def get_coords( axes = 'gene',
rows = None,
time_val = None,
spatial_idxs = None,
ids = None):
bdnet = nio.getBDTNP()
gene_matrix = array([v['vals'][:,time_val]
for v in bdnet.values()
if str(time_val + 1) in v['steps']])
gene_matrix_keys = [k
for k in bdnet.keys() if str(time_val +1) in v['steps']]
if axes == 'gene':
import scipy.sparse as ssp
import scipy.sparse.linalg as las
import scipy.sparse.lil as ll
adj = ssp.csr_matrix(gene_matrix.T)
n_c = 3
U,s, Vh = svd = las.svds(adj, n_c)
filtered_genes = ll.lil_matrix(U)*ll.lil_matrix(diag(s)) *ll.lil_matrix(Vh)
xs_gene = U[ids,0]
ys_gene = U[ids,1]
zs_gene = U[ids,2]
elif axes == 'space':
space_space =array([[ [r[idxs] for idxs in sidxs]
for sidxs in spatial_idxs]
for r in rows])
space_space = space_space[:, : , time_val]
xs_gene = space_space[ids, 0]
ys_gene = space_space[ids, 1]
zs_gene = space_space[ids, 2]
return xs_gene, ys_gene, zs_gene
def check_bdtnp(**kwargs):
ids = id_map(**mem.sr(kwargs))
btgs = nio.getBDTNP()
stfs,stgs = nio.getNet()
sxs = dict([(i, {}) for i in ids.keys()])
for i, elt in enumerate(ids.iteritems()):
gid, gene_val = elt
if stfs.has_key(gid) : sxs[gid]['stf'] = True;
if btgs.has_key(gid) : sxs[gid]['btg'] = True;
if stgs.has_key(gid) : sxs[gid]['stg'] = True;
return sxs
def set_term_network( **kwargs):
nterms = kwargs.get('nterms')
name = kwargs.get('name')
if name == 'bdtnp': gene_list = nio.getBDTNP().keys()
elif name == 'kn': gene_list = graphs['kn'].nodes()
grps = term_groups(**mem.sr(kwargs,
name = name))
network = nx.Graph()
network.add_nodes_from(gene_list)
for g in grps:
edgelist = [[g1[0],g2[0]]
for g1 in g[1] for g2 in g[1]]
network.add_edges_from( edgelist )
return network
def set_term_groups(**kwargs):
nterms = kwargs.get('nterms')
if name == 'bdtnp': gene_list = nio.getBDTNP().keys()
elif name == 'kn': gene_list = graphs['kn'].nodes()
#GET ALL CONTROLLED VOCAB TERMS APPLYING TO A GIVEN GENE LIST
terms = [(gname,gt) for gname in gene_list for gt in gene_terms(gname)
]
all_terms = set([t[1] for t in terms])
term_groups_tmp =[(k, list(g)) for k, g in
it.groupby(
sorted(terms, key = lambda x: x[1]),
key = lambda x: x[1])
]
#SORT THE TERM GROUPS BY GENE COUNT AND ONLY TAKE TOP N
if nterms == -1: nterms = len(term_groups_tmp)
term_groups = sorted(term_groups_tmp,
key = lambda x: len(x[1]))[::-1][:nterms]
return term_groups
def set_nx(**kwargs):
targets = kwargs.get('targets')
restriction = kwargs.get('restriction')
nodes_allowed = kwargs.get('nodes_allowed')
if nodes_allowed != None:
edges = [(tf, tg, float(wt))
for tg, elt in targets.iteritems() if tg in nodes_allowed
for tf, wt in zip(elt['tfs'], elt['weights']) if tf in nodes_allowed]
else:
edges = [(tf, tg, float(wt))
for tg, elt in targets.iteritems()
for tf, wt in zip(elt['tfs'], elt['weights']) ]
graph = nx.DiGraph()
graph.add_weighted_edges_from(edges)
if restriction != 'none':
if restriction == 'bdtnp':
allowed_nodes = nio.getBDTNP().keys()
graph = restricted_graph(graph, allowed_nodes)
else: raise (Exception('unrecognized restriction {0}'.\
format(restriction)))
return graph
def get_clusters(cluster_id = 4, ):
all_members, ct_data = exp.recall_c2()
all_members = array(all_members)
c = all_members[cluster_id]
c_unq = set(list(c))
tissues = dict([('t_{0}'.format(i) ,
dict(cts = ct_data[equal(c,elt)]))
for i, elt in enumerate(c_unq)])
bdnet = nio.getBDTNP()
gene_cols, misc_cols, rows, row_nns = bdparse.read()
spatial_idxs = array([misc_cols['x']['idxs'],
misc_cols['y']['idxs'],
misc_cols['z']['idxs']])
#CHOOSE A TIME m
time_val = cluster_id
#ORGANIZE A BUNCH OF DATA.
tsrt = sorted([(k,v) for k, v in tissues.iteritems()],
key = lambda x: len(x[1]['cts']))[::-1]
mods, genes, tfs = get_results(tsrt = tsrt,
name = 'cluster_{0}'.format(cluster_id))
return mods, genes,tfs
def check_network(net_name = 'binding',
dataset_name = 'reinitz',
data_ofs = 4,
max_edges = -1,
node_restriction = 'reinitz'):
reinitz_keys =set( get_reinitz_data()[1].keys())
if dataset_name == 'reinitz':
coords, values = get_reinitz_data(ofs = data_ofs)
elif dataset_name == 'bdtnp':
data = nio.getBDTNP()
meta = nio.getBDTNP(misc = True)
values = dict([( k, v['vals'][:,data_ofs] ) for k,v in data.iteritems()])
coords = array([meta['x']['vals'][:,data_ofs],meta['y']['vals'][:,data_ofs]])
elif dataset_name == 'tc':
data = nio.getTC()
if node_restriction == 'reinitz':
data = dict([(k,v) for k,v in data.iteritems() if k in reinitz_keys])
#values = dict([( k, v['vals'][:,data_ofs] ) for k,v in data.iteritems()])
#coords = array([meta['x']['vals'][:,data_ofs],meta['y']['vals'][:,data_ofs]])
values = data
else:
raise Exception('data set {0} not yet implemented'.format(dataset_name))
nets = comp.get_graphs()
if net_name == 'binding':
network = nets['bn']
elif net_name == 'unsup':
network = nets['unsup']
elif net_name == 'logistic':
network = nets['logistic']
elif net_name =='clusters':
network = get_soheil_network(max_edges = max_edges,
node_restriction = values.keys())
else:
raise Exception('type not implemented: {0}'.format(net_name))
nodes = values.keys()
nodes_allowed = set(nodes)
f = myplots.fignum(1,(8,8))
ax = f.add_subplot(111)
targets = {}
edges = []
for n in nodes:
targets[n] = []
if n in network:
targets[n] = nodes_allowed.intersection(network[n].keys())
xax = linspace(-1,1,20)
edges = list(it.chain(*[[(e,v2) for v2 in v] for e, v in targets.iteritems()]))
ccofs = [e for e in [ corrcoef(values[tf], values[tg])[0,1] for tf, tg in edges] if not isnan(e)]
count, kde = make_kde(ccofs)
ax.hist(ccofs,xax,label = net_name)
h =histogram(ccofs,xax)
ax.fill_between(xax,kde(xax)*max(h[0]),label = net_name,zorder = 1,alpha = .5)
myplots.maketitle(ax,'edge correlations kde for {0}'.format('\n{2} data (data offset={0})\n(net_name={1})\n(max_edges={3})'
.format(data_ofs, net_name, dataset_name, max_edges) ),\
subtitle = 'n_edges = {0}'.format(len(edges)))
ax.legend()
f.savefig(myplots.figpath('network_edge_corrs_data_ofs={0}_net={1}_expr={2}_max_edges={3}'
.format(data_ofs,net_name,dataset_name, max_edges)))
def run_sig(genes, show_disc = False, weighted = True):
genes2 = []
for g in genes:
genes2.append((g[0], [[gelt[0], gelt[1]] for gelt in g[1]], g[2]))
genes = genes2
modules = [m[0] for m in genes]
if len(modules[0]) == 2:
module_type = 'doubles'
else:
module_type = 'triples'
counts = [m[1] for m in genes]
tgs,tfs = nio.getNet()
bd = nio.getBDTNP()
nodes_allowed = set(bd.keys())
cnodes = list(nodes_allowed)
dnodes = []
dedges = []
cedges = []
cnodes = []
for m in genes:
for tginfo in m[1]:
tg = tginfo[0]
tg_mcount = tginfo[1]
dtgnode = '{0}_{1}_mod{2}'.format(tg,tg,m[0])
ctgnode = '{0}'.format(tg)
dnodes.append(dtgnode)
cnodes.append(ctgnode)
for tf in m[0]:
dtfnode = '{0}_{1}_mod{2}'.format(tf,tg,m[0])
ctfnode = '{0}'.format(tf)
dnodes.append(dtfnode)
cnodes.append(ctfnode)
dedges.append((dtfnode, dtgnode,tg_mcount))
cedges.append((ctfnode, ctgnode,tg_mcount))
nodes_allowed = list(set(cnodes))
if show_disc:
dgraph, cgraph = [nx.Graph() for i in range(2)]
dgraph.add_nodes_from(list(set(dnodes)))
dgraph.add_weighted_edges_from(list(set(dedges)))
f = myplots.fignum(4, (8,8))
ax = f.add_subplot(111)
pos=nx.graphviz_layout(dgraph,prog="neato")
# color nodes the same in each connected subgraph
C=nx.connected_component_subgraphs(dgraph)
for g in C:
c=[random.random()]*nx.number_of_nodes(g) # random color...
nx.draw(g,
pos,
node_size=40,
node_color=c,
vmin=0.0,
vmax=1.0,
with_labels=False
)
figtitle = 'mcmc_disc'
f.savefig(figtemplate.format(figtitle))
return
cgraph = nx.DiGraph()
cgraph.add_nodes_from(cnodes)
cedgegrps = [(k,list(g)) for k, g in it.groupby(\
sorted(cedges, key = lambda x: (x[0],x[1])),
key = lambda x: (x[0],x[1]))]
cedges = [ (k[0],k[1], sum([gelt[2] for gelt in g]))
for k,g in cedgegrps]
if weighted == False:
for ce in cedges:
ce[2] = 1
cgraph.add_weighted_edges_from(list(set(cedges)))
sfRN = [(tf, tg, float(wt))
for tg, elt in tgs.iteritems() if tg in nodes_allowed
for tf, wt in zip(elt['tfs'], elt['weights']) if tf in nodes_allowed]
fg = nx.DiGraph()
fg.add_nodes_from(cnodes)
fg.add_weighted_edges_from(sfRN)
colors = mycolors.getct(len(cnodes))
f = myplots.fignum(5, (8,8))
ax =f.add_subplot(111)
pos=nx.graphviz_layout(fg,prog="neato")
# color nodes the same in each connected subgraph
nx.draw(cgraph,
pos,
node_size=100,
node_color=colors,
vmin=0.0,
vmax=1.0,
with_labels=False,
alpha = 1.
)
ax.set_title('connectivity of MCMC for network {0}'.format(module_type))
figtitle = 'mcmc_network_{0}{1}'.\
format(module_type,'' if weighted else 'unweighted')
f.savefig(figtemplate.format(figtitle))
f = myplots.fignum(5, (8,8))
ax =f.add_subplot(111)
#pos=nx.graphviz_layout(fg,prog="neato")
# color nodes the same in each connected subgraph
nx.draw(fg,
pos,
node_size=100,
node_color=colors,
vmin=0.0,
vmax=1.0,
with_labels=False
)
ax.set_title('connectivity of reference for network {0}'.format(module_type))
figtitle = 'mcmc_ref_network_{0}{1}'.\
format(module_type,'' if weighted else 'unweighted')
f.savefig(figtemplate.format(figtitle))
graphs = {'mcmc':cgraph,'network':fg}
v0 = graphs.values()
k0 = graphs.keys()
for k,g in zip(k0,v0):
for prc in [1,50,95]:
thr = percentile([e[2]['weight']
for e in nx.to_edgelist(g)], prc)
graphs.update([('{0}_thr{1}%'.format(k,prc),
nfu.thr_graph(g,thr))])
v0 = graphs.values()
k0 = graphs.keys()
for k, v in zip(k0,v0):
tot_edges = len(nx.to_edgelist(fg))
for n_c in [2,4,6,8,12,20]:
for max_edges in array([.5,1.,2.]) * tot_edges :
gfilt = nfu.filter_graph(v, n_c = n_c)
gfilt = nfu.top_edges(gfilt, max_edges = max_edges)
gthr = nfu.thr_graph(gfilt, 1e-8)
graphs.update([('{0}_flt{1}'.format(k,n_c),gfilt)])
graphs.update([('{0}_flt{1}_thr0'.format(k,n_c),gthr)])
return graphs
def run2( reset = False,
base_net = 'kn',
comp_net = 'fn',
demand_bdtnp = False):
bd = nio.getBDTNP()
ktgs,ktfs = nio.getKNet()
tgs,tfs = nio.getNet()
sush = nio.getSush(on_fail = 'compute')
tfset = set(ktfs.keys())
tgset = set(ktgs.keys())
tg_int = set(tgs.keys()).intersection(ktgs.keys())
tf_int = set(tfs.keys()).intersection(ktfs.keys())
if demand_bdtnp:
tg_int = tg_int.intersection(bd.keys())
tf_int = tf_int.intersection(bd.keys())
if base_net =='kn':
b_edges = [(tf, tg, float(wt))
for tg, elt in ktgs.iteritems() if tg in tg_int
for tf, wt in zip(elt['tfs'], elt['weights']) if tf in tf_int]
if comp_net == 'fn':
c_edges = [(tf, tg, float(wt))
for tg, elt in tgs.iteritems() if tg in tg_int
for tf, wt in zip(elt['tfs'], elt['weights']) if tf in tf_int]
elif comp_net == 'sn':
#Sushmita network with signed edges
c_edges = [(tf, tg, float(wt))
for tg, elt in sush.iteritems() if tg in tg_int
for tf, wt in zip(elt['tfs'], elt['weights']) if tf in tf_int]
elif comp_net == 'sna':
#Sushmita network with unsigned edges
c_edges = [(tf, tg, abs(float(wt)))
for tg, elt in sush.iteritems() if tg in tg_int
for tf, wt in zip(elt['tfs'], elt['weights']) if tf in tf_int]
elif comp_net == 'kn':
c_edges = [(tf, tg, float(wt))
for tg, elt in ktgs.iteritems() if tg in tg_int
for tf, wt in zip(elt['tfs'], elt['weights']) if tf in tf_int]
ng = 4
nodes = array(list(tf_int.union(tg_int)))
bg = nx.DiGraph()
bg.add_nodes_from(nodes)
bg.add_weighted_edges_from(b_edges)
cg = nx.DiGraph()
cg.add_nodes_from(nodes)
cg.add_weighted_edges_from(c_edges)
cgraphs = {comp_net:cg}
v0 = cgraphs.values()
k0 = cgraphs.keys()
for k,g in zip(k0,v0):
for prc in [10]:
thr = percentile([e[2]['weight']
for e in nx.to_edgelist(g)], prc)
cgraphs.update([('{0}_thr{1:2.2}'.format(k,thr),
nfu.thr_graph(g,thr))])
gt = nfu.thr_graph(g,thr)
v0 = cgraphs.values()
k0 = cgraphs.keys()
for k, v in zip(k0,v0):
tot_edges = len(nx.to_edgelist(v))
for n_c in [1,2,4]:
for max_edges in array([.2,.5,1.]) * tot_edges :
if not 'thr' in k:
continue
gfilt = nfu.filter_graph(v, n_c = n_c)
gfilt = nfu.top_edges(gfilt, max_edges = max_edges)
gthr = nfu.thr_graph(gfilt, 1e-8)
cgraphs.update([('{0}_flt{1}_nedge{2}'.format(k,n_c,max_edges),gfilt)])
cgraphs.update([('{0}_flt{1}_nedge{2}_thr0'.format(k,n_c,max_edges),gthr)])
'''
When you don't have hidden variables, networks can be modelled mby information criterion.
In what settings can you incur causality from datasets.
You need a prior to limit the number of arrowsin your graph:
The idea: come up with an idea from computational learning theory
and come up with a model for interventions.
Spatial, genetic, time data to penalize network edges...
Granger causality uses time varying data to
'''
#nfplots.show(kg,pos,node_color = 'none')
#nfplots.show(fg,pos,node_color = 'white', alpha = .2, with_labels = False)
return bg, cgraphs
def run( reset = False,
base_net = 'kn',
comp_net = 'fn',
demand_bdtnp = False):
tgs,tfs = nio.getNet()
ktgs,ktfs = nio.getKNet()
bd = nio.getBDTNP()
#btgs,btfs = nio.getBDTNP()
sush = nio.getSush(on_fail = 'compute')
tfset = set(ktfs.keys())
tgset = set(ktgs.keys())
tg_int = set(tgs.keys()).intersection(ktgs.keys())
tf_int = set(tfs.keys()).intersection(ktfs.keys())
if demand_bdtnp:
tg_int = tg_int.intersection(bd.keys())
tf_int = tf_int.intersection(bd.keys())
sfRN = [(tf, tg, float(wt))
for tg, elt in tgs.iteritems() if tg in tg_int
for tf, wt in zip(elt['tfs'], elt['weights']) if tf in tf_int]
kRN = [(tf, tg, float(wt))
for tg, elt in ktgs.iteritems() if tg in tg_int
for tf, wt in zip(elt['tfs'], elt['weights']) if tf in tf_int]
#Sushmita network with signed edges
suRN = [(tf, tg, float(wt))
for tg, elt in sush.iteritems() if tg in tg_int
for tf, wt in zip(elt['tfs'], elt['weights']) if tf in tf_int]
#Sushmita network with unsigned edges
suaRN = [(tf, tg, abs(float(wt)))
for tg, elt in sush.iteritems() if tg in tg_int
for tf, wt in zip(elt['tfs'], elt['weights']) if tf in tf_int]
edges = [ kRN, sfRN, suRN, suaRN]
ng = 4
fg, kg, sug, suag = [nx.DiGraph() for i in range(4)]
nodes = array(list(tf_int.union(tg_int)))
graphs = {'kg':kg,'fg':fg,'sug':sug,'suag':suag}
for g, edges in zip(graphs.values(), edges):
g.add_nodes_from(nodes)
g.add_weighted_edges_from(edges)
for gname in ['fg','suag']:
for prc in [10,50,75,85,90,95,98,99]:
thr = percentile([e[2]['weight'] for e in nx.to_edgelist(graphs[gname])], prc)
graphs.update([('{0}_thr{1:2.2}'.format(gname,thr),
nfu.thr_graph(graphs[gname],thr))])
v0 = graphs.values()
k0 = graphs.keys()
tot_edges = len(nx.to_edgelist(graphs['fg']))
for k, v in zip(k0,v0):
for n_c in [2,4,8 ,12]:
for max_edges in array([.5,1.,2.,5.]) * tot_edges :
if not 'thr' in k:
continue
gfilt = nfu.filter_graph(v, n_c = n_c)
gfilt = nfu.top_edges(gfilt, max_edges = max_edges)
gthr = nfu.thr_graph(gfilt, 1e-8)
graphs.update([('{0}_flt{1}'.format(k,n_c),gfilt)])
graphs.update([('{0}_flt{1}_thr0'.format(k,n_c),gthr)])
#nfplots.show(kg,pos,node_color = 'none')
#nfplots.show(fg,pos,node_color = 'white', alpha = .2, with_labels = False)
return graphs
def run(num = 2):
dfile = sio.loadmat(cfg.dataPath('soheil/expression_c4d_n4_intercluster.mat'))
trgs, tfs = nio.getNet()
bdgenes = nio.getBDTNP()
bdset = set(bdgenes.keys())
xs, ys, colors, corrs,lcorrs = [[] for i in range(5)]
count = 0
for k, v in bdgenes.iteritems():
count += 1
if count < num:
continue
if not trgs.has_key(k): continue
trg = trgs[k]
fsub = set(tfs.keys()).intersection(bdset)
gexpr = bdgenes[k]['vals'][::50,4].flatten() #squeeze(dfile[k])
fexpr = [bdgenes[fname]['vals'][::50,4].flatten() for fname in fsub]#[squeeze(dfile[fname]) for fname in fsub]
print shape(fexpr)
if len(fexpr )< 3: continue
ct = mycolors.getct(len(fexpr))
for idx, f in enumerate(fexpr):
c = corrcoef(f, gexpr)[0,1]
if not isfinite(c): c = 0
lc = corrcoef(log(f), log(gexpr))[0,1]
if not isfinite(lc): lc = 0
corrs.append(c)
lcorrs.append(lc)
ys.append(gexpr)
xs.append(f)
colors.append([ct[idx]]* len(f))
break
if len(xs) > 10000:
break
cbest = argsort(-1 * abs(array(corrs)))
f = plt.figure(1)
f.clear()
ax = f.add_subplot(111)
inds = argsort(gexpr)
for idx in cbest[:3]:
import scipy.signal as ss
import cb.utils.sigsmooth as sgs
#k = sgs.gauss_kern(15)[8,:].flatten()
#xconv = ss.convolve(xs[idx][inds],k)
xv = ss.medfilt(xs[idx][inds],1)
yv = ys[idx][inds]
print corrcoef(xv,yv)[0,1]
print corrs[idx]
ax.plot(ss.medfilt(xs[idx][inds],1), linewidth = 10, color = colors[idx][0])
ax.plot(ys[idx][inds], linewidth = 10)
def view0(modules,
data_src = 'bdtnp',
net_src = 'fRN',
max_rank = 4,
module_type = 'doubles'):
'''
A routine to view the sign of interaction coefficients for
a given transcription factor split per-cluster and per-module
size.
Designed to be run on the output of view_output.modules()
'''
#COMPUTE BULK STATISTICS FOR EACH TF
bd_data = nio.getBDTNP()
genes = bd_data.keys()
tfs =sorted(set(it.chain(*[k for k in modules.keys()])))
tf_net = nx.Graph()
tf_net.add_nodes_from(tfs)
tf_edges = it.chain(*[[(e0, e1)
for e0 in term
for e1 in term
if e0 != e1]
for term in modules.keys()])
tf_net.add_edges_from(tf_edges)
pos = nx.graphviz_layout(tf_net)
fig = myplots.fignum(1, (8,8))
tfnodes = tf_net.nodes()
tfnames = tfnodes
all_coefs = \
list(it.chain(*[t['coefs'] for t in modules.values()]))
cstd = std(all_coefs)
def colorfun(coefs):
coef = median(coefs)
arr = array([1.,0.,0.]) if coef < 0\
else array([0.,0.,1.])
return arr*min([1, abs(coef/cstd*2)])
def widthfun(coefs, maxwid):
return max([1,5.* len(coefs) /maxwid])
for tf in tfs:
fig.clf()
ax = fig.add_subplot(111)
ecols,ewids, estyles, ealphas =\
[{} for i in range(4)]
edges = []
tf_doublet_terms = [(k, v)
for k, v in modules.iteritems()
if tf in k and len(set(k)) == 2 ]
tf_triplet_terms = [(k, v)
for k, v in modules.iteritems()
if tf in k and len(set(k)) == 3 ]
isdub = dict([(k,0.) for k in tfnames])
istrip =dict([(k,0.) for k in tfnames])
coflens = [len(e[1]['coefs'])
for e in tf_triplet_terms + tf_doublet_terms]
max_l = max(coflens)
for tt,v in sorted(tf_triplet_terms,
key = lambda x: len(x[1]['genes']))[::-1][:max_rank]:
partners =tuple( [t for t in set(tt) if not t==tf])
for p in partners: istrip[p] = 1 #istrip[[tfnodes.index(p) for p in partners]] = 1
edge = partners
ecols[edge] = colorfun(modules[tt]['coefs'])
ewids[edge] = widthfun(modules[tt]['coefs'],max_l)
ealphas[edge] = 1 if module_type in ['triples','all'] \
else .1
estyles[edge] = 'dotted'
edges.append(edge)
for td,v in sorted(tf_doublet_terms,
key = lambda x: len(x[1]['genes']))[::-1][:max_rank]:
partners = tuple([t for t in set(td) if not t==tf])
for p in partners: isdub[p] = 1
edge = (tuple([tf] + list(partners)))
ecols[edge] = colorfun(modules[td]['coefs'])
ewids[edge] = widthfun(modules[td]['coefs'], max_l)
ealphas[edge] = 1 if module_type in ['doubles','all'] \
else .1
estyles[edge] = 'solid'
edges.append(edge)
tf_graph = nx.DiGraph()
tf_graph.add_nodes_from(tfnodes)
tf_graph.add_edges_from(edges)
ckw = dict([ (k, dict(color = ecols[k], #array([1,0,0])*isdub[k] +\
# array([0,0,1])*istrip[k],
alpha = ealphas[k],
linestyle = estyles[k],
linewidth = ewids[k],
arrowstyle = '-'))
for k in tf_graph.edges()])
circlepoints = dict([ (k, dict(facecolor ='white', #array([1,0,0])*isdub[k] +\
# array([0,0,1])*istrip[k],
alpha = round(ealphas[k],2),
edgecolor = ecols[k],
linestyle = estyles[k],
linewidth = 3,))
for k in tf_graph.edges()])
ax.set_title('Top modules for TF: {0}'.format(tf))
myplots.padded_limits(ax, *zip(*pos.values()))
nodes = tf_graph.nodes()
gd.draw(tf_graph,pos,edges,
scatter_nodes =tf_graph.nodes(),
skw = {'s':[200 if n == tf else 2
for n in nodes],
'facecolor':[colorfun(modules[tuple([n])]['coefs'])
if n == tf
else 'black'
for n in nodes],
'edgecolor':'black',
'linewidth':2,
'alpha':1},#[1 if n == tf else .1 for n in nodes]},
ckw = {})
colors,alphas,tripoints = [{} for i in range(3)]
for e in edges:
colors[e] = 'black'
alphas[e] = .2
tripoints[e] = array(pos[tf])
plot_tri = False
plot_circ = True
if plot_tri:
gd.overlay(tf_graph, pos, edges,
tripoints = tripoints,
colors = colors,
alphas = alphas)
if plot_circ:
gd.overlay(tf_graph, pos, edges,
circlepoints =circlepoints)
ax2 = fig.add_axes([.05,.05,.2,.2])
ax2.set_xticks([])
ax2.set_yticks([])
coefs = modules[tuple([tf])]['coefs']
l = len(coefs)
sx = sy = ceil(sqrt(l))
xs = mod(arange(l), sx)
ys = floor( arange(l) / sx)
cs = [colorfun([c/2]) for c in sorted(coefs)]
ss = 100
ax2.scatter(xs, ys, s = ss, color = cs)
fig.savefig(figtemplate.format('tf_{0}_net_rank{1}_{2}'.\
format(tf,max_rank,module_type)))