debug.printDebug(
"ERROR", "Unsupported transition {0}".format(fn_name))
sys.exit()
time_course = gate.find('./{' + self.cml + '}time_course')
# tau is divided by self.q10factor in make_function() thus, it gets
# divided irrespective of <time_course> tag present or not.
if time_course is not None:
self.make_cml_function(time_course, 'tau', concdep)
steady_state = gate.find('./{' + self.cml + '}steady_state')
if steady_state is not None:
self.make_cml_function(steady_state, 'inf', concdep)
if concdep is None:
ca_name = '' # no Ca dependence
else:
# Ca dependence
ca_name = ',' + concdep.attrib['variable_name']
# Create tau() and inf() if not present, from alpha() and beta()
for fn_element, fn_name, fn_expr in [
(time_course, 'tau', "1/(alpha+beta)"),
(steady_state, 'inf', "alpha/(alpha+beta)")
]:
# put in args for alpha and beta, could be v and Ca dep.
expr_string = self.replace(fn_expr, 'alpha',
'self.alpha(v' + ca_name + ')')
expr_string = self.replace(expr_string, 'beta',
'self.beta(v' + ca_name + ')')
# if time_course/steady_state are not present, then alpha annd
# beta transition elements should be present, and fns created.
if fn_element is None:
self.make_function(fn_name,
'generic',
expr_string=expr_string,
concdep=concdep)
# non Ca dependent channel
if concdep is None:
# while calculating, use the units used in xml defn, while
# filling in table, I convert to SI units.
v0 = VMIN_here - vNegOffset
n_entries = NDIVS_here + 1
tableA = [0.0] * n_entries
tableB = [0.0] * n_entries
for i in range(n_entries):
v = v0 + (i * dv_here)
inf = self.inf(v)
tau = self.tau(v)
# convert to SI before writing to table
# qfactor is already in inf and tau
tableA[i] = (inf / tau) / Tfactor
tableB[i] = (1.0 / tau) / Tfactor
moosegate.tableA = tableA
moosegate.tableB = tableB
## Ca dependent channel
else:
# UNITS: while calculating, use the units used in xml defn,
# while filling in table, I convert to SI units. Note here Ca
# units do not enter, but units of CaMIN, CaMAX and ca_conc in
# fn expr should match.
v = VMIN_here - vNegOffset
CaMIN = float(concdep.attrib['min_conc'])
CaMAX = float(concdep.attrib['max_conc'])
CaNDIVS = 100
dCa = (CaMAX - CaMIN) / CaNDIVS
# CAREFUL!: tableA = [[0.0]*(CaNDIVS+1)]*(NDIVS_here+1) will not
# work! * does a shallow copy, same list will get repeated 200
# times! Thus setting tableA[35][1] = 5.0 will set all rows,
# 1st col to 5.0!!!!
tableA = [[0.0] * (CaNDIVS + 1) for i in range(NDIVS_here + 1)]
tableB = [[0.0] * (CaNDIVS + 1) for i in range(NDIVS_here + 1)]
for i in range(NDIVS_here + 1):
Ca = CaMIN
for j in range(CaNDIVS + 1):
inf = self.inf(v, Ca)
tau = self.tau(v, Ca)
# convert to SI (Tfactor) before writing to table
# qfactor is already in inf and tau
tableA[i][j] = (inf / tau) / Tfactor
tableB[i][j] = (1.0 / tau) / Tfactor
Ca += dCa
v += dv_here
# Presently HHGate2D doesn't allow the setting of tables as 2D
# vectors directly
#moosegate.tableA = tableA #moosegate.tableB = tableB
# Instead, I wrap the interpol2D objects inside HHGate2D and set
# the tables
moosegate_tableA = moose.Interpol2D(moosegate.path + '/tableA')
# set SI values inside MOOSE
moosegate_tableA.xmin = VMIN_here * Vfactor
moosegate_tableA.xmax = VMAX_here * Vfactor
moosegate_tableA.xdivs = NDIVS_here
#moosegate_tableA.dx = dv_here*Vfactor
moosegate_tableA.ymin = CaMIN * concfactor
moosegate_tableA.ymax = CaMAX * concfactor
moosegate_tableA.ydivs = CaNDIVS
#moosegate_tableA.dy = dCa*concfactor
moosegate_tableA.tableVector2D = tableA
moosegate_tableB = moose.Interpol2D(moosegate.path + '/tableB')
## set SI values inside MOOSE
moosegate_tableB.xmin = VMIN_here * Vfactor
moosegate_tableB.xmax = VMAX_here * Vfactor
moosegate_tableB.xdivs = NDIVS_here
#moosegate_tableB.dx = dv_here*Vfactor
moosegate_tableB.ymin = CaMIN * concfactor
moosegate_tableB.ymax = CaMAX * concfactor
moosegate_tableB.ydivs = CaNDIVS
#moosegate_tableB.dy = dCa*concfactor
moosegate_tableB.tableVector2D = tableB
