5) RIP1 Hypothesis 2: RIP1-unmod =! RIP1-deub 5a) RIP1 de-ubiquitination in the 2o complex 5a) TRADD can bind RIP1-unmod as well as RIP1-deub 6) Bid-po4 sequesters RIP1 7) C3 inhibits MLKL """ # From irvin_modules irvin.Initials_Fas_to_DISC() irvin.TNFR1_to_ComplexII_Initials() irvin.SecondaryComplex_to_Bid_initials() irvin.rip1_to_MLKL_initials() irvin.TNFR1_to_ComplexI() #1 irvin.FADD_to_C8() irvin.cFlip_competitive_inhibition() #2 irvin.NFkB_cFlip_interaction() #3 irvin.cFLIP_L_Bid_interaction() #4 irvin.RIP1_Hypothesis_2() #5 irvin.ComplexI_to_NFkB() irvin.ComplexII_Hypothesis_2() #5 irvin.TRADD_RIP1unmod_Hypothesis_2() #5a irvin.RIP1_deubiqutination_Hypothesis_1() #5a irvin.RIP1_to_SecondaryComplex() irvin.RIP1_truncation() irvin.Bid_Hypothesis() #6 irvin.C8_catalyzed_truncations() irvin.rip1_to_MLKL() irvin.C3_inhibits_MLKL() #7 # From lopez_modules
5) RIP1 Hypothesis 1: RIP1-unmod = RIP1-deub 5a) RIP1 deubiquitination in 2o complex 5b) RIP1-unmod can bind TRADD-active 6) Bid-po4 does sequester RIP1 7) C3 inhibits MLKL """ # From irvin_modules irvin.Initials_Fas_to_DISC() irvin.TNFR1_to_ComplexII_Initials() irvin.SecondaryComplex_to_Bid_initials() irvin.rip1_to_MLKL_initials() irvin.TNFR1_to_ComplexI() #1 irvin.FADD_to_C8() irvin.cFlip_competitive_inhibition() #2 irvin.NFkB_cFlip_interaction() #3 irvin.cFLIP_L_Bid_interaction() #4 irvin.RIP1_Hypothesis_1()#5 irvin.ComplexI_to_NFkB() irvin.ComplexII_Hypothesis_1() #5 irvin.RIP1_deubiqutination_Hypothesis_1()#5 irvin.RIP1_to_SecondaryComplex() irvin.RIP1_truncation() irvin.Bid_Hypothesis() #6 irvin.C8_catalyzed_truncations() irvin.rip1_to_MLKL() irvin.C3_inhibits_MLKL()#7 # From lopez_modules lopez.declare_initial_conditions()