Esempio n. 1
0
def loadExptGrps(mouse_set):

    expts = lab.ExperimentSet(os.path.join(metadata_path, 'expt_metadata.xml'),
                              behaviorDataPath=os.path.join(
                                  data_path, 'behavior'),
                              dataPath=os.path.join(data_path, 'imaging'))

    mouse_sets = {}
    mouse_sets['GOL'] = ('jz096', 'jz097', 'jz098', 'jz100', 'jz101', 'jz102',
                         'jz106', 'jz113', 'jz114', 'jz121', 'jz135', 'jz136')
    mouse_sets['RF'] = ('jz049', 'jz051', 'jz052', 'jz053', 'jz054', 'jz058',
                        'jz059', 'jz060', 'jz064', 'jz066', 'jz067')

    if mouse_set not in mouse_sets:
        raise ValueError('Unrecognized mouse set')

    exptGrps = {}
    WT = []
    Df = []
    for mouse in [expts.grabMouse(m) for m in mouse_sets[mouse_set]]:
        genotype = mouse.get('genotype').lower()
        if 'df16ap' in genotype:
            Df.append(mouse)
        elif 'df16an' in genotype:
            WT.append(mouse)

    exptGrps['WT_mice'] = WT
    exptGrps['Df_mice'] = Df

    if mouse_set == 'GOL':
        exptGrps['WT_hidden_behavior_set'] = \
            lab.classes.HiddenRewardExperimentGroup.from_json(
                WT_behavior_set, expts, label=WT_label)
        exptGrps['Df_hidden_behavior_set'] = \
            lab.classes.HiddenRewardExperimentGroup.from_json(
                Df_behavior_set, expts, label=Df_label)

        exptGrps['WT_place_set'] = \
            lab.classes.pcExperimentGroup.from_json(
                WT_imaging_set, expts, imaging_label=IMAGING_LABEL,
                label=WT_label)
        exptGrps['Df_place_set'] = \
            lab.classes.pcExperimentGroup.from_json(
                Df_imaging_set, expts, imaging_label=IMAGING_LABEL,
                label=Df_label)

    elif mouse_set == 'RF':
        exptGrps['WT_place_set'] = \
            lab.classes.pcExperimentGroup.from_json(
                WT_RF_set, expts, imaging_label=IMAGING_LABEL,
                label=WT_label).pair()
        exptGrps['Df_place_set'] = \
            lab.classes.pcExperimentGroup.from_json(
                Df_RF_set, expts, imaging_label=IMAGING_LABEL,
                label=Df_label).pair()

    return exptGrps
def main():
    expts = lab.ExperimentSet(
        os.path.join(df.metadata_path, 'expt_metadata.xml'),
        behaviorDataPath=os.path.join(df.data_path, 'behavior'),
        dataPath=os.path.join(df.data_path, 'imaging'))

    sal_grp = lab.classes.HiddenRewardExperimentGroup.from_json(
        sal_json, expts, label='saline to muscimol')
    mus_grp = lab.classes.HiddenRewardExperimentGroup.from_json(
        mus_json, expts, label='muscimol to saline')

    fig = plt.figure(figsize=(8.5, 11))
    gs = plt.GridSpec(1, 1, top=0.9, bottom=0.7, left=0.1, right=0.4)
    ax = fig.add_subplot(gs[0, 0])

    for expt in mus_grp:
        if 'saline' in expt.get('drug'):
            expt.attrib['drug_condition'] = 'reversal'
        elif 'muscimol' in expt.get('drug'):
            expt.attrib['drug_condition'] = 'learning'
    for expt in sal_grp:
        if 'saline' in expt.get('drug'):
            expt.attrib['drug_condition'] = 'learning'
        elif 'muscimol' in expt.get('drug'):
            expt.attrib['drug_condition'] = 'reversal'

    plotting.plot_metric(
        ax, [sal_grp, mus_grp], metric_fn=ra.fraction_licks_in_reward_zone,
        label_groupby=False, plotby=['X_drug_condition'],
        plot_method='swarm', rotate_labels=False,
        activity_label='Fraction of licks in reward zone',
        colors=sns.color_palette('deep'), plot_bar=True)
    ax.set_yticks([0, 0.1, 0.2, 0.3, 0.4])
    ax.set_ylim(top=0.4)
    ax.set_xticklabels(['Days 1-3', 'Day 4'])

    sns.despine(fig)
    ax.set_title('')
    ax.set_xlabel('')

    misc.save_figure(
        fig, filename, save_dir=save_dir)

    plt.close('all')
def main():

    raw_data, data = emd.load_data('wt',
                                   session_filter='C',
                                   root=os.path.join(df.data_path,
                                                     'enrichment_model'))
    expts = lab.ExperimentSet(os.path.join(df.metadata_path,
                                           'expt_metadata.xml'),
                              behaviorDataPath=os.path.join(
                                  df.data_path, 'behavior'),
                              dataPath=os.path.join(df.data_path, 'imaging'))

    params = pickle.load(open(params_path))

    fig = plt.figure(figsize=(8.5, 11))
    gs1 = plt.GridSpec(1,
                       2,
                       left=0.1,
                       bottom=0.65,
                       right=0.9,
                       top=0.9,
                       wspace=0.05)
    fov1_ax = fig.add_subplot(gs1[0, 0])
    fov2_ax = fig.add_subplot(gs1[0, 1])
    cmap_ax = fig.add_axes([0.49, 0.65, 0.02, 0.25])
    gs2 = plt.GridSpec(2,
                       2,
                       left=0.1,
                       bottom=0.3,
                       right=0.5,
                       top=0.6,
                       wspace=0.5,
                       hspace=0.5)
    recur_ax = fig.add_subplot(gs2[0, 0])
    shift_ax = fig.add_subplot(gs2[0, 1])
    shift_compare_ax = fig.add_subplot(gs2[1, 0])
    var_compare_ax = fig.add_subplot(gs2[1, 1])

    #
    # Tuning maps
    #

    e1 = expts.grabExpt('jz135', '2015-10-12-14h33m47s')
    e2 = expts.grabExpt('jz135', '2015-10-12-15h34m38s')

    cmap = mpl.colors.ListedColormap(sns.color_palette("husl", 256))

    for ax, expt in ((fov1_ax, e1), (fov2_ax, e2)):
        place.plot_spatial_tuning_overlay(ax,
                                          lab.classes.pcExperimentGroup(
                                              [expt], imaging_label='soma'),
                                          labels_visible=False,
                                          alpha=0.9,
                                          lw=0.1,
                                          cmap=cmap)
        plot_ROI_outlines(ax,
                          expt,
                          channel='Ch2',
                          label='soma',
                          roi_filter=None,
                          ls='-',
                          color='k',
                          lw=0.1)
        # Add a 50-um scale bar
        plotting.add_scalebar(
            ax=ax,
            matchx=False,
            matchy=False,
            sizey=0,
            sizex=50 / expt.imagingParameters()['micronsPerPixel']['XAxis'],
            bar_color='w',
            bar_thickness=3)

    fov1_ax.set_title('Session 1')
    fov2_ax.set_title('Session 2')

    gradient = np.linspace(0, 1, 256)
    gradient = np.vstack((gradient, gradient)).T
    cmap_ax.imshow(gradient, aspect='auto', cmap=cmap)
    sns.despine(ax=cmap_ax, top=True, left=True, right=True, bottom=True)
    cmap_ax.tick_params(left=False,
                        labelleft=False,
                        bottom=False,
                        labelbottom=False)
    cmap_ax.set_ylabel('belt position')

    # Figure out the reward window width
    reward_poss, windows = [], []
    for expt in [e1, e2]:
        reward_poss.append(expt.rewardPositions(units='normalized')[0])
        track_length = expt[0].behaviorData()['trackLength']
        window = float(expt.get('operantSpatialWindow'))
        windows.append(window / track_length)
    reward_pos = np.mean(reward_poss)
    window = np.mean(windows)

    # Add reward zone
    cmap_ax.plot([0, 1], [reward_pos, reward_pos],
                 transform=cmap_ax.transAxes,
                 color='k',
                 ls=':')
    cmap_ax.plot([0, 1], [reward_pos + window, reward_pos + window],
                 transform=cmap_ax.transAxes,
                 color='k',
                 ls=':')
    cmap_ax.set_ylim(0, 256)

    #
    # Recurrence by position
    #

    recur_x_vals = np.linspace(-np.pi, np.pi, 1000)

    recur_data = emd.recurrence_by_position(data, method='cv')
    recur_knots = np.linspace(-np.pi, np.pi,
                              params['position_recurrence']['n_knots'])
    recur_splines = splines.CyclicSpline(recur_knots)
    recur_n = recur_splines.design_matrix(recur_x_vals)

    recur_fit = splines.prob(params['position_recurrence']['theta'], recur_n)

    recur_boots_fits = [
        splines.prob(boot, recur_n)
        for boot in params['position_recurrence']['boots_theta']
    ]
    recur_ci_up_fit = np.percentile(recur_boots_fits, 95, axis=0)
    recur_ci_low_fit = np.percentile(recur_boots_fits, 5, axis=0)

    recur_ax.plot(recur_x_vals, recur_fit, color=WT_color)
    recur_ax.fill_between(recur_x_vals,
                          recur_ci_low_fit,
                          recur_ci_up_fit,
                          facecolor=WT_color,
                          alpha=0.5)
    sns.regplot(recur_data[:, 0],
                recur_data[:, 1],
                ax=recur_ax,
                color=WT_color,
                y_jitter=0.2,
                fit_reg=False,
                scatter_kws={'s': 1},
                marker=WT_marker)
    recur_ax.axvline(ls='--', color='0.4', lw=0.5)
    recur_ax.set_xlim(-np.pi, np.pi)
    recur_ax.set_xticks([-np.pi, -np.pi / 2, 0, np.pi / 2, np.pi])
    recur_ax.set_xticklabels(['-0.50', '-0.25', '0', '0.25', '0.50'])
    recur_ax.set_ylim(-0.3, 1.3)
    recur_ax.set_yticks([0, 0.5, 1])
    recur_ax.tick_params(length=3, pad=1, top=False)
    recur_ax.set_xlabel('Initial distance from reward (fraction of belt)')
    recur_ax.set_ylabel('Place cell recurrence probability')
    recur_ax.set_title('')
    recur_ax_2 = recur_ax.twinx()
    recur_ax_2.tick_params(length=3, pad=1, top=False)
    recur_ax_2.set_ylim(-0.3, 1.3)
    recur_ax_2.set_yticks([0, 1])
    recur_ax_2.set_yticklabels(['non-recur', 'recur'])

    #
    # Place field stability
    #

    shift_x_vals = np.linspace(-np.pi, np.pi, 1000)

    shift_knots = params['position_stability']['all_pairs']['knots']
    shift_spline = splines.CyclicSpline(shift_knots)
    shift_n = shift_spline.design_matrix(shift_x_vals)
    shift_theta_b = params['position_stability']['all_pairs']['theta_b']
    shift_b_fit = np.dot(shift_n, shift_theta_b)
    shift_theta_k = params['position_stability']['all_pairs']['theta_k']
    shift_k_fit = splines.get_k(shift_theta_k, shift_n)
    shift_fit_var = 1. / shift_k_fit

    shift_data = emd.paired_activity_centroid_distance_to_reward(data)
    shift_data = shift_data.dropna()
    shifts = shift_data['second'] - shift_data['first']
    shifts[shifts < -np.pi] += 2 * np.pi
    shifts[shifts >= np.pi] -= 2 * np.pi

    shift_ax.plot(shift_x_vals, shift_b_fit, color=WT_color)
    shift_ax.fill_between(shift_x_vals,
                          shift_b_fit - shift_fit_var,
                          shift_b_fit + shift_fit_var,
                          facecolor=WT_color,
                          alpha=0.5)
    sns.regplot(shift_data['first'],
                shifts,
                ax=shift_ax,
                color=WT_color,
                fit_reg=False,
                scatter_kws={'s': 1},
                marker=WT_marker)

    shift_ax.axvline(ls='--', color='0.4', lw=0.5)
    shift_ax.axhline(ls='--', color='0.4', lw=0.5)
    shift_ax.plot([-np.pi, np.pi], [np.pi, -np.pi], color='g', ls=':', lw=2)
    shift_ax.tick_params(length=3, pad=1, top=False)
    shift_ax.set_xlabel('Initial distance from reward (fraction of belt)')
    shift_ax.set_ylabel(r'$\Delta$ position (fraction of belt)')
    shift_ax.set_xlim(-np.pi, np.pi)
    shift_ax.set_xticks([-np.pi, -np.pi / 2, 0, np.pi / 2, np.pi])
    shift_ax.set_xticklabels(['-0.50', '-0.25', '0', '0.25', '0.50'])
    shift_ax.set_ylim(-np.pi, np.pi)
    shift_ax.set_yticks([-np.pi, -np.pi / 2, 0, np.pi / 2, np.pi])
    shift_ax.set_yticklabels(['-0.50', '-0.25', '0', '0.25', '0.50'])
    shift_ax.set_title('')

    #
    # Stability by distance to reward
    #

    shift_x_vals = np.linspace(-np.pi, np.pi, 1000)

    shift_knots = params['position_stability']['all_pairs']['knots']
    shift_spline = splines.CyclicSpline(shift_knots)
    shift_n = shift_spline.design_matrix(shift_x_vals)

    shift_theta_b = params['position_stability']['all_pairs']['theta_b']
    shift_b_fit = np.dot(shift_n, shift_theta_b)
    shift_boots_b_fit = [
        np.dot(shift_n, boot)
        for boot in params['position_stability']['all_pairs']['boots_theta_b']
    ]
    shift_b_ci_up_fit = np.percentile(shift_boots_b_fit, 95, axis=0)
    shift_b_ci_low_fit = np.percentile(shift_boots_b_fit, 5, axis=0)

    shift_compare_ax.plot(shift_x_vals, shift_b_fit, color=WT_color)
    shift_compare_ax.fill_between(shift_x_vals,
                                  shift_b_ci_low_fit,
                                  shift_b_ci_up_fit,
                                  facecolor=WT_color,
                                  alpha=0.5)

    shift_compare_ax.axvline(ls='--', color='0.4', lw=0.5)
    shift_compare_ax.axhline(ls='--', color='0.4', lw=0.5)
    shift_compare_ax.tick_params(length=3, pad=1, top=False)
    shift_compare_ax.set_xlim(-np.pi, np.pi)
    shift_compare_ax.set_xticks([-np.pi, -np.pi / 2, 0, np.pi / 2, np.pi])
    shift_compare_ax.set_xticklabels(['-0.50', '-0.25', '0', '0.25', '0.50'])
    shift_compare_ax.set_ylim(-0.10 * 2 * np.pi, 0.10 * 2 * np.pi)
    y_ticks = np.array(['-0.10', '-0.05', '0', '0.05', '0.10'])
    shift_compare_ax.set_yticks(y_ticks.astype('float') * 2 * np.pi)
    shift_compare_ax.set_yticklabels(y_ticks)
    shift_compare_ax.set_xlabel(
        'Initial distance from reward (fraction of belt)')
    shift_compare_ax.set_ylabel(r'$\Delta$ position (fraction of belt)')

    shift_theta_k = params['position_stability']['all_pairs']['theta_k']
    shift_k_fit = splines.get_k(shift_theta_k, shift_n)
    shift_boots_k_fit = [
        splines.get_k(boot, shift_n)
        for boot in params['position_stability']['all_pairs']['boots_theta_k']
    ]
    shift_k_ci_up_fit = np.percentile(shift_boots_k_fit, 95, axis=0)
    shift_k_ci_low_fit = np.percentile(shift_boots_k_fit, 5, axis=0)

    var_compare_ax.plot(shift_x_vals, 1. / shift_k_fit, color=WT_color)
    var_compare_ax.fill_between(shift_x_vals,
                                1. / shift_k_ci_low_fit,
                                1. / shift_k_ci_up_fit,
                                facecolor=WT_color,
                                alpha=0.5)

    var_compare_ax.axvline(ls='--', color='0.4', lw=0.5)
    var_compare_ax.tick_params(length=3, pad=1, top=False)
    var_compare_ax.set_xlim(-np.pi, np.pi)
    var_compare_ax.set_xticks([-np.pi, -np.pi / 2, 0, np.pi / 2, np.pi])
    var_compare_ax.set_xticklabels(['-0.50', '-0.25', '0', '0.25', '0.50'])
    y_ticks = np.array(['0.005', '0.010', '0.015', '0.020'])
    var_compare_ax.set_yticks(y_ticks.astype('float') * (2 * np.pi)**2)
    var_compare_ax.set_yticklabels(y_ticks)
    var_compare_ax.set_xlabel(
        'Initial distance from reward (fraction of belt)')
    var_compare_ax.set_ylabel(r'$\Delta$ position variance')

    misc.save_figure(fig, filename, save_dir=save_dir)

    plt.close('all')
def main():
    all_grps = df.loadExptGrps('GOL')
    expts = lab.ExperimentSet(os.path.join(df.metadata_path,
                                           'expt_metadata.xml'),
                              behaviorDataPath=os.path.join(
                                  df.data_path, 'behavior'),
                              dataPath=os.path.join(df.data_path, 'imaging'))

    WT_expt_grp = all_grps['WT_place_set']
    Df_expt_grp = all_grps['Df_place_set']
    expt_grps = [WT_expt_grp, Df_expt_grp]

    WT_label = WT_expt_grp.label()
    Df_label = Df_expt_grp.label()

    fig = plt.figure(figsize=(8.5, 11))

    gs2 = plt.GridSpec(48, 1, right=.6)
    wt_trace_ax = fig.add_subplot(gs2[12:16, 0])
    wt_position_ax = fig.add_subplot(gs2[16:18, 0])
    df_trace_ax = fig.add_subplot(gs2[18:22, 0])
    df_position_ax = fig.add_subplot(gs2[22:24, 0])

    gs3 = plt.GridSpec(2, 2, hspace=0.3, left=.62, bottom=0.5, top=0.7)
    wt_transients_ax = fig.add_subplot(gs3[0, 0], polar=True)
    df_transients_ax = fig.add_subplot(gs3[1, 0], polar=True)
    wt_vector_ax = fig.add_subplot(gs3[0, 1], polar=True)
    df_vector_ax = fig.add_subplot(gs3[1, 1], polar=True)

    gs4 = plt.GridSpec(1, 4, top=0.48, bottom=0.35, wspace=0.3)
    pf_fraction_ax = fig.add_subplot(gs4[0, 0])
    pf_per_cell_ax = fig.add_subplot(gs4[0, 1])
    pf_width_ax = fig.add_subplot(gs4[0, 2])
    circ_var_ax = fig.add_subplot(gs4[0, 3])

    pf_fraction_inset_ax = fig.add_axes([0.22, 0.36, 0.04, 0.06])
    pf_width_inset_ax = fig.add_axes([0.63, 0.41, 0.04, 0.06])
    circ_var_inset_ax = fig.add_axes([0.84, 0.36, 0.04, 0.06])

    #
    # PC Examples
    #

    wt_expt = expts.grabExpt('jz121', '2015-02-21-16h06m30s')
    df_expt = expts.grabExpt('jz098', '2014-11-08-16h14m02s')
    pc_expt_grp = place.pcExperimentGroup([wt_expt, df_expt],
                                          imaging_label='soma')
    wt_id = '0422-0349'
    df_id = '0074-0339'
    wt_idx = wt_expt.roi_ids().index(wt_id)
    df_idx = df_expt.roi_ids().index(df_id)

    wt_imaging_data = wt_expt.imagingData(channel='Ch2',
                                          label='soma',
                                          dFOverF='from_file')
    df_imaging_data = df_expt.imagingData(channel='Ch2',
                                          label='soma',
                                          dFOverF='from_file')
    wt_transients = wt_expt.transientsData(threshold=95,
                                           channel='Ch2',
                                           label='soma')
    df_transients = df_expt.transientsData(threshold=95,
                                           channel='Ch2',
                                           label='soma')

    place.plotImagingData(roi_tSeries=wt_imaging_data[wt_idx, :, 0],
                          ax=wt_trace_ax,
                          roi_transients=wt_transients[wt_idx][0],
                          position=None,
                          imaging_interval=wt_expt.frame_period(),
                          placeField=None,
                          xlabel_visible=False,
                          ylabel_visible=True,
                          right_label=True,
                          placeFieldColor=None,
                          title='',
                          rasterized=False,
                          color='.4',
                          transients_color=WT_color)
    sns.despine(ax=wt_trace_ax, top=True, left=False, bottom=True, right=True)
    wt_trace_ax.set_ylabel(WT_label, rotation='horizontal', ha='right')
    wt_trace_ax.tick_params(bottom=False, labelbottom=False)
    wt_trace_ax.tick_params(axis='y', direction='in', length=3, pad=3)
    wt_trace_ax.spines['left'].set_linewidth(1)
    wt_trace_ax.spines['left'].set_position(('outward', 5))

    place.plotImagingData(roi_tSeries=df_imaging_data[df_idx, :, 0],
                          ax=df_trace_ax,
                          roi_transients=df_transients[df_idx][0],
                          position=None,
                          imaging_interval=df_expt.frame_period(),
                          placeField=None,
                          xlabel_visible=False,
                          ylabel_visible=True,
                          right_label=True,
                          placeFieldColor=None,
                          title='',
                          rasterized=False,
                          color='.4',
                          transients_color=Df_color)
    sns.despine(ax=df_trace_ax, top=True, left=False, bottom=True, right=True)
    df_trace_ax.set_ylabel(Df_label, rotation='horizontal', ha='right')
    df_trace_ax.tick_params(bottom=False, labelbottom=False)
    df_trace_ax.tick_params(axis='y', direction='in', length=3, pad=3)
    df_trace_ax.spines['left'].set_linewidth(1)
    df_trace_ax.spines['left'].set_position(('outward', 5))

    y_min = min(wt_trace_ax.get_ylim()[0], df_trace_ax.get_ylim()[0])
    y_max = max(wt_trace_ax.get_ylim()[1], df_trace_ax.get_ylim()[1])
    wt_trace_ax.set_ylim(y_min, y_max)
    df_trace_ax.set_ylim(y_min, y_max)
    wt_trace_ax.set_yticks([0, y_max])
    df_trace_ax.set_yticks([0, y_max])
    wt_trace_ax.set_yticklabels(['0', '{:0.1f}'.format(y_max)])
    df_trace_ax.set_yticklabels(['0', '{:0.1f}'.format(y_max)])
    wt_trace_ax.set_xlim(0, 600)
    df_trace_ax.set_xlim(0, 600)

    place.plotPosition(wt_expt.find('trial'),
                       ax=wt_position_ax,
                       rasterized=False,
                       position_kwargs={'color': 'k'})
    sns.despine(ax=wt_position_ax,
                top=True,
                left=True,
                bottom=True,
                right=True)
    wt_position_ax.set_ylabel('')
    wt_position_ax.set_xlabel('')
    wt_position_ax.tick_params(left=False,
                               bottom=False,
                               top=False,
                               right=False,
                               labelleft=False,
                               labelbottom=False,
                               labelright=False,
                               labeltop=False)
    plotting.add_scalebar(wt_position_ax,
                          matchx=False,
                          matchy=False,
                          hidex=False,
                          hidey=False,
                          sizex=60,
                          labelx='1 min',
                          bar_thickness=.02,
                          pad=0,
                          loc=4)
    wt_position_ax.set_yticks([0, 1])
    wt_position_ax.set_ylim(0, 1)

    place.plotPosition(df_expt.find('trial'),
                       ax=df_position_ax,
                       rasterized=False,
                       position_kwargs={'color': 'k'})
    sns.despine(ax=df_position_ax, top=True, bottom=True, right=True)
    df_position_ax.tick_params(bottom=False,
                               top=False,
                               right=False,
                               labelbottom=False,
                               labelright=False,
                               labeltop=False,
                               direction='in',
                               length=3,
                               pad=3)
    df_position_ax.spines['left'].set_linewidth(1)
    df_position_ax.spines['left'].set_position(('outward', 5))
    df_position_ax.set_ylabel('Position')
    df_position_ax.set_xlabel('')
    df_position_ax.set_yticks([0, 1])
    df_position_ax.set_ylim(0, 1)

    trans_kwargs = {
        'color': WT_color,
        'marker': 'o',
        'linestyle': 'None',
        'markersize': 3
    }
    wt_pf = [pc_expt_grp.pfs_n()[wt_expt][wt_idx]]
    place.plotPosition(wt_expt.find('trial'),
                       ax=wt_transients_ax,
                       polar=True,
                       placeFields=wt_pf,
                       placeFieldColors=[WT_color],
                       trans_roi_filter=lambda roi: roi.id == wt_id,
                       rasterized=False,
                       running_trans_only=True,
                       demixed=False,
                       position_kwargs={'color': '0.5'},
                       trans_kwargs=trans_kwargs)
    wt_transients_ax.set_xlabel('')
    wt_transients_ax.set_ylabel('')
    wt_transients_ax.set_rticks([])
    prep_polar_ax(wt_transients_ax)

    trans_kwargs['color'] = Df_color
    df_pf = [pc_expt_grp.pfs_n()[df_expt][df_idx]]
    place.plotPosition(df_expt.find('trial'),
                       ax=df_transients_ax,
                       polar=True,
                       placeFields=df_pf,
                       placeFieldColors=[Df_color],
                       trans_roi_filter=lambda roi: roi.id == df_id,
                       rasterized=False,
                       running_trans_only=True,
                       demixed=False,
                       position_kwargs={'color': '0.5'},
                       trans_kwargs=trans_kwargs)
    df_transients_ax.set_xlabel('')
    df_transients_ax.set_ylabel('')
    df_transients_ax.set_rticks([])
    prep_polar_ax(df_transients_ax)

    place.plotTransientVectors(place.pcExperimentGroup([wt_expt],
                                                       imaging_label='soma'),
                               wt_idx,
                               wt_vector_ax,
                               mean_zorder=99,
                               color=WT_color,
                               mean_color='g')
    place.plotTransientVectors(place.pcExperimentGroup([df_expt],
                                                       imaging_label='soma'),
                               df_idx,
                               df_vector_ax,
                               mean_zorder=99,
                               color=Df_color,
                               mean_color='g')

    #
    # Stats
    #

    groupby = [['expt'], ['mouseID']]

    plotting.plot_metric(pf_fraction_ax,
                         expt_grps,
                         metric_fn=place.place_cell_percentage,
                         groupby=None,
                         plotby=None,
                         colorby=None,
                         plot_method='cdf',
                         roi_filters=roi_filters,
                         activity_kwargs=None,
                         colors=colors,
                         activity_label='Place cell fraction',
                         rotate_labels=False,
                         return_full_dataframes=False,
                         linestyles=linestyles)
    pf_fraction_ax.legend(loc='upper left', fontsize=6)
    pf_fraction_ax.set_title('')
    pf_fraction_ax.set_ylabel('Cumulative fraction')
    pf_fraction_ax.set_xticks([0, .2, .4, .6, .8])
    pf_fraction_ax.set_xlim(0, .8)
    pf_fraction_ax.spines['left'].set_linewidth(1)
    pf_fraction_ax.spines['bottom'].set_linewidth(1)

    plotting.plot_metric(pf_fraction_inset_ax,
                         expt_grps,
                         metric_fn=place.place_cell_percentage,
                         groupby=groupby,
                         plotby=None,
                         colorby=None,
                         plot_method='swarm',
                         roi_filters=roi_filters,
                         activity_kwargs=None,
                         colors=colors,
                         activity_label='Place cell fraction',
                         rotate_labels=False,
                         linewidth=0.2,
                         edgecolor='gray')
    pf_fraction_inset_ax.set_title('')
    pf_fraction_inset_ax.set_ylabel('')
    pf_fraction_inset_ax.set_xlabel('')
    pf_fraction_inset_ax.set_yticks([0, 0.5])
    pf_fraction_inset_ax.set_ylim([0, 0.5])
    pf_fraction_inset_ax.get_legend().set_visible(False)
    sns.despine(ax=pf_fraction_inset_ax)
    pf_fraction_inset_ax.tick_params(bottom=False, labelbottom=False)
    pf_fraction_inset_ax.spines['left'].set_linewidth(1)
    pf_fraction_inset_ax.spines['bottom'].set_linewidth(1)
    pf_fraction_inset_ax.set_xlim(-0.6, 0.6)

    n_pf_kwargs = {'per_mouse_fractions': True, 'max_n_place_fields': 3}
    plotting.plot_metric(pf_per_cell_ax,
                         expt_grps,
                         metric_fn=place.n_place_fields,
                         groupby=None,
                         plotby=['number'],
                         plot_method='swarm',
                         roi_filters=roi_filters,
                         activity_kwargs=n_pf_kwargs,
                         colors=colors,
                         activity_label='Fraction of place cells',
                         rotate_labels=False,
                         plot_bar=True,
                         edgecolor='k',
                         linewidth=0.5,
                         size=3)
    sns.despine(ax=pf_per_cell_ax)
    pf_per_cell_ax.set_title('')
    pf_per_cell_ax.set_xlabel('Place fields per cell')
    pf_per_cell_ax.set_ylabel('Fraction of place cells')
    pf_per_cell_ax.set_xticklabels(['1', '2', '3+'])
    pf_per_cell_ax.set_yticks([0, 0.2, 0.4, 0.6, 0.8, 1])

    plotting.plot_metric(pf_width_ax,
                         expt_grps,
                         metric_fn=place.place_field_width,
                         groupby=[['roi_id', 'expt']],
                         plotby=None,
                         plot_method='hist',
                         roi_filters=roi_filters,
                         activity_kwargs=None,
                         activity_label='Place field width (cm)',
                         normed=True,
                         plot_mean=True,
                         bins=20,
                         range=(0, 120),
                         colors=colors,
                         rotate_labels=False,
                         filled=False,
                         mean_kwargs={'ls': ':'},
                         return_full_dataframes=False,
                         linestyles=linestyles)
    pf_width_ax.set_title('')
    pf_width_ax.legend(loc='lower right', fontsize=6)
    pf_width_ax.set_xticks([0, 40, 80, 120])
    pf_width_ax.set_yticks([0, 0.02, 0.04, 0.06, 0.08])
    pf_width_ax.set_ylim(0, 0.08)
    pf_width_ax.set_ylabel('Normalized density')
    pf_width_ax.spines['left'].set_linewidth(1)
    pf_width_ax.spines['bottom'].set_linewidth(1)

    plotting.plot_metric(pf_width_inset_ax,
                         expt_grps,
                         metric_fn=place.place_field_width,
                         groupby=[['roi_id', 'expt'], ['expt'], ['mouseID']],
                         plotby=None,
                         plot_method='swarm',
                         roi_filters=roi_filters,
                         activity_kwargs=None,
                         activity_label='Place field width (cm)',
                         colors=colors,
                         rotate_labels=False,
                         linewidth=0.2,
                         edgecolor='gray')
    pf_width_inset_ax.set_title('')
    pf_width_inset_ax.set_ylabel('')
    pf_width_inset_ax.set_xlabel('')
    pf_width_inset_ax.get_legend().set_visible(False)
    sns.despine(ax=pf_width_inset_ax)
    pf_width_inset_ax.tick_params(bottom=False, labelbottom=False)
    pf_width_inset_ax.set_ylim(25, 40)
    pf_width_inset_ax.set_yticks([25, 40])
    pf_width_inset_ax.spines['left'].set_linewidth(1)
    pf_width_inset_ax.spines['bottom'].set_linewidth(1)
    pf_width_inset_ax.set_xlim(-0.6, 0.6)

    plotting.plot_metric(circ_var_ax,
                         expt_grps,
                         metric_fn=place.circular_variance,
                         groupby=[['roi_id', 'expt']],
                         plotby=None,
                         plot_method='cdf',
                         roi_filters=roi_filters,
                         activity_kwargs=None,
                         activity_label='Circular variance',
                         colors=colors,
                         rotate_labels=False,
                         return_full_dataframes=False,
                         linestyles=linestyles)
    circ_var_ax.set_title('')
    circ_var_ax.legend(loc='upper left', fontsize=6)
    circ_var_ax.set_ylabel('Cumulative fraction')
    circ_var_ax.set_xlim(-0.1, 1)
    circ_var_ax.set_xticks([0, 0.5, 1])
    circ_var_ax.spines['left'].set_linewidth(1)
    circ_var_ax.spines['bottom'].set_linewidth(1)

    plotting.plot_metric(circ_var_inset_ax,
                         expt_grps,
                         metric_fn=place.circular_variance,
                         groupby=groupby,
                         plotby=None,
                         plot_method='swarm',
                         roi_filters=roi_filters,
                         activity_kwargs=None,
                         activity_label='Circular variance',
                         colors=colors,
                         rotate_labels=False,
                         linewidth=0.2,
                         edgecolor='gray')
    circ_var_inset_ax.set_title('')
    circ_var_inset_ax.set_ylabel('')
    circ_var_inset_ax.set_xlabel('')
    circ_var_inset_ax.get_legend().set_visible(False)
    sns.despine(ax=circ_var_inset_ax)
    circ_var_inset_ax.tick_params(bottom=False, labelbottom=False)
    circ_var_inset_ax.set_ylim(0, 0.6)
    circ_var_inset_ax.set_yticks([0, 0.6])
    circ_var_inset_ax.spines['left'].set_linewidth(1)
    circ_var_inset_ax.spines['bottom'].set_linewidth(1)
    circ_var_inset_ax.set_xlim(-0.6, 0.6)

    misc.save_figure(fig, filename, save_dir=save_dir)

    plt.close('all')
Esempio n. 5
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def main():
    all_expt_grps = df.loadExptGrps('GOL')

    WT_expt_grp_hidden = all_expt_grps['WT_place_set']
    Df_expt_grp_hidden = all_expt_grps['Df_place_set']
    expt_grps = [WT_expt_grp_hidden, Df_expt_grp_hidden]

    paired_grps = [grp.pair(
        'consecutive groups', groupby=['condition_day']) for grp in expt_grps]

    fig = plt.figure(figsize=(8.5, 11))

    gs1 = plt.GridSpec(
        3, 8, top=0.9, bottom=0.7, left=0.1, right=0.9, wspace=0.4)
    ax2 = fig.add_subplot(gs1[:, :2])
    pf_fraction_ax = fig.add_subplot(gs1[:, 2:4])
    circ_var_ax = fig.add_subplot(gs1[:, 4:6])

    trans_ax1 = fig.add_subplot(gs1[0, 6], polar=True)
    trans_ax2 = fig.add_subplot(gs1[0, 7], polar=True)
    trans_ax3 = fig.add_subplot(gs1[1, 6], polar=True)
    trans_ax4 = fig.add_subplot(gs1[1, 7], polar=True)
    trans_ax5 = fig.add_subplot(gs1[2, 6], polar=True)
    trans_ax6 = fig.add_subplot(gs1[2, 7], polar=True)
    trans_axs = [
        trans_ax1, trans_ax2, trans_ax3, trans_ax4, trans_ax5, trans_ax6]

    #
    # Stability by distance to fabric transitions
    #

    filter_fn = lambda df: df['second_condition_day_session'] == 'B_0_0'
    filter_columns = ['second_condition_day_session']

    label_order = ['before', 'middle', 'after']

    data_to_plot = [[], [], []]
    all_data, shuffles = [], []
    for expt_grp, roi_filter in zip(paired_grps, roi_filters):

        fabric_map = {expt: expt.belt().fabric_transitions(
            units='normalized') for expt in expt_grp}

        def norm_diff(n1, n2):
            d = n1 - n2
            d = d + 1.0 if d < -0.5 else d
            d = d - 1.0 if d >= 0.5 else d
            return d

        def closest_transition(row):
            expt = row['first_expt']
            centroid = complex_to_norm(row['first_centroid'])
            positions = fabric_map[expt]['position']
            distances = [norm_diff(centroid, t) for t in positions]
            row['closest'] = distances[np.argmin(np.abs(distances))]
            return row

        data, shuffle = place.activity_centroid_shift(
            expt_grp, roi_filter=roi_filter, activity_filter='active_both',
            circ_var_pcs=False, units='norm', shuffle=True)

        plotting.prepare_dataframe(data, include_columns=filter_columns)
        data = data[filter_fn(data)]

        plotting.prepare_dataframe(shuffle, include_columns=filter_columns)

        data = data.apply(closest_transition, axis=1)
        shuffle = shuffle.apply(closest_transition, axis=1)

        def categorize(row):
            if row['closest'] < 0 and -1 / 9. < row['closest']:
                row['category'] = 'before'
            elif row['closest'] > 0 and 1 / 9. > row['closest']:
                row['category'] = 'after'
            else:
                row['category'] = 'middle'
            return row

        data = data.apply(categorize, axis=1)
        shuffle = shuffle.apply(categorize, axis=1)

        groupby = [
            ['second_condition_day_session', 'second_mouse', 'category']]

        for gb in groupby:
            plotting.prepare_dataframe(data, include_columns=gb)
            plotting.prepare_dataframe(shuffle, include_columns=gb)
            data = data.groupby(gb, as_index=False).mean()
            shuffle = shuffle.groupby(gb, as_index=False).mean()

        for category, group in data.groupby(['category']):
            idx = label_order.index(category)
            data_to_plot[idx].append(group['value'])

        shuffles.append(shuffle)
        all_data.append(data)

    shuffle_df = pd.concat(shuffles, ignore_index=True)
    for category, group in shuffle_df.groupby(['category']):
        idx = label_order.index(category)
        data_to_plot[idx].append(group['value'])

    plotting.grouped_bar(
        ax2, data_to_plot, condition_labels=label_order,
        cluster_labels=df.labels + ('shuffle',),
        bar_colors=sns.color_palette('deep')[3:], scatter_points=False,
        scatterbar_colors=None, jitter_x=False, loc='best', error_bars='sem')
    sns.despine(ax=ax2)
    ax2.set_yticks([0, 0.1, 0.2, 0.3])
    ax2.set_ylabel('Centroid shift (fraction of belt)')

    #
    # Burlap belt
    #

    expts = lab.ExperimentSet(
        os.path.join(df.metadata_path, 'expt_metadata.xml'),
        behaviorDataPath=os.path.join(df.data_path, 'behavior'),
        dataPath=os.path.join(df.data_path, 'imaging'))

    burlap_expt_grp = lab.classes.pcExperimentGroup.from_json(
        cue_free_json, expts, imaging_label=df.IMAGING_LABEL, label='cue-free')

    acute_grps = df.loadExptGrps('RF')

    WT_expt_grp_acute = acute_grps['WT_place_set'].unpair()
    WT_expt_grp_acute.label('cue-rich')

    burlap_colors = ('k', '0.9')
    example_expt = expts.grabExptByPath('/jz128/TSeries-07262015-burlap-000')
    cv = place.circular_variance_p(burlap_expt_grp)
    cv = cv[cv['expt'] == example_expt]
    cv = cv.sort_values(by=['value'])

    trans_kwargs = {
        'color': '0.9', 'marker': 'o', 'linestyle': 'None',
        'markersize': 3}
    for ax, (idx, row) in zip(trans_axs, cv.iloc[:6].iterrows()):
        expt = row['expt']
        roi_idx = expt.rois().index(row['roi'])
        pf = None
        place.plotPosition(
            expt.find('trial'), ax=ax, polar=True,
            placeFields=pf, placeFieldColors=['0.9'],
            trans_roi_filter=lambda roi: roi.id == expt.roi_ids()[roi_idx],
            rasterized=False, running_trans_only=True, demixed=False,
            position_kwargs={'color': '0.5'}, trans_kwargs=trans_kwargs)
        ax.set_xlabel('')
        ax.set_ylabel('')
        ax.set_rticks([])
        prep_polar_ax(ax)
    for ax in trans_axs[:-1]:
        ax.set_xticklabels(['', '', '', ''])

    activity_kwargs = {'circ_var': True}

    plotting.plot_metric(
        pf_fraction_ax, [WT_expt_grp_acute, burlap_expt_grp],
        metric_fn=place.place_cell_percentage,
        groupby=None, plotby=None, colorby=None, plot_method='swarm',
        roi_filters=[WT_filter, WT_filter], activity_kwargs=activity_kwargs,
        colors=burlap_colors, activity_label='Place cell fraction',
        rotate_labels=False, plot_bar=True)
    pf_fraction_ax.set_title('')
    pf_fraction_ax.set_xlabel('')
    sns.despine(ax=pf_fraction_ax)
    pf_fraction_ax.set_yticks([0.0, 0.1, 0.2, 0.3, 0.4])

    plotting.plot_metric(
        circ_var_ax, [WT_expt_grp_acute, burlap_expt_grp],
        metric_fn=place.circular_variance,
        groupby=[['roi_id', 'expt']], plotby=None, plot_method='cdf',
        roi_filters=[WT_filter, WT_filter], activity_kwargs=None,
        activity_label='Circular variance', colors=burlap_colors,
        rotate_labels=False)
    circ_var_ax.set_title('')
    circ_var_ax.get_legend().set_visible(False)
    circ_var_ax.set_xticks([0, 0.5, 1])

    save_figure(fig, filename, save_dir=save_dir)

    plt.close('all')
def main():
    all_grps = df.loadExptGrps('GOL')
    expts = lab.ExperimentSet(os.path.join(df.metadata_path,
                                           'expt_metadata.xml'),
                              behaviorDataPath=os.path.join(
                                  df.data_path, 'behavior'),
                              dataPath=os.path.join(df.data_path, 'imaging'))

    WT_expt_grp = all_grps['WT_hidden_behavior_set']
    Df_expt_grp = all_grps['Df_hidden_behavior_set']
    expt_grps = [WT_expt_grp, Df_expt_grp]

    if MALES_ONLY:
        for expt_grp in expt_grps:
            expt_grp.filter(lambda expt: expt.parent.get('sex') == 'M')
    labels = [expt_grp.label() for expt_grp in expt_grps]

    fig = plt.figure(figsize=(8.5, 11))

    HORIZONTAL = False

    if HORIZONTAL:
        gs1 = plt.GridSpec(8, 6)
        wt_lick_axs = [
            fig.add_subplot(gs1[0, 0]),
            fig.add_subplot(gs1[0, 1]),
            fig.add_subplot(gs1[0, 2]),
            fig.add_subplot(gs1[0, 3]),
            fig.add_subplot(gs1[0, 4]),
            fig.add_subplot(gs1[0, 5])
        ]
        df_lick_axs = [
            fig.add_subplot(gs1[1, 0]),
            fig.add_subplot(gs1[1, 1]),
            fig.add_subplot(gs1[1, 2]),
            fig.add_subplot(gs1[1, 3]),
            fig.add_subplot(gs1[1, 4]),
            fig.add_subplot(gs1[1, 5])
        ]

        gs2 = plt.GridSpec(4, 2, hspace=0.5, wspace=0.2)
        reward_zone_ax = fig.add_subplot(gs2[1, 0])
    else:
        gs1 = plt.GridSpec(10, 6)
        wt_lick_axs = [
            fig.add_subplot(gs1[0, 0]),
            fig.add_subplot(gs1[1, 0]),
            fig.add_subplot(gs1[2, 0]),
            fig.add_subplot(gs1[3, 0]),
            fig.add_subplot(gs1[4, 0]),
            fig.add_subplot(gs1[5, 0])
        ]
        df_lick_axs = [
            fig.add_subplot(gs1[0, 1]),
            fig.add_subplot(gs1[1, 1]),
            fig.add_subplot(gs1[2, 1]),
            fig.add_subplot(gs1[3, 1]),
            fig.add_subplot(gs1[4, 1]),
            fig.add_subplot(gs1[5, 1])
        ]

        gs2 = plt.GridSpec(10, 1, hspace=0.5, wspace=0.8, left=0.47, right=0.9)
        reward_zone_ax = fig.add_subplot(gs2[0:4, :])
        gs3 = plt.GridSpec(10, 3, hspace=0.5, wspace=0.1, left=0.47, right=0.9)
        fraction_licks_by_session_A_ax = fig.add_subplot(gs3[5:7, 0])
        fraction_licks_by_session_B_ax = fig.add_subplot(gs3[5:7, 1])
        fraction_licks_by_session_C_ax = fig.add_subplot(gs3[5:7, 2])

    #
    # Lick plots
    #

    wt_lick_expts = [
        expts.grabExpt('jz101', '2014-11-06-23h37m54s'),
        expts.grabExpt('jz101', '2014-11-08-22h53m27s'),
        expts.grabExpt('jz101', '2014-11-09-23h06m56s'),
        expts.grabExpt('jz101', '2014-11-11-23h13m16s'),
        expts.grabExpt('jz101', '2014-11-12-19h29m41s'),
        expts.grabExpt('jz101', '2014-11-14-19h59m09s')
    ]
    df_lick_expts = [
        expts.grabExpt('jz106', '2014-12-11-17h06m49s'),
        expts.grabExpt('jz106', '2014-12-13-19h00m01s'),
        expts.grabExpt('jz106', '2014-12-14-17h17m17s'),
        expts.grabExpt('jz106', '2014-12-16-17h43m05s'),
        expts.grabExpt('jz106', '2014-12-17-17h57m51s'),
        expts.grabExpt('jz106', '2014-12-19-17h13m52s')
    ]

    shade_color = sns.xkcd_rgb['light green']
    for ax, expt in zip(wt_lick_axs, wt_lick_expts):
        expt.licktogram(ax=ax,
                        plot_belt=False,
                        nPositionBins=20,
                        color=WT_color,
                        linewidth=0,
                        shade_reward=True,
                        shade_color=shade_color)
    for ax, expt in zip(df_lick_axs, df_lick_expts):
        expt.licktogram(ax=ax,
                        plot_belt=False,
                        nPositionBins=20,
                        color=Df_color,
                        linewidth=0,
                        shade_reward=True,
                        shade_color=shade_color)

    for ax in wt_lick_axs + df_lick_axs:
        ax.set_ylim(0, 0.6)
        ax.set_yticks([0, 0.3, 0.6])
        ax.set_xticks([0, 0.5, 1])
        ax.set_xticklabels(['0.0', '0.5', '1.0'])
        sns.despine(ax=ax)
        ax.set_title('')

    if HORIZONTAL:
        for ax in wt_lick_axs:
            ax.tick_params(labelbottom=False)
            ax.set_xlabel('')

        for ax in df_lick_axs[1:]:
            ax.set_xlabel('')

        for ax, label in zip(wt_lick_axs, [
                r'Condition $\mathrm{I}$' + '\nDay 1',
                r'Condition $\mathrm{I}$' + '\nDay 3',
                r'Condition $\mathrm{II}$' + '\nDay 1',
                r'Condition $\mathrm{II}$' + '\nDay 3',
                r'Condition $\mathrm{III}$' + '\nDay 1',
                r'Condition $\mathrm{III}$' + '\nDay 3'
        ]):
            ax.set_title(label)

        for ax in it.chain(wt_lick_axs[1:], df_lick_axs[1:]):
            ax.set_ylabel('')
            sns.despine(ax=ax, left=True, top=True, right=True)

        for ax in wt_lick_axs + df_lick_axs:
            ax.spines['bottom'].set_linewidth(0.5)

        wt_lick_axs[0].tick_params(labelbottom=False)
        for ax in wt_lick_axs[1:]:
            ax.tick_params(labelleft=False, left=False, labelbottom=False)
        for ax in df_lick_axs[1:]:
            ax.tick_params(labelleft=False, left=False)

        right_label(wt_lick_axs[-1], labels[0])
        right_label(df_lick_axs[-1], labels[1])

        df_lick_axs[0].set_yticks([0, 0.6])
        wt_lick_axs[0].set_yticks([0, 0.6])
        df_lick_axs[0].set_ylabel('Fraction of licks')
        wt_lick_axs[0].set_ylabel('')
        df_lick_axs[0].spines['left'].set_linewidth(0.5)
        wt_lick_axs[0].spines['left'].set_linewidth(0.5)
    else:
        for ax in wt_lick_axs + df_lick_axs:
            ax.spines['bottom'].set_linewidth(0.5)
        for ax in wt_lick_axs + df_lick_axs[1:]:
            sns.despine(ax=ax, left=True, top=True, right=True)
        sns.despine(ax=df_lick_axs[0], left=True, top=True, right=False)

        for ax in wt_lick_axs[:-1] + df_lick_axs[:-1]:
            ax.set_xlabel('')

        for ax in df_lick_axs:
            ax.set_ylabel('')

        for ax, label in zip(wt_lick_axs, [
                r'Condition $\mathrm{I}$' + '\nDay 1',
                r'Condition $\mathrm{I}$' + '\nDay 3',
                r'Condition $\mathrm{II}$' + '\nDay 1',
                r'Condition $\mathrm{II}$' + '\nDay 3',
                r'Condition $\mathrm{III}$' + '\nDay 1',
                r'Condition $\mathrm{III}$' + '\nDay 3'
        ]):
            ax.set_ylabel(label,
                          rotation='horizontal',
                          ha='right',
                          multialignment='center',
                          labelpad=3,
                          va='center')

        for ax in wt_lick_axs[:-1] + df_lick_axs[:-1]:
            ax.tick_params(labelleft=False, left=False, labelbottom=False)

        for ax in (wt_lick_axs[-1], df_lick_axs[-1]):
            ax.tick_params(labelleft=False, left=False)

        wt_lick_axs[0].set_title(labels[0])
        df_lick_axs[0].set_title(labels[1])

        df_lick_axs[0].yaxis.tick_right()
        df_lick_axs[0].yaxis.set_label_position("right")
        df_lick_axs[0].set_yticks([0, 0.6])
        df_lick_axs[0].tick_params(axis='y', length=2, pad=2, direction='in')
        df_lick_axs[0].set_ylabel('Fraction of licks')
        df_lick_axs[0].spines['right'].set_linewidth(0.5)

    filter_fn = None
    filter_columns = None

    behavior_fn = ra.fraction_licks_in_reward_zone
    behavior_kwargs = {}
    activity_label = 'Fraction of licks in reward zone'

    plot_metric(reward_zone_ax,
                expt_grps,
                metric_fn=behavior_fn,
                activity_kwargs=behavior_kwargs,
                groupby=[['expt'], ['mouseID', 'X_condition', 'X_day']],
                plotby=['X_condition', 'X_day'],
                plot_method='line',
                activity_label=activity_label,
                colors=colors,
                linestyles=linestyles,
                label_every_n=1,
                label_groupby=False,
                markers=markers,
                markersize=5,
                rotate_labels=False,
                filter_fn=filter_fn,
                filter_columns=filter_columns,
                return_full_dataframes=False)
    reward_zone_ax.set_yticks([0, .1, .2, .3, .4])
    sns.despine(ax=reward_zone_ax)
    reward_zone_ax.set_xlabel('Day in Condition')
    reward_zone_ax.set_title('')
    day_number_only_label(reward_zone_ax)
    label_conditions(reward_zone_ax)
    reward_zone_ax.legend(loc='lower left', fontsize=8)
    # reward_zone_ax.get_legend().set_visible(False)
    # stackedText(reward_zone_ax, labels, colors=colors, loc=3, size=10)

    groupby = [['expt']]
    plotby = ['X_condition', 'X_session']

    filter_fn = lambda df: (df['X_session'] != '1') & (df['X_condition'] == 'A'
                                                       )
    filter_columns = ['X_session', 'X_condition']
    line_kwargs = {'markersize': 4}
    plot_metric(fraction_licks_by_session_A_ax,
                expt_grps,
                metric_fn=behavior_fn,
                activity_kwargs=behavior_kwargs,
                groupby=groupby,
                plotby=plotby,
                plot_method='box_and_line',
                activity_label=activity_label,
                colors=colors,
                notch=False,
                label_every_n=1,
                label_groupby=False,
                markers=markers,
                rotate_labels=False,
                line_kwargs=line_kwargs,
                linestyles=linestyles,
                filter_fn=filter_fn,
                filter_columns=filter_columns,
                flierprops={
                    'markersize': 2,
                    'marker': 'o'
                },
                box_width=0.4,
                box_spacing=0.2,
                return_full_dataframes=False,
                whis='range')
    sns.despine(ax=fraction_licks_by_session_A_ax, top=True, right=True)
    fraction_licks_by_session_A_ax.set_xticklabels(['first', 'last'])
    fraction_licks_by_session_A_ax.set_xlabel('')
    fraction_licks_by_session_A_ax.set_ylim(-0.02, 0.6)
    fraction_licks_by_session_A_ax.set_yticks([0, 0.2, 0.4, 0.6])
    fraction_licks_by_session_A_ax.set_title('')
    fraction_licks_by_session_A_ax.legend(loc='upper left', fontsize=6)
    # fraction_licks_by_session_A_ax.get_legend().set_visible(False)
    fraction_licks_by_session_A_ax.text(
        0.5,
        .95,
        r'$\mathrm{I}$',
        ha='center',
        va='center',
        transform=fraction_licks_by_session_A_ax.transAxes,
        fontsize=12)

    filter_fn = lambda df: (df['X_session'] != '1') & (df['X_condition'] == 'B'
                                                       )
    filter_columns = ['X_session', 'X_condition']
    plot_metric(fraction_licks_by_session_B_ax,
                expt_grps,
                metric_fn=behavior_fn,
                activity_kwargs=behavior_kwargs,
                groupby=groupby,
                plotby=plotby,
                plot_method='box_and_line',
                activity_label=activity_label,
                colors=colors,
                label_every_n=1,
                label_groupby=False,
                markers=markers,
                rotate_labels=False,
                line_kwargs=line_kwargs,
                linestyles=linestyles,
                filter_fn=filter_fn,
                filter_columns=filter_columns,
                notch=False,
                flierprops={
                    'markersize': 2,
                    'marker': 'o'
                },
                box_width=0.4,
                box_spacing=0.2,
                return_full_dataframes=False,
                whis='range')
    sns.despine(ax=fraction_licks_by_session_B_ax,
                top=True,
                right=True,
                left=True)
    fraction_licks_by_session_B_ax.tick_params(left=False, labelleft=False)
    fraction_licks_by_session_B_ax.set_xticklabels(['first', 'last'])
    fraction_licks_by_session_B_ax.set_xlabel('Session in day')
    fraction_licks_by_session_B_ax.set_ylabel('')
    fraction_licks_by_session_B_ax.set_ylim(-0.02, 0.6)
    fraction_licks_by_session_B_ax.set_title('')
    fraction_licks_by_session_B_ax.get_legend().set_visible(False)
    fraction_licks_by_session_B_ax.text(
        0.5,
        .95,
        r'$\mathrm{II}$',
        ha='center',
        va='center',
        transform=fraction_licks_by_session_B_ax.transAxes,
        fontsize=12)

    filter_fn = lambda df: (df['X_session'] != '1') & (df['X_condition'] == 'C'
                                                       )
    filter_columns = ['X_session', 'X_condition']
    plot_metric(fraction_licks_by_session_C_ax,
                expt_grps,
                metric_fn=behavior_fn,
                activity_kwargs=behavior_kwargs,
                groupby=groupby,
                plotby=plotby,
                plot_method='box_and_line',
                activity_label=activity_label,
                colors=colors,
                notch=False,
                label_every_n=1,
                label_groupby=False,
                markers=markers,
                rotate_labels=False,
                line_kwargs=line_kwargs,
                linestyles=linestyles,
                filter_fn=filter_fn,
                filter_columns=filter_columns,
                return_full_dataframes=False,
                flierprops={
                    'markersize': 2,
                    'marker': 'o'
                },
                box_width=0.4,
                box_spacing=0.2,
                whis='range')
    sns.despine(ax=fraction_licks_by_session_C_ax,
                top=True,
                right=True,
                left=True)
    fraction_licks_by_session_C_ax.tick_params(left=False, labelleft=False)
    fraction_licks_by_session_C_ax.set_xticklabels(['first', 'last'])
    fraction_licks_by_session_C_ax.set_xlabel('')
    fraction_licks_by_session_C_ax.set_ylabel('')
    fraction_licks_by_session_C_ax.set_ylim(-0.02, 0.6)
    fraction_licks_by_session_C_ax.set_title('')
    fraction_licks_by_session_C_ax.get_legend().set_visible(False)
    fraction_licks_by_session_C_ax.text(
        0.5,
        .95,
        r'$\mathrm{III}$',
        ha='center',
        va='center',
        transform=fraction_licks_by_session_C_ax.transAxes,
        fontsize=12)

    misc.save_figure(fig, filename, save_dir=save_dir)

    plt.close('all')