def test_replacement(self):
logging.info("Start test test_replacement")
# case 1
out = replace_missing_values.replace_missing(self.TEST_STR_IND, "NA",
0.42, 0.42, " ")
data = loadtxt(self.TEST_042)
assert data.shape == out.shape
for i in range(data.shape[0]):
assert tools.correlation(
data[i, :], out[i, :], 1e-2
) #-2 because we fist generated data with float64 then we changed it to use float32
# case 2
out = replace_missing_values.replace_missing(self.TEST_FLOAT_IND,
"9.0", 0.5, 0.5, " ")
data = loadtxt(self.TEST_05)
assert data.shape == out.shape
for i in range(data.shape[0]):
assert tools.correlation(data[i, :], out[i, :], 1e-12)
#case 3
data = loadtxt(self.TEST_042_05)
out = replace_missing_values.replace_missing(self.TEST_FLOAT_IND, 9,
0.42, 0.5, " ")
assert data.shape == out.shape
for i in range(data.shape[0]):
assert tools.correlation(data[i, :], out[i, :], 1e-12)
logging.info("PASS")
def _test_regress_out(self):
"""
check linear regression (y-x)
"""
logging.info("Testing linear regression: regress_out")
y = loadtxt(self.LIN_REG_Y)
x = loadtxt(self.LIN_REG_X)
orig_residuals = loadtxt(self.LIN_REG_RESIDUALS)
if y.ndim != 1:
raise ("TEST WASNT IMPLEMENTED")
return
# test 1 dim
residuals = LinearRegression.regress_out(y, x)
y_2dim = y.reshape(-1, 1)
residuals2 = LinearRegression.regress_out(y_2dim, x)
assert tools.correlation(orig_residuals, residuals)
assert tools.correlation(residuals2, residuals)
assert len(residuals) == len(x)
# test 2 dim
y2 = column_stack((y, y))
residuals = LinearRegression.regress_out(y2, x)
for i in range(len(y2[0])):
assert tools.correlation(orig_residuals, residuals[:, i])
assert len(residuals[:, i]) == len(x)
logging.info("PASS")
def test_impute(self):
logging.info("Testing test_impute...")
imputed = loadtxt(self.MANUALLY_IMPUTED_FILE)
self.module.impute(self.MIN_SCORE, self.SNPS_FILE, self.GENO_FILE,
self.IND_FILE, self.MIN_MISSING_VALUES)
assert (imputed.shape[0] == self.module.site_imputation.shape[0])
assert (imputed.shape[1] == self.module.site_imputation.shape[1])
for i in range(imputed.shape[1]):
assert (tools.correlation(imputed[:, i],
self.module.site_imputation[:, i]))
for i in range(imputed.shape[0]):
assert (tools.correlation(imputed[i, :],
self.module.site_imputation[i, :]))
logging.info("PASS")
def test_euclidean_distance(self):
logging.info("Testing euclidean distance...")
euc_dist = loadtxt(self.EUC_DIST)
out = tools.euclidean_distance(self.meth_data.data[:500,:].transpose(), self.meth_data.data[500:,:].transpose())
assert tests_tools.correlation(out, euc_dist)
logging.info("PASS")
def test_exclude_sites_with_low_mean(self):
logging.info("Testing excluded mean below 0.5...")
data = self.meth_data.copy()
data.exclude_sites_with_low_mean(self.MIN_MEAN_TH)
res = loadtxt(self.FAKE_DATA_MIN_MEANS)
for i in range(res.shape[0]):
assert tools.correlation(res[i, :], data.data[i, :], 1e-14)
logging.info("PASS")
def test_remove_lowest_std_sites():
logging.info("Testing stdth again...")
data_after_std = methylation_data.MethylationDataLoader(
datafile=DATA_STDTH)
data_after_std.remove_lowest_std_sites(0.02)
data = loadtxt(STDTH_RES)
for i in range(data.shape[0]):
assert tools.correlation(data[i, :], data_after_std.data[i, :], 1e-12)
logging.info("PASS")
def test_low_rank_approx(self):
logging.info("Testing low rank approximation")
low_rank_approx = loadtxt(self.LOW_RANK_APPROX)
lra_met_data = self.meth_data.copy()
res = tools.low_rank_approximation(lra_met_data.data.transpose(), self.K)
res = res.transpose()
for i in range(lra_met_data.sites_size):
assert tests_tools.correlation(res[i,:], low_rank_approx[i,:])
logging.info("PASS")
def __init__(self):
logging.info("Testing Started on PCATester")
pca_res_p = loadtxt(self.PCA_P_RES)
meth_data = methylation_data.MethylationDataLoader(
datafile=self.DATA_FILE)
pca_out = pca.PCA(meth_data.data.transpose())
for i in range(10):
assert tools.correlation(pca_out.P[:, i], pca_res_p[:, i])
logging.info("PASS")
logging.info("Testing Finished on PCATester")
def test_components(self):
logging.info("Testing houseman components...")
comp = loadtxt(self.OUT_COMP)
module = houseman.Houseman(
self.meth_data,
open(houseman_parser.HOUSEMAN_DEFAULT_REFERENCE, 'r'))
module.components
assert module.components.shape == comp.shape
for i in range(module.components.shape[1]):
assert tools.correlation(module.components[:, i], comp[:, i], 1e-2)
logging.info("PASS")
def test_remove_covariates(self):
logging.info("Testing removing covariates...")
covar_meth_data = self.meth_data.copy()
covar_meth_data.regress_out(
self.meth_data.covar) # regress out all covariates
coavr, covarnames = covar_meth_data._load_and_validate_covar(
[self.DEMO_COVAR], covar_meth_data.samples_size,
covar_meth_data.samples_ids)
# remove "manually"
for i, site in enumerate(self.meth_data.data):
residuals = LinearRegression.regress_out(site, coavr)
assert len(residuals) == len(site)
assert tools.correlation(residuals, covar_meth_data.data[i])
logging.info("PASS")
def test_senario1(self):
logging.info("Testing clean refactor components...")
refactor_meth_data = self.meth_data.copy()
comp = loadtxt(self.RES1)
ranked = loadtxt(self.RES1_RANKED, dtype=str)
module = refactor.Refactor(methylation_data=refactor_meth_data,
k=5,
t=500,
stdth=0,
bad_probes_list=self.bad_probes,
use_phenos=None,
use_covars=None)
module.run()
assert self._validate_ranked_lists(module, ranked)
assert module.components.shape == comp.shape
for i in range(module.components.shape[1]):
assert tools.correlation(module.components[:, i], comp[:, i])
logging.info("PASS")
def test_senario3(self):
logging.info("Testing controls feature selection...")
refactor_meth_data = self.meth_data.copy()
comp = loadtxt(self.RES3)
ranked = loadtxt(self.RES3_RANKED, dtype=str)
module = refactor.Refactor(methylation_data=refactor_meth_data,
k=5,
t=500,
stdth=0,
bad_probes_list=self.bad_probes,
feature_selection='controls',
use_phenos=['p2'],
use_covars=[])
module.run()
assert self._validate_ranked_lists(module, ranked)
assert module.components.shape == comp.shape
for i in range(module.components.shape[1]):
assert tools.correlation(module.components[:, i], comp[:, i])
logging.info("PASS")
def test_get_mean_per_site(self):
logging.info("Testing mean oer site...")
meth_data_means = self.meth_data.get_mean_per_site()
means = loadtxt(self.FAKE_DATA_MEANS)
assert tools.correlation(means, meth_data_means)
logging.info("PASS")
