def testOLSdegenerate(self):
X = W((40,10))
X[:,0] = X[:,1] + X[:,2]
Y = W((40,))
model = OLSModel(design=X)
results = model.fit(Y)
self.assertEquals(results.df_resid, 31)
def test_altprotocol():
block, bT, bF = protocol(descriptions['block'], 'block', *delay.spectral)
event, eT, eF = protocol(descriptions['event'], 'event', *delay.spectral)
blocka, baT, baF = altprotocol(altdescr['block'], 'block', *delay.spectral)
eventa, eaT, eaF = altprotocol(altdescr['event'], 'event', *delay.spectral)
for c in bT.keys():
baf = baT[c]
if not isinstance(baf, formula.Formula):
baf = formula.Formula([baf])
bf = bT[c]
if not isinstance(bf, formula.Formula):
bf = formula.Formula([bf])
X = baf.design(t, return_float=True)
Y = bf.design(t, return_float=True)
if X.ndim == 1:
X.shape = (X.shape[0], 1)
m = OLSModel(X)
r = m.fit(Y)
remaining = (r.resid**2).sum() / (Y**2).sum()
yield assert_almost_equal, remaining, 0
for c in bF.keys():
baf = baF[c]
if not isinstance(baf, formula.Formula):
baf = formula.Formula([baf])
bf = bF[c]
if not isinstance(bf, formula.Formula):
bf = formula.Formula([bf])
X = baf.design(t, return_float=True)
Y = bf.design(t, return_float=True)
if X.ndim == 1:
X.shape = (X.shape[0], 1)
m = OLSModel(X)
r = m.fit(Y)
remaining = (r.resid**2).sum() / (Y**2).sum()
yield assert_almost_equal, remaining, 0
def test_scipy_stats():
# Using scipy.stats.models
X, cons = twoway.design(D, contrasts=contrasts)
Y = D['Days']
m = OLSModel(X)
f = m.fit(Y)
F_m = {}
df_m = {}
p_m = {}
for n, c in cons.items():
r = f.Fcontrast(c)
F_m[n] = r.F
df_m[n] = r.df_num
p_m[n] = scipy.stats.f.sf(F_m[n], df_m[n], r.df_den)
assert_almost_equal(F[n], F_m[n])
assert_almost_equal(df[n], df_m[n])
assert_almost_equal(p[n], p_m[n])
tempdict = {}
for v in ['sd', 't', 'effect']:
tempdict[v] = np.zeros(mask_array.sum())
output[contrast_id] = tempdict
########################################
# Perform a GLM analysis
########################################
print 'Fitting a GLM (this takes time)...'
fmri_image = load(data_path)
Y = fmri_image.get_data()[mask_array]
X = design_matrix.matrix
m = OLSModel(X)
# Fit the model, storing an estimate of an AR(1) parameter at each voxel
result = m.fit(Y.T)
ar1 = ((result.resid[1:] * result.resid[:-1]).sum(0) /
(result.resid ** 2).sum(0))
ar1 *= 100
ar1 = ar1.astype(np.int) / 100.
for val in np.unique(ar1):
armask = np.equal(ar1, val)
m = ARModel(X, val)
d = Y[armask]
results = m.fit(d.T)
# Output the results for each contrast
def testOLS(self):
X = W((40,10))
Y = W((40,))
model = OLSModel(design=X)
results = model.fit(Y)
self.assertEquals(results.df_resid, 30)
def run_model(subj, run):
"""
Single subject fitting of FIAC model
"""
#----------------------------------------------------------------------
# Set initial parameters of the FIAC dataset
#----------------------------------------------------------------------
# Number of volumes in the fMRI data
nvol = 191
# The TR of the experiment
TR = 2.5
# The time of the first volume
Tstart = 0.0
# The array of times corresponding to each
# volume in the fMRI data
volume_times = np.arange(nvol)*TR + Tstart
# This recarray of times has one column named 't'
# It is used in the function design.event_design
# to create the design matrices.
volume_times_rec = formula.make_recarray(volume_times, 't')
# Get a path description dictionary that contains all the path data
# relevant to this subject/run
path_info = futil.path_info(subj,run)
#----------------------------------------------------------------------
# Experimental design
#----------------------------------------------------------------------
# Load the experimental description from disk. We have utilities in futil
# that reformat the original FIAC-supplied format into something where the
# factorial structure of the design is more explicit. This has already
# been run once, and get_experiment_initial() will simply load the
# newly-formatted design description files (.csv) into record arrays.
experiment, initial = futil.get_experiment_initial(path_info)
# Create design matrices for the "initial" and "experiment" factors,
# saving the default contrasts.
# The function event_design will create
# design matrices, which in the case of "experiment"
# will have num_columns =
# (# levels of speaker) * (# levels of sentence) * len(delay.spectral) =
# 2 * 2 * 2 = 8
# For "initial", there will be
# (# levels of initial) * len([hrf.glover]) = 1 * 1 = 1
# Here, delay.spectral is a sequence of 2 symbolic HRFs that
# are described in
#
# Liao, C.H., Worsley, K.J., Poline, J-B., Aston, J.A.D., Duncan, G.H.,
# Evans, A.C. (2002). \'Estimating the delay of the response in fMRI
# data.\' NeuroImage, 16:593-606.
# The contrasts, cons_exper,
# is a dictionary with keys: ['constant_0', 'constant_1', 'speaker_0',
# 'speaker_1',
# 'sentence_0', 'sentence_1', 'sentence:speaker_0', 'sentence:speaker_1']
# representing the four default contrasts: constant, main effects +
# interactions,
# each convolved with 2 HRFs in delay.spectral. Its values
# are matrices with 8 columns.
# XXX use the hrf __repr__ for naming contrasts
X_exper, cons_exper = design.event_design(experiment, volume_times_rec,
hrfs=delay.spectral)
# The contrasts for 'initial' are ignored
# as they are "uninteresting" and are included
# in the model as confounds.
X_initial, _ = design.event_design(initial, volume_times_rec,
hrfs=[hrf.glover])
# In addition to factors, there is typically a "drift" term
# In this case, the drift is a natural cubic spline with
# a not at the midpoint (volume_times.mean())
vt = volume_times # shorthand
drift = np.array( [vt**i for i in range(4)] +
[(vt-vt.mean())**3 * (np.greater(vt, vt.mean()))] )
for i in range(drift.shape[0]):
drift[i] /= drift[i].max()
# We transpose the drift so that its shape is (nvol,5) so that it will have
# the same number of rows as X_initial and X_exper.
drift = drift.T
# There are helper functions to create these drifts: design.fourier_basis,
# design.natural_spline. Therefore, the above is equivalent (except for
# the normalization by max for numerical stability) to
#
# >>> drift = design.natural_spline(t, [volume_times.mean()])
# Stack all the designs, keeping the new contrasts which has the same keys
# as cons_exper, but its values are arrays with 15 columns, with the
# non-zero entries matching the columns of X corresponding to X_exper
X, cons = design.stack_designs((X_exper, cons_exper),
(X_initial, {}),
(drift, {}))
# Sanity check: delete any non-estimable contrasts
# XXX - this seems to be broken right now, it's producing bogus warnings.
## for k in cons.keys():
## if not isestimable(X, cons[k]):
## del(cons[k])
## warnings.warn("contrast %s not estimable for this run" % k)
# The default contrasts are all t-statistics. We may want to output
# F-statistics for 'speaker', 'sentence', 'speaker:sentence' based on the
# two coefficients, one for each HRF in delay.spectral
cons['speaker'] = np.vstack([cons['speaker_0'], cons['speaker_1']])
cons['sentence'] = np.vstack([cons['sentence_0'], cons['sentence_1']])
cons['sentence:speaker'] = np.vstack([cons['sentence:speaker_0'],
cons['sentence:speaker_1']])
#----------------------------------------------------------------------
# Data loading
#----------------------------------------------------------------------
# Load in the fMRI data, saving it as an array
# It is transposed to have time as the first dimension,
# i.e. fmri[t] gives the t-th volume.
fmri, anat = futil.get_fmri_anat(path_info)
fmri = np.transpose(fmri, [3,0,1,2])
nvol, volshape = fmri.shape[0], fmri.shape[1:]
nslice, sliceshape = volshape[0], volshape[1:]
#----------------------------------------------------------------------
# Model fit
#----------------------------------------------------------------------
# The model is a two-stage model, the first stage being an OLS (ordinary
# least squares) fit, whose residuals are used to estimate an AR(1)
# parameter for each voxel.
m = OLSModel(X)
ar1 = np.zeros(volshape)
# Fit the model, storing an estimate of an AR(1) parameter at each voxel
for s in range(nslice):
d = np.array(fmri[:,s])
flatd = d.reshape((d.shape[0], -1))
result = m.fit(flatd)
ar1[s] = ((result.resid[1:] * result.resid[:-1]).sum(0) /
(result.resid**2).sum(0)).reshape(sliceshape)
# We round ar1 to nearest one-hundredth
# and group voxels by their rounded ar1 value,
# fitting an AR(1) model to each batch of voxels.
# XXX smooth here?
# ar1 = smooth(ar1, 8.0)
ar1 *= 100
ar1 = ar1.astype(np.int) / 100.
# We split the contrasts into F-tests and t-tests.
# XXX helper function should do this
fcons = {}; tcons = {}
for n, v in cons.items():
v = np.squeeze(v)
if v.ndim == 1:
tcons[n] = v
else:
fcons[n] = v
# Setup a dictionary to hold all the output
# XXX ideally these would be memmap'ed Image instances
output = {}
for n in tcons:
tempdict = {}
for v in ['sd', 't', 'effect']:
tempdict[v] = np.memmap(NamedTemporaryFile(prefix='%s%s.nii' \
% (n,v)), dtype=np.float,
shape=volshape, mode='w+')
output[n] = tempdict
for n in fcons:
output[n] = np.memmap(NamedTemporaryFile(prefix='%s%s.nii' \
% (n,v)), dtype=np.float,
shape=volshape, mode='w+')
# Loop over the unique values of ar1
for val in np.unique(ar1):
armask = np.equal(ar1, val)
m = ARModel(X, val)
d = fmri[:,armask]
results = m.fit(d)
# Output the results for each contrast
for n in tcons:
resT = results.Tcontrast(tcons[n])
output[n]['sd'][armask] = resT.sd
output[n]['t'][armask] = resT.t
output[n]['effect'][armask] = resT.effect
for n in fcons:
output[n][armask] = results.Fcontrast(fcons[n]).F
# Dump output to disk
odir = futil.output_dir(path_info,tcons,fcons)
for n in tcons:
for v in ['t', 'sd', 'effect']:
im = api.Image(output[n][v], anat.coordmap.copy())
save_image(im, pjoin(odir, n, '%s.nii' % v))
for n in fcons:
im = api.Image(output[n], anat.coordmap.copy())
save_image(im, pjoin(odir, n, "F.nii"))
