A_B=45000 / -54e-3, # 2727272.73,
A_C=-1,
A_vhalf=-0.054,
A_vslope=-0.012,
B_rate=450,
B_B=0,
B_C=1,
B_vhalf=0.025,
B_vslope=0.013)
Ca_Y_params = []
SKparam = ChannelSettings(Xpow=0, Ypow=0, Zpow=1, Erev=krev, name='SKCa')
SK_Z_params = ZChannelParams(Kd=0.00035,
power=4.6,
tau=0.002,
taumax=0.0037928,
tau_power=4.3,
cahalf=0.002703)
# BK channel
BKparam = ChannelSettings(Xpow=1, Ypow=0, Zpow=0, Erev=krev, name='BKCa')
BK_X_params = [
BKChannelParams(alphabeta=480, K=0.18, delta=-0.84),
BKChannelParams(alphabeta=280, K=0.011, delta=-1.0)
]
Channels = NamedDict(
'Channels',
KDr=TypicalOneD(KDrparam, KDr_X_params, KDr_Y_params),
Kv3=TypicalOneD(Kv3param, Kv3_X_params, Kv3_Y_params),
KvF=TypicalOneD(KvFparam, KvF_X_params, KvF_Y_params),
A_B=10000,
A_C=-1.0,
A_vhalf=0.11,
A_vslope=17e-3,
B_rate=20,
B_B=0,
B_C=0.0,
B_vhalf=0.0,
B_vslope=-30.0e-3)
#Reference: Maylie Bond Herson Lee Adelman 2004, Fig 2 steady state
#Fast component has tau~4 ms; not used: slow tau = 70 ms
#Fast component, tau=4.9ms from Hirschberg et al., 1998 figure 13.
SKparam = ChannelSettings(Xpow=0, Ypow=0, Zpow=1, Erev=krev, name='SKCa')
SK_Z_params = ZChannelParams(Kd=0.57e-3, power=5.2, tau=4.9e-3)
#Reference: Berkefeld et al. Science 2006 314(5799):615-20. Moczydlowski and Latorre 1983, J. Gen. Physiol. 82:511-542.
BKparam = ChannelSettings(Xpow=1, Ypow=0, Zpow=0, Erev=krev, name='BKCa')
BK_X_params = [
BKChannelParams(alphabeta=480, K=0.18, delta=-0.84),
BKChannelParams(alphabeta=280, K=0.011, delta=-1.0)
]
#These CDI params can be used with every channel, make ZpowCDI=2
#If ZpowCDI=0 the CDI will not be used, power=-4 is to transform
#(Ca/Kd)^pow/(1+(Ca/Kd)^pow) to 1/(1+(ca/Kd)^-pow)
CDI_Z_params = ZChannelParams(Kd=0.12e-3, power=-4, tau=142e-3)
# Calcium-activated chloride channel params
A_vhalf=0.11,
A_vslope=0.017,
B_rate=20,
B_B=0,
B_C=0.0,
B_vhalf=0.0,
B_vslope=-0.03)
# Reference: Maylie Bond Herson Lee Adelman 2004, Fig 2 steady state
# Fast component has tau~4 ms; not used: slow tau = 70 ms
# Fast component, tau=4.9ms from Hirschberg et al., 1998 figure 13.
SKparam = ChannelSettings(Xpow=0, Ypow=0, Zpow=1, Erev=krev, name='SKCa')
SK_Z_params = ZChannelParams(Kd=0.00057,
power=5.2,
tau=0.0049,
taumax=0,
tau_power=0,
cahalf=0)
# Reference: Berkefeld et al. Science 2006 314(5799):615-20. Moczydlowski and Latorre 1983, J. Gen. Physiol. 82:511-542.
BKparam = ChannelSettings(Xpow=1, Ypow=0, Zpow=0, Erev=krev, name='BKCa')
BK_X_params = [
BKChannelParams(alphabeta=480, K=0.18, delta=-0.84),
BKChannelParams(alphabeta=280, K=0.011, delta=-1.0)
]
# These CDI params can be used with every channel, make ZpowCDI=2
# If ZpowCDI=0 the CDI will not be used, power=-4 is to transform
# (Ca/Kd)^pow/(1+(Ca/Kd)^pow) to 1/(1+(ca/Kd)^-pow)
CDI_Z_params = ZChannelParams(Kd=0.00012,
A_C = -1.0,
A_vhalf = 0.11,
A_vslope = 17e-3,
B_rate =20,
B_B = 0,
B_C = 0.0,
B_vhalf = 0.0,
B_vslope = -30.0e-3)
#Reference: Maylie Bond Herson Lee Adelman 2004, Fig 2 steady state
#Fast component has tau~4 ms; not used: slow tau = 70 ms
#Fast component, tau=4.9ms from Hirschberg et al., 1998 figure 13.
SKparam = ChannelSettings(Xpow=0, Ypow=0, Zpow=1, Erev=krev, name='SKCa')
SK_Z_params = ZChannelParams(Kd = 0.57e-3,
power = 5.2,
tau = 4.9e-3)
#Reference: Berkefeld et al. Science 2006 314(5799):615-20. Moczydlowski and Latorre 1983, J. Gen. Physiol. 82:511-542.
BKparam = ChannelSettings(Xpow=1, Ypow=0, Zpow=0, Erev=krev, name='BKCa')
BK_X_params=[BKChannelParams(alphabeta=480, K=0.18, delta=-0.84),
BKChannelParams(alphabeta=280, K=0.011, delta=-1.0)]
#These CDI params can be used with every channel, make ZpowCDI=2
#If ZpowCDI=0 the CDI will not be used, power=-4 is to transform
#(Ca/Kd)^pow/(1+(Ca/Kd)^pow) to 1/(1+(ca/Kd)^-pow)
CDI_Z_params = ZChannelParams(Kd = 0.12e-3,
power = -4,
tau = 142e-3)