def __init__(self, parent=None):
widget.OWWidget.__init__(self, parent)
self.min_value, self.max_value = \
self.thresholds.get(self.Scores[self.score_index][0], (1, 0))
#: Input data set
self.data = None
#: Current target group selection
self.targets = []
#: The computed scores
self.scores = None
#: The computed scores from label permutations
self.nulldist = None
self.__scores_future = self.__scores_state = None
self.__in_progress = False
self.test_f = {
OWFeatureSelection.LowTail: test_low,
OWFeatureSelection.HighTail: test_high,
OWFeatureSelection.TwoTail: test_two_tail,
}
self.histogram = Histogram(enableMouse=False,
enableMenu=False,
background="w")
self.histogram.enableAutoRange(enable=True)
self.histogram.getViewBox().setMouseEnabled(False, False)
self.histogram.selectionChanged.connect(
self.__on_histogram_plot_selection_changed)
self.histogram.selectionEdited.connect(self._invalidate_selection)
self.mainArea.layout().addWidget(self.histogram)
box = gui.widgetBox(self.controlArea, "Info")
self.dataInfoLabel = gui.widgetLabel(box, "No data on input.\n")
self.dataInfoLabel.setWordWrap(True)
self.selectedInfoLabel = gui.widgetLabel(box, "\n")
box1 = gui.widgetBox(self.controlArea, "Scoring Method")
gui.comboBox(
box1,
self,
"score_index",
items=[sm[0] for sm in self.Scores],
callback=[self.on_scoring_method_changed, self.update_scores])
box = gui.widgetBox(self.controlArea, "Target Labels")
self.label_selection_widget = guiutils.LabelSelectionWidget(self)
self.label_selection_widget.setMaximumHeight(150)
box.layout().addWidget(self.label_selection_widget)
self.label_selection_widget.groupChanged.connect(
self.on_label_activated)
self.label_selection_widget.groupSelectionChanged.connect(
self.on_target_changed)
box = gui.widgetBox(self.controlArea, "Selection")
box.layout().setSpacing(0)
self.max_value_spin = gui.doubleSpin(box,
self,
"max_value",
minv=-1e6,
maxv=1e6,
step=1e-6,
label="Upper threshold:",
callback=self.update_boundary,
callbackOnReturn=True)
self.low_value_spin = gui.doubleSpin(box,
self,
"min_value",
minv=-1e6,
maxv=1e6,
step=1e-6,
label="Lower threshold:",
callback=self.update_boundary,
callbackOnReturn=True)
check = gui.checkBox(box,
self,
"compute_null",
"Compute null distribution",
callback=self.update_scores)
perm_spin = gui.spin(box,
self,
"permutations_count",
minv=1,
maxv=50,
label="Permutations:",
callback=self.update_scores,
callbackOnReturn=True)
check.disables.append(perm_spin)
box1 = gui.widgetBox(box, orientation='horizontal')
pval_spin = gui.doubleSpin(box1,
self,
"alpha_value",
minv=2e-7,
maxv=1.0,
step=1e-7,
label="α-value:")
pval_select = gui.button(box1,
self,
"Select",
callback=self.select_p_best,
autoDefault=False)
check.disables.append(pval_spin)
check.disables.append(pval_select)
check.makeConsistent()
box1 = gui.widgetBox(box, orientation='horizontal')
gui.spin(box1, self, "n_best", 0, 10000, step=1, label="Best Ranked:")
gui.button(box1,
self,
"Select",
callback=self.select_n_best,
autoDefault=False)
box = gui.widgetBox(self.controlArea, "Output")
acbox = gui.auto_commit(box, self, "auto_commit", "Commit", box=None)
acbox.button.setDefault(True)
gui.checkBox(box,
self,
"add_scores_to_output",
"Add gene scores to output",
callback=self._invalidate_selection)
gui.rubber(self.controlArea)
self.on_scoring_method_changed()
self._executor = concurrent.ThreadExecutor()
def __init__(self):
super().__init__()
self.data = None # type: Optional[Orange.data.Table]
self.learner = None # type: Optional[Learner]
self.default_learner = SimpleTreeLearner()
self.modified = False
self.executor = qconcurrent.ThreadExecutor(self)
self.__task = None
main_layout = QVBoxLayout()
main_layout.setContentsMargins(10, 10, 10, 10)
self.controlArea.layout().addLayout(main_layout)
box = QGroupBox(title=self.tr("Default Method"), flat=False)
box_layout = QVBoxLayout(box)
main_layout.addWidget(box)
button_group = QButtonGroup()
button_group.buttonClicked[int].connect(self.set_default_method)
for method, _ in list(METHODS.items())[1:-1]:
imputer = self.create_imputer(method)
button = QRadioButton(imputer.name)
button.setChecked(method == self.default_method_index)
button_group.addButton(button, method)
box_layout.addWidget(button)
self.default_button_group = button_group
box = QGroupBox(title=self.tr("Individual Attribute Settings"),
flat=False)
main_layout.addWidget(box)
horizontal_layout = QHBoxLayout(box)
main_layout.addWidget(box)
self.varview = QListView(selectionMode=QListView.ExtendedSelection,
uniformItemSizes=True)
self.varview.setItemDelegate(DisplayFormatDelegate())
self.varmodel = itemmodels.VariableListModel()
self.varview.setModel(self.varmodel)
self.varview.selectionModel().selectionChanged.connect(
self._on_var_selection_changed)
self.selection = self.varview.selectionModel()
horizontal_layout.addWidget(self.varview)
method_layout = QVBoxLayout()
horizontal_layout.addLayout(method_layout)
button_group = QButtonGroup()
for method in Method:
imputer = self.create_imputer(method)
button = QRadioButton(text=imputer.name)
button_group.addButton(button, method)
method_layout.addWidget(button)
self.value_combo = QComboBox(
minimumContentsLength=8,
sizeAdjustPolicy=QComboBox.AdjustToMinimumContentsLength,
activated=self._on_value_selected)
self.value_double = QDoubleSpinBox(
editingFinished=self._on_value_selected,
minimum=-1000.,
maximum=1000.,
singleStep=.1,
decimals=3,
)
self.value_stack = value_stack = QStackedWidget()
value_stack.addWidget(self.value_combo)
value_stack.addWidget(self.value_double)
method_layout.addWidget(value_stack)
button_group.buttonClicked[int].connect(
self.set_method_for_current_selection)
method_layout.addStretch(2)
reset_button = QPushButton("Restore All to Default",
checked=False,
checkable=False,
clicked=self.reset_variable_state,
default=False,
autoDefault=False)
method_layout.addWidget(reset_button)
self.variable_button_group = button_group
box = gui.auto_commit(self.controlArea,
self,
"autocommit",
"Apply",
orientation=Qt.Horizontal,
checkbox_label="Apply automatically")
box.button.setFixedWidth(180)
box.layout().insertStretch(0)
def __init__(self, parent=None):
super().__init__(parent)
self._changedFlag = False
self.__invalidated = False
self.__runstate = OWKEGGPathwayBrowser.Initializing
self.__in_setProgress = False
self.controlArea.setMaximumWidth(250)
box = gui.widgetBox(self.controlArea, "Info")
self.infoLabel = gui.widgetLabel(box, "No data on input\n")
gui.separator(self.controlArea)
gui.checkBox(self.controlArea,
self,
"useReference",
"From signal",
box="Reference",
callback=self.Update)
gui.separator(self.controlArea)
gui.checkBox(
self.controlArea,
self,
"showOrthology",
"Show pathways in full orthology",
box="Orthology",
callback=self.UpdateListView,
)
gui.checkBox(
self.controlArea,
self,
"autoResize",
"Resize to fit",
box="Image",
callback=self.UpdatePathwayViewTransform,
)
box = gui.widgetBox(self.controlArea, "Cache Control")
gui.button(
box,
self,
"Clear cache",
callback=self.ClearCache,
tooltip="Clear all locally cached KEGG data.",
default=False,
autoDefault=False,
)
gui.separator(self.controlArea)
gui.auto_commit(self.controlArea, self, "autoCommit", "Commit")
gui.rubber(self.controlArea)
spliter = QSplitter(Qt.Vertical, self.mainArea)
self.pathwayView = PathwayView(self, spliter)
self.pathwayView.scene().selectionChanged.connect(
self._onSelectionChanged)
self.mainArea.layout().addWidget(spliter)
self.listView = QTreeWidget(allColumnsShowFocus=True,
selectionMode=QTreeWidget.SingleSelection,
sortingEnabled=True,
maximumHeight=200)
spliter.addWidget(self.listView)
self.listView.setColumnCount(4)
self.listView.setHeaderLabels(
["Pathway", "P value", "Genes", "Reference"])
self.listView.itemSelectionChanged.connect(self.UpdatePathwayView)
select = QAction("Select All", self, shortcut=QKeySequence.SelectAll)
select.triggered.connect(self.selectAll)
self.addAction(select)
self.data = None
self.input_genes = []
self.tax_id = None
self.use_attr_names = None
self.gene_id_attribute = None
self.gene_id_column = None
self.ref_data = None
self.ref_genes = []
self.ref_tax_id = None
self.ref_use_attr_names = None
self.ref_gene_id_attribute = None
self.ref_gene_id_column = None
self.pathways = {}
self.org = None
self._executor = concurrent.ThreadExecutor()
self.setEnabled(False)
self.setBlocking(True)
progress = concurrent.methodinvoke(self, "setProgress", (float, ))
def get_genome():
"""Return a KEGGGenome with the common org entries precached."""
genome = kegg.KEGGGenome()
essential = genome.essential_organisms()
common = genome.common_organisms()
# Remove duplicates of essential from common.
# (essential + common list as defined here will be used in the
# GUI.)
common = [c for c in common if c not in essential]
# TODO: Add option to specify additional organisms not
# in the common list.
keys = list(map(genome.org_code_to_entry_key, essential + common))
genome.pre_cache(keys, progress_callback=progress)
return (keys, genome)
self._genomeTask = task = concurrent.Task(function=get_genome)
task.finished.connect(self.__initialize_finish)
self.progressBarInit()
self.infoLabel.setText("Fetching organism definitions\n")
self._executor.submit(task)
def __init__(self):
super().__init__()
self.data = None # type: Optional[Orange.data.Table]
self.learner = None # type: Optional[Learner]
self.default_learner = SimpleTreeLearner(min_instances=10,
max_depth=10)
self.modified = False
self.executor = qconcurrent.ThreadExecutor(self)
self.__task = None
main_layout = self.controlArea.layout()
box = gui.vBox(self.controlArea, "默认方法")
box_layout = QGridLayout()
box_layout.setSpacing(8)
box.layout().addLayout(box_layout)
button_group = QButtonGroup()
button_group.buttonClicked[int].connect(self.set_default_method)
for i, (method, _) in enumerate(list(METHODS.items())[1:-1]):
imputer = self.create_imputer(method)
button = QRadioButton(imputer.name)
button.setChecked(method == self.default_method_index)
button_group.addButton(button, method)
box_layout.addWidget(button, i % 3, i // 3)
def set_default_time(datetime):
datetime = datetime.toSecsSinceEpoch()
if datetime != self.default_time:
self.default_time = datetime
if self.default_method_index == Method.Default:
self._invalidate()
hlayout = QHBoxLayout()
box.layout().addLayout(hlayout)
button = QRadioButton("固定值; 数值变量:")
button_group.addButton(button, Method.Default)
button.setChecked(Method.Default == self.default_method_index)
hlayout.addWidget(button)
self.numeric_value_widget = DoubleSpinBox(
minimum=DBL_MIN,
maximum=DBL_MAX,
singleStep=.1,
value=self.default_numeric_value,
alignment=Qt.AlignRight,
enabled=self.default_method_index == Method.Default,
)
self.numeric_value_widget.editingFinished.connect(
self.__on_default_numeric_value_edited)
self.connect_control("default_numeric_value",
self.numeric_value_widget.setValue)
hlayout.addWidget(self.numeric_value_widget)
hlayout.addWidget(QLabel(", 时间:"))
self.time_widget = gui.DateTimeEditWCalendarTime(self)
self.time_widget.setEnabled(
self.default_method_index == Method.Default)
self.time_widget.setKeyboardTracking(False)
self.time_widget.setContentsMargins(0, 0, 0, 0)
self.time_widget.set_datetime(
QDateTime.fromSecsSinceEpoch(self.default_time))
self.connect_control(
"default_time", lambda value: self.time_widget.set_datetime(
QDateTime.fromSecsSinceEpoch(value)))
self.time_widget.dateTimeChanged.connect(set_default_time)
hlayout.addWidget(self.time_widget)
self.default_button_group = button_group
box = gui.hBox(self.controlArea, self.tr("设置单个属性"), flat=False)
self.varview = ListViewSearch(
selectionMode=QListView.ExtendedSelection, uniformItemSizes=True)
self.varview.setItemDelegate(DisplayFormatDelegate())
self.varmodel = itemmodels.VariableListModel()
self.varview.setModel(self.varmodel)
self.varview.selectionModel().selectionChanged.connect(
self._on_var_selection_changed)
self.selection = self.varview.selectionModel()
box.layout().addWidget(self.varview)
vertical_layout = QVBoxLayout(margin=0)
self.methods_container = QWidget(enabled=False)
method_layout = QVBoxLayout(margin=0)
self.methods_container.setLayout(method_layout)
button_group = QButtonGroup()
for method in Method:
imputer = self.create_imputer(method)
button = QRadioButton(text=imputer.name)
button_group.addButton(button, method)
method_layout.addWidget(button)
self.value_combo = QComboBox(
minimumContentsLength=8,
sizeAdjustPolicy=QComboBox.AdjustToMinimumContentsLengthWithIcon,
activated=self._on_value_selected)
self.value_double = DoubleSpinBox(
editingFinished=self._on_value_selected,
minimum=DBL_MIN,
maximum=DBL_MAX,
singleStep=.1,
)
self.value_stack = value_stack = QStackedWidget()
value_stack.addWidget(self.value_combo)
value_stack.addWidget(self.value_double)
method_layout.addWidget(value_stack)
button_group.buttonClicked[int].connect(
self.set_method_for_current_selection)
self.reset_button = QPushButton(
"Restore All to Default",
enabled=False,
default=False,
autoDefault=False,
clicked=self.reset_variable_state,
)
vertical_layout.addWidget(self.methods_container)
vertical_layout.addStretch(2)
vertical_layout.addWidget(self.reset_button)
box.layout().addLayout(vertical_layout)
self.variable_button_group = button_group
gui.auto_apply(self.buttonsArea, self, "autocommit")
def __init__(self, parent=None):
super().__init__(parent)
self.selectedDatabase = 0
self.uniqueRows = True
gui.button(gui.widgetBox(self.controlArea, "Cache", addSpace=True),
self,
"Clear cache",
tooltip="Clear saved query results",
callback=self.clearCache)
self.serviceindex = 0
self.serviceCombo = gui.comboBox(self.controlArea,
self,
"serviceindex",
"Mart Service",
callback=self._setServiceUrl)
for name, url in MartServices:
self.serviceCombo.addItem(name, userData=url)
idx = self.serviceCombo.findData(self.selectedService, Qt.UserRole)
self.serviceCombo.setCurrentIndex(idx)
# self.selectedService = self.serviceCombo.itemData(self.serviceCombo.currentItem())
self.martsCombo = gui.comboBox(self.controlArea,
self,
"selectedDatabase",
"Database",
callback=self.setSelectedMart,
addSpace=True)
self.martsCombo.setMaximumWidth(250)
self.datasetsCombo = gui.comboBox(self.controlArea,
self,
"selectedDataset",
"Dataset",
callback=self.setSelectedDataset,
addSpace=True)
self.datasetsCombo.setMaximumWidth(250)
gui.rubber(self.controlArea)
box = gui.widgetBox(self.controlArea, "Results")
gui.checkBox(
box,
self,
"uniqueRows",
"Unique results only",
tooltip="Return unique results only.",
)
self.commitButton = gui.button(
box,
self,
"Get Results",
callback=self.commit,
tooltip="Query the BioMart server and output the results",
autoDefault=True)
self.commitButton.setEnabled(False)
self.mainWidget = gui.widgetBox(self.mainArea,
orientation=QStackedLayout())
self.mainTab = QTabWidget()
self.mainWidget.layout().addWidget(self.mainTab)
self.attributesConfigurationBox = gui.createTabPage(
self.mainTab, "Attributes")
if self.SHOW_FILTERS: # ??
self.filtersConfigurationBox = gui.createTabPage(
self.mainTab, "Filters")
self.error(0)
self.setEnabled(False)
self._task = None
self._executor = concurrent.ThreadExecutor(threadPool=QThreadPool(
maxThreadCount=2))
service = self.selectedService
self._task = task = concurrent.Task(
function=partial(self._get_registry, url=service))
task.resultReady.connect(self.setBioMartRegistry)
task.exceptionReady.connect(self._handleException)
self._executor.submit(task)
self._setServiceUrl()
self._afterInitQueue = []
try:
from Bio import SeqIO
self.hasBiopython = True
except ImportError:
self.warning(
100,
"Biopython package not found.\nTo retrieve FASTA sequence data from BioMart install Biopython."
)
self.hasBiopython = False
def __init__(self, parent=None):
super().__init__(parent)
# GUI
box = gui.widgetBox(self.controlArea, "Info", addSpace=True)
self.infoBox = gui.widgetLabel(box, "No data on input.")
box = gui.widgetBox(self.controlArea, "Split by", addSpace=True)
self.groupCombo = gui.comboBox(box,
self,
"selectedGroup",
callback=self.onGroupSelection)
gui.comboBox(self.controlArea,
self,
"selectedCenterMethod",
box="Center Fold-change Using",
items=[name for name, _ in self.CENTER_METHODS],
callback=self.onCenterMethodChange,
addSpace=True)
gui.comboBox(self.controlArea,
self,
"selectedMergeMethod",
box="Merge Replicates",
items=[name for name, _ in self.MERGE_METHODS],
tooltip="Select the method for replicate merging",
callback=self.onMergeMethodChange,
addSpace=True)
box = gui.doubleSpin(self.controlArea,
self,
"zCutoff",
0.0,
3.0,
0.01,
box="Z-Score Cutoff",
callback=[self.replotMA, self.commitIf])
gui.separator(self.controlArea)
box = gui.widgetBox(self.controlArea, "Ouput")
gui.checkBox(box,
self,
"appendZScore",
"Append Z-Scores",
tooltip="Append calculated Z-Scores to output",
callback=self.commitIf)
gui.checkBox(box,
self,
"appendRIValues",
"Append Log Ratio and Intensity values",
tooltip="Append calculated Log Ratio and Intensity "
"values to output data",
callback=self.commitIf)
gui.rubber(self.controlArea)
gui.auto_commit(self.controlArea, self, "autoCommit", "Commit")
self.graph = pg.PlotWidget(background="w")
self.graph.getAxis("bottom").setLabel(
"Intensity: log<sub>10</sub>(R*G)")
self.graph.getAxis("left").setLabel("Log ratio: log<sub>2</sub>(R/G)")
self.mainArea.layout().addWidget(self.graph)
self.groups = []
self.split_data = None, None
self.merged_splits = None, None
self.centered = None, None
self.changedFlag = False
self.data = None
self._executor = concurrent.ThreadExecutor(threadPool=QThreadPool(
maxThreadCount=1))
