def streamlines_in_mask(sft, target_mask, all_in=False):
"""
Parameters
----------
sft : StatefulTractogram
StatefulTractogram containing the streamlines to segment.
target_mask : numpy.ndarray
Binary mask in which the streamlines should pass.
Returns
-------
ids : list
Ids of the streamlines passing through the mask.
"""
sft.to_vox()
sft.to_corner()
# Copy-Paste from Dipy to get indices
if all_in:
target_mask = np.array(target_mask, dtype=bool, copy=True)
target_mask = np.invert(target_mask)
tractogram_mask = compute_tract_counts_map(sft.streamlines,
target_mask.shape)
tractogram_mask[tractogram_mask > 0] = 1
tmp_mask = tractogram_mask.astype(np.uint8) * target_mask.astype(
np.uint8)
streamlines_case = _streamlines_in_mask(list(sft.streamlines),
tmp_mask, np.eye(3), [0, 0, 0])
return np.where(streamlines_case == [0, 1][False])[0].tolist()
else:
target_mask = np.array(target_mask, dtype=np.uint8, copy=True)
streamlines_case = _streamlines_in_mask(list(sft.streamlines),
target_mask, np.eye(3),
[0, 0, 0])
return np.where(streamlines_case == [0, 1][True])[0].tolist()
def main():
parser = _build_arg_parser()
args = parser.parse_args()
assert_inputs_exist(parser, args.in_bundle, optional=args.reference)
assert_outputs_exist(parser, args, args.out_img)
max_ = np.iinfo(np.int16).max
if args.binary is not None and (args.binary <= 0 or args.binary > max_):
parser.error(
'The value of --binary ({}) '
'must be greater than 0 and smaller or equal to {}'.format(
args.binary, max_))
sft = load_tractogram_with_reference(parser, args, args.in_bundle)
sft.to_vox()
sft.to_corner()
streamlines = sft.streamlines
transformation, dimensions, _, _ = sft.space_attributes
streamline_count = compute_tract_counts_map(streamlines, dimensions)
if args.binary is not None:
streamline_count[streamline_count > 0] = args.binary
nib.save(
nib.Nifti1Image(streamline_count.astype(np.int16), transformation),
args.out_img)
def compute_voxel_measures(args):
bundle_filename, bundle_reference = args[0]
tracking_mask = args[1]
gs_binary_3d = args[2]
bundle_sft = load_tractogram(bundle_filename, bundle_reference)
bundle_sft.to_vox()
bundle_sft.to_corner()
bundle_streamlines = bundle_sft.streamlines
_, bundle_dimensions, _, _ = bundle_sft.space_attributes
if not bundle_streamlines:
logging.info('{} is empty'.format(bundle_filename))
return None
binary_3d = compute_tract_counts_map(bundle_streamlines, bundle_dimensions)
binary_3d[binary_3d > 0] = 1
binary_3d_indices = np.where(binary_3d.flatten() > 0)[0]
gs_binary_3d_indices = np.where(gs_binary_3d.flatten() > 0)[0]
voxels_binary = binary_classification(
binary_3d_indices,
gs_binary_3d_indices,
int(np.prod(tracking_mask.shape)),
mask_count=np.count_nonzero(tracking_mask))
return dict(
zip([
'sensitivity_voxels', 'specificity_voxels', 'precision_voxels',
'accuracy_voxels', 'dice_voxels', 'kappa_voxels', 'youden_voxels'
], voxels_binary))
def _average_wrapper(args):
hdf5_filenames = args[0]
key = args[1]
binary = args[2]
out_dir = args[3]
hdf5_file_ref = h5py.File(hdf5_filenames[0], 'r')
affine = hdf5_file_ref.attrs['affine']
dimensions = hdf5_file_ref.attrs['dimensions']
density_data = np.zeros(dimensions, dtype=np.float32)
for hdf5_filename in hdf5_filenames:
hdf5_file = h5py.File(hdf5_filename, 'r')
if not (np.allclose(hdf5_file.attrs['affine'], affine)
and np.allclose(hdf5_file.attrs['dimensions'], dimensions)):
raise IOError('{} do not have a compatible header'.format(
hdf5_filename))
# scil_decompose_connectivity.py saves the streamlines in VOX/CORNER
streamlines = reconstruct_streamlines_from_hdf5(hdf5_file, key)
density = compute_tract_counts_map(streamlines, dimensions)
hdf5_file.close()
if binary:
density_data[density > 0] += 1
elif np.max(density) > 0:
density_data += density / np.max(density)
if np.max(density_data) > 0:
density_data /= len(hdf5_filenames)
nib.save(nib.Nifti1Image(density_data, affine),
os.path.join(out_dir, '{}.nii.gz'.format(key)))
def main():
parser = _build_arg_parser()
args = parser.parse_args()
assert_inputs_exist(parser, args.in_bundles)
output_streamlines_filename = '{}streamlines.trk'.format(
args.output_prefix)
output_voxels_filename = '{}voxels.nii.gz'.format(args.output_prefix)
assert_outputs_exist(parser, args,
[output_voxels_filename, output_streamlines_filename])
if not 0 <= args.ratio_voxels <= 1 or not 0 <= args.ratio_streamlines <= 1:
parser.error('Ratios must be between 0 and 1.')
fusion_streamlines = []
if args.reference:
reference_file = args.reference
else:
reference_file = args.in_bundles[0]
sft_list = []
for name in args.in_bundles:
tmp_sft = load_tractogram_with_reference(parser, args, name)
tmp_sft.to_vox()
tmp_sft.to_corner()
if not is_header_compatible(reference_file, tmp_sft):
raise ValueError('Headers are not compatible.')
sft_list.append(tmp_sft)
fusion_streamlines.append(tmp_sft.streamlines)
fusion_streamlines, _ = union_robust(fusion_streamlines)
transformation, dimensions, _, _ = get_reference_info(reference_file)
volume = np.zeros(dimensions)
streamlines_vote = dok_matrix(
(len(fusion_streamlines), len(args.in_bundles)))
for i in range(len(args.in_bundles)):
sft = sft_list[i]
binary = compute_tract_counts_map(sft.streamlines, dimensions)
volume[binary > 0] += 1
if args.same_tractogram:
_, indices = intersection_robust(
[fusion_streamlines, sft.streamlines])
streamlines_vote[list(indices), [i]] += 1
if args.same_tractogram:
real_indices = []
ratio_value = int(args.ratio_streamlines * len(args.in_bundles))
real_indices = np.where(
np.sum(streamlines_vote, axis=1) >= ratio_value)[0]
new_sft = StatefulTractogram.from_sft(fusion_streamlines[real_indices],
sft_list[0])
save_tractogram(new_sft, output_streamlines_filename)
volume[volume < int(args.ratio_voxels * len(args.in_bundles))] = 0
volume[volume > 0] = 1
nib.save(nib.Nifti1Image(volume.astype(np.uint8), transformation),
output_voxels_filename)
def _compute_streamline_mean(cur_ind, cur_min, cur_max, data):
# From the precomputed indices, compute the binary map
# and use it to weight the metric data for this specific streamline.
cur_range = tuple(cur_max - cur_min)
streamline_density = compute_tract_counts_map(ArraySequence([cur_ind]),
cur_range)
streamline_data = data[cur_min[0]:cur_max[0], cur_min[1]:cur_max[1],
cur_min[2]:cur_max[2]]
streamline_average = np.average(streamline_data,
weights=streamline_density)
return streamline_average
def compute_gt_masks(gt_bundles, parser, args):
"""
Compute ground-truth masks. If the ground-truth is
already a mask, load it. If the ground-truth is a
bundle, compute the mask.
Parameters
----------
gt_bundles: list
List of either StatefulTractograms or niftis.
parser: ArgumentParser
Argument parser which handles the script's arguments.
args: Namespace
List of arguments passed to the script.
Returns
-------
mask_1: numpy.ndarray
"Head" of the mask.
mask_2: numpy.ndarray
"Tail" of the mask.
"""
gt_bundle_masks = []
gt_bundle_inv_masks = []
for gt_bundle in args.gt_bundles:
# Support ground truth as streamlines or masks
# Will be converted to binary masks immediately
_, ext = split_name_with_nii(gt_bundle)
if ext in ['.gz', '.nii.gz']:
gt_img = nib.load(gt_bundle)
gt_mask = get_data_as_mask(gt_img)
affine = gt_img.affine
dimensions = gt_mask.shape
else:
gt_sft = load_tractogram_with_reference(parser,
args,
gt_bundle,
bbox_check=False)
gt_sft.to_vox()
gt_sft.to_corner()
affine, dimensions, _, _ = gt_sft.space_attributes
gt_mask = compute_tract_counts_map(gt_sft.streamlines,
dimensions).astype(np.int16)
gt_inv_mask = np.zeros(dimensions, dtype=np.int16)
gt_inv_mask[gt_mask == 0] = 1
gt_mask[gt_mask > 0] = 1
gt_bundle_masks.append(gt_mask)
gt_bundle_inv_masks.append(gt_inv_mask)
return gt_bundle_masks, gt_bundle_inv_masks, affine, dimensions
def main():
parser = _build_arg_parser()
args = parser.parse_args()
assert_inputs_exist(parser,
[args.in_bundle, args.in_centroid],
optional=args.reference)
assert_outputs_exist(parser, args, args.out_map)
sft_bundle = load_tractogram_with_reference(parser, args, args.in_bundle)
sft_centroid = load_tractogram_with_reference(parser, args,
args.in_centroid)
if not len(sft_bundle.streamlines):
logging.error('Empty bundle file {}. '
'Skipping'.format(args.in_bundle))
raise ValueError
if not len(sft_centroid.streamlines):
logging.error('Centroid file {} should contain one streamline. '
'Skipping'.format(args.in_centroid))
raise ValueError
sft_bundle.to_vox()
bundle_streamlines_vox = sft_bundle.streamlines
bundle_streamlines_vox._data *= args.upsample
sft_centroid.to_vox()
centroid_streamlines_vox = sft_centroid.streamlines
centroid_streamlines_vox._data *= args.upsample
upsampled_shape = [s * args.upsample for s in sft_bundle.dimensions]
tdi_mask = compute_tract_counts_map(bundle_streamlines_vox,
upsampled_shape) > 0
tdi_mask_nzr = np.nonzero(tdi_mask)
tdi_mask_nzr_ind = np.transpose(tdi_mask_nzr)
min_dist_ind, _ = min_dist_to_centroid(tdi_mask_nzr_ind,
centroid_streamlines_vox[0])
# Save the (upscaled) labels mask
labels_mask = np.zeros(tdi_mask.shape)
labels_mask[tdi_mask_nzr] = min_dist_ind + 1 # 0 is background value
rescaled_affine = sft_bundle.affine
rescaled_affine[:3, :3] /= args.upsample
labels_img = nib.Nifti1Image(labels_mask, rescaled_affine)
upsampled_spacing = sft_bundle.voxel_sizes / args.upsample
labels_img.header.set_zooms(upsampled_spacing)
nib.save(labels_img, args.out_map)
def get_binary_maps(streamlines, sft):
"""
Extract a mask from a bundle
Parameters
----------
streamlines: list
List of streamlines.
dimensions: tuple of ints
Dimensions of the mask.
sft : StatefulTractogram
Reference tractogram.
invalid: bool
If true, remove invalid streamlines from tractogram.
Returns
-------
bundles_voxels: numpy.ndarray
Mask representing the bundle volume.
endpoints_voxels: numpy.ndarray
Mask representing the bundle's endpoints.
"""
dimensions = sft.dimensions
if not len(streamlines):
return np.zeros(dimensions), np.zeros(dimensions)
elif len(streamlines) == 1:
streamlines = [streamlines]
tmp_sft = StatefulTractogram.from_sft(streamlines, sft)
tmp_sft.to_vox()
tmp_sft.to_corner()
if len(tmp_sft) == 1:
return np.zeros(dimensions), np.zeros(dimensions)
bundles_voxels = compute_tract_counts_map(tmp_sft.streamlines,
dimensions).astype(np.int16)
endpoints_voxels = get_endpoints_density_map(tmp_sft.streamlines,
dimensions).astype(np.int16)
bundles_voxels[bundles_voxels > 0] = 1
endpoints_voxels[endpoints_voxels > 0] = 1
return bundles_voxels, endpoints_voxels
def plot_glass_brain(args, sft, img, output_filenames):
sft.to_vox()
sft.to_corner()
_, dimensions, _, _ = sft.space_attributes
data = compute_tract_counts_map(sft.streamlines, dimensions)
data[data > 100] = 100
img = nib.Nifti1Image(data, img.affine)
axes = 'yz'
if args.right:
axes = 'r' + axes
else:
axes = 'l' + axes
for i, axe in enumerate(axes):
display = plotting.plot_glass_brain(img,
black_bg=True,
display_mode=axe,
alpha=0.5)
display.savefig(output_filenames[i], dpi=300)
def compute_measures(filename_tuple):
sft = load_tractogram(filename_tuple[0], filename_tuple[1])
_, dimensions, voxel_size, _ = sft.space_attributes
nbr_streamlines = len(sft)
if not nbr_streamlines:
logging.warning('{} is empty'.format(filename_tuple[0]))
return dict(
zip([
'volume', 'volume_endpoints', 'streamlines_count',
'avg_length', 'std_length', 'min_length', 'max_length',
'mean_curvature'
], [0, 0, 0, 0, 0, 0, 0, 0]))
length_list = list(length(list(sft.streamlines)))
length_avg = float(np.average(length_list))
length_std = float(np.std(length_list))
length_min = float(np.min(length_list))
length_max = float(np.max(length_list))
sft.to_vox()
sft.to_corner()
streamlines = sft.streamlines
density = compute_tract_counts_map(streamlines, dimensions)
endpoints_density = get_endpoints_density_map(streamlines, dimensions)
curvature_list = np.zeros((nbr_streamlines, ))
for i in range(nbr_streamlines):
curvature_list[i] = mean_curvature(sft.streamlines[i])
return dict(
zip([
'volume', 'volume_endpoints', 'streamlines_count', 'avg_length',
'std_length', 'min_length', 'max_length', 'mean_curvature'
], [
np.count_nonzero(density) * np.product(voxel_size),
np.count_nonzero(endpoints_density) * np.product(voxel_size),
nbr_streamlines, length_avg, length_std, length_min, length_max,
float(np.mean(curvature_list))
]))
def main():
parser = _build_arg_parser()
args = parser.parse_args()
assert_inputs_exist(parser, args.in_bundle, optional=args.reference)
sft = load_tractogram_with_reference(parser, args, args.in_bundle)
sft.to_vox()
sft.to_corner()
bundle_name, _ = os.path.splitext(os.path.basename(args.in_bundle))
stats = {bundle_name: {}}
if len(sft.streamlines) == 0:
stats[bundle_name]['volume'] = None
print(json.dumps(stats, indent=args.indent, sort_keys=args.sort_keys))
return
tdi = compute_tract_counts_map(sft.streamlines, tuple(sft.dimensions))
voxel_volume = np.prod(np.prod(sft.voxel_sizes))
stats[bundle_name]['volume'] = np.count_nonzero(tdi) * voxel_volume
print(json.dumps(stats, indent=args.indent, sort_keys=args.sort_keys))
def get_bundle_metrics_mean_std(streamlines,
metrics_files,
density_weighting=True):
"""
Returns the mean value of each metric for the whole bundle, only
considering voxels that are crossed by streamlines. The mean values are
weighted by the number of streamlines crossing a voxel by default.
If false, every voxel traversed by a streamline has the same weight.
Parameters
------------
streamlines : list of numpy.ndarray
Input streamlines under which to compute stats.
metrics_files : sequence
list of nibabel objects representing the metrics files
density_weighting : bool
weigh by the mean by the density of streamlines going through the voxel
Returns
---------
stats : list
list of tuples where the first element of the tuple is the mean
of a metric, and the second element is the standard deviation, for each
metric.
"""
# Compute weighting matrix taking the possible compression into account
anat_dim = metrics_files[0].header.get_data_shape()
weights = compute_tract_counts_map(streamlines, anat_dim)
if not density_weighting:
weights = weights > 0
return map(
lambda metric_file: weighted_mean_stddev(
weights,
metric_file.get_data().astype(np.float64)), metrics_files)
def _processing_wrapper(args):
hdf5_filename = args[0]
labels_img = args[1]
in_label, out_label = args[2]
measures_to_compute = copy.copy(args[3])
if args[4] is not None:
similarity_directory = args[4][0]
weighted = args[5]
include_dps = args[6]
min_lesion_vol = args[7]
hdf5_file = h5py.File(hdf5_filename, 'r')
key = '{}_{}'.format(in_label, out_label)
if key not in hdf5_file:
return
streamlines = reconstruct_streamlines_from_hdf5(hdf5_file, key)
if len(streamlines) == 0:
return
affine, dimensions, voxel_sizes, _ = get_reference_info(labels_img)
measures_to_return = {}
if not (np.allclose(hdf5_file.attrs['affine'], affine, atol=1e-03)
and np.array_equal(hdf5_file.attrs['dimensions'], dimensions)):
raise ValueError('Provided hdf5 have incompatible headers.')
# Precompute to save one transformation, insert later
if 'length' in measures_to_compute:
streamlines_copy = list(streamlines)
# scil_decompose_connectivity.py requires isotropic voxels
mean_length = np.average(length(streamlines_copy))*voxel_sizes[0]
# If density is not required, do not compute it
# Only required for volume, similarity and any metrics
if not ((len(measures_to_compute) == 1 and
('length' in measures_to_compute or
'streamline_count' in measures_to_compute)) or
(len(measures_to_compute) == 2 and
('length' in measures_to_compute and
'streamline_count' in measures_to_compute))):
density = compute_tract_counts_map(streamlines,
dimensions)
if 'volume' in measures_to_compute:
measures_to_return['volume'] = np.count_nonzero(density) * \
np.prod(voxel_sizes)
measures_to_compute.remove('volume')
if 'streamline_count' in measures_to_compute:
measures_to_return['streamline_count'] = len(streamlines)
measures_to_compute.remove('streamline_count')
if 'length' in measures_to_compute:
measures_to_return['length'] = mean_length
measures_to_compute.remove('length')
if 'similarity' in measures_to_compute and similarity_directory:
density_sim = load_node_nifti(similarity_directory,
in_label, out_label,
labels_img)
if density_sim is None:
ba_vox = 0
else:
ba_vox = compute_bundle_adjacency_voxel(density, density_sim)
measures_to_return['similarity'] = ba_vox
measures_to_compute.remove('similarity')
for measure in measures_to_compute:
# Maps
if isinstance(measure, str) and os.path.isdir(measure):
map_dirname = measure
map_data = load_node_nifti(map_dirname,
in_label, out_label,
labels_img)
measures_to_return[map_dirname] = np.average(
map_data[map_data > 0])
elif isinstance(measure, tuple):
if not isinstance(measure[0], tuple) \
and os.path.isfile(measure[0]):
metric_filename = measure[0]
metric_img = measure[1]
if not is_header_compatible(metric_img, labels_img):
logging.error('{} do not have a compatible header'.format(
metric_filename))
raise IOError
metric_data = metric_img.get_fdata(dtype=np.float64)
if weighted:
avg_value = np.average(metric_data, weights=density)
else:
avg_value = np.average(metric_data[density > 0])
measures_to_return[metric_filename] = avg_value
# lesion
else:
lesion_filename = measure[0][0]
computed_lesion_labels = measure[0][1]
lesion_img = measure[1]
if not is_header_compatible(lesion_img, labels_img):
logging.error('{} do not have a compatible header'.format(
lesion_filename))
raise IOError
voxel_sizes = lesion_img.header.get_zooms()[0:3]
lesion_img.set_filename('tmp.nii.gz')
lesion_atlas = get_data_as_label(lesion_img)
tmp_dict = compute_lesion_stats(
density.astype(bool), lesion_atlas,
voxel_sizes=voxel_sizes, single_label=True,
min_lesion_vol=min_lesion_vol,
precomputed_lesion_labels=computed_lesion_labels)
tmp_ind = _streamlines_in_mask(list(streamlines),
lesion_atlas.astype(np.uint8),
np.eye(3), [0, 0, 0])
streamlines_count = len(
np.where(tmp_ind == [0, 1][True])[0].tolist())
if tmp_dict:
measures_to_return[lesion_filename+'vol'] = \
tmp_dict['lesion_total_volume']
measures_to_return[lesion_filename+'count'] = \
tmp_dict['lesion_count']
measures_to_return[lesion_filename+'sc'] = \
streamlines_count
else:
measures_to_return[lesion_filename+'vol'] = 0
measures_to_return[lesion_filename+'count'] = 0
measures_to_return[lesion_filename+'sc'] = 0
if include_dps:
for dps_key in hdf5_file[key].keys():
if dps_key not in ['data', 'offsets', 'lengths']:
out_file = os.path.join(include_dps, dps_key)
if 'commit' in dps_key:
measures_to_return[out_file] = np.sum(
hdf5_file[key][dps_key])
else:
measures_to_return[out_file] = np.average(
hdf5_file[key][dps_key])
return {(in_label, out_label): measures_to_return}
def compute_measures(filename_tuple):
sft = load_tractogram(filename_tuple[0], filename_tuple[1])
_, dimensions, voxel_size, _ = sft.space_attributes
uniformize_bundle_sft(sft)
nbr_streamlines = len(sft)
if not nbr_streamlines:
logging.warning('{} is empty'.format(filename_tuple[0]))
return dict(
zip([
'volume', 'volume_endpoints', 'streamlines_count',
'avg_length', 'std_length', 'min_length', 'max_length', 'span',
'curl', 'diameter', 'elongation', 'surface_area',
'end_surface_area_head', 'end_surface_area_tail',
'radius_head', 'radius_tail', 'irregularity',
'irregularity_of_end_surface_head',
'irregularity_of_end_surface_tail', 'mean_curvature',
'fractal_dimension'
], [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0
]))
streamline_cords = list(sft.streamlines)
length_list = list(length(streamline_cords))
length_avg = float(np.average(length_list))
length_std = float(np.std(length_list))
length_min = float(np.min(length_list))
length_max = float(np.max(length_list))
sft.to_vox()
sft.to_corner()
streamlines = sft.streamlines
density = compute_tract_counts_map(streamlines, dimensions)
endpoints_density = get_endpoints_density_map(streamlines, dimensions)
span_list = list(map(compute_span, streamline_cords))
span = float(np.average(span_list))
curl = length_avg / span
volume = np.count_nonzero(density) * np.product(voxel_size)
diameter = 2 * np.sqrt(volume / (np.pi * length_avg))
elon = length_avg / diameter
roi = np.where(density != 0, 1, density)
surf_area = approximate_surface_node(roi) * (voxel_size[0]**2)
irregularity = surf_area / (np.pi * diameter * length_avg)
endpoints_map_head, endpoints_map_tail = \
get_head_tail_density_maps(sft.streamlines, dimensions)
endpoints_map_head_roi = \
np.where(endpoints_map_head != 0, 1, endpoints_map_head)
endpoints_map_tail_roi = \
np.where(endpoints_map_tail != 0, 1, endpoints_map_tail)
end_sur_area_head = \
approximate_surface_node(endpoints_map_head_roi) * (voxel_size[0] ** 2)
end_sur_area_tail = \
approximate_surface_node(endpoints_map_tail_roi) * (voxel_size[0] ** 2)
endpoints_coords_head = np.array(np.where(endpoints_map_head_roi)).T
endpoints_coords_tail = np.array(np.where(endpoints_map_tail_roi)).T
radius_head = 1.5 * np.average(
np.sqrt(((endpoints_coords_head -
np.average(endpoints_coords_head, axis=0))**2).sum(axis=1)))
radius_tail = 1.5 * np.average(
np.sqrt(((endpoints_coords_tail -
np.average(endpoints_coords_tail, axis=0))**2).sum(axis=1)))
end_irreg_head = (np.pi * radius_head**2) / end_sur_area_head
end_irreg_tail = (np.pi * radius_tail**2) / end_sur_area_tail
fractal_dimension = compute_fractal_dimension(density)
curvature_list = np.zeros((nbr_streamlines, ))
for i in range(nbr_streamlines):
curvature_list[i] = mean_curvature(sft.streamlines[i])
return dict(
zip([
'volume', 'volume_endpoints', 'streamlines_count', 'avg_length',
'std_length', 'min_length', 'max_length', 'span', 'curl',
'diameter', 'elongation', 'surface_area', 'end_surface_area_head',
'end_surface_area_tail', 'radius_head', 'radius_tail',
'irregularity', 'irregularity_of_end_surface_head',
'irregularity_of_end_surface_tail', 'mean_curvature',
'fractal_dimension'
], [
volume,
np.count_nonzero(endpoints_density) * np.product(voxel_size),
nbr_streamlines, length_avg, length_std, length_min, length_max,
span, curl, diameter, elon, surf_area, end_sur_area_head,
end_sur_area_tail, radius_head, radius_tail, irregularity,
end_irreg_head, end_irreg_tail,
float(np.mean(curvature_list)), fractal_dimension
]))
def load_data_tmp_saving(args):
filename = args[0]
reference = args[1]
init_only = args[2]
disable_centroids = args[3]
# Since data is often re-use when comparing multiple bundles, anything
# that can be computed once is saved temporarily and simply loaded on demand
hash_tmp = hashlib.md5(filename.encode()).hexdigest()
tmp_density_filename = os.path.join('tmp_measures/',
'{}_density.nii.gz'.format(hash_tmp))
tmp_endpoints_filename = os.path.join('tmp_measures/',
'{}_endpoints.nii.gz'.format(hash_tmp))
tmp_centroids_filename = os.path.join('tmp_measures/',
'{}_centroids.trk'.format(hash_tmp))
sft = load_tractogram(filename, reference)
sft.to_vox()
sft.to_corner()
streamlines = sft.get_streamlines_copy()
if not streamlines:
if init_only:
logging.warning('{} is empty'.format(filename))
return None
if os.path.isfile(tmp_density_filename) \
and os.path.isfile(tmp_endpoints_filename) \
and os.path.isfile(tmp_centroids_filename):
# If initilization, loading the data is useless
if init_only:
return None
density = nib.load(tmp_density_filename).get_fdata(dtype=np.float32)
endpoints_density = nib.load(tmp_endpoints_filename).get_fdata(dtype=np.float32)
sft_centroids = load_tractogram(tmp_centroids_filename, reference)
sft_centroids.to_vox()
sft_centroids.to_corner()
centroids = sft_centroids.get_streamlines_copy()
else:
transformation, dimensions, _, _ = sft.space_attributes
density = compute_tract_counts_map(streamlines, dimensions)
endpoints_density = get_endpoints_density_map(streamlines, dimensions,
point_to_select=3)
thresholds = [32, 24, 12, 6]
if disable_centroids:
centroids = []
else:
centroids = qbx_and_merge(streamlines, thresholds,
rng=RandomState(0),
verbose=False).centroids
# Saving tmp files to save on future computation
nib.save(nib.Nifti1Image(density.astype(np.float32), transformation),
tmp_density_filename)
nib.save(nib.Nifti1Image(endpoints_density.astype(np.int16),
transformation),
tmp_endpoints_filename)
# Saving in vox space and corner.
centroids_sft = StatefulTractogram.from_sft(centroids, sft)
save_tractogram(centroids_sft, tmp_centroids_filename)
return density, endpoints_density, streamlines, centroids
def main():
parser = _build_arg_parser()
args = parser.parse_args()
if args.verbose:
logging.basicConfig(level=logging.INFO)
assert_inputs_exist(parser, args.in_bundles)
assert_outputs_exist(parser, args, args.out_json)
if (not args.streamlines_measures) and (not args.voxels_measures):
parser.error('At least one of the two modes is needed')
nbr_cpu = validate_nbr_processes(parser, args)
all_binary_metrics = []
bundles_references_tuple_extended = link_bundles_and_reference(
parser, args, args.in_bundles)
if args.streamlines_measures:
# Gold standard related indices are computed once
wb_sft = load_tractogram_with_reference(parser, args,
args.streamlines_measures[1])
wb_sft.to_vox()
wb_sft.to_corner()
wb_streamlines = wb_sft.streamlines
gs_sft = load_tractogram_with_reference(parser, args,
args.streamlines_measures[0])
gs_sft.to_vox()
gs_sft.to_corner()
gs_streamlines = gs_sft.streamlines
_, gs_dimensions, _, _ = gs_sft.space_attributes
# Prepare the gold standard only once
_, gs_streamlines_indices = perform_streamlines_operation(
intersection, [wb_streamlines, gs_streamlines], precision=0)
if nbr_cpu == 1:
streamlines_dict = []
for i in bundles_references_tuple_extended:
streamlines_dict.append(
compute_streamlines_measures(
[i, wb_streamlines, gs_streamlines_indices]))
else:
pool = multiprocessing.Pool(nbr_cpu)
streamlines_dict = pool.map(
compute_streamlines_measures,
zip(bundles_references_tuple_extended,
itertools.repeat(wb_streamlines),
itertools.repeat(gs_streamlines_indices)))
pool.close()
pool.join()
all_binary_metrics.extend(streamlines_dict)
if not args.voxels_measures:
gs_binary_3d = compute_tract_counts_map(gs_streamlines, gs_dimensions)
gs_binary_3d[gs_binary_3d > 0] = 1
tracking_mask_data = compute_tract_counts_map(wb_streamlines,
gs_dimensions)
tracking_mask_data[tracking_mask_data > 0] = 1
else:
gs_binary_3d = get_data_as_mask(nib.load(args.voxels_measures[0]))
gs_binary_3d[gs_binary_3d > 0] = 1
tracking_mask_data = get_data_as_mask(nib.load(
args.voxels_measures[1]))
tracking_mask_data[tracking_mask_data > 0] = 1
if nbr_cpu == 1:
voxels_dict = []
for i in bundles_references_tuple_extended:
voxels_dict.append(
compute_voxel_measures([i, tracking_mask_data, gs_binary_3d]))
else:
voxels_dict = pool.map(
compute_voxel_measures,
zip(bundles_references_tuple_extended,
itertools.repeat(tracking_mask_data),
itertools.repeat(gs_binary_3d)))
pool.close()
pool.join()
all_binary_metrics.extend(voxels_dict)
# After all processing, write the json file and skip None value
output_binary_dict = {}
for binary_dict in all_binary_metrics:
if binary_dict is not None:
for measure_name in binary_dict.keys():
if measure_name not in output_binary_dict:
output_binary_dict[measure_name] = []
output_binary_dict[measure_name].append(
float(binary_dict[measure_name]))
with open(args.out_json, 'w') as outfile:
json.dump(output_binary_dict,
outfile,
indent=args.indent,
sort_keys=args.sort_keys)
def main():
parser = _build_args_parser()
args = parser.parse_args()
assert_inputs_exist(parser, args.in_bundles)
output_streamlines_filename = '{}streamlines.trk'.format(
args.output_prefix)
output_voxels_filename = '{}voxels.nii.gz'.format(args.output_prefix)
assert_outputs_exist(parser, args,
[output_voxels_filename, output_streamlines_filename])
if not 0 <= args.ratio_voxels <= 1 or not 0 <= args.ratio_streamlines <= 1:
parser.error('Ratios must be between 0 and 1.')
fusion_streamlines = []
for name in args.in_bundles:
fusion_streamlines.extend(
load_tractogram_with_reference(parser, args, name).streamlines)
fusion_streamlines, _ = perform_streamlines_operation(
union, [fusion_streamlines], 0)
fusion_streamlines = ArraySequence(fusion_streamlines)
if args.reference:
reference_file = args.reference
else:
reference_file = args.in_bundles[0]
transformation, dimensions, _, _ = get_reference_info(reference_file)
volume = np.zeros(dimensions)
streamlines_vote = dok_matrix(
(len(fusion_streamlines), len(args.in_bundles)))
for i, name in enumerate(args.in_bundles):
if not is_header_compatible(reference_file, name):
raise ValueError('Both headers are not the same')
sft = load_tractogram_with_reference(parser, args, name)
bundle = sft.get_streamlines_copy()
sft.to_vox()
bundle_vox_space = sft.get_streamlines_copy()
binary = compute_tract_counts_map(bundle_vox_space, dimensions)
volume[binary > 0] += 1
if args.same_tractogram:
_, indices = perform_streamlines_operation(
intersection, [fusion_streamlines, bundle], 0)
streamlines_vote[list(indices), i] += 1
if args.same_tractogram:
real_indices = []
for i in range(len(fusion_streamlines)):
ratio_value = int(args.ratio_streamlines * len(args.in_bundles))
if np.sum(streamlines_vote[i]) >= ratio_value:
real_indices.append(i)
new_streamlines = fusion_streamlines[real_indices]
sft = StatefulTractogram(new_streamlines, reference_file, Space.RASMM)
save_tractogram(sft, output_streamlines_filename)
volume[volume < int(args.ratio_streamlines * len(args.in_bundles))] = 0
volume[volume > 0] = 1
nib.save(nib.Nifti1Image(volume.astype(np.uint8), transformation),
output_voxels_filename)
def _processing_wrapper(args):
bundles_dir = args[0]
in_label, out_label = args[1]
measures_to_compute = copy.copy(args[2])
weighted = args[3]
if args[4] is not None:
similarity_directory = args[4][0]
in_filename_1 = os.path.join(bundles_dir,
'{}_{}.trk'.format(in_label, out_label))
in_filename_2 = os.path.join(bundles_dir,
'{}_{}.trk'.format(out_label, in_label))
if os.path.isfile(in_filename_1):
in_filename = in_filename_1
elif os.path.isfile(in_filename_2):
in_filename = in_filename_2
else:
return
sft = load_tractogram(in_filename, 'same')
affine, dimensions, voxel_sizes, _ = sft.space_attributes
measures_to_return = {}
# Precompute to save one transformation, insert later
if 'length' in measures_to_compute:
streamlines_copy = list(sft.get_streamlines_copy())
mean_length = np.average(length(streamlines_copy))
# If density is not required, do not compute it
# Only required for volume, similarity and any metrics
if not ((len(measures_to_compute) == 1 and
('length' in measures_to_compute
or 'streamline_count' in measures_to_compute)) or
(len(measures_to_compute) == 2 and
('length' in measures_to_compute
and 'streamline_count' in measures_to_compute))):
sft.to_vox()
sft.to_corner()
density = compute_tract_counts_map(sft.streamlines, dimensions)
if 'volume' in measures_to_compute:
measures_to_return['volume'] = np.count_nonzero(density) * \
np.prod(voxel_sizes)
measures_to_compute.remove('volume')
if 'streamline_count' in measures_to_compute:
measures_to_return['streamline_count'] = len(sft)
measures_to_compute.remove('streamline_count')
if 'length' in measures_to_compute:
measures_to_return['length'] = mean_length
measures_to_compute.remove('length')
if 'similarity' in measures_to_compute and similarity_directory:
density_sim = load_node_nifti(similarity_directory, in_label,
out_label, in_filename)
ba_vox = compute_bundle_adjacency_voxel(density, density_sim)
measures_to_return['similarity'] = ba_vox
measures_to_compute.remove('similarity')
for measure in measures_to_compute:
if os.path.isdir(measure):
map_dirname = measure
map_data = load_node_nifti(map_dirname, in_label, out_label,
in_filename)
measures_to_return[map_dirname] = np.average(
map_data[map_data > 0])
elif os.path.isfile(measure):
metric_filename = measure
if not is_header_compatible(metric_filename, sft):
logging.error(
'{} and {} do not have a compatible header'.format(
in_filename, metric_filename))
raise IOError
metric_data = nib.load(metric_filename).get_data()
if weighted:
density = density / np.max(density)
voxels_value = metric_data * density
voxels_value = voxels_value[voxels_value > 0]
else:
voxels_value = metric_data[density > 0]
measures_to_return[metric_filename] = np.average(voxels_value)
return {(in_label, out_label): measures_to_return}
def main():
parser = _build_arg_parser()
args = parser.parse_args()
set_sft_logger_level('ERROR')
assert_inputs_exist(parser, [args.in_bundle, args.in_centroid],
optional=args.reference)
assert_outputs_exist(parser,
args,
args.out_labels_map,
optional=[
args.out_labels_npz, args.out_distances_npz,
args.labels_color_dpp, args.distances_color_dpp
])
sft_bundle = load_tractogram_with_reference(parser, args, args.in_bundle)
sft_centroid = load_tractogram_with_reference(parser, args,
args.in_centroid)
if not len(sft_bundle.streamlines):
logging.error('Empty bundle file {}. '
'Skipping'.format(args.in_bundle))
raise ValueError
if len(sft_centroid.streamlines) < 1 \
or len(sft_centroid.streamlines) > 1:
logging.error('Centroid file {} should contain one streamline. '
'Skipping'.format(args.in_centroid))
raise ValueError
if not is_header_compatible(sft_centroid, sft_bundle):
raise IOError('{} and {}do not have a compatible header'.format(
args.in_centroid, args.in_bundle))
sft_bundle.to_vox()
sft_bundle.to_corner()
# Slightly cut the bundle at the edgge to clean up single streamline voxels
# with no neighbor. Remove isolated voxels to keep a single 'blob'
binary_bundle = compute_tract_counts_map(
sft_bundle.streamlines, sft_bundle.dimensions).astype(bool)
structure = ndi.generate_binary_structure(3, 1)
if np.count_nonzero(binary_bundle) > args.min_voxel_count \
and len(sft_bundle) > args.min_streamline_count:
binary_bundle = ndi.binary_dilation(binary_bundle,
structure=np.ones((3, 3, 3)))
binary_bundle = ndi.binary_erosion(binary_bundle,
structure=structure,
iterations=2)
bundle_disjoint, _ = ndi.label(binary_bundle)
unique, count = np.unique(bundle_disjoint, return_counts=True)
val = unique[np.argmax(count[1:]) + 1]
binary_bundle[bundle_disjoint != val] = 0
# Chop off some streamlines
cut_sft = cut_outside_of_mask_streamlines(sft_bundle, binary_bundle)
else:
cut_sft = sft_bundle
if args.nb_pts is not None:
sft_centroid = resample_streamlines_num_points(sft_centroid,
args.nb_pts)
else:
args.nb_pts = len(sft_centroid.streamlines[0])
# Generate a centroids labels mask for the centroid alone
sft_centroid.to_vox()
sft_centroid.to_corner()
sft_centroid = _affine_slr(sft_bundle, sft_centroid)
# Map every streamlines points to the centroids
binary_centroid = compute_tract_counts_map(
sft_centroid.streamlines, sft_centroid.dimensions).astype(bool)
# TODO N^2 growth in RAM, should split it if we want to do nb_pts = 100
min_dist_label, min_dist = min_dist_to_centroid(
cut_sft.streamlines._data, sft_centroid.streamlines._data)
min_dist_label += 1 # 0 means no labels
# It is not allowed that labels jumps labels for consistency
# Streamlines should have continous labels
curr_ind = 0
final_streamlines = []
final_label = []
final_dist = []
for i, streamline in enumerate(cut_sft.streamlines):
next_ind = curr_ind + len(streamline)
curr_labels = min_dist_label[curr_ind:next_ind]
curr_dist = min_dist[curr_ind:next_ind]
curr_ind = next_ind
# Flip streamlines so the labels increase (facilitate if/else)
# Should always be ordered in nextflow pipeline
gradient = np.gradient(curr_labels)
if len(np.argwhere(gradient < 0)) > len(np.argwhere(gradient > 0)):
streamline = streamline[::-1]
curr_labels = curr_labels[::-1]
curr_dist = curr_dist[::-1]
# Find jumps, cut them and find the longest
gradient = np.ediff1d(curr_labels)
max_jump = max(args.nb_pts // 5, 1)
if len(np.argwhere(np.abs(gradient) > max_jump)) > 0:
pos_jump = np.where(np.abs(gradient) > max_jump)[0] + 1
split_chunk = np.split(curr_labels, pos_jump)
max_len = 0
max_pos = 0
for j, chunk in enumerate(split_chunk):
if len(chunk) > max_len:
max_len = len(chunk)
max_pos = j
curr_labels = split_chunk[max_pos]
gradient_chunk = np.ediff1d(chunk)
if len(np.unique(np.sign(gradient_chunk))) > 1:
continue
streamline = np.split(streamline, pos_jump)[max_pos]
curr_dist = np.split(curr_dist, pos_jump)[max_pos]
final_streamlines.append(streamline)
final_label.append(curr_labels)
final_dist.append(curr_dist)
# Re-arrange the new cut streamlines and their metadata
# Compute the voxels equivalent of the labels maps
new_sft = StatefulTractogram.from_sft(final_streamlines, sft_bundle)
tdi_mask_nzr = np.nonzero(binary_bundle)
tdi_mask_nzr_ind = np.transpose(tdi_mask_nzr)
min_dist_ind, _ = min_dist_to_centroid(tdi_mask_nzr_ind,
sft_centroid.streamlines[0])
img_labels = np.zeros(binary_centroid.shape, dtype=np.int16)
img_labels[tdi_mask_nzr] = min_dist_ind + 1 # 0 is background value
nib.save(nib.Nifti1Image(img_labels, sft_bundle.affine),
args.out_labels_map)
if args.labels_color_dpp or args.distances_color_dpp \
or args.out_labels_npz or args.out_distances_npz:
labels_array = ArraySequence(final_label)
dist_array = ArraySequence(final_dist)
# WARNING: WILL NOT WORK WITH THE INPUT TRK !
# These will fit only with the TRK saved below.
if args.out_labels_npz:
np.savez_compressed(args.out_labels_npz, labels_array._data)
if args.out_distances_npz:
np.savez_compressed(args.out_distances_npz, dist_array._data)
cmap = plt.get_cmap(args.colormap)
new_sft.data_per_point['color'] = ArraySequence(new_sft.streamlines)
# Nicer visualisation for MI-Brain
if args.labels_color_dpp:
new_sft.data_per_point['color']._data = cmap(
labels_array._data / np.max(labels_array._data))[:, 0:3] * 255
save_tractogram(new_sft, args.labels_color_dpp)
if args.distances_color_dpp:
new_sft.data_per_point['color']._data = cmap(
dist_array._data / np.max(dist_array._data))[:, 0:3] * 255
save_tractogram(new_sft, args.distances_color_dpp)
def get_bundle_metrics_mean_std_per_point(streamlines,
bundle_name,
distances_to_centroid_streamline,
metrics,
labels,
density_weighting=False,
distance_weighting=False):
"""
Compute the mean and std PER POiNT of the bundle for every given metric.
Parameters
----------
streamlines: list of numpy.ndarray
Input streamlines under which to compute stats.
bundle_name: str
Name of the bundle. Will be used as a key in the dictionary.
distances_to_centroid_streamline: np.ndarray
List of distances obtained with scil_label_and_distance_maps.py
metrics: sequence
list of nibabel objects representing the metrics files
labels: np.ndarray
List of labels obtained with scil_label_and_distance_maps.py
density_weighting: bool
If true, weight statistics by the number of streamlines passing through
each voxel. [False]
distance_weighting: bool
If true, weight statistics by the inverse of the distance between a
streamline and the centroid.
Returns
-------
stats
"""
# Computing infos on bundle
unique_labels = np.unique(labels)
num_digits_labels = len(str(np.max(unique_labels)))
if density_weighting:
track_count = compute_tract_counts_map(
streamlines, metrics[0].shape).astype(np.float64)
else:
track_count = np.ones(metrics[0].shape)
# Bigger weight near the centroid streamline
distances_to_centroid_streamline = 1.0 / distances_to_centroid_streamline
# Keep data as int to get the underlying voxel
bundle_data_int = streamlines.data.astype(np.int)
# Get stats
stats = {bundle_name: {}}
for metric in metrics:
metric_data = metric.get_fdata()
current_metric_fname, _ = split_name_with_nii(
os.path.basename(metric.get_filename()))
stats[bundle_name][current_metric_fname] = {}
for i in unique_labels:
number_key = '{}'.format(i).zfill(num_digits_labels)
label_stats = {}
stats[bundle_name][current_metric_fname][number_key] = label_stats
label_indices = bundle_data_int[labels == i]
label_metric = metric_data[label_indices[:, 0],
label_indices[:, 1], label_indices[:,
2]]
track_weight = track_count[label_indices[:, 0],
label_indices[:, 1], label_indices[:,
2]]
label_weight = track_weight
if distance_weighting:
label_weight *= distances_to_centroid_streamline[labels == i]
if np.sum(label_weight) == 0:
logging.warning('Weights sum to zero, can\'t be normalized. '
'Disabling weighting')
label_weight = None
label_mean = np.average(label_metric, weights=label_weight)
label_std = np.sqrt(
np.average((label_metric - label_mean)**2,
weights=label_weight))
label_stats['mean'] = float(label_mean)
label_stats['std'] = float(label_std)
return stats
def compute_masks(gt_files, parser, args):
"""
Compute ground-truth masks. If the file is already a mask, load it.
If it is a bundle, compute the mask.
Parameters
----------
gt_files: list
List of either StatefulTractograms or niftis.
parser: ArgumentParser
Argument parser which handles the script's arguments.
args: Namespace
List of arguments passed to the script.
Returns
-------
mask_1: numpy.ndarray
"Head" of the mask.
mask_2: numpy.ndarray
"Tail" of the mask.
"""
save_ref = args.reference
gt_bundle_masks = []
gt_bundle_inv_masks = []
affine = None
dimensions = None
for gt_bundle in gt_files:
if gt_bundle is not None:
# Support ground truth as streamlines or masks
# Will be converted to binary masks immediately
_, ext = split_name_with_nii(gt_bundle)
if ext in ['.gz', '.nii.gz']:
gt_img = nib.load(gt_bundle)
gt_mask = get_data_as_mask(gt_img)
if affine is not None:
# compare affines.
# todO
logging.debug('Previous affine discarded. (todo)')
affine = gt_img.affine
dimensions = gt_mask.shape
else:
# Cheating ref because it may send a lot of warning if loading
# many trk with ref (reference was maybe added only for some
# of these files)
if ext == '.trk':
args.reference = None
else:
args.reference = save_ref
gt_sft = load_tractogram_with_reference(parser,
args,
gt_bundle,
bbox_check=False)
gt_sft.to_vox()
gt_sft.to_corner()
_affine, _dimensions, _, _ = gt_sft.space_attributes
if affine is not None:
# compare affines.
# todO
logging.debug('Previous affine discarded. (todo)')
affine = _affine
dimensions = _dimensions
gt_mask = compute_tract_counts_map(gt_sft.streamlines,
dimensions).astype(np.int16)
gt_inv_mask = np.zeros(dimensions, dtype=np.int16)
gt_inv_mask[gt_mask == 0] = 1
gt_mask[gt_mask > 0] = 1
else:
gt_mask = None
gt_inv_mask = None
gt_bundle_masks.append(gt_mask)
gt_bundle_inv_masks.append(gt_inv_mask)
return gt_bundle_masks, gt_bundle_inv_masks, affine, dimensions
def _processing_wrapper(args):
hdf5_filename = args[0]
labels_img = args[1]
in_label, out_label = args[2]
measures_to_compute = copy.copy(args[3])
if args[4] is not None:
similarity_directory = args[4][0]
weighted = args[5]
include_dps = args[6]
hdf5_file = h5py.File(hdf5_filename, 'r')
key = '{}_{}'.format(in_label, out_label)
if key not in hdf5_file:
return
streamlines = reconstruct_streamlines_from_hdf5(hdf5_file, key)
affine, dimensions, voxel_sizes, _ = get_reference_info(labels_img)
measures_to_return = {}
if not (np.allclose(hdf5_file.attrs['affine'], affine, atol=1e-03)
and np.array_equal(hdf5_file.attrs['dimensions'], dimensions)):
raise ValueError('Provided hdf5 have incompatible headers.')
# Precompute to save one transformation, insert later
if 'length' in measures_to_compute:
streamlines_copy = list(streamlines)
# scil_decompose_connectivity.py requires isotropic voxels
mean_length = np.average(length(streamlines_copy)) * voxel_sizes[0]
# If density is not required, do not compute it
# Only required for volume, similarity and any metrics
if not ((len(measures_to_compute) == 1 and
('length' in measures_to_compute
or 'streamline_count' in measures_to_compute)) or
(len(measures_to_compute) == 2 and
('length' in measures_to_compute
and 'streamline_count' in measures_to_compute))):
density = compute_tract_counts_map(streamlines, dimensions)
if 'volume' in measures_to_compute:
measures_to_return['volume'] = np.count_nonzero(density) * \
np.prod(voxel_sizes)
measures_to_compute.remove('volume')
if 'streamline_count' in measures_to_compute:
measures_to_return['streamline_count'] = len(streamlines)
measures_to_compute.remove('streamline_count')
if 'length' in measures_to_compute:
measures_to_return['length'] = mean_length
measures_to_compute.remove('length')
if 'similarity' in measures_to_compute and similarity_directory:
density_sim = load_node_nifti(similarity_directory, in_label,
out_label, labels_img)
if density_sim is None:
ba_vox = 0
else:
ba_vox = compute_bundle_adjacency_voxel(density, density_sim)
measures_to_return['similarity'] = ba_vox
measures_to_compute.remove('similarity')
for measure in measures_to_compute:
if isinstance(measure, str) and os.path.isdir(measure):
map_dirname = measure
map_data = load_node_nifti(map_dirname, in_label, out_label,
labels_img)
measures_to_return[map_dirname] = np.average(
map_data[map_data > 0])
elif isinstance(measure, tuple) and os.path.isfile(measure[0]):
metric_filename = measure[0]
metric_img = measure[1]
if not is_header_compatible(metric_img, labels_img):
logging.error('{} do not have a compatible header'.format(
metric_filename))
raise IOError
metric_data = metric_img.get_fdata(dtype=np.float64)
if weighted:
density = density / np.max(density)
voxels_value = metric_data * density
voxels_value = voxels_value[voxels_value > 0]
else:
voxels_value = metric_data[density > 0]
measures_to_return[metric_filename] = np.average(voxels_value)
if include_dps:
for dps_key in hdf5_file[key].keys():
if dps_key not in ['data', 'offsets', 'lengths']:
out_file = os.path.join(include_dps, dps_key)
measures_to_return[out_file] = np.average(
hdf5_file[key][dps_key])
return {(in_label, out_label): measures_to_return}
def main():
parser = _build_arg_parser()
args = parser.parse_args()
if (not args.bundle) and (not args.bundle_mask) \
and (not args.bundle_labels_map):
parser.error('One of the option --bundle or --map must be used')
assert_inputs_exist(parser, [args.in_lesion],
optional=[args.bundle, args.bundle_mask,
args.bundle_labels_map])
assert_outputs_exist(parser, args, args.out_json,
optional=[args.out_lesion_stats,
args.out_streamlines_stats])
lesion_img = nib.load(args.in_lesion)
lesion_data = get_data_as_mask(lesion_img, dtype=bool)
if args.bundle:
bundle_name, _ = split_name_with_nii(os.path.basename(args.bundle))
sft = load_tractogram_with_reference(parser, args, args.bundle)
sft.to_vox()
sft.to_corner()
streamlines = sft.get_streamlines_copy()
map_data = compute_tract_counts_map(streamlines,
lesion_data.shape)
map_data[map_data > 0] = 1
elif args.bundle_mask:
bundle_name, _ = split_name_with_nii(
os.path.basename(args.bundle_mask))
map_img = nib.load(args.bundle_mask)
map_data = get_data_as_mask(map_img)
else:
bundle_name, _ = split_name_with_nii(os.path.basename(
args.bundle_labels_map))
map_img = nib.load(args.bundle_labels_map)
map_data = get_data_as_label(map_img)
is_single_label = args.bundle_labels_map is None
voxel_sizes = lesion_img.header.get_zooms()[0:3]
lesion_atlas, _ = ndi.label(lesion_data)
lesion_load_dict = compute_lesion_stats(
map_data, lesion_atlas, single_label=is_single_label,
voxel_sizes=voxel_sizes, min_lesion_vol=args.min_lesion_vol)
if args.out_lesion_atlas:
lesion_atlas *= map_data.astype(bool)
nib.save(nib.Nifti1Image(lesion_atlas, lesion_img.affine),
args.out_lesion_atlas)
volume_dict = {bundle_name: lesion_load_dict}
with open(args.out_json, 'w') as outfile:
json.dump(volume_dict, outfile,
sort_keys=args.sort_keys, indent=args.indent)
if args.out_streamlines_stats or args.out_lesion_stats:
lesion_dict = {}
for lesion in np.unique(lesion_atlas)[1:]:
curr_vol = np.count_nonzero(lesion_atlas[lesion_atlas == lesion]) \
* np.prod(voxel_sizes)
if curr_vol >= args.min_lesion_vol:
key = str(lesion).zfill(4)
lesion_dict[key] = {'volume': curr_vol}
if args.bundle:
tmp = np.zeros(lesion_atlas.shape)
tmp[lesion_atlas == lesion] = 1
new_sft, _ = filter_grid_roi(sft, tmp, 'any', False)
lesion_dict[key]['strs_count'] = len(new_sft)
lesion_vol_dict = {bundle_name: {}}
streamlines_count_dict = {bundle_name: {'streamlines_count': {}}}
for key in lesion_dict.keys():
lesion_vol_dict[bundle_name][key] = lesion_dict[key]['volume']
if args.bundle:
streamlines_count_dict[bundle_name]['streamlines_count'][key] = \
lesion_dict[key]['strs_count']
if args.out_lesion_stats:
with open(args.out_lesion_stats, 'w') as outfile:
json.dump(lesion_vol_dict, outfile,
sort_keys=args.sort_keys, indent=args.indent)
if args.out_streamlines_stats:
with open(args.out_streamlines_stats, 'w') as outfile:
json.dump(streamlines_count_dict, outfile,
sort_keys=args.sort_keys, indent=args.indent)
def main():
parser = _build_arg_parser()
args = parser.parse_args()
assert_inputs_exist(parser,
[args.in_bundle, args.label_map, args.distance_map] +
args.metrics)
sft = load_tractogram_with_reference(parser, args, args.in_bundle)
sft.to_vox()
sft.to_corner()
stats = {}
bundle_name, _ = os.path.splitext(os.path.basename(args.in_bundle))
if len(sft) == 0:
stats[bundle_name] = None
print(json.dumps(stats, indent=args.indent, sort_keys=args.sort_keys))
return
assert_same_resolution(args.metrics)
metrics = [nib.load(metric) for metric in args.metrics]
if args.density_weighting:
track_count = compute_tract_counts_map(
sft.streamlines, metrics[0].shape).astype(np.float64)
else:
track_count = np.ones(metrics[0].shape)
label_file = np.load(args.label_map)
labels = label_file['arr_0']
unique_labels = np.unique(labels)
num_digits_labels = len(str(np.max(unique_labels)))
distance_file = np.load(args.distance_map)
distances_to_centroid_streamline = distance_file['arr_0']
# Bigger weight near the centroid streamline
distances_to_centroid_streamline = 1.0 / distances_to_centroid_streamline
if len(labels) != len(distances_to_centroid_streamline):
raise Exception('Label map doesn\'t contain the same number of '
'entries as the distance map. {} != {}'.format(
len(labels),
len(distances_to_centroid_streamline)))
bundle_data_int = sft.streamlines.data.astype(np.int)
stats[bundle_name] = {}
for metric in metrics:
metric_data = metric.get_fdata()
current_metric_fname, _ = split_name_with_nii(
os.path.basename(metric.get_filename()))
stats[bundle_name][current_metric_fname] = {}
for i in unique_labels:
number_key = '{}'.format(i).zfill(num_digits_labels)
label_stats = {}
stats[bundle_name][current_metric_fname][number_key] = label_stats
label_indices = bundle_data_int[labels == i]
label_metric = metric_data[label_indices[:, 0],
label_indices[:, 1], label_indices[:,
2]]
track_weight = track_count[label_indices[:, 0],
label_indices[:, 1], label_indices[:,
2]]
label_weight = track_weight
if args.distance_weighting:
label_weight *= distances_to_centroid_streamline[labels == i]
if np.sum(label_weight) == 0:
logging.warning('Weights sum to zero, can\'t be normalized. '
'Disabling weighting')
label_weight = None
label_mean = np.average(label_metric, weights=label_weight)
label_std = np.sqrt(
np.average((label_metric - label_mean)**2,
weights=label_weight))
label_stats['mean'] = float(label_mean)
label_stats['std'] = float(label_std)
print(json.dumps(stats, indent=args.indent, sort_keys=args.sort_keys))
