def runSim(self, index, prefix, data):
simRef = prefix + str(index)
densities = data["densities"]
channels = data["channels"]
locations = data["locations"]
self.logger.debug("Going to run simulation: " + simRef)
stim = self.myProject.elecInputInfo.getStim(self.stimulation)
self.logger.debug("Stimulation data: " + str(stim))
cell = self.myProject.cellManager.getCell(self.cellName)
# hier werden die oben ausgelesenen Daten einzeln dem Konstruktor der Simulation übergeben:
for i in range(len(densities)):
chanMech = ChannelMechanism(channels[i], densities[i]) # Konstruktor
cell.associateGroupWithChanMech(locations[i], chanMech)
self.myProject.simulationParameters.setReference(simRef)
self.myProject.neuronFileManager.generateTheNeuronFiles(self.simConfig, None, NeuronFileManager.RUN_HOC, self.simulatorSeed)
self.logger.debug("Generated NEURON files for: " + simRef)
compileProcess = ProcessManager(self.myProject.neuronFileManager.getMainHocFile())
compileSuccess = compileProcess.compileFileWithNeuron(0, 0)
self.logger.debug("Compiled NEURON files for: " + simRef)
if compileSuccess:
self.pm.doRunNeuron(self.simConfig)
self.logger.info("Set running simulation: " + simRef)
self.simsRunning.append(simRef)
return True
self.logger.error("Could not run simulation: " + simRef)
return False
project.generatedNetworkConnections.addSynapticConnection('aEPSP_Vervaeke_pf',
0, 0, 0, 0.5, 0,
stim_seg_detailed,
0.5, 0, None)
# delete all existing probes
project.generatedPlotSaves.reset()
# set up voltage recording at the specified points along the dendrite being stimulated
project.generatedPlotSaves.addPlotSaveDetails('Golgi_reduced_v', project.simPlotInfo.getSimPlot('Golgi_reduced_v'), ArrayList([0]), ArrayList(rec_segs_reduced), False, False)
project.generatedPlotSaves.addPlotSaveDetails('Golgi_detailed_v', project.simPlotInfo.getSimPlot('Golgi_detailed_v'), ArrayList([0]), ArrayList(rec_segs_detailed), False, False)
# generate and compile neuron files
print "Generating NEURON scripts..."
simulator_seed = random.getrandbits(32)
project.neuronFileManager.generateTheNeuronFiles(sim_config, None, NeuronFileManager.RUN_HOC,simulator_seed)
compile_process = ProcessManager(project.neuronFileManager.getMainHocFile())
compile_success = compile_process.compileFileWithNeuron(0,0)
# simulate
if compile_success:
print "Simulating: simulation reference " + sim_ref
pm.doRunNeuron(sim_config)
timefile_path = sim_path + '/time.dat'
while not os.path.exists(timefile_path):
time.sleep(0.1)
data_string = "Data reference " + sim_ref
for k,i in enumerate(rec_segs_detailed):
data_string = data_string + " " + str(i) + " " + str(rec_dists_detailed[k])
print data_string
System.exit(0)
print "group generated: "+simConfig.getCellGroups().toString()
print "going to stimulate: "+simConfig.getInputs().toString()
print "going to record: "+simConfig.getPlots().toString()
pm.doGenerate(simConfig.getName(), randomseed)
while pm.isGenerating():
print "Waiting for the project to be generated..."
time.sleep(2)
myProject.neuronFileManager.setSuggestedRemoteRunTime(10)
myProject.neuronFileManager.generateTheNeuronFiles(simConfig, None, NeuronFileManager.RUN_HOC, randomseed)
print "Generated NEURON files for: "+simRef
compileProcess = ProcessManager(myProject.neuronFileManager.getMainHocFile())
compileSuccess = compileProcess.compileFileWithNeuron(0,0)
print "Compiled NEURON files for: "+simRef
if compileSuccess:
pm.doRunNeuron(simConfig)
print "Set running simulation: "+simRef
time.sleep(5) # wait for the process to be sent out
#####################'''
'''##### Rerunning the same configuration + background exc #####
simRef = prefix+"syn"+str(synapses)+"E1500_"+str(t)
print "Simref: "+simRef
def make_fF_Curve(self,
projFile,
simulator,
simConfig,
nTrains,
simDuration,
analyseStartTime, analyseStopTime,
analyseThreshold,
maxNumSimultaneousSims = 4):
# Load neuroConstruct project
print "Loading project from file: " + projFile.getAbsolutePath()+", exists: "+ str(projFile.exists())
pm = ProjectManager()
self.myProject = pm.loadProject(projFile)
self.simulator = simulator
simConfig = self.myProject.simConfigInfo.getSimConfig(simConfig)
simConfig.setSimDuration(simDuration)
pm.doGenerate(simConfig.getName(), self.neuroConstructSeed)
while pm.isGenerating():
print "Waiting for the project to be generated with Simulation Configuration: "+str(simConfig)
time.sleep(2)
numGenerated = self.myProject.generatedCellPositions.getNumberInAllCellGroups()
print "Number of cells generated: " + str(numGenerated)
simReferences = {}
if numGenerated > 0:
print "Generating scripts for simulator: %s..."%simulator
if simulator == 'NEURON':
self.myProject.neuronFileManager.setQuitAfterRun(1) # Remove this line to leave the NEURON sim windows open after finishing
self.myProject.neuronSettings.setCopySimFiles(1) # 1 copies hoc/mod files to PySim_0 etc. and will allow multiple sims to run at once
self.myProject.neuronSettings.setGraphicsMode(0) # 0 hides graphs during execution
if simulator == 'GENESIS':
self.myProject.genesisFileManager.setQuitAfterRun(1) # Remove this line to leave the NEURON sim windows open after finishing
self.myProject.genesisSettings.setCopySimFiles(1) # 1 copies hoc/mod files to PySim_0 etc. and will allow multiple sims to run at once
self.myProject.genesisSettings.setGraphicsMode(0) # 0 hides graphs during execution
currentTrain = 0
ADD_TO_START_FINITIALIZE = self.myProject.neuronSettings.getNativeBlock(NativeCodeLocation.START_FINITIALIZE)
ADD_TO_RECORD_I = self.myProject.neuronSettings.getNativeBlock(NativeCodeLocation.AFTER_SIMULATION)
while currentTrain <= nTrains:
while (len(self.simsRunning)>=maxNumSimultaneousSims):
print "Sims currently running: "+str(self.simsRunning)
print "Waiting..."
time.sleep(3) # wait a while...
self.updateSimsRunning()
simRef = "PySim_"+str(currentTrain)
print "Going to run simulation: "+simRef
######## Adjusting the amplitude of the Voltage clamp ###############
TEXT_BEFORE_CREATION = """objref vector, gTrainFile\n""" + "objectvar clamp\n"
### TEXT_BEFORE_INIT = "GranuleCell_mod_tonic[0].Soma {\n" + "clampobj = new VClamp(0.5)\n" + "clampobj.dur[0] = " + str(stimDur) + "\n" + "clampobj.amp[0] = " + str(stimAmp) + "\n" + "}\n" # This should do the trick
TEXT_START_FINITIALIZE = "\n" + "gTrainFile = new File() \n" + "vector = new Vector(100000) \n" + "access GranuleCell_mod_tonic[0].Soma \n" + "clamp = new SEClamp(0.5) \n" + "clamp.amp1 = 0 \n" + "clamp.dur1 = 1e9 \n" + """gTrainFile.ropen("E:/neuroConstruct/models/Dan_GranCell/gTrains_nS/gAMPA_""" + str(currentTrain) + """.txt") \n""" + "vector.scanf(gTrainFile) \n" + "gTrainFile.close \n" + "for i = 0, vector.size() -1 { \n" + " if (vector.x[i] <= 0) { \n" + " vector.x[i] = 1e-20 \n" + " } \n" + " } \n" + "for i = 0, vector.size() -1 { \n" + " vector.x[i] = ( 1 / vector.x[i] ) * 1000 \n" + " } \n" + "vector.play(&clamp.rs, 0.03) \n" # This
TEXT_START_FINITIALIZE = TEXT_START_FINITIALIZE + ADD_TO_START_FINITIALIZE
TEXT_TO_RECORD_I = """// currently not used \n"""
TEXT_TO_RECORD_I = TEXT_TO_RECORD_I + ADD_TO_RECORD_I
self.myProject.neuronSettings.setNativeBlock(NativeCodeLocation.BEFORE_CELL_CREATION, TEXT_BEFORE_CREATION)
self.myProject.neuronSettings.setNativeBlock(NativeCodeLocation.START_FINITIALIZE, TEXT_START_FINITIALIZE)
self.myProject.neuronSettings.setNativeBlock(NativeCodeLocation.AFTER_SIMULATION, TEXT_TO_RECORD_I)
print "Next Train: "+ str(currentTrain)
self.myProject.simulationParameters.setReference(simRef)
if simulator == "NEURON":
self.myProject.neuronFileManager.generateTheNeuronFiles(simConfig,
None,
NeuronFileManager.RUN_HOC,
self.simulatorSeed)
print "Generated NEURON files for: "+simRef
compileProcess = ProcessManager(self.myProject.neuronFileManager.getMainHocFile())
compileSuccess = compileProcess.compileFileWithNeuron(0,0)
print "Compiled NEURON files for: "+simRef
if compileSuccess:
pm.doRunNeuron(simConfig)
print "Set running simulation: "+simRef
self.simsRunning.append(simRef)
if simulator == "GENESIS":
compartmentalisation = GenesisCompartmentalisation()
self.myProject.genesisFileManager.generateTheGenesisFiles(simConfig,
None,
compartmentalisation,
self.simulatorSeed)
print "Generated GENESIS files for: "+simRef
pm.doRunGenesis(simConfig)
print "Set running simulation: "+simRef
self.simsRunning.append(simRef)
time.sleep(1) # Wait for sim to be kicked off
simReferences[simRef] = currentTrain
currentTrain = currentTrain + 1
print
print "Finished running "+str(len(simReferences))+" simulations for project "+ projFile.getAbsolutePath()
print "These can be loaded and replayed in the previous simulation browser in the GUI"
print
while (len(self.simsRunning)>0):
print "Sims currently running: "+str(self.simsRunning)
print "Waiting..."
time.sleep(4) # wait a while...
self.updateSimsRunning()
#simReferences = {'PySim_0.3':0.3,'PySim_0.4':0.4,'PySim_0.5':0.5}
plotFrameFf = PlotManager.getPlotterFrame("F-f curve from project: "+str(self.myProject.getProjectFile())+" on "+simulator , 1, 1)
plotFrameVolts = PlotManager.getPlotterFrame("VoltageTraces from project: "+str(self.myProject.getProjectFile())+" on "+simulator , 1, 1)
plotFrameFf.setViewMode(PlotCanvas.INCLUDE_ORIGIN_VIEW)
info = "F-f curve for Simulation Configuration: "+str(simConfig)
dataSet = DataSet(info, info, "Hz", "Hz", "Input_Freq", "Output_Freq")
dataSet.setGraphFormat(PlotCanvas.USE_CIRCLES_FOR_PLOT)
simList = simReferences.keys()
simList.sort()
traininfos = open("E:/neuroConstruct/models/Dan_GranCell/gAMPA_traininfo.txt")
train_info_list = traininfos.readlines()
currentTrain = 0
for sim in simList:
simDir = File(projFile.getParentFile(), "E:/neuroConstruct/models/Dan_GranCell/simulations/"+sim)
print
print "--- Reloading data from simulation in directory: %s"%simDir.getCanonicalPath()
try:
simData = SimulationData(simDir)
simData.initialise()
print "Data loaded: "
print simData.getAllLoadedDataStores()
times = simData.getAllTimes()
cellSegmentRef = simConfig.getCellGroups().get(0)+"_0"
volts = simData.getVoltageAtAllTimes(cellSegmentRef)
time.sleep(2)
traceInfo = "Voltage at: %s in simulation: %s"%(cellSegmentRef, sim)
dataSetV = DataSet(traceInfo, traceInfo, "ms", "mV", "Time", "Membrane Potential")
Spike_List = []
Spike_List.append(0.00)
for i in range(len(times)):
dataSetV.addPoint(times[i], volts[i])
for i in range(len(times)):
if (volts[i] > 0.0):
if (times[i] - Spike_List[len(Spike_List)-1] > 0.50):
Spike_List.append(times[i])
Spike_List.remove(0.00)
plotFrameVolts.addDataSet(dataSetV)
spikeTimes = SpikeAnalyser.getSpikeTimes(volts, times, analyseThreshold, analyseStartTime, analyseStopTime)
currentTrain_Freq = float(train_info_list[currentTrain-1])
print "Number of spikes in sim %s: %i"%(sim, len(spikeTimes))
avgFreq = 0
if len(Spike_List)>0:
avgFreq = 1000.0 / ((Spike_List[len(Spike_List)-1] - Spike_List[0]) / (len(Spike_List) -1))
dataSet.addPoint(currentTrain_Freq,avgFreq)
currentTrain = currentTrain + 1
except:
print "Error analysing simulation data from: %s"%simDir.getCanonicalPath()
print sys.exc_info()[0]
plotFrameFf.addDataSet(dataSet)
def generateF_ICurve(self,
projFile,
simulator,
simConfig,
preStimAmp, preStimDel, preStimDur,
stimAmpLow, stimAmpInc, stimAmpHigh,
stimDel, stimDur,
simDuration,
analyseStartTime, analyseStopTime,
analyseThreshold,
maxNumSimultaneousSims = 4):
# Load neuroConstruct project
print "Loading project from file: " + projFile.getAbsolutePath()+", exists: "+ str(projFile.exists())
pm = ProjectManager()
self.myProject = pm.loadProject(projFile)
self.simulator = simulator
simConfig = self.myProject.simConfigInfo.getSimConfig(simConfig)
simConfig.setSimDuration(simDuration)
pm.doGenerate(simConfig.getName(), self.neuroConstructSeed)
while pm.isGenerating():
print "Waiting for the project to be generated with Simulation Configuration: "+str(simConfig)
time.sleep(2)
numGenerated = self.myProject.generatedCellPositions.getNumberInAllCellGroups()
print "Number of cells generated: " + str(numGenerated)
simReferences = {}
if numGenerated > 0:
print "Generating scripts for simulator: %s..."%simulator
if simulator == 'NEURON':
self.myProject.neuronFileManager.setQuitAfterRun(1) # Remove this line to leave the NEURON sim windows open after finishing
self.myProject.neuronSettings.setCopySimFiles(1) # 1 copies hoc/mod files to PySim_0 etc. and will allow multiple sims to run at once
self.myProject.neuronSettings.setGraphicsMode(0) # 0 hides graphs during execution
if simulator == 'GENESIS':
self.myProject.genesisFileManager.setQuitAfterRun(1) # Remove this line to leave the NEURON sim windows open after finishing
self.myProject.genesisSettings.setCopySimFiles(1) # 1 copies hoc/mod files to PySim_0 etc. and will allow multiple sims to run at once
self.myProject.genesisSettings.setGraphicsMode(0) # 0 hides graphs during execution
stimAmp = stimAmpLow
while stimAmp <= stimAmpHigh:
while (len(self.simsRunning)>=maxNumSimultaneousSims):
print "Sims currently running: "+str(self.simsRunning)
print "Waiting..."
time.sleep(3) # wait a while...
self.updateSimsRunning()
simRef = "PySim_"+str(float(stimAmp))
print "Going to run simulation: "+simRef
######## Adjusting the amplitude of the current clamp ###############
# preStim = self.myProject.elecInputInfo.getStim(simConfig.getInputs().get(0))
preStim = self.myProject.elecInputInfo.getStim("Input_3")
preStim.setAmp(NumberGenerator(preStimAmp))
preStim.setDel(NumberGenerator(preStimDel))
preStim.setDur(NumberGenerator(preStimDur))
self.myProject.elecInputInfo.updateStim(preStim)
# stim = self.myProject.elecInputInfo.getStim(simConfig.getInputs().get(1))
stim = self.myProject.elecInputInfo.getStim("Input_4")
stim.setAmp(NumberGenerator(stimAmp))
stim.setDel(NumberGenerator(stimDel))
stim.setDur(NumberGenerator(stimDur))
self.myProject.elecInputInfo.updateStim(stim)
print "Next stim: "+ str(stim)
self.myProject.simulationParameters.setReference(simRef)
if simulator == "NEURON":
self.myProject.neuronFileManager.generateTheNeuronFiles(simConfig,
None,
NeuronFileManager.RUN_HOC,
self.simulatorSeed)
print "Generated NEURON files for: "+simRef
compileProcess = ProcessManager(self.myProject.neuronFileManager.getMainHocFile())
compileSuccess = compileProcess.compileFileWithNeuron(0,0)
print "Compiled NEURON files for: "+simRef
if compileSuccess:
pm.doRunNeuron(simConfig)
print "Set running simulation: "+simRef
self.simsRunning.append(simRef)
if simulator == "GENESIS":
compartmentalisation = GenesisCompartmentalisation()
self.myProject.genesisFileManager.generateTheGenesisFiles(simConfig,
None,
compartmentalisation,
self.simulatorSeed)
print "Generated GENESIS files for: "+simRef
pm.doRunGenesis(simConfig)
print "Set running simulation: "+simRef
self.simsRunning.append(simRef)
time.sleep(1) # Wait for sim to be kicked off
simReferences[simRef] = stimAmp
stimAmp = stimAmp +stimAmpInc
print
print "Finished running "+str(len(simReferences))+" simulations for project "+ projFile.getAbsolutePath()
print "These can be loaded and replayed in the previous simulation browser in the GUI"
print
while (len(self.simsRunning)>0):
print "Sims currently running: "+str(self.simsRunning)
print "Waiting..."
time.sleep(4) # wait a while...
self.updateSimsRunning()
#simReferences = {'PySim_0.3':0.3,'PySim_0.4':0.4,'PySim_0.5':0.5}
plotFrameFI = PlotManager.getPlotterFrame("F-I curve from project: "+str(self.myProject.getProjectFile())+" on "+simulator , 1, 1)
plotFrameVolts = PlotManager.getPlotterFrame("VoltageTraces from project: "+str(self.myProject.getProjectFile())+" on "+simulator , 1, 1)
plotFrameFI.setViewMode(PlotCanvas.INCLUDE_ORIGIN_VIEW)
info = "F-I curve for Simulation Configuration: "+str(simConfig)
dataSet = DataSet(info, info, "nA", "Hz", "Current injected", "Firing frequency")
dataSet.setGraphFormat(PlotCanvas.USE_CIRCLES_FOR_PLOT)
simList = simReferences.keys()
simList.sort()
for sim in simList:
simDir = File(projFile.getParentFile(), "/neuroConstruct/models/Dan_GranCell/simulations/"+sim)
print
print "--- Reloading data from simulation in directory: %s"%simDir.getCanonicalPath()
try:
simData = SimulationData(simDir)
simData.initialise()
print "Data loaded: "
print simData.getAllLoadedDataStores()
times = simData.getAllTimes()
cellSegmentRef = simConfig.getCellGroups().get(0)+"_0"
volts = simData.getVoltageAtAllTimes(cellSegmentRef)
traceInfo = "Voltage at: %s in simulation: %s"%(cellSegmentRef, sim)
dataSetV = DataSet(traceInfo, traceInfo, "mV", "ms", "Membrane potential", "Time")
for i in range(len(times)):
dataSetV.addPoint(times[i], volts[i])
plotFrameVolts.addDataSet(dataSetV)
spikeTimes = SpikeAnalyser.getSpikeTimes(volts, times, analyseThreshold, analyseStartTime, analyseStopTime)
stimAmp = simReferences[sim]
print "Number of spikes at %f nA in sim %s: %i"%(stimAmp, sim, len(spikeTimes))
avgFreq = 0
if len(spikeTimes)>1:
avgFreq = len(spikeTimes)/ ((analyseStopTime - analyseStartTime)/1000.0)
dataSet.addPoint(stimAmp,avgFreq)
except:
print "Error analysing simulation data from: %s"%simDir.getCanonicalPath()
print sys.exc_info()[0]
plotFrameFI.addDataSet(dataSet)
def generateV_ICurve(self,
projFile,
simulator,
simConfig,
stimAmpLow, stimAmpInc, stimAmpHigh,
stimDur,
simDuration,
maxNumSimultaneousSims = 4):
# Load neuroConstruct project
print "Loading project from file: " + projFile.getAbsolutePath()+", exists: "+ str(projFile.exists())
pm = ProjectManager()
self.myProject = pm.loadProject(projFile)
self.simulator = simulator
simConfig = self.myProject.simConfigInfo.getSimConfig(simConfig)
simConfig.setSimDuration(simDuration)
pm.doGenerate(simConfig.getName(), self.neuroConstructSeed)
while pm.isGenerating():
print "Waiting for the project to be generated with Simulation Configuration: "+str(simConfig)
time.sleep(2)
numGenerated = self.myProject.generatedCellPositions.getNumberInAllCellGroups()
print "Number of cells generated: " + str(numGenerated)
simReferences = {}
if numGenerated > 0:
print "Generating scripts for simulator: %s..."%simulator
if simulator == 'NEURON':
self.myProject.neuronFileManager.setQuitAfterRun(1) # Remove this line to leave the NEURON sim windows open after finishing
self.myProject.neuronSettings.setCopySimFiles(1) # 1 copies hoc/mod files to PySim_0 etc. and will allow multiple sims to run at once
self.myProject.neuronSettings.setGraphicsMode(0) # 0 hides graphs during execution
if simulator == 'GENESIS':
self.myProject.genesisFileManager.setQuitAfterRun(1) # Remove this line to leave the NEURON sim windows open after finishing
self.myProject.genesisSettings.setCopySimFiles(1) # 1 copies hoc/mod files to PySim_0 etc. and will allow multiple sims to run at once
self.myProject.genesisSettings.setGraphicsMode(0) # 0 hides graphs during execution
stimAmp = stimAmpLow
ADD_TO_BEFORE_INIT = self.myProject.neuronSettings.getNativeBlock(NativeCodeLocation.BEFORE_INITIAL)
ADD_TO_RECORD_I = self.myProject.neuronSettings.getNativeBlock(NativeCodeLocation.AFTER_SIMULATION)
ADD_TO_START_FINITIALIZE = self.myProject.neuronSettings.getNativeBlock(NativeCodeLocation.START_FINITIALIZE)
while stimAmp <= stimAmpHigh:
while (len(self.simsRunning)>=maxNumSimultaneousSims):
print "Sims currently running: "+str(self.simsRunning)
print "Waiting..."
time.sleep(3) # wait a while...
self.updateSimsRunning()
simRef = "PySim_"+str(float(stimAmp))
print "Going to run simulation: "+simRef
######## Adjusting the amplitude of the Voltage clamp ###############
TEXT_BEFORE_CREATION = "objref clampobj" + "\n" + "objref record_current" + "\n" + "objref data_save" + "\n"
# TEXT_BEFORE_INIT = "GranuleCell_mod_tonic[0].Soma {\n" + "clampobj = new SEClamp(0.5)\n" + "clampobj.dur1 = 150.0" + "\n" + "clampobj.amp1 = -100.0" + "\n" + "clampobj.dur2 = " + str(stimDur) + "\n" + "clampobj.amp2 = " + str(stimAmp) + "\n" + "clampobj.dur3 = 150.0" + "\n" + "clampobj.amp3 = -100.0" + "\n" + "clampobj.rs = 0.00001\n " + "}\n" # This should do the trick
# TEXT_BEFORE_INIT = TEXT_BEFORE_INIT + ADD_TO_BEFORE_INIT
TEXT_START_FINITIALIZE = "GranuleCell_mod_tonic[0].Soma {\n" + "clampobj = new SEClamp(0.5)\n" + "clampobj.dur1 = 150.0" + "\n" + "clampobj.amp1 = -100.0" + "\n" + "clampobj.dur2 = " + str(stimDur) + "\n" + "clampobj.amp2 = " + str(stimAmp) + "\n" + "clampobj.dur3 = 150.0" + "\n" + "clampobj.amp3 = -40.0" + "\n" + "clampobj.rs = 0.00001\n" + "record_current = new Vector()" + "\n" + "record_current.record(&clampobj.i)" + "\n" + "}\n" #This should do the trick
TEXT_START_FINITIALIZE = TEXT_START_FINITIALIZE + ADD_TO_START_FINITIALIZE
TEXT_TO_RECORD_I = """data_save = new File() \n""" + """strdef filename \n""" + """sprint(filename, """" + self.myProject.getProjectMainDirectory().getAbsolutePath() + """/simulations/current%.3f.txt", clampobj.amp2) \n""" + """data_save.wopen(filename) \n""" + """record_current.printf(data_save) \n""" + """data_save.close() \n"""
TEXT_TO_RECORD_I = TEXT_TO_RECORD_I + ADD_TO_RECORD_I
self.myProject.neuronSettings.setNativeBlock(NativeCodeLocation.BEFORE_CELL_CREATION, TEXT_BEFORE_CREATION)
# self.myProject.neuronSettings.setNativeBlock(NativeCodeLocation.BEFORE_INITIAL, TEXT_BEFORE_INIT)
self.myProject.neuronSettings.setNativeBlock(NativeCodeLocation.START_FINITIALIZE, TEXT_START_FINITIALIZE)
self.myProject.neuronSettings.setNativeBlock(NativeCodeLocation.AFTER_SIMULATION, TEXT_TO_RECORD_I)
print "Next stim: "+ str(stimAmp)
self.myProject.simulationParameters.setReference(simRef)
if simulator == "NEURON":
self.myProject.neuronFileManager.generateTheNeuronFiles(simConfig,
None,
NeuronFileManager.RUN_HOC,
self.simulatorSeed)
print "Generated NEURON files for: "+simRef
compileProcess = ProcessManager(self.myProject.neuronFileManager.getMainHocFile())
compileSuccess = compileProcess.compileFileWithNeuron(0,0)
print "Compiled NEURON files for: "+simRef
if compileSuccess:
pm.doRunNeuron(simConfig)
print "Set running simulation: "+simRef
self.simsRunning.append(simRef)
if simulator == "GENESIS":
compartmentalisation = GenesisCompartmentalisation()
self.myProject.genesisFileManager.generateTheGenesisFiles(simConfig,
None,
compartmentalisation,
self.simulatorSeed)
print "Generated GENESIS files for: "+simRef
pm.doRunGenesis(simConfig)
print "Set running simulation: "+simRef
self.simsRunning.append(simRef)
time.sleep(1) # Wait for sim to be kicked off
simReferences[simRef] = stimAmp
stimAmp = stimAmp +stimAmpInc
print
print "Finished running "+str(len(simReferences))+" simulations for project "+ projFile.getAbsolutePath()
print "These can be loaded and replayed in the previous simulation browser in the GUI"
print
while (len(self.simsRunning)>0):
print "Sims currently running: "+str(self.simsRunning)
print "Waiting..."
time.sleep(4) # wait a while...
self.updateSimsRunning()
#simReferences = {'PySim_0.3':0.3,'PySim_0.4':0.4,'PySim_0.5':0.5}
plotFrameVI = PlotManager.getPlotterFrame("V-I curve from project: "+str(self.myProject.getProjectFile())+" on "+simulator , 1, 1)
plotFrameVI.setViewMode(PlotCanvas.INCLUDE_ORIGIN_VIEW)
info = "V-I curve for Simulation Configuration: "+str(simConfig)
dataSet = DataSet(info, info, "mV", "nA", "Voltage", "Current")
dataSet.setGraphFormat(PlotCanvas.USE_CIRCLES_FOR_PLOT)
simList = simReferences.keys()
simList.sort()
for sim in simList:
simDir = File(projFile.getParentFile(), "/neuroConstruct/models/Dan_GranCell/simulations/"+sim)
print
print "--- Reloading data from simulation in directory: %s"%simDir.getCanonicalPath()
try:
simData = SimulationData(simDir)
simData.initialise()
print "Data loaded: "
print simData.getAllLoadedDataStores()
times = simData.getAllTimes()
cellSegmentRef = simConfig.getCellGroups().get(0)+"_0"
cfilename = "E:/neuroConstruct/models/Dan_GranCell/simulations/" + sim + "/current.txt"
trace = "E:/neuroConstruct/models/Dan_GranCell/simulations/" + sim + ".txt"
# cFILE = open(cfilename, "r")
strom = 0.0
volts = simData.getVoltageAtAllTimes(cellSegmentRef)
traceInfo = "Voltage at: %s in simulation: %s"%(cellSegmentRef, sim)
stimAmp = simReferences[sim]
print "Current at %f mV in sim %s: %f"%(stimAmp, sim, float(strom))
dataSet.addPoint(stimAmp,float(strom))
except:
print "Error analysing simulation data from: %s"%simDir.getCanonicalPath()
print sys.exc_info()[0]
plotFrameVI.addDataSet(dataSet)
cell.associateGroupWithChanMech("all", chanMech)
print "Channels present: "+str(cell.getChanMechsVsGroups())
############################################################################
'''
myProject.simulationParameters.setReference(simRef)
myProject.neuronFileManager.generateTheNeuronFiles(simConfig, None, NeuronFileManager.RUN_HOC, simulatorSeed)
print "Generated NEURON files for: "+simRef
compileProcess = ProcessManager(myProject.neuronFileManager.getMainHocFile())
compileSuccess = compileProcess.compileFileWithNeuron(0,modCompileConfirmation)
print "Compiled NEURON files for: "+simRef
if compileSuccess:
pm.doRunNeuron(simConfig)
print "Set running simulation: "+simRef
simsRunning.append(simRef)
time.sleep(1) # Wait for sim to be kicked off
print
print "Finished running "+str(numSimulationsToRun)+" simulations for project "+ projFile.getAbsolutePath()
print "These can be loaded and replayed in the previous simulation browser in the GUI"
cell.associateGroupWithChanMech("all", chanMech)
print "Channels present: "+str(cell.getChanMechsVsGroups())
############################################################################
'''
myProject.simulationParameters.setReference(simRef)
myProject.neuronFileManager.generateTheNeuronFiles(
simConfig, None, NeuronFileManager.RUN_HOC, simulatorSeed)
print "Generated NEURON files for: " + simRef
compileProcess = ProcessManager(
myProject.neuronFileManager.getMainHocFile())
compileSuccess = compileProcess.compileFileWithNeuron(
0, modCompileConfirmation)
print "Compiled NEURON files for: " + simRef
if compileSuccess:
pm.doRunNeuron(simConfig)
print "Set running simulation: " + simRef
simsRunning.append(simRef)
time.sleep(1) # Wait for sim to be kicked off
print
print "Finished running " + str(
