def get_train_transform(landmarks_path, resection_params=None):
spatial_transform = tio.Compose((
tio.OneOf({
tio.RandomAffine(): 0.9,
tio.RandomElasticDeformation(): 0.1,
}),
tio.RandomFlip(),
))
resolution_transform = tio.OneOf(
(
tio.RandomAnisotropy(),
tio.RandomBlur(),
),
p=0.75,
)
transforms = []
if resection_params is not None:
transforms.append(get_simulation_transform(resection_params))
if landmarks_path is not None:
transforms.append(
tio.HistogramStandardization({'image': landmarks_path}))
transforms.extend([
# tio.RandomGamma(p=0.2),
resolution_transform,
tio.RandomGhosting(p=0.2),
tio.RandomSpike(p=0.2),
tio.RandomMotion(p=0.2),
tio.RandomBiasField(p=0.5),
tio.ZNormalization(masking_method=tio.ZNormalization.mean),
tio.RandomNoise(p=0.75), # always after ZNorm and after blur!
spatial_transform,
get_tight_crop(),
])
return tio.Compose(transforms)
def test_transforms(self):
landmarks_dict = dict(
t1=np.linspace(0, 100, 13),
t2=np.linspace(0, 100, 13),
)
elastic = torchio.RandomElasticDeformation(max_displacement=1)
transforms = (
torchio.CropOrPad((9, 21, 30)),
torchio.ToCanonical(),
torchio.Resample((1, 1.1, 1.25)),
torchio.RandomFlip(axes=(0, 1, 2), flip_probability=1),
torchio.RandomMotion(),
torchio.RandomGhosting(axes=(0, 1, 2)),
torchio.RandomSpike(),
torchio.RandomNoise(),
torchio.RandomBlur(),
torchio.RandomSwap(patch_size=2, num_iterations=5),
torchio.Lambda(lambda x: 2 * x, types_to_apply=torchio.INTENSITY),
torchio.RandomBiasField(),
torchio.RescaleIntensity((0, 1)),
torchio.ZNormalization(masking_method='label'),
torchio.HistogramStandardization(landmarks_dict=landmarks_dict),
elastic,
torchio.RandomAffine(),
torchio.OneOf({
torchio.RandomAffine(): 3,
elastic: 1
}),
torchio.Pad((1, 2, 3, 0, 5, 6), padding_mode='constant', fill=3),
torchio.Crop((3, 2, 8, 0, 1, 4)),
)
transform = torchio.Compose(transforms)
transform(self.sample)
def byol_aug(filename):
"""
BYOL minimizes the distance between representations of each sample and a transformation of that sample.
Examples of transformations include: translation, rotation, blurring, color inversion, color jitter, gaussian noise.
Return an augmented dataset that consisted the above mentioned transformation. Will be used in the training.
"""
image = tio.ScalarImage(filename)
get_foreground = tio.ZNormalization.mean
training_transform = tio.Compose([
tio.CropOrPad((180, 220, 170)), # zero mean, unit variance of foreground
tio.ZNormalization(
masking_method=get_foreground),
tio.RandomBlur(p=0.25), # blur 25% of times
tio.RandomNoise(p=0.25), # Gaussian noise 25% of times
tio.OneOf({ # either
tio.RandomAffine(): 0.8, # random affine
tio.RandomElasticDeformation(): 0.2, # or random elastic deformation
}, p=0.8), # applied to 80% of images
tio.RandomBiasField(p=0.3), # magnetic field inhomogeneity 30% of times
tio.OneOf({ # either
tio.RandomMotion(): 1, # random motion artifact
tio.RandomSpike(): 2, # or spikes
tio.RandomGhosting(): 2, # or ghosts
}, p=0.5), # applied to 50% of images
])
tfs_image = training_transform(image)
return tfs_image
def test_no_bias(self):
transform = tio.RandomBiasField(coefficients=0.)
transformed = transform(self.sample_subject)
self.assertTensorAlmostEqual(
self.sample_subject.t1.data,
transformed.t1.data,
)
def __call__(self, sample, metadata=None):
if np.random.random() < self.p:
# Get params
random_bias_field = tio.Compose([
tio.RandomBiasField(coefficients=self.coefficients,
order=self.order,
p=self.p)
])
# Save params
metadata[MetadataKW.BIAS_FIELD] = [random_bias_field]
else:
metadata[MetadataKW.BIAS_FIELD] = [None]
if any(metadata[MetadataKW.BIAS_FIELD]):
# Apply random bias field
data_out, history = tio_transform(x=sample,
transform=random_bias_field)
# Keep data type
data_out = data_out.astype(sample.dtype)
# Update metadata to history
metadata[MetadataKW.BIAS_FIELD] = [history]
return data_out, metadata
else:
return sample, metadata
def get_transform(self, channels, is_3d=True, labels=True):
landmarks_dict = {
channel: np.linspace(0, 100, 13)
for channel in channels
}
disp = 1 if is_3d else (1, 1, 0.01)
elastic = tio.RandomElasticDeformation(max_displacement=disp)
cp_args = (9, 21, 30) if is_3d else (21, 30, 1)
resize_args = (10, 20, 30) if is_3d else (10, 20, 1)
flip_axes = axes_downsample = (0, 1, 2) if is_3d else (0, 1)
swap_patch = (2, 3, 4) if is_3d else (3, 4, 1)
pad_args = (1, 2, 3, 0, 5, 6) if is_3d else (0, 0, 3, 0, 5, 6)
crop_args = (3, 2, 8, 0, 1, 4) if is_3d else (0, 0, 8, 0, 1, 4)
remapping = {1: 2, 2: 1, 3: 20, 4: 25}
transforms = [
tio.CropOrPad(cp_args),
tio.EnsureShapeMultiple(2, method='crop'),
tio.Resize(resize_args),
tio.ToCanonical(),
tio.RandomAnisotropy(downsampling=(1.75, 2), axes=axes_downsample),
tio.CopyAffine(channels[0]),
tio.Resample((1, 1.1, 1.25)),
tio.RandomFlip(axes=flip_axes, flip_probability=1),
tio.RandomMotion(),
tio.RandomGhosting(axes=(0, 1, 2)),
tio.RandomSpike(),
tio.RandomNoise(),
tio.RandomBlur(),
tio.RandomSwap(patch_size=swap_patch, num_iterations=5),
tio.Lambda(lambda x: 2 * x, types_to_apply=tio.INTENSITY),
tio.RandomBiasField(),
tio.RescaleIntensity(out_min_max=(0, 1)),
tio.ZNormalization(),
tio.HistogramStandardization(landmarks_dict),
elastic,
tio.RandomAffine(),
tio.OneOf({
tio.RandomAffine(): 3,
elastic: 1,
}),
tio.RemapLabels(remapping=remapping, masking_method='Left'),
tio.RemoveLabels([1, 3]),
tio.SequentialLabels(),
tio.Pad(pad_args, padding_mode=3),
tio.Crop(crop_args),
]
if labels:
transforms.append(tio.RandomLabelsToImage(label_key='label'))
return tio.Compose(transforms)
def get_context(device, variables, augmentation_mode, **kwargs):
context = base_config.get_context(device, variables, **kwargs)
context.file_paths.append(os.path.abspath(__file__))
context.config.update({'augmentation_mode': augmentation_mode})
# training_transform is a tio.Compose where the second transform is the augmentation
dataset_defn = context.get_component_definition("dataset")
training_transform = dataset_defn['params']['transforms']['training']
dwi_augmentation = ReconstructMeanDWI(num_dwis=(1, 7),
num_directions=(1, 3),
directionality=(4, 10))
noise = tio.RandomNoise(std=0.035, p=0.3)
blur = tio.RandomBlur((0, 1), p=0.2)
standard_augmentations = tio.Compose([
tio.RandomFlip(axes=(0, 1, 2)),
tio.RandomElasticDeformation(p=0.5,
num_control_points=(7, 7, 4),
locked_borders=1,
image_interpolation='bspline',
exclude="full_dwi"),
tio.RandomBiasField(p=0.5),
tio.RescaleIntensity((0, 1), (0.01, 99.9)),
tio.RandomGamma(p=0.8),
tio.RescaleIntensity((-1, 1)),
tio.OneOf([
tio.Compose([blur, noise]),
tio.Compose([noise, blur]),
])
],
exclude="full_dwi")
if augmentation_mode == 'no_augmentation':
training_transform.transforms.pop(1)
elif augmentation_mode == 'standard':
training_transform.transforms[1] = standard_augmentations
elif augmentation_mode == 'dwi_reconstruction':
training_transform.transforms[1] = dwi_augmentation
elif augmentation_mode == 'combined':
training_transform.transforms[1] = tio.Compose(
[dwi_augmentation, standard_augmentations])
else:
raise ValueError(f"Invalid augmentation mode {augmentation_mode}")
return context
def get_transform(self, channels, is_3d=True, labels=True):
landmarks_dict = {
channel: np.linspace(0, 100, 13)
for channel in channels
}
disp = 1 if is_3d else (1, 1, 0.01)
elastic = torchio.RandomElasticDeformation(max_displacement=disp)
cp_args = (9, 21, 30) if is_3d else (21, 30, 1)
flip_axes = axes_downsample = (0, 1, 2) if is_3d else (0, 1)
swap_patch = (2, 3, 4) if is_3d else (3, 4, 1)
pad_args = (1, 2, 3, 0, 5, 6) if is_3d else (0, 0, 3, 0, 5, 6)
crop_args = (3, 2, 8, 0, 1, 4) if is_3d else (0, 0, 8, 0, 1, 4)
transforms = [
torchio.CropOrPad(cp_args),
torchio.ToCanonical(),
torchio.RandomDownsample(downsampling=(1.75, 2),
axes=axes_downsample),
torchio.Resample((1, 1.1, 1.25)),
torchio.RandomFlip(axes=flip_axes, flip_probability=1),
torchio.RandomMotion(),
torchio.RandomGhosting(axes=(0, 1, 2)),
torchio.RandomSpike(),
torchio.RandomNoise(),
torchio.RandomBlur(),
torchio.RandomSwap(patch_size=swap_patch, num_iterations=5),
torchio.Lambda(lambda x: 2 * x, types_to_apply=torchio.INTENSITY),
torchio.RandomBiasField(),
torchio.RescaleIntensity((0, 1)),
torchio.ZNormalization(),
torchio.HistogramStandardization(landmarks_dict),
elastic,
torchio.RandomAffine(),
torchio.OneOf({
torchio.RandomAffine(): 3,
elastic: 1,
}),
torchio.Pad(pad_args, padding_mode=3),
torchio.Crop(crop_args),
]
if labels:
transforms.append(torchio.RandomLabelsToImage(label_key='label'))
return torchio.Compose(transforms)
add_noise = tio.RandomNoise(std=0.5, seed=42) standard = standardize(fpg_ras) noisy = add_noise(standard) show_fpg(noisy) #MRI-specific transforms #TorchIO includes some transforms to simulate image artifacts specific to MRI modalities. #Random bias field (DID NOT WORK - REWORK) #Magnetic field inhomogeneities in the MRI scanner produce low-frequency intensity distortions #in the images, which are typically corrected using algorithms such as N4ITK. #To simulate this artifact, we can use RandomBiasField. #For this example, we will use an image that has been preprocessed so it's meant to be unbiased. add_bias = tio.RandomBiasField(coefficients=1, seed=0) mni_bias = add_bias(fpg_ras) mni_bias.seg = mni_bias.heart show_fpg(mni_bias) #k -space transforms #MR images are generated by computing the inverse Fourier transform of the k-space, which is the signal received by the coils #in the scanner. If the k-space is altered, an artifact will be created in the image. These artifacts are typically # accidental, but we can use transforms to simulate them. #Random spike #Sometimes, signal peaks can appear in k-space. If one adds a high-energy component at e.g. 440 Hz in the spectrum of # an audio signal, a tone of that frequency will be audible in the time domain. Similarly, spikes in k-space manifest # as stripes in image space. They can be simulated using RandomSpike. The number of spikes doesn't affect the transform # run time, so try adding more!
def get_context(device, variables, fold=0, **kwargs):
context = TorchContext(device, name="msseg2", variables=variables)
context.file_paths.append(os.path.abspath(__file__))
context.config = config = {'fold': fold, 'patch_size': 96}
input_images = ["flair_time01", "flair_time02"]
subject_loader = ComposeLoaders([
ImageLoader(glob_pattern="flair_time01*",
image_name='flair_time01',
image_constructor=tio.ScalarImage),
ImageLoader(glob_pattern="flair_time02*",
image_name='flair_time02',
image_constructor=tio.ScalarImage),
ImageLoader(glob_pattern="brain_mask.*",
image_name='brain_mask',
image_constructor=tio.LabelMap,
label_values={"brain": 1}),
ImageLoader(glob_pattern="ground_truth.*",
image_name="ground_truth",
image_constructor=tio.LabelMap,
label_values={"lesion": 1}),
])
cohorts = {}
cohorts['all'] = RequireAttributes(input_images)
cohorts['validation'] = RandomFoldFilter(num_folds=5,
selection=fold,
seed=0xDEADBEEF)
cohorts['training'] = NegateFilter(cohorts['validation'])
common_transforms_1 = tio.Compose([
SetDataType(torch.float),
EnforceConsistentAffine(source_image_name='flair_time01'),
TargetResample(target_spacing=1, tolerance=0.11),
CropToMask('brain_mask'),
MinSizePad(config['patch_size'])
])
augmentations = tio.Compose([
RandomPermuteDimensions(),
tio.RandomFlip(axes=(0, 1, 2)),
tio.OneOf(
{
tio.RandomElasticDeformation():
0.2,
tio.RandomAffine(scales=0.2,
degrees=45,
default_pad_value='otsu'):
0.8,
},
p=0.75),
tio.RandomBiasField(p=0.5),
tio.RescaleIntensity((0, 1), (0.01, 99.9)),
tio.RandomGamma(p=0.8),
tio.RescaleIntensity((-1, 1)),
tio.RandomBlur((0, 1), p=0.2),
tio.RandomNoise(std=0.1, p=0.35)
])
common_transforms_2 = tio.Compose([
tio.RescaleIntensity((-1, 1.), (0.05, 99.5)),
ConcatenateImages(image_names=["flair_time01", "flair_time02"],
image_channels=[1, 1],
new_image_name="X"),
RenameProperty(old_name='ground_truth', new_name='y'),
CustomOneHot(include="y"),
])
transforms = {
'default':
tio.Compose([common_transforms_1, common_transforms_2]),
'training':
tio.Compose([
common_transforms_1, augmentations, common_transforms_2,
ImageFromLabels(new_image_name="patch_probability",
label_weights=[('brain_mask', 'brain', 1),
('y', 'lesion', 100)])
]),
}
context.add_component("dataset",
SubjectFolder,
root='$DATASET_PATH',
subject_path="",
subject_loader=subject_loader,
cohorts=cohorts,
transforms=transforms)
context.add_component("model",
ModularUNet,
in_channels=2,
out_channels=2,
filters=[40, 40, 80, 80, 120, 120],
depth=6,
block_params={'residual': True},
downsample_class=BlurConv3d,
downsample_params={
'kernel_size': 3,
'stride': 2,
'padding': 1
},
upsample_class=BlurConvTranspose3d,
upsample_params={
'kernel_size': 3,
'stride': 2,
'padding': 1,
'output_padding': 0
})
context.add_component("optimizer",
SGD,
params="self.model.parameters()",
lr=0.001,
momentum=0.95)
context.add_component("criterion",
HybridLogisticDiceLoss,
logistic_class_weights=[1, 100])
training_evaluators = [
ScheduledEvaluation(evaluator=SegmentationEvaluator(
'y_pred_eval', 'y_eval'),
log_name='training_segmentation_eval',
interval=15),
ScheduledEvaluation(evaluator=LabelMapEvaluator('y_pred_eval'),
log_name='training_label_eval',
interval=15),
ScheduledEvaluation(evaluator=ContourImageEvaluator(
"random",
'flair_time02',
'y_pred_eval',
'y_eval',
slice_id=0,
legend=True,
ncol=2,
interesting_slice=True,
split_subjects=False),
log_name=f"contour_image",
interval=15),
]
validation_evaluators = [
ScheduledEvaluation(evaluator=SegmentationEvaluator(
"y_pred_eval", "y_eval"),
log_name="segmentation_eval",
cohorts=["validation"],
interval=50),
ScheduledEvaluation(evaluator=ContourImageEvaluator(
"interesting",
'flair_time02',
'y_pred_eval',
'y_eval',
slice_id=0,
legend=True,
ncol=1,
interesting_slice=True,
split_subjects=True),
log_name=f"contour_image",
cohorts=["validation"],
interval=50),
]
def scoring_function(evaluation_dict):
# Grab the output of the SegmentationEvaluator
seg_eval = evaluation_dict['segmentation_eval']['validation']
# Take mean dice, while accounting for subjects which have no lesions.
# Dice is 0/0 = nan when the model correctly outputs no lesions. This is counted as a score of 1.0.
# Dice is (>0)/0 = posinf when the model incorrectly predicts lesions when there are none.
# This is counted as a score of 0.0.
dice = torch.tensor(seg_eval["subject_stats"]['dice.lesion'])
dice = dice.nan_to_num(nan=1.0, posinf=0.0)
score = dice.mean()
return score
train_predictor = StandardPredict(image_names=['X', 'y'])
validation_predictor = PatchPredict(patch_batch_size=32,
patch_size=config['patch_size'],
patch_overlap=(config['patch_size'] //
8),
padding_mode=None,
overlap_mode='average',
image_names=['X'])
patch_sampler = tio.WeightedSampler(patch_size=config['patch_size'],
probability_map='patch_probability')
train_dataloader_factory = PatchDataLoader(max_length=100,
samples_per_volume=1,
sampler=patch_sampler)
validation_dataloader_factory = StandardDataLoader(
sampler=SequentialSampler)
context.add_component(
"trainer",
SegmentationTrainer,
training_batch_size=4,
save_rate=100,
scoring_interval=50,
scoring_function=scoring_function,
one_time_evaluators=[],
training_evaluators=training_evaluators,
validation_evaluators=validation_evaluators,
max_iterations_with_no_improvement=2000,
train_predictor=train_predictor,
validation_predictor=validation_predictor,
train_dataloader_factory=train_dataloader_factory,
validation_dataloader_factory=validation_dataloader_factory)
return context
def test_wrong_coefficient_type(self):
with self.assertRaises(ValueError):
tio.RandomBiasField(coefficients='wrong')
normalization = tio.ZNormalization(masking_method=tio.ZNormalization.mean)
onehot = tio.OneHot()
prefix += '_bias_flip_elastic_noise'
# spatial = tio.OneOf({
# tio.RandomAffine(scales=0.1,degrees=30): 0.8,
# tio.RandomElasticDeformation(): 0.2,
# },
# p=0.75,
# )
spatial = tio.RandomAffine(scales=0.05,degrees=10,p=0.75)
bias = tio.RandomBiasField(p=0.3)
flip = tio.RandomFlip(axes=('LR',), flip_probability=0.5)
noise = tio.RandomNoise(std=0.25, p=0.25)
transforms = [bias, normalization, flip, spatial, noise, onehot]#, bias, normalization, flip, spatial, noise, onehot]
training_transform = tio.Compose(transforms)
validation_transform = tio.Compose([normalization, onehot])
#subject = dataset[0]
#transformed_subject = training_transform(subject)
#transformed_subject.plot()
#%%
def test_small_image(self):
# https://github.com/fepegar/torchio/issues/300
tio.RandomBiasField()(torch.rand(1, 2, 3, 4))
def test_wrong_order_type(self):
with self.assertRaises(TypeError):
tio.RandomBiasField(order='wrong')
def test_negative_order(self):
with self.assertRaises(ValueError):
tio.RandomBiasField(order=-1)
zt1=ScannerInfoT1[site],
zt2=ScannerInfoT2[site],
zpd=ScannerInfoPD[site],
)
subjects.append(subject)
subjects = subjects[:max_subjects]
dataset = tio.SubjectsDataset(subjects)
print('Dataset size:', len(dataset), 'subjects')
#%%
normalization = tio.ZNormalization()
spatial = tio.RandomAffine(scales=0.1, degrees=10, translation=0, p=0.75)
bias = tio.RandomBiasField(coefficients=0.5, p=0.3)
flip = tio.RandomFlip(axes=('LR', ), flip_probability=0.5)
noise = tio.RandomNoise(std=0.1, p=0.25)
transforms = [flip, spatial, normalization]
training_transform = tio.Compose(transforms)
validation_transform = tio.Compose([normalization])
#%%
seed = 42 # for reproducibility
num_subjects = len(dataset)
num_training_subjects = int(training_split_ratio * num_subjects)
num_validation_subjects = num_subjects - num_training_subjects
def get_context(
device,
variables,
fold=0,
predict_hbt=False,
training_batch_size=4,
):
context = TorchContext(device, name="dmri-hippo", variables=variables)
context.file_paths.append(os.path.abspath(__file__))
context.config.update({'fold': fold})
input_images = ["mean_dwi", "md", "fa"]
output_labels = ["whole_roi", "hbt_roi"]
subject_loader = ComposeLoaders([
ImageLoader(glob_pattern="mean_dwi.*",
image_name='mean_dwi',
image_constructor=tio.ScalarImage),
ImageLoader(glob_pattern="md.*",
image_name='md',
image_constructor=tio.ScalarImage),
ImageLoader(glob_pattern="fa.*",
image_name='fa',
image_constructor=tio.ScalarImage),
# ImageLoader(glob_pattern="full_dwi.*", image_name='full_dwi', image_constructor=tio.ScalarImage),
# TensorLoader(glob_pattern="full_dwi_grad.b", tensor_name="grad", belongs_to="full_dwi"),
ImageLoader(glob_pattern="whole_roi.*",
image_name="whole_roi",
image_constructor=tio.LabelMap,
label_values={
"left_whole": 1,
"right_whole": 2
}),
ImageLoader(glob_pattern="whole_roi_alt.*",
image_name="whole_roi_alt",
image_constructor=tio.LabelMap,
label_values={
"left_whole": 1,
"right_whole": 2
}),
ImageLoader(glob_pattern="hbt_roi.*",
image_name="hbt_roi",
image_constructor=tio.LabelMap,
label_values={
"left_head": 1,
"left_body": 2,
"left_tail": 3,
"right_head": 4,
"right_body": 5,
"right_tail": 6
}),
ImageLoader(glob_pattern="../../atlas/whole_roi_union.*",
image_name="whole_roi_union",
image_constructor=tio.LabelMap,
uniform=True),
AttributeLoader(glob_pattern='attributes.*'),
AttributeLoader(
glob_pattern='../../attributes/cross_validation_split.json',
multi_subject=True,
uniform=True),
AttributeLoader(
glob_pattern='../../attributes/ab300_validation_subjects.json',
multi_subject=True,
uniform=True),
AttributeLoader(
glob_pattern='../../attributes/cbbrain_test_subjects.json',
multi_subject=True,
uniform=True),
])
cohorts = {}
cohorts['all'] = RequireAttributes(input_images)
cohorts['cross_validation'] = RequireAttributes(['fold'])
cohorts['training'] = ComposeFilters(
[cohorts['cross_validation'],
ForbidAttributes({"fold": fold})])
cohorts['cbbrain_validation'] = ComposeFilters(
[cohorts['cross_validation'],
RequireAttributes({"fold": fold})])
cohorts['cbbrain_test'] = RequireAttributes({'cbbrain_test': True})
cohorts['ab300_validation'] = RequireAttributes({'ab300_validation': True})
cohorts['ab300_validation_plot'] = ComposeFilters(
[cohorts['ab300_validation'],
RandomSelectFilter(num_subjects=20)])
cohorts['cbbrain'] = RequireAttributes({"protocol": "cbbrain"})
cohorts['ab300'] = RequireAttributes({"protocol": "ab300"})
cohorts['rescans'] = ForbidAttributes({"rescan_id": "None"})
cohorts['fasd'] = RequireAttributes({"pathologies": "FASD"})
cohorts['inter_rater'] = RequireAttributes(["whole_roi_alt"])
common_transforms_1 = tio.Compose([
tio.CropOrPad((96, 88, 24),
padding_mode='minimum',
mask_name='whole_roi_union'),
CustomRemapLabels(remapping=[("right_whole", 2, 1)],
masking_method="Right",
include=["whole_roi"]),
CustomRemapLabels(remapping=[("right_head", 4, 1),
("right_body", 5, 2),
("right_tail", 6, 3)],
masking_method="Right",
include=["hbt_roi"]),
])
noise = tio.RandomNoise(std=0.035, p=0.3)
blur = tio.RandomBlur((0, 1), p=0.2)
standard_augmentations = tio.Compose([
tio.RandomFlip(axes=(0, 1, 2)),
tio.RandomElasticDeformation(p=0.5,
num_control_points=(7, 7, 4),
locked_borders=1,
image_interpolation='bspline',
exclude=["full_dwi"]),
tio.RandomBiasField(p=0.5),
tio.RescaleIntensity((0, 1), (0.01, 99.9)),
tio.RandomGamma(p=0.8),
tio.RescaleIntensity((-1, 1)),
tio.OneOf([
tio.Compose([blur, noise]),
tio.Compose([noise, blur]),
])
],
exclude="full_dwi")
common_transforms_2 = tio.Compose([
tio.RescaleIntensity((-1., 1.), (0.5, 99.5)),
ConcatenateImages(image_names=["mean_dwi", "md", "fa"],
image_channels=[1, 1, 1],
new_image_name="X"),
RenameProperty(old_name="hbt_roi" if predict_hbt else "whole_roi",
new_name="y"),
CustomOneHot(include=["y"])
])
transforms = {
'default':
tio.Compose([common_transforms_1, common_transforms_2]),
'training':
tio.Compose(
[common_transforms_1, standard_augmentations,
common_transforms_2]),
}
context.add_component("dataset",
SubjectFolder,
root='$DATASET_PATH',
subject_path="subjects",
subject_loader=subject_loader,
cohorts=cohorts,
transforms=transforms)
context.add_component("model",
NestedResUNet,
input_channels=3,
output_channels=4 if predict_hbt else 2,
filters=40,
dropout_p=0.2)
context.add_component("optimizer",
Adam,
params="self.model.parameters()",
lr=0.0002)
context.add_component("criterion", HybridLogisticDiceLoss)
training_evaluators = [
ScheduledEvaluation(evaluator=SegmentationEvaluator(
'y_pred_eval', 'y_eval'),
log_name='training_segmentation_eval',
interval=10),
ScheduledEvaluation(evaluator=ContourImageEvaluator(
"Axial",
'mean_dwi',
'y_pred_eval',
'y_eval',
slice_id=12,
legend=True,
ncol=2,
split_subjects=False),
log_name=f"contour_image_training",
interval=50),
]
curve_params = {
"left_whole":
np.array([-1.96312119e-01, 9.46668029e+00, 2.33635173e+03]),
"right_whole":
np.array([-2.68467331e-01, 1.67925603e+01, 2.07224236e+03])
}
validation_evaluators = [
ScheduledEvaluation(evaluator=LabelMapEvaluator(
'y_pred_eval',
curve_params=curve_params,
curve_attribute='age',
stats_to_output=('volume', 'error', 'absolute_error',
'squared_error', 'percent_diff')),
log_name="predicted_label_eval",
cohorts=['cbbrain_validation', 'ab300_validation'],
interval=50),
ScheduledEvaluation(evaluator=SegmentationEvaluator(
"y_pred_eval", "y_eval"),
log_name="segmentation_eval",
cohorts=['cbbrain_validation'],
interval=50),
ScheduledEvaluation(
evaluator=ContourImageEvaluator("Axial",
"mean_dwi",
"y_pred_eval",
"y_eval",
slice_id=10,
legend=True,
ncol=5,
split_subjects=False),
log_name="contour_image_axial",
cohorts=['cbbrain_validation', 'ab300_validation_plot'],
interval=250),
ScheduledEvaluation(
evaluator=ContourImageEvaluator("Coronal",
"mean_dwi",
"y_pred_eval",
"y_eval",
slice_id=44,
legend=True,
ncol=2,
split_subjects=False),
log_name="contour_image_coronal",
cohorts=['cbbrain_validation', 'ab300_validation_plot'],
interval=250),
]
def scoring_function(evaluation_dict):
# Grab the output of the SegmentationEvaluator
seg_eval_cbbrain = evaluation_dict['segmentation_eval'][
'cbbrain_validation']["summary_stats"]
# Get the mean dice for each label (the mean is across subjects)
cbbrain_dice = seg_eval_cbbrain['mean', :, 'dice']
# Now take the mean across all labels
cbbrain_dice = cbbrain_dice.mean()
score = cbbrain_dice
return score
train_predictor = StandardPredict(sagittal_split=True,
image_names=['X', 'y'])
validation_predictor = StandardPredict(sagittal_split=True,
image_names=['X'])
train_dataloader_factory = StandardDataLoader(sampler=RandomSampler)
validation_dataloader_factory = StandardDataLoader(
sampler=SequentialSampler)
context.add_component(
"trainer",
SegmentationTrainer,
training_batch_size=training_batch_size,
save_rate=100,
scoring_interval=50,
scoring_function=scoring_function,
one_time_evaluators=[],
training_evaluators=training_evaluators,
validation_evaluators=validation_evaluators,
max_iterations_with_no_improvement=2000,
train_predictor=train_predictor,
validation_predictor=validation_predictor,
train_dataloader_factory=train_dataloader_factory,
validation_dataloader_factory=validation_dataloader_factory)
return context
