def PredictModel(model=settings.options.predictmodel,
image=settings.options.predictimage,
imageheader=None,
outdir=settings.options.segmentation,
seg=None):
if (model != None and image != None and outdir != None):
os.environ["CUDA_DEVICE_ORDER"] = "PCI_BUS_ID" # see issue #152
numpypredict, origheader, origseg = preprocess.reorient(image,
segloc=seg)
assert numpypredict.shape[0:2] == (settings._globalexpectedpixel,
settings._globalexpectedpixel)
resizepredict = preprocess.resize_to_nn(numpypredict)
resizepredict = preprocess.window(resizepredict,
settings.options.hu_lb,
settings.options.hu_ub)
resizepredict = preprocess.rescale(resizepredict,
settings.options.hu_lb,
settings.options.hu_ub)
if settings.options.D3 or settings.options.D25:
dataid = np.ones((resizepredict.shape[0]))
idx = np.array([1])
resizepredict2 = thick_slices(resizepredict,
settings.options.thickness, dataid,
idx)
else:
resizepredict2 = resizepredict
if seg:
origseg = preprocess.resize_to_nn(origseg)
origseg = preprocess.livermask(origseg)
if settings.options.D25:
dataid_origseg = np.ones((origseg.shape[0]))
origseg = thick_slices(origseg, 1, dataid_origseg, idx)
origseg = origseg[..., 0]
# if not settings.options.D25 and not settings.options.D3:
# origseg = origseg.transpose((0,2,1)).astype(settings.FLOAT_DTYPE)
origseg_img = nib.Nifti1Image(
preprocess.resize_to_original(origseg), None)
origseg_img.to_filename(outdir.replace('.nii', '-trueseg.nii'))
###
### set up model
###
loaded_model = load_model(model,
custom_objects={
'dsc_l2': dsc_l2,
'l1': l1,
'dsc': dsc,
'dsc_int': dsc,
'ISTA': ISTA
},
compile=False)
#loaded_model.summary()
if settings.options.D25:
segout_float = loaded_model.predict(resizepredict2)[..., 0]
else:
segout_float = loaded_model.predict(
resizepredict2[..., np.newaxis])[..., 0]
segout_int = (segout_float >= settings.options.segthreshold).astype(
settings.SEG_DTYPE)
if settings.options.D3:
segout_float = unthick_slices(segout_float,
settings.options.thickness, dataid,
idx)
segout_int = unthick_slices(segout_int, settings.options.thickness)
elif settings.options.D25:
resizepredict = resizepredict.transpose((0, 2, 1))
#segout_int = preprocess.largest_connected_component(segout_int).astype(settings.SEG_DTYPE)
segin_windowed = preprocess.resize_to_original(resizepredict)
segin_windowed_img = nib.Nifti1Image(segin_windowed,
None,
header=origheader)
segin_windowed_img.to_filename(
outdir.replace('.nii', '-imgin-windowed.nii'))
segout_float_resize = preprocess.resize_to_original(segout_float)
segout_float_img = nib.Nifti1Image(segout_float_resize,
None,
header=origheader)
segout_float_img.to_filename(outdir.replace('.nii', '-pred-float.nii'))
segout_int_resize = preprocess.resize_to_original(segout_int)
segout_int_img = nib.Nifti1Image(segout_int_resize,
None,
header=origheader)
segout_int_img.to_filename(outdir.replace('.nii', '-pred-seg.nii'))
if seg:
#score = dsc_l2_3D(origseg, segout_int)
score = dsc_l2_3D(origseg.astype(settings.FLOAT_DTYPE),
segout_float)
print('dsc:\t', 1.0 - score)
return segout_float_resize, segout_int_resize
def PredictDropout(model=settings.options.predictmodel,
image=settings.options.predictimage,
outdir=settings.options.segmentation,
seg=None):
if not (model != None and image != None and outdir != None):
return
if model is None:
model = settings.options.predictmodel
if outdir is None:
outdir = settings.options.segmentation
os.environ["CUDA_DEVICE_ORDER"] = "PCI_BUS_ID" # see issue #152
numpypredict, origheader, origseg = preprocess.reorient(image, segloc=seg)
assert numpypredict.shape[0:2] == (settings._globalexpectedpixel,
settings._globalexpectedpixel)
resizepredict = preprocess.resize_to_nn(numpypredict)
resizepredict = preprocess.window(resizepredict, settings.options.hu_lb,
settings.options.hu_ub)
resizepredict = preprocess.rescale(resizepredict, settings.options.hu_lb,
settings.options.hu_ub)
if seg:
origseg = preprocess.resize_to_nn(origseg)
origseg = preprocess.livermask(origseg)
# save unprocessed image_in
img_in_nii = nib.Nifti1Image(image, None, header=origheader)
img_in_nii.to_filename(outdir.replace('.nii', '-imgin.nii'))
# save preprocessed image_in
segin_windowed_img = nib.Nifti1Image(resizepredict, None)
segin_windowed_img.to_filename(
outdir.replace('.nii', '-imgin-windowed.nii'))
# save true segmentation
if seg:
origseg_img = nib.Nifti1Image(origseg, None)
origseg_img.to_filename(outdir.replace('.nii', '-seg.nii'))
###
### set up model
###
loaded_model = load_model(model,
custom_objects={
'dsc_l2': dsc_l2,
'l1': l1,
'dsc': dsc,
'dsc_int': dsc,
'ISTA': ISTA
})
###
### making baseline prediction and saving to file
###
print('\tmaking baseline predictions...')
segout_float = loaded_model.predict(resizepredict[..., np.newaxis])[..., 0]
segout_int = (segout_float >= settings.options.segthreshold).astype(
settings.SEG_DTYPE)
segout_int = preprocess.largest_connected_component(segout_int).astype(
settings.SEG_DTYPE)
segout_float_img = nib.Nifti1Image(segout_float, None)
segout_float_img.to_filename(outdir.replace('.nii', '-pred-float.nii'))
segout_int_img = nib.Nifti1Image(segout_int, None)
segout_int_img.to_filename(outdir.replace('.nii', '-pred-seg.nii'))
if seg:
score = dsc_l2_3D(origseg, segout_int)
print('\t\t\tdsc:\t', 1.0 - score)
###
### making predictions using different Bernoulli draws for dropout
###
print('\tmaking predictions with different dropouts trials...')
f = K.function([loaded_model.layers[0].input,
K.learning_phase()], [loaded_model.layers[-1].output])
results = np.zeros(resizepredict.shape + (settings.options.ntrials, ))
for jj in range(settings.options.ntrials):
results[..., jj] = f([resizepredict[..., np.newaxis], 1])[0][..., 0]
print('\tcalculating statistics...')
pred_avg = results.mean(axis=-1)
pred_var = results.var(axis=-1)
pred_ent = np.zeros(pred_avg.shape)
ent_idx0 = pred_avg > 0
ent_idx1 = pred_avg < 1
ent_idx = np.logical_and(ent_idx0, ent_idx1)
pred_ent[ent_idx] = -1*np.multiply( pred_avg[ent_idx], np.log( pred_avg[ent_idx])) \
-1*np.multiply(1.0 - pred_avg[ent_idx], np.log(1.0 - pred_avg[ent_idx]))
print('\tsaving trial statistics...')
# save pred_avg
pred_avg_img = nib.Nifti1Image(pred_avg, None)
pred_avg_img.to_filename(outdir.replace('.nii', '-pred-avg.nii'))
# save pred_var
pred_var_img = nib.Nifti1Image(pred_var, None)
pred_var_img.to_filename(outdir.replace('.nii', '-pred-var.nii'))
# save pred_ent
pred_ent_img = nib.Nifti1Image(pred_ent, None)
pred_ent_img.to_filename(outdir.replace('.nii', '-pred-ent.nii'))
print('\n')
return segout_int, segout_float
def TrainModel(idfold=0):
from setupmodel import GetSetupKfolds, GetCallbacks, GetOptimizer, GetLoss
from buildmodel import get_unet
os.environ['TF_FORCE_GPU_ALLOW_GROWTH'] = 'true'
###
### load data
###
kfolds = settings.options.kfolds
logfileoutputdir = '%s/%03d/%03d' % (settings.options.outdir, kfolds,
idfold)
os.system('mkdir -p ' + logfileoutputdir)
os.system('mkdir -p ' + logfileoutputdir + '/nii')
os.system('mkdir -p ' + logfileoutputdir + '/tumor')
print("Output to\t", logfileoutputdir)
print('loading memory map db for large dataset')
numpydatabase = np.load(settings._globalnpfile)
(train_index, test_index,
valid_index) = GetSetupKfolds(settings.options.dbfile, kfolds, idfold)
print('copy data subsets into memory...')
axialbounds = numpydatabase['axialtumorbounds']
dataidarray = numpydatabase['dataid']
dbtrainindex = np.isin(dataidarray, train_index)
dbtestindex = np.isin(dataidarray, test_index)
dbvalidindex = np.isin(dataidarray, valid_index)
subsetidx_train = np.all(np.vstack((axialbounds, dbtrainindex)), axis=0)
subsetidx_test = np.all(np.vstack((axialbounds, dbtestindex)), axis=0)
subsetidx_valid = np.all(np.vstack((axialbounds, dbvalidindex)), axis=0)
if np.sum(subsetidx_train) + np.sum(subsetidx_test) + np.sum(
subsetidx_valid) != min(np.sum(axialbounds), np.sum(dbtrainindex)):
raise ("data error: slice numbers dont match")
print('copy memory map from disk to RAM...')
trainingsubset = numpydatabase[subsetidx_train]
validsubset = numpydatabase[subsetidx_valid]
testsubset = numpydatabase[subsetidx_test]
del numpydatabase
del axialbounds
del dataidarray
del dbtrainindex
del dbtestindex
del dbvalidindex
del subsetidx_train
del subsetidx_test
del subsetidx_valid
np.random.seed(seed=0)
np.random.shuffle(trainingsubset)
ntrainslices = len(trainingsubset)
nvalidslices = len(validsubset)
x_train = trainingsubset['imagedata']
y_train = trainingsubset['truthdata']
x_valid = validsubset['imagedata']
y_valid = validsubset['truthdata']
print('\nkfolds : ', kfolds)
print("idfold : ", idfold)
print("slices training : ", ntrainslices)
print("slices validation : ", nvalidslices)
###
### data preprocessing : applying liver mask
###
y_train_typed = y_train.astype(settings.SEG_DTYPE)
y_train_liver = preprocess.livermask(y_train_typed)
y_train_tumor = preprocess.tumormask(y_train_typed)
x_train_typed = x_train
x_train_typed = preprocess.window(x_train_typed, settings.options.hu_lb,
settings.options.hu_ub)
x_train_typed = preprocess.rescale(x_train_typed, settings.options.hu_lb,
settings.options.hu_ub)
x_train_masked = x_train_typed * y_train_liver.astype(
settings.IMG_DTYPE) - (1.0 - y_train_liver.astype(settings.IMG_DTYPE))
y_valid_typed = y_valid.astype(settings.SEG_DTYPE)
y_valid_liver = preprocess.livermask(y_valid_typed)
y_valid_tumor = preprocess.tumormask(y_valid_typed)
x_valid_typed = x_valid
x_valid_typed = preprocess.window(x_valid_typed, settings.options.hu_lb,
settings.options.hu_ub)
x_valid_typed = preprocess.rescale(x_valid_typed, settings.options.hu_lb,
settings.options.hu_ub)
x_valid_masked = x_valid_typed * y_valid_liver.astype(
settings.IMG_DTYPE) - (1.0 - y_valid_liver.astype(settings.IMG_DTYPE))
###
### create and run model
###
opt = GetOptimizer()
callbacks, modelloc = GetCallbacks(logfileoutputdir, "tumor")
lss, met = GetLoss()
model = get_unet()
model.compile(loss=lss, metrics=met, optimizer=opt)
print("\n\n\tlivermask training...\tModel parameters: {0:,}".format(
model.count_params()))
if settings.options.augment:
train_datagen = ImageDataGenerator(
brightness_range=[0.9, 1.1],
fill_mode='nearest',
preprocessing_function=preprocess.post_augment)
train_maskgen = ImageDataGenerator()
else:
train_datagen = ImageDataGenerator()
train_maskgen = ImageDataGenerator()
test_datagen = ImageDataGenerator()
sd = 2
# dataflow = train_datagen.flow(x_train_typed[...,np.newaxis],
dataflow = train_datagen.flow(x_train_masked[..., np.newaxis],
batch_size=settings.options.trainingbatch,
seed=sd,
shuffle=True)
maskflow = train_maskgen.flow(y_train_tumor[..., np.newaxis],
batch_size=settings.options.trainingbatch,
seed=sd,
shuffle=True)
train_generator = zip(dataflow, maskflow)
valid_datagen = ImageDataGenerator()
valid_maskgen = ImageDataGenerator()
valid_dataflow = valid_datagen.flow(
x_valid_masked[..., np.newaxis],
batch_size=settings.options.validationbatch,
seed=sd,
shuffle=True)
valid_maskflow = valid_maskgen.flow(
y_valid_tumor[..., np.newaxis],
batch_size=settings.options.validationbatch,
seed=sd,
shuffle=True)
valid_generator = zip(valid_dataflow, valid_maskflow)
history_tumor = model.fit_generator(
train_generator,
steps_per_epoch=ntrainslices / settings.options.trainingbatch,
epochs=settings.options.numepochs,
validation_data=valid_generator,
callbacks=callbacks,
shuffle=True,
validation_steps=nvalidslices / settings.options.validationbatch,
)
del x_train
del y_train
del x_train_typed
del y_train_typed
del y_train_liver
del y_train_tumor
del x_train_masked
###
### make predicions on validation set
###
print("\n\n\tapplying models...")
y_pred_float = model.predict(x_valid_masked[..., np.newaxis])
y_pred_seg = (y_pred_float[..., 0] >=
settings.options.segthreshold).astype(settings.SEG_DTYPE)
print("\tsaving to file...")
trueinnii = nib.Nifti1Image(x_valid, None)
truesegnii = nib.Nifti1Image(y_valid, None)
truelivernii = nib.Nifti1Image(y_valid_liver, None)
truetumornii = nib.Nifti1Image(y_valid_tumor, None)
windownii = nib.Nifti1Image(x_valid_typed, None)
maskednii = nib.Nifti1Image(x_valid_masked, None)
predsegnii = nib.Nifti1Image(y_pred_seg, None)
predfloatnii = nib.Nifti1Image(y_pred_float, None)
trueinnii.to_filename(logfileoutputdir + '/nii/trueimg.nii.gz')
truesegnii.to_filename(logfileoutputdir + '/nii/trueseg.nii.gz')
truetumornii.to_filename(logfileoutputdir + '/nii/truetumor.nii.gz')
truelivernii.to_filename(logfileoutputdir + '/nii/trueliver.nii.gz')
windownii.to_filename(logfileoutputdir + '/nii/windowedimg.nii.gz')
maskednii.to_filename(logfileoutputdir + '/nii/masked.nii.gz')
predsegnii.to_filename(logfileoutputdir + '/nii/predtumorseg.nii.gz')
predfloatnii.to_filename(logfileoutputdir + '/nii/predtumorfloat.nii.gz')
del x_valid
del y_valid
del x_valid_typed
del y_valid_typed
del y_valid_liver
del y_valid_tumor
del x_valid_masked
print("\done saving.")
return modelloc
def TrainModel(idfold=0):
from setupmodel import GetSetupKfolds, GetCallbacks, GetOptimizer, GetLoss
from buildmodel import get_unet
###
### set up output, logging, and callbacks
###
kfolds = settings.options.kfolds
logfileoutputdir = '%s/%03d/%03d' % (settings.options.outdir, kfolds,
idfold)
os.system('mkdir -p ' + logfileoutputdir)
os.system('mkdir -p ' + logfileoutputdir + '/nii')
os.system('mkdir -p ' + logfileoutputdir + '/liver')
print("Output to\t", logfileoutputdir)
###
### load data
###
print('loading memory map db for large dataset')
numpydatabase = np.load(settings._globalnpfile)
(train_index, test_index,
valid_index) = GetSetupKfolds(settings.options.dbfile, kfolds, idfold)
print('copy data subsets into memory...')
axialbounds = numpydatabase['axialliverbounds']
dataidarray = numpydatabase['dataid']
dbtrainindex = np.isin(dataidarray, train_index)
dbtestindex = np.isin(dataidarray, test_index)
dbvalidindex = np.isin(dataidarray, valid_index)
subsetidx_train = np.all(np.vstack((axialbounds, dbtrainindex)), axis=0)
subsetidx_test = np.all(np.vstack((axialbounds, dbtestindex)), axis=0)
subsetidx_valid = np.all(np.vstack((axialbounds, dbvalidindex)), axis=0)
if np.sum(subsetidx_train) + np.sum(subsetidx_test) + np.sum(
subsetidx_valid) != min(np.sum(axialbounds), np.sum(dbtrainindex)):
raise ("data error: slice numbers dont match")
print('copy memory map from disk to RAM...')
trainingsubset = numpydatabase[subsetidx_train]
validsubset = numpydatabase[subsetidx_valid]
testsubset = numpydatabase[subsetidx_test]
# trimg = trainingsubset['imagedata']
# trseg = trainingsubset['truthdata']
# vaimg = validsubset['imagedata']
# vaseg = validsubset['truthdata']
# teimg = testsubset['imagedata']
# teseg = testsubset['truthdata']
# trimg_img = nib.Nifti1Image(trimg, None)
# trimg_img.to_filename( logfileoutputdir+'/nii/train-img.nii.gz')
# vaimg_img = nib.Nifti1Image(vaimg, None)
# vaimg_img.to_filename( logfileoutputdir+'/nii/valid-img.nii.gz')
# teimg_img = nib.Nifti1Image(teimg, None)
# teimg_img.to_filename( logfileoutputdir+'/nii/test-img.nii.gz')
#
# trseg_img = nib.Nifti1Image(trseg, None)
# trseg_img.to_filename( logfileoutputdir+'/nii/train-seg.nii.gz')
# vaseg_img = nib.Nifti1Image(vaseg, None)
# vaseg_img.to_filename( logfileoutputdir+'/nii/valid-seg.nii.gz')
# teseg_img = nib.Nifti1Image(teseg, None)
# teseg_img.to_filename( logfileoutputdir+'/nii/test-seg.nii.gz')
np.random.seed(seed=0)
np.random.shuffle(trainingsubset)
ntrainslices = len(trainingsubset)
nvalidslices = len(validsubset)
x_train = trainingsubset['imagedata']
y_train = trainingsubset['truthdata']
x_valid = validsubset['imagedata']
y_valid = validsubset['truthdata']
print("\nkfolds : ", kfolds)
print("idfold : ", idfold)
print("slices training : ", ntrainslices)
print("slices validation : ", nvalidslices)
###
### data preprocessing : applying liver mask
###
y_train_typed = y_train.astype(settings.SEG_DTYPE)
y_train_liver = preprocess.livermask(y_train_typed)
x_train_typed = x_train
x_train_typed = preprocess.window(x_train_typed, settings.options.hu_lb,
settings.options.hu_ub)
x_train_typed = preprocess.rescale(x_train_typed, settings.options.hu_lb,
settings.options.hu_ub)
y_valid_typed = y_valid.astype(settings.SEG_DTYPE)
y_valid_liver = preprocess.livermask(y_valid_typed)
x_valid_typed = x_valid
x_valid_typed = preprocess.window(x_valid_typed, settings.options.hu_lb,
settings.options.hu_ub)
x_valid_typed = preprocess.rescale(x_valid_typed, settings.options.hu_lb,
settings.options.hu_ub)
###
### create and run model
###
opt = GetOptimizer()
callbacks, modelloc = GetCallbacks(logfileoutputdir, "liver")
lss, met = GetLoss()
model = get_unet()
model.compile(loss=lss, metrics=met, optimizer=opt)
print("\n\n\tlivermask training...\tModel parameters: {0:,}".format(
model.count_params()))
if settings.options.augment:
train_datagen = ImageDataGenerator(
brightness_range=[0.9, 1.1],
preprocessing_function=preprocess.post_augment,
)
train_maskgen = ImageDataGenerator()
else:
train_datagen = ImageDataGenerator()
train_maskgen = ImageDataGenerator()
sd = 2 # arbitrary but fixed seed for ImageDataGenerators()
dataflow = train_datagen.flow(x_train_typed[..., np.newaxis],
batch_size=settings.options.trainingbatch,
seed=sd,
shuffle=True)
maskflow = train_maskgen.flow(y_train_liver[..., np.newaxis],
batch_size=settings.options.trainingbatch,
seed=sd,
shuffle=True)
train_generator = zip(dataflow, maskflow)
# train_generator = train_datagen.flow(x_train_typed[...,np.newaxis],
# y=y_train_liver[...,np.newaxis],
# batch_size=settings.options.trainingbatch,
# seed=sd,
# shuffle=True)
valid_datagen = ImageDataGenerator()
valid_maskgen = ImageDataGenerator()
validdataflow = valid_datagen.flow(
x_valid_typed[..., np.newaxis],
batch_size=settings.options.validationbatch,
seed=sd,
shuffle=True)
validmaskflow = valid_maskgen.flow(
y_valid_liver[..., np.newaxis],
batch_size=settings.options.validationbatch,
seed=sd,
shuffle=True)
valid_generator = zip(validdataflow, validmaskflow)
###
### visualize augmentation
###
#
# import matplotlib
# matplotlib.use('TkAgg')
# from matplotlib import pyplot as plt
# for i in range(8):
# plt.subplot(4,4,2*i + 1)
# imbatch = dataflow.next()
# sgbatch = maskflow.next()
# imaug = imbatch[0][:,:,0]
# sgaug = sgbatch[0][:,:,0]
# plt.imshow(imaug)
# plt.subplot(4,4,2*i + 2)
# plt.imshow(sgaug)
# plt.show()
# return
#
history_liver = model.fit_generator(
train_generator,
steps_per_epoch=ntrainslices / settings.options.trainingbatch,
epochs=settings.options.numepochs,
validation_data=valid_generator,
callbacks=callbacks,
shuffle=True,
validation_steps=nvalidslices / settings.options.validationbatch,
)
###
### make predicions on validation set
###
print("\n\n\tapplying models...")
y_pred_float = model.predict(x_valid_typed[..., np.newaxis])
y_pred_seg = (y_pred_float[..., 0] >=
settings.options.segthreshold).astype(settings.SEG_DTYPE)
print("\tsaving to file...")
trueinnii = nib.Nifti1Image(x_valid, None)
truesegnii = nib.Nifti1Image(y_valid, None)
# windownii = nib.Nifti1Image(x_valid_typed, None)
truelivernii = nib.Nifti1Image(y_valid_liver, None)
predsegnii = nib.Nifti1Image(y_pred_seg, None)
predfloatnii = nib.Nifti1Image(y_pred_float, None)
trueinnii.to_filename(logfileoutputdir + '/nii/trueimg.nii.gz')
truesegnii.to_filename(logfileoutputdir + '/nii/trueseg.nii.gz')
# windownii.to_filename( logfileoutputdir+'/nii/windowedimg.nii.gz')
truelivernii.to_filename(logfileoutputdir + '/nii/trueliver.nii.gz')
predsegnii.to_filename(logfileoutputdir + '/nii/predtumorseg.nii.gz')
predfloatnii.to_filename(logfileoutputdir + '/nii/predtumorfloat.nii.gz')
print("\done saving.")
return modelloc
def TrainModel(idfold=0):
from setupmodel import GetSetupKfolds, GetCallbacks, GetOptimizer, GetLoss
from buildmodel import get_unet, thick_slices, unthick_slices, unthick
###
### set up output, logging and callbacks
###
kfolds = settings.options.kfolds
logfileoutputdir= '%s/%03d/%03d' % (settings.options.outdir, kfolds, idfold)
os.system ('mkdir -p ' + logfileoutputdir)
os.system ('mkdir -p ' + logfileoutputdir + '/nii')
os.system ('mkdir -p ' + logfileoutputdir + '/liver')
print("Output to\t", logfileoutputdir)
###
### load data
###
print('loading memory map db for large dataset')
numpydatabase = np.load(settings._globalnpfile)
(train_index,test_index,valid_index) = GetSetupKfolds(settings.options.dbfile, kfolds, idfold)
print('copy data subsets into memory...')
axialbounds = numpydatabase['axialliverbounds']
dataidarray = numpydatabase['dataid']
dbtrainindex = np.isin(dataidarray, train_index )
dbtestindex = np.isin(dataidarray, test_index )
dbvalidindex = np.isin(dataidarray, valid_index )
subsetidx_train = np.all( np.vstack((axialbounds , dbtrainindex)) , axis=0 )
subsetidx_test = np.all( np.vstack((axialbounds , dbtestindex )) , axis=0 )
subsetidx_valid = np.all( np.vstack((axialbounds , dbvalidindex)) , axis=0 )
print(np.sum(subsetidx_train) + np.sum(subsetidx_test) + np.sum(subsetidx_valid))
print(min(np.sum(axialbounds ),np.sum(dbtrainindex )))
if np.sum(subsetidx_train) + np.sum(subsetidx_test) + np.sum(subsetidx_valid) != min(np.sum(axialbounds ),np.sum(dbtrainindex )) :
raise("data error: slice numbers dont match")
print('copy memory map from disk to RAM...')
trainingsubset = numpydatabase[subsetidx_train]
validsubset = numpydatabase[subsetidx_valid]
testsubset = numpydatabase[subsetidx_test]
# np.random.seed(seed=0)
# np.random.shuffle(trainingsubset)
ntrainslices = len(trainingsubset)
nvalidslices = len(validsubset)
if settings.options.D3:
x_data = trainingsubset['imagedata']
y_data = trainingsubset['truthdata']
x_valid = validsubset['imagedata']
y_valid = validsubset['truthdata']
x_train = thick_slices(x_data, settings.options.thickness, trainingsubset['dataid'], train_index)
y_train = thick_slices(y_data, settings.options.thickness, trainingsubset['dataid'], train_index)
x_valid = thick_slices(x_valid, settings.options.thickness, validsubset['dataid'], valid_index)
y_valid = thick_slices(y_valid, settings.options.thickness, validsubset['dataid'], valid_index)
np.random.seed(seed=0)
train_shuffle = np.random.permutation(x_train.shape[0])
valid_shuffle = np.random.permutation(x_valid.shape[0])
x_train = x_train[train_shuffle,...]
y_train = y_train[train_shuffle,...]
x_valid = x_valid[valid_shuffle,...]
y_valid = y_valid[valid_shuffle,...]
elif settings.options.D25:
x_data = trainingsubset['imagedata']
y_data = trainingsubset['truthdata']
x_valid = validsubset['imagedata']
y_valid = validsubset['truthdata']
x_train = thick_slices(x_data, settings.options.thickness, trainingsubset['dataid'], train_index)
x_valid = thick_slices(x_valid, settings.options.thickness, validsubset['dataid'], valid_index)
y_train = thick_slices(y_data, 1, trainingsubset['dataid'], train_index)
y_valid = thick_slices(y_valid, 1, validsubset['dataid'], valid_index)
np.random.seed(seed=0)
train_shuffle = np.random.permutation(x_train.shape[0])
valid_shuffle = np.random.permutation(x_valid.shape[0])
x_train = x_train[train_shuffle,...]
y_train = y_train[train_shuffle,...]
x_valid = x_valid[valid_shuffle,...]
y_valid = y_valid[valid_shuffle,...]
else:
np.random.seed(seed=0)
np.random.shuffle(trainingsubset)
x_train=trainingsubset['imagedata']
y_train=trainingsubset['truthdata']
x_valid=validsubset['imagedata']
y_valid=validsubset['truthdata']
# slicesplit = int(0.9 * totnslice)
# TRAINING_SLICES = slice( 0, slicesplit)
# VALIDATION_SLICES = slice(slicesplit, totnslice )
print("\nkfolds : ", kfolds)
print("idfold : ", idfold)
print("slices training : ", ntrainslices)
print("slices validation : ", nvalidslices)
try:
print("slices testing : ", len(testsubset))
except:
print("slices testing : 0")
###
### data preprocessing : applying liver mask
###
y_train_typed = y_train.astype(settings.SEG_DTYPE)
y_train_liver = preprocess.livermask(y_train_typed)
x_train_typed = x_train
x_train_typed = preprocess.window(x_train_typed, settings.options.hu_lb, settings.options.hu_ub)
x_train_typed = preprocess.rescale(x_train_typed, settings.options.hu_lb, settings.options.hu_ub)
y_valid_typed = y_valid.astype(settings.SEG_DTYPE)
y_valid_liver = preprocess.livermask(y_valid_typed)
x_valid_typed = x_valid
x_valid_typed = preprocess.window(x_valid_typed, settings.options.hu_lb, settings.options.hu_ub)
x_valid_typed = preprocess.rescale(x_valid_typed, settings.options.hu_lb, settings.options.hu_ub)
# liver_idx = y_train_typed > 0
# y_train_liver = np.zeros_like(y_train_typed)
# y_train_liver[liver_idx] = 1
#
# tumor_idx = y_train_typed > 1
# y_train_tumor = np.zeros_like(y_train_typed)
# y_train_tumor[tumor_idx] = 1
#
# x_masked = x_train * y_train_liver - 100.0*(1.0 - y_train_liver)
# x_masked = x_masked.astype(settings.IMG_DTYPE)
###
### create and run model tf.keras.losses.mean_squared_error,
###
opt = GetOptimizer()
callbacks, modelloc = GetCallbacks(logfileoutputdir, "liver")
lss, met = GetLoss()
model = get_unet()
model.compile(loss = lss,
metrics = met,
optimizer = opt)
print("\n\n\tlivermask training...\tModel parameters: {0:,}".format(model.count_params()))
if settings.options.D3:
if settings.options.augment:
train_datagen = ImageDataGenerator3D(
brightness_range=[0.9,1.1],
width_shift_range=[-0.1,0.1],
height_shift_range=[-0.1,0.1],
horizontal_flip=True,
vertical_flip=True,
zoom_range=0.1,
fill_mode='nearest',
preprocessing_function=preprocess.post_augment
)
train_maskgen = ImageDataGenerator3D()
else:
train_datagen = ImageDataGenerator3D()
train_maskgen = ImageDataGenerator3D()
valid_datagen = ImageDataGenerator3D()
valid_maskgen = ImageDataGenerator3D()
else:
if settings.options.augment:
train_datagen = ImageDataGenerator2D(
brightness_range=[0.9,1.1],
width_shift_range=[-0.1,0.1],
height_shift_range=[-0.1,0.1],
horizontal_flip=True,
vertical_flip=True,
zoom_range=0.1,
fill_mode='nearest',
preprocessing_function=preprocess.post_augment
)
train_maskgen = ImageDataGenerator2D()
else:
train_datagen = ImageDataGenerator2D()
train_maskgen = ImageDataGenerator2D()
valid_datagen = ImageDataGenerator2D()
valid_maskgen = ImageDataGenerator2D()
sd = 2 # arbitrary but fixed seed for ImageDataGenerators()
if settings.options.D25:
dataflow = train_datagen.flow(x_train_typed,
batch_size=settings.options.trainingbatch,
seed=sd,
shuffle=True)
maskflow = train_maskgen.flow(y_train_liver,
batch_size=settings.options.trainingbatch,
seed=sd,
shuffle=True)
validdataflow = valid_datagen.flow(x_valid_typed,
batch_size=settings.options.validationbatch,
seed=sd,
shuffle=True)
validmaskflow = valid_maskgen.flow(y_valid_liver,
batch_size=settings.options.validationbatch,
seed=sd,
shuffle=True)
else:
dataflow = train_datagen.flow(x_train_typed[...,np.newaxis],
batch_size=settings.options.trainingbatch,
seed=sd,
shuffle=True)
maskflow = train_maskgen.flow(y_train_liver[...,np.newaxis],
batch_size=settings.options.trainingbatch,
seed=sd,
shuffle=True)
validdataflow = valid_datagen.flow(x_valid_typed[...,np.newaxis],
batch_size=settings.options.validationbatch,
seed=sd,
shuffle=True)
validmaskflow = valid_maskgen.flow(y_valid_liver[...,np.newaxis],
batch_size=settings.options.validationbatch,
seed=sd,
shuffle=True)
train_generator = zip(dataflow, maskflow)
valid_generator = zip(validdataflow, validmaskflow)
history_liver = model.fit_generator(
train_generator,
steps_per_epoch= ntrainslices // settings.options.trainingbatch,
validation_steps = nvalidslices // settings.options.validationbatch,
epochs=settings.options.numepochs,
validation_data=valid_generator,
callbacks=callbacks,
shuffle=True)
###
### make predicions on validation set
###
print("\n\n\tapplying models...")
if settings.options.D25:
y_pred_float = model.predict( x_valid_typed )[...,0] #[...,settings.options.thickness] )
else:
y_pred_float = model.predict( x_valid_typed[...,np.newaxis] )[...,0]
y_pred_seg = (y_pred_float >= settings.options.segthreshold).astype(settings.SEG_DTYPE)
if settings.options.D3:
x_valid = unthick(x_valid, settings.options.thickness, validsubset['dataid'], valid_index)
y_valid = unthick(y_valid, settings.options.thickness, validsubset['dataid'], valid_index)
y_valid_liver = unthick(y_valid_liver, settings.options.thickness, validsubset['dataid'], valid_index)
y_pred_float = unthick(y_pred_float, settings.options.thickness, validsubset['dataid'], valid_index)
y_pred_seg = unthick(y_pred_seg, settings.options.thickness, validsubset['dataid'], valid_index)
print("\tsaving to file...")
trueinnii = nib.Nifti1Image(x_valid, None)
truesegnii = nib.Nifti1Image(y_valid, None)
# windownii = nib.Nifti1Image(x_valid_typed, None)
truelivernii = nib.Nifti1Image(y_valid_liver, None)
predsegnii = nib.Nifti1Image(y_pred_seg, None )
predfloatnii = nib.Nifti1Image(y_pred_float, None)
trueinnii.to_filename( logfileoutputdir+'/nii/trueimg.nii.gz')
truesegnii.to_filename( logfileoutputdir+'/nii/truseg.nii.gz')
# windownii.to_filename( logfileoutputdir+'/nii/windowedimg.nii.gz')
truelivernii.to_filename( logfileoutputdir+'/nii/trueliver.nii.gz')
predsegnii.to_filename( logfileoutputdir+'/nii/predtumorseg.nii.gz')
predfloatnii.to_filename( logfileoutputdir+'/nii/predtumorfloat.nii.gz')
print("t\done saving.")
return modelloc