def measure_ttest_py (mean1fname, mean2fname,\
var1fname, var2fname, \
std1fname, std2fname, \
numsubjs1, numsubjs2, \
experimentname, outdir, exclude_idx=-1):
if not os.path.exists (outdir):
os.mkdir (outdir)
#following the equation:
#t = (m1 - m2) / sqrt( (v1^2)/N1 + (v2^2)/N2 )
#from:
#http://en.wikipedia.org/wiki/Student%27s_t-test#Unequal_sample_sizes.2C_unequal_variance
aff = nib.load(mean1fname).get_affine()
mean1 = nib.load(mean1fname).get_data()
mean2 = nib.load(mean2fname).get_data()
var1 = nib.load( var1fname).get_data()
var2 = nib.load( var2fname).get_data()
ttest = (mean1 - mean2) / np.sqrt((np.square(var1) / numsubjs1) + (np.square(var2) / numsubjs2))
ttest[np.isnan(ttest)] = 0
ttest[np.isinf(ttest)] = 0
#ttest = np.nan_to_num(ttest)
ttstfname = outdir + os.path.sep + experimentname + '_ttest' + au.ext_str()
au.save_nibabel(ttstfname, ttest, aff)
return ttstfname
def volstats (invol, groupname, groupsize, outdir=''):
slicesdir = os.path.dirname(invol)
if not outdir:
outdir = slicesdir
base = os.path.basename(au.remove_ext(invol))
outmeanf = outdir + os.path.sep + base + '_' + au.mean_str()
outvarf = outdir + os.path.sep + base + '_' + au.var_str()
outstdf = outdir + os.path.sep + base + '_' + au.std_str()
outsumsf = outdir + os.path.sep + base + '_' + au.sums_str()
vol = nib.load(invol).get_data()
aff = nib.load(invol).get_affine()
if not os.path.exists(outmeanf):
mean = np.mean(vol, axis=3)
au.save_nibabel(outmeanf, mean, aff)
if not os.path.exists(outstdf):
std = np.std(vol, axis=3)
au.save_nibabel(outstdf, std, aff)
if not os.path.exists(outvarf):
var = np.var(vol, axis=3)
au.save_nibabel(outvarf, var, aff)
if not os.path.exists(outsumsf):
sums = np.sum(vol, axis=3)
au.save_nibabel(outsumsf, sums, aff)
return [outsumsf,outmeanf,outvarf,outstdf]
def volstats(invol, groupname, groupsize, outdir=''):
slicesdir = os.path.dirname(invol)
if not outdir:
outdir = slicesdir
base = os.path.basename(au.remove_ext(invol))
outmeanf = outdir + os.path.sep + base + '_' + au.mean_str()
outvarf = outdir + os.path.sep + base + '_' + au.var_str()
outstdf = outdir + os.path.sep + base + '_' + au.std_str()
outsumsf = outdir + os.path.sep + base + '_' + au.sums_str()
vol = nib.load(invol).get_data()
aff = nib.load(invol).get_affine()
if not os.path.exists(outmeanf):
mean = np.mean(vol, axis=3)
au.save_nibabel(outmeanf, mean, aff)
if not os.path.exists(outstdf):
std = np.std(vol, axis=3)
au.save_nibabel(outstdf, std, aff)
if not os.path.exists(outvarf):
var = np.var(vol, axis=3)
au.save_nibabel(outvarf, var, aff)
if not os.path.exists(outsumsf):
sums = np.sum(vol, axis=3)
au.save_nibabel(outsumsf, sums, aff)
return [outsumsf, outmeanf, outvarf, outstdf]
def change_to_absolute_values (niifname, outfname=''):
niifname = au.add_extension_if_needed(niifname, au.ext_str())
if not outfname:
outfname = niifname
try:
#load data
vol = nib.load(niifname).get_data()
aff = nib.load(niifname).get_affine()
vol = np.abs(vol)
#save nifti file
au.save_nibabel (outfname, vol, aff)
except:
au.log.error ("Change_to_absolute_values:: Unexpected error: ", sys.exc_info()[0])
raise
def measure_bhattacharyya_distance_py (mean1fname, mean2fname, \
var1fname, var2fname, \
std1fname, std2fname, \
numsubjs1, numsubjs2, \
experimentname, outdir, exclude_idx=-1):
if not os.path.exists(outdir):
os.mkdir(outdir)
#following the equations:
#1/4 * (m1-m2)^2/(var1+var2) + 1/2 * log( (var1+var2)/(2*std1*std2) )
#from:
#1
#Bhattacharyya clustering with applications to mixture simplifications
#Frank Nielsen, Sylvain Boltz, and Olivier Schwander
#2010 International Conference on Pattern Recognition
#2
#The Divergence and Bhattacharyya Distance Measures in Signal Selection
#Kailath, T.
#http://dx.doi.org/10.1109/TCOM.1967.1089532
aff = nib.load(mean1fname).get_affine()
m1 = nib.load(mean1fname).get_data()
m2 = nib.load(mean2fname).get_data()
v1 = nib.load(var1fname).get_data()
v2 = nib.load(var2fname).get_data()
s1 = nib.load(std1fname).get_data()
s2 = nib.load(std2fname).get_data()
b1 = 0.25 * (np.square(m1 - m2) / (v1 + v2)) + 0.5 * (np.log(
(v1 + v2) / (2 * s1 * s2)))
b1[np.isnan(b1)] = 0
b1[np.isinf(b1)] = 0
#b1 = np.nan_to_num(b1)
bhatta = outdir + os.path.sep + experimentname + '_' + au.bhattacharyya_str(
) + au.ext_str()
au.save_nibabel(bhatta, b1, aff)
return bhatta
def change_to_absolute_values(niifname, outfname=''):
niifname = au.add_extension_if_needed(niifname, au.ext_str())
if not outfname:
outfname = niifname
try:
#load data
vol = nib.load(niifname).get_data()
aff = nib.load(niifname).get_affine()
vol = np.abs(vol)
#save nifti file
au.save_nibabel(outfname, vol, aff)
except:
au.log.error("Change_to_absolute_values:: Unexpected error: ",
sys.exc_info()[0])
raise
def measure_bhattacharyya_distance_py (mean1fname, mean2fname, \
var1fname, var2fname, \
std1fname, std2fname, \
numsubjs1, numsubjs2, \
experimentname, outdir, exclude_idx=-1):
if not os.path.exists (outdir):
os.mkdir (outdir)
#following the equations:
#1/4 * (m1-m2)^2/(var1+var2) + 1/2 * log( (var1+var2)/(2*std1*std2) )
#from:
#1
#Bhattacharyya clustering with applications to mixture simplifications
#Frank Nielsen, Sylvain Boltz, and Olivier Schwander
#2010 International Conference on Pattern Recognition
#2
#The Divergence and Bhattacharyya Distance Measures in Signal Selection
#Kailath, T.
#http://dx.doi.org/10.1109/TCOM.1967.1089532
aff = nib.load(mean1fname).get_affine()
m1 = nib.load(mean1fname).get_data()
m2 = nib.load(mean2fname).get_data()
v1 = nib.load (var1fname).get_data()
v2 = nib.load (var2fname).get_data()
s1 = nib.load (std1fname).get_data()
s2 = nib.load (std2fname).get_data()
b1 = 0.25 * (np.square(m1 - m2) / (v1 + v2)) + 0.5 * (np.log((v1 + v2) / (2*s1*s2)))
b1[np.isnan(b1)] = 0
b1[np.isinf(b1)] = 0
#b1 = np.nan_to_num(b1)
bhatta = outdir + os.path.sep + experimentname + '_' + au.bhattacharyya_str() + au.ext_str()
au.save_nibabel(bhatta, b1, aff)
return bhatta
def remove_subject_from_stats(meanfname,
varfname,
samplesize,
subjvolfname,
newmeanfname,
newvarfname,
newstdfname=''):
meanfname = au.add_extension_if_needed(meanfname, au.ext_str())
varfname = au.add_extension_if_needed(varfname, au.ext_str())
subjvolfname = au.add_extension_if_needed(subjvolfname, au.ext_str())
newmeanfname = au.add_extension_if_needed(newmeanfname, au.ext_str())
newvarfname = au.add_extension_if_needed(newvarfname, au.ext_str())
if newstdfname:
newstdfname = au.add_extension_if_needed(newstdfname, au.ext_str())
#load data
n = samplesize
meanv = nib.load(meanfname).get_data()
varv = nib.load(varfname).get_data()
subjv = nib.load(subjvolfname).get_data()
aff = nib.load(meanfname).get_affine()
#calculate new mean: ((oldmean*N) - x)/(N-1)
newmean = meanv.copy()
newmean = ((newmean * n) - subjv) / (n - 1)
newmean = np.nan_to_num(newmean)
#calculate new variance:
# oldvar = (n/(n-1)) * (sumsquare/n - oldmu^2)
# s = ((oldvar * (n/(n-1)) ) + oldmu^2) * n
# newvar = ((n-1)/(n-2)) * (((s - x^2)/(n-1)) - newmu^2)
s = varv.copy()
s = ((s * (n / (n - 1))) + np.square(meanv)) * n
newvar = ((n - 1) / (n - 2)) * (((s - np.square(subjv)) /
(n - 1)) - np.square(newmean))
newvar = np.nan_to_num(newvar)
#save nifti files
au.save_nibabel(newmeanfname, newmean, aff)
au.save_nibabel(newvarfname, newvar, aff)
#calculate new standard deviation: sqrt(newvar)
if newstdfname:
newstd = np.sqrt(newvar)
newstd = np.nan_to_num(newstd)
au.save_nibabel(newstdfname, newstd, aff)
def remove_subject_from_stats (meanfname, varfname, samplesize, subjvolfname, newmeanfname, newvarfname, newstdfname=''):
meanfname = au.add_extension_if_needed(meanfname, au.ext_str())
varfname = au.add_extension_if_needed(varfname, au.ext_str())
subjvolfname = au.add_extension_if_needed(subjvolfname, au.ext_str())
newmeanfname = au.add_extension_if_needed(newmeanfname, au.ext_str())
newvarfname = au.add_extension_if_needed(newvarfname, au.ext_str())
if newstdfname:
newstdfname = au.add_extension_if_needed(newstdfname, au.ext_str())
#load data
n = samplesize
meanv = nib.load(meanfname).get_data()
varv = nib.load( varfname).get_data()
subjv = nib.load(subjvolfname).get_data()
aff = nib.load(meanfname).get_affine()
#calculate new mean: ((oldmean*N) - x)/(N-1)
newmean = meanv.copy()
newmean = ((newmean * n) - subjv)/(n-1)
newmean = np.nan_to_num(newmean)
#calculate new variance:
# oldvar = (n/(n-1)) * (sumsquare/n - oldmu^2)
# s = ((oldvar * (n/(n-1)) ) + oldmu^2) * n
# newvar = ((n-1)/(n-2)) * (((s - x^2)/(n-1)) - newmu^2)
s = varv.copy()
s = ((s * (n/(n-1)) ) + np.square(meanv)) * n
newvar = ((n-1)/(n-2)) * (((s - np.square(subjv))/(n-1)) - np.square(newmean))
newvar = np.nan_to_num(newvar)
#save nifti files
au.save_nibabel (newmeanfname, newmean, aff)
au.save_nibabel (newvarfname , newvar, aff)
#calculate new standard deviation: sqrt(newvar)
if newstdfname:
newstd = np.sqrt(newvar)
newstd = np.nan_to_num(newstd)
au.save_nibabel (newstdfname, newstd, aff)
def measure_pearson(datafname,
labelsfile,
outfname,
maskfname='',
exclufname='',
exclude_idx=-1):
#reading label file
labels = np.loadtxt(labelsfile, dtype=int)
if exclufname:
exclus = np.loadtxt(exclufname, dtype=int)
#reading input volume
vol = nib.load(datafname)
n = vol.get_shape()[3]
if n != len(labels):
err = 'Numbers do not match: ' + datafname + ' and ' + labelsfile
raise IOError(err)
elif exclufname:
if n != len(exclus):
err = 'Numbers do not match: ' + datafname + ' and ' + excludef
raise IOError(err)
exclude_log = ''
if exclude_idx > -1:
exclude_log = ' excluding subject ' + str(exclude_idx)
au.log.debug('Pearson correlation of ' + os.path.basename(datafname) +
exclude_log)
#reading volume
data = vol.get_data()
#excluding subjects
if exclufname and exclude_idx > -1:
exclus[exclude_idx] = 1
if exclufname:
data = data[:, :, :, exclus == 0]
labels = labels[exclus == 0]
elif exclude_idx > -1:
exclus = np.zeros(n, dtype=int)
exclus[exclude_idx] = 1
data = data[:, :, :, exclus == 0]
labels = labels[exclus == 0]
subsno = data.shape[3]
#preprocessing data
shape = data.shape[0:3]
siz = np.prod(shape)
temp = data.reshape(siz, subsno)
ind = range(len(temp))
if maskfname:
mask = nib.load(maskfname)
mskdat = mask.get_data()
mskdat = mskdat.reshape(siz)
ind = np.where(mskdat != 0)[0]
#creating output volume file
odat = np.zeros(shape, dtype=vol.get_data_dtype())
for i in range(len(ind)):
idx = ind[i]
x = temp[idx, :]
p = stats.pearsonr(labels, x)[0]
#ldemean = labels - np.mean(labels)
#xdemean = x - np.mean(x)
#p = np.sum(ldemean * xdemean) / (np.sqrt(np.sum(np.square(ldemean))) * np.sqrt(np.sum(np.square(xdemean))))
if math.isnan(p): p = 0
odat[np.unravel_index(idx, shape)] = p
au.save_nibabel(outfname, odat, vol.get_affine())
return outfname
def do_darya_localizations ():
import scipy.io as sio
sys.path.append('/home/alexandre/Dropbox/Documents/work/visualize_volume')
import visualize_volume as vis
import aizkolari_utils as au
au.setup_logger()
locd = '/home/alexandre/Dropbox/ELM 2013/ELM-2013-Darya/localization'
wd, xd, dd, labelsf, phenof, dataf, masks, dilmasks, templates, pipe = get_filepaths()
maskf = dilmasks[0]
mask, hdr, aff = au.get_nii_data(maskf)
indices = np.array(np.where(mask > 0))
tmpltf = templates[0]
tmplt, _, _ = au.get_nii_data(tmpltf)
flist = os.listdir(locd)
flist = au.find(flist, '.mat')
flist.sort()
for f in flist:
data = sio.loadmat(os.path.join(locd, f))
name = au.remove_ext(f)
if f.find('cobre') >= 0:
p = data['pearson'].squeeze()
locs = p > 0
lidx = indices[:, locs].squeeze()
if f.find('reho') >= 0:
preho = p.copy()
elif f.find('alff') >= 0:
palff = p.copy()
else:
locs = data[name].squeeze()
locs -= 1
if f.find('pearson') >= 0:
if f.find('reho') >= 0:
lidx = indices[:, preho > 0]
elif f.find('alff') >= 0:
lidx = indices[:, palff > 0]
lidx = lidx[:, locs]
else:
lidx = indices[:, locs].squeeze()
locvol = np.zeros_like(mask, dtype=np.float)
locvol[tuple(lidx)] = 1
#save nifti volume
au.save_nibabel (os.path.join(locd, name + '.nii.gz'), locvol, aff, hdr)
#save image
fig = vis.show_many_slices(tmplt, locvol, volaxis=1, vol2_colormap=plt.cm.autumn, figtitle=name)
aizc.save_fig_to_png(fig, os.path.join(locd, name + '.png'))
if os.access (os.path.join(xd,'innercrop'), os.X_OK):
au.exec_command (os.path.join(xd,'innercrop') + ' -o white ' + fig2name + ' ' + fig2name)
def measure_pearson (datafname, labelsfile, outfname, maskfname='', exclufname='', exclude_idx=-1):
#reading label file
labels = np.loadtxt(labelsfile, dtype=int)
if exclufname:
exclus = np.loadtxt(exclufname, dtype=int)
#reading input volume
vol = nib.load(datafname)
n = vol.get_shape()[3]
if n != len(labels):
err = 'Numbers do not match: ' + datafname + ' and ' + labelsfile
raise IOError(err)
elif exclufname:
if n != len(exclus):
err = 'Numbers do not match: ' + datafname + ' and ' + excludef
raise IOError(err)
exclude_log = ''
if exclude_idx > -1:
exclude_log = ' excluding subject ' + str(exclude_idx)
au.log.debug ('Pearson correlation of ' + os.path.basename(datafname) + exclude_log)
#reading volume
data = vol.get_data()
#excluding subjects
if exclufname and exclude_idx > -1:
exclus[exclude_idx] = 1
if exclufname:
data = data [:,:,:,exclus == 0]
labels = labels[exclus == 0]
elif exclude_idx > -1:
exclus = np.zeros(n, dtype=int)
exclus[exclude_idx] = 1
data = data [:,:,:,exclus == 0]
labels = labels[exclus == 0]
subsno = data.shape[3]
#preprocessing data
shape = data.shape[0:3]
siz = np.prod(shape)
temp = data.reshape(siz, subsno)
ind = range(len(temp))
if maskfname:
mask = nib.load(maskfname)
mskdat = mask.get_data()
mskdat = mskdat.reshape(siz)
ind = np.where(mskdat!=0)[0]
#creating output volume file
odat = np.zeros(shape, dtype=vol.get_data_dtype())
for i in range(len(ind)):
idx = ind[i]
x = temp[idx,:]
p = stats.pearsonr (labels,x)[0];
#ldemean = labels - np.mean(labels)
#xdemean = x - np.mean(x)
#p = np.sum(ldemean * xdemean) / (np.sqrt(np.sum(np.square(ldemean))) * np.sqrt(np.sum(np.square(xdemean))))
if math.isnan (p): p = 0
odat[np.unravel_index(idx, shape)] = p
au.save_nibabel(outfname, odat, vol.get_affine())
return outfname
