def run(self,burn_in=None,thinning=None,minimum_TN=None):
folds_test = mask.compute_folds_attempts(I=self.I,J=self.J,no_folds=self.folds,attempts=attempts_generate_M,M=self.M)
folds_training = mask.compute_Ms(folds_test)
performances_test = {measure:[] for measure in measures}
for i,(train,test) in enumerate(zip(folds_training,folds_test)):
print "Fold %s." % (i+1)
# Run the line search
line_search = LineSearch(
classifier=self.classifier,
values_K=self.values_K,
R=self.R,
M=train,
priors=self.priors,
initUV=self.init_UV,
iterations=self.iterations,
restarts=self.restarts)
line_search.search(burn_in=burn_in,thinning=thinning,minimum_TN=minimum_TN)
# Store the model fits, and find the best one according to the metric
all_performances = line_search.all_values(metric=self.quality_metric)
self.fout.write("All model fits for fold %s, metric %s: %s.\n" % (i+1,self.quality_metric,all_performances))
self.fout.flush()
best_K = line_search.best_value(metric=self.quality_metric)
self.fout.write("Best K for fold %s: %s.\n" % (i+1,best_K))
# Train a model with this K and measure performance on the test set
performance = self.run_model(train,test,best_K,burn_in=burn_in,thinning=thinning,minimum_TN=minimum_TN)
self.fout.write("Performance: %s.\n\n" % performance)
self.fout.flush()
for measure in measures:
performances_test[measure].append(performance[measure])
# Store the final performances and average
average_performance_test = self.compute_average_performance(performances_test)
message = "Average performance: %s. \nPerformances test: %s." % (average_performance_test,performances_test)
print message
self.fout.write(message)
self.fout.flush()
R_1d2d, M_1d2d = load_data_filter(location_features_drugs+"drug_1d2d.txt", drugs)
#R_1d2d_std, M_1d2d_std = load_data_filter(location_features_drugs+"drug_1d2d_std.txt", drugs)
features_drugs = [R_fp, R_targets, R_1d2d]
features_cell_lines = [R_cnv, R_mutation]
''' Split the mask M into folds '''
no_folds = 10
I,J = R_main.shape
ATTEMPTS_GENERATE_M = 100
numpy.random.seed(0)
random.seed(0)
folds_test = mask.compute_folds_attempts(I=I,J=J,no_folds=no_folds,attempts=ATTEMPTS_GENERATE_M,M=M_main)
folds_training = mask.compute_Ms(folds_test)
''' Function for assembling features X '''
def assemble_X(Rs_rows,Rs_cols,M):
indices = [(i,j) for i,j in itertools.product(range(0,I),range(0,J)) if M[i,j]]
X = [[] for datapoint in range(0,len(indices))]
for n,(i,j) in enumerate(indices):
for R in Rs_rows:
X[n] += list(R[i,:])
for R in Rs_cols:
X[n] += list(R[j,:])
return numpy.array(X)
''' Function for assembling outcomes y '''
def assemble_y(R,M):