def __init__(self, therapy):
# selected therapy
self._therapy = therapy
# simulation time step
self._delta_t = DELTA_T
# calculate the adjusted discount rate
self._adjDiscountRate = DISCOUNT * DELTA_T
# initial health state
self._initialHealthState = HealthStats.WELL
# annual treatment cost
if self._therapy == Therapies.STANDARD:
self._annualTreatmentCost = ((TEST_COST * POP_SIZE * 0.13) /
SIM_LENGTH)
else:
self._annualTreatmentCost = ((TEST_COST * POP_SIZE) / SIM_LENGTH)
# transition probability matrix of the selected therapy
self._prob_matrix = []
if therapy == Therapies.STANDARD:
self._prob_matrix[:], p = MarkovCls.continuous_to_discrete(
standard_transition, DELTA_T)
elif therapy == Therapies.POPULATION:
self._prob_matrix[:], p = MarkovCls.continuous_to_discrete(
population_transition, DELTA_T)
# annual state costs and utilities
self._annualStateCosts = []
self._annualStateUtilities = []
def __init__(self, therapy):
# selected therapy
self._therapy = therapy
# simulation time step
self._delta_t = DELTA_T
# calculate the adjusted discount rate
self._adjDiscountRate = DISCOUNT * DELTA_T
# initial health state
self._initialHealthState = HealthStats.WELL
# annual treatment cost
if self._therapy == Therapies.NONE:
self._annualTreatmentCost = COST_NONE
else:
self._annualTreatmentCost = COST_ANTICOAG
# transition probability matrix of the selected therapy
self._prob_matrix = []
if therapy == Therapies.NONE:
self._prob_matrix[:], p = MarkovCls.continuous_to_discrete(problem1transmat, DELTA_T)
elif therapy == Therapies.ANTICOAG:
self._prob_matrix[:], p = MarkovCls.continuous_to_discrete(problem2transmat, DELTA_T)
# annual state costs and utilities
self._annualStateCosts = []
self._annualStateUtilities = []
def __init__(self, therapy):
# selected therapy
self._therapy = therapy
# simulation time step
self._delta_t = Data.DELTA_T
# calculate the adjusted discount rate
self._adjDiscountRate = Data.DISCOUNT * Data.DELTA_T
# initial health state
self._initialHealthState = HealthStats.WELL
# annual treatment cost
if self._therapy == Therapies.ASPIRIN:
self._annualTreatmentCost = 10.0
if self._therapy == Therapies.DABIGITRAN110:
self._annualTreatmentCost = 3240
if self._therapy == Therapies.DABIGITRAN150:
self._annualTreatmentCost = 3240
else:
self._annualTreatmentCost = Data.WARFARIN_COST
# transition rate matrix of the selected therapy
self._rate_matrix = []
self._prob_matrix = []
# treatment relative risk
self._treatmentRR = 0
# calculate transition probabilities depending of which therapy options is in use
if therapy == Therapies.ASPIRIN:
self._rate_matrix = Data.TRANS_MATRIX_ASPIRIN
# convert rate to probability
self._prob_matrix[:], p = MarkovCls.continuous_to_discrete(
self._rate_matrix, Data.DELTA_T)
# print('Upper bound on the probability of two transitions within delta_t:', p)
# calculate transition probabilities depending of which therapy options is in use
if therapy == Therapies.DABIGITRAN110:
self._rate_matrix = Data.TRANS_MATRIX_DABIGATRAN110
# convert rate to probability
self._prob_matrix[:], p = MarkovCls.continuous_to_discrete(
self._rate_matrix, Data.DELTA_T)
# print('Upper bound on the probability of two transitions within delta_t:', p)
# calculate transition probabilities depending of which therapy options is in use
if therapy == Therapies.DABIGITRAN150:
self._rate_matrix = Data.TRANS_MATRIX_DABIGATRAN150
# convert rate to probability
self._prob_matrix[:], p = MarkovCls.continuous_to_discrete(
self._rate_matrix, Data.DELTA_T)
# print('Upper bound on the probability of two transitions within delta_t:', p)
else:
self._rate_matrix = Data.TRANS_MATRIX_WARFARIN
self._prob_matrix[:], p = MarkovCls.continuous_to_discrete(
self._rate_matrix, Data.DELTA_T)
# print('Upper bound on the probability of two transitions within delta_t:', p)
# annual state costs and utilities
self._annualStateCosts = Data.ANNUAL_STATE_COST
self._annualStateUtilities = Data.ANNUAL_STATE_UTILITY
def __init__(self, therapy):
# selected therapy
self._therapy = therapy
# simulation time step
self._delta_t = Data.DELTA_T
self._adjDiscountRate = Data.DISCOUNT * Data.DELTA_T
# initial health state
self._initialHealthState = HealthStats.WELL
# annual treatment cost
if self._therapy == Therapies.NONE:
self._annualTreatmentCost = 0
if self._therapy == Therapies.ANTICOAG:
self._annualTreatmentCost = Data.Anticoag_COST
# transition probability matrix of the selected therapy
self._prob_matrix = []
# treatment relative risk
self._treatmentRR = 0
# calculate transition probabilities depending of which therapy options is in use
if therapy == Therapies.NONE:
self._prob_matrix[:], p = MarkovCls.continuous_to_discrete(
Data.RATE_MATRIX, Data.DELTA_T)
else:
self._prob_matrix[:], p = MarkovCls.continuous_to_discrete(
Data.RATE_ANTICOAG_MATRIX, Data.DELTA_T)
self._annualStateCosts = Data.HEALTH_COST
self._annualStateUtilities = Data.HEALTH_UTILITY
def __init__(self, therapy):
#initialize base class
_Parameters.__init__(self,therapy)
if therapy == Therapies.ANNUAL:
self._rate_matrix = Data.TRANS_MATRIX
self._prob_matrix[:], p = MarkovCls.continuous_to_discrete(self._rate_matrix, Data.DELTA_T)
else:
self._rate_matrix = Data.TRANS_MATRIX_SEMI
self._prob_matrix[:], p = MarkovCls.continuous_to_discrete(self._rate_matrix, Data.DELTA_T)
self._annualStateCosts = Data.ANNUAL_STATE_COST
self._annualStateUtilities = Data.ANNUAL_STATE_UTILITY
def __init__(self, therapy):
# selected therapy
self._therapy = therapy
# simulation time step
if self._therapy == Therapies.MONO:
self._delta_t = Data.DELTA_T_G
else:
self._delta_t = Data.DELTA_T_GC
# calculate the adjusted discount rate
if self._therapy == Therapies.MONO:
self._adjDiscountRate = Data.DISCOUNT * Data.DELTA_T_G
else:
self._adjDiscountRate = Data.DISCOUNT * Data.DELTA_T_GC
# initial health state
self._initialHealthState = HealthStats.ProgressFree
# annual treatment cost
if self._therapy == Therapies.MONO:
self._annualTreatmentCost = 0
else:
self._annualTreatmentCost = Data.GC_COST
# transition rate matrix of the selected therapy
self._rate_matrix = []
self._prob_matrix = []
# treatment relative risk
self._treatmentRR = 0
# calculate transition probabilities depending of which therapy options is in use
if therapy == Therapies.MONO:
self._rate_matrix = Data.TRANS_MATRIX
# convert rate to probability
self._prob_matrix[:], p = MarkovCls.continuous_to_discrete(
self._rate_matrix, Data.DELTA_T_G)
# print('Upper bound on the probability of two transitions within delta_t:', p)
else:
self._rate_matrix = Data.TRANS_MATRIX_GC
self._prob_matrix[:], p = MarkovCls.continuous_to_discrete(
self._rate_matrix, Data.DELTA_T_GC)
# print('Upper bound on the probability of two transitions within delta_t:', p)
# annual state costs and utilities
self._annualStateCosts = Data.MONTHLY_STATE_COST
self._annualStateUtilities = Data.MONTHLY_STATE_Utility
def calculate_prob_matrix_with():
prob_matrix = []
# convert back to transition probability matrix, but more frequently, not use "1 year"
prob_matrix[:], p = MarkovCls.continuous_to_discrete(
Data.TRANS_MATRIX_WITH, Data.DELTA_T)
return [prob_matrix, p]
def __init__(self, therapy):
# selected therapy
self._therapy = therapy
# simulation time step
self._delta_t = Data.DELTA_T
self._adjDiscountRate = Data.DISCOUNT * Data.DELTA_T
# initial health state
self._initialHealthState = HealthStats.WELL
##THIS IS CHECKED
# cost treatment per preg
if self._therapy == Therapies.BASELINE:
self._annualTreatmentCost = 0
elif self._therapy == Therapies.SUPPLIES_NO_TRAINING:
self._annualTreatmentCost = Data.COST_SUPPLIES
elif self._therapy == Therapies.BETTER_TRAINING:
self._annualTreatmentCost = Data.COST_TRAINING
else:
self._annualTreatmentCost = Data.COST_TRAINING + Data.COST_SUPPLIES
# transition probability matrix of the selected therapy
self._prob_matrix = []
self._continuous_matrix = []
# calculate transition probabilities depending of which therapy options is in use
# if therapy == Therapies.BASELINE:
# self._prob_matrix = Data.BASELINE_MATRIX
# elif therapy == Therapies.SUPPLIES_NO_TRAINING:
# self._prob_matrix = Data.SUPPLIES_NO_TRAINING_MATRIX
# elif therapy == Therapies.BETTER_TRAINING:
# self._prob_matrix = Data.BETTER_TRAINING_MATRIX
# else:
# self._prob_matrix = Data.BETTER_SUPPLIES_AND_TRAINING_MATRIX
#checked above
# calculate transition probabilities depending of which therapy options is in use
if therapy == Therapies.BASELINE:
self._continuous_matrix = SupportLibrary.discrete_to_continuous(
Data.BASELINE_MATRIX, Data.DELTA_T)
elif therapy == Therapies.SUPPLIES_NO_TRAINING:
self._continuous_matrix = SupportLibrary.discrete_to_continuous(
Data.SUPPLIES_NO_TRAINING_MATRIX, Data.DELTA_T)
elif therapy == Therapies.BETTER_TRAINING:
self._continuous_matrix = SupportLibrary.discrete_to_continuous(
Data.BETTER_TRAINING_MATRIX, Data.DELTA_T)
else:
self._continuous_matrix = SupportLibrary.discrete_to_continuous(
Data.BETTER_SUPPLIES_AND_TRAINING_MATRIX, Data.DELTA_T)
self._prob_matrix, p = SupportLibrary.continuous_to_discrete(
self._continuous_matrix, Data.DELTA_T)
#annual state cvsots and utilities
self._annualStateCosts = Data.HEALTH_COST
self._annualStateUtilities = Data.HEALTH_UTILITY
# adjusted discount rate
self._adjDiscountRate = Data.DISCOUNT_RATE * Data.DELTA_T
def add_background_mortality(prob_matrix):
# find the transition rate matrix
rate_matrix = MarkovCls.discrete_to_continuous(prob_matrix, 1)
# add mortality rates
for s in HealthStats:
if s not in [HealthStats.HIV_DEATH, HealthStats.BACKGROUND_DEATH]:
rate_matrix[s.value][HealthStats.BACKGROUND_DEATH.value] \
= -np.log(1 - Data.ANNUAL_PROB_BACKGROUND_MORT)
# convert back to transition probability matrix
prob_matrix[:], p = MarkovCls.continuous_to_discrete(rate_matrix, Data.DELTA_T)
def add_background_mortality(prob_matrix):
rate_matrix, p = MarkovCls.discrete_to_continuous(prob_matrix, 1)
#add all cause mortality rates
for s in HealthStats:
if s not in [HealthStats.STROKEDEATH]:
rate_matrix[s.value][HealthStats.value] \
= -np.log(1-Data.ANNUAL_ALL_CAUSE_MORT)
# convert back to transition probability matrix
prob_matrix = MarkovCls.continuous_to_discrete(rate_matrix, Data.DELTA_T)
print ('All-Cause Mortality. Upper bound of the probabilty of two transitions within delta_t:', p)
def calculate_prob_matrix_anticoag():
""" :returns transition probability matrix for disease under no therapy """
# create an empty matrix populated with zeros
anticoag_matrix = []
for l in anticoag_matrix:
anticoag_matrix.append[0] * len(l)
# call the transition rate matrix
rate_matrix = Data.ANTICOAG_MATRIX
# convert to transition probability matrix
anticoag_matrix[:], p = MarkovCls.continuous_to_discrete(
rate_matrix=rate_matrix, delta_t=Data.DELTA_T)
return anticoag_matrix
def add_background_mortality(prob_matrix):
# find the transition rate matrix
rate_matrix = Data.RATE_MATRIX # MarkovCls.discrete_to_continuous(prob_matrix, 1)
# add mortality rates
#for s in HealthStats:
# add background rates to non-death states (background mortality rate for death-state is assumed 0)
# if s not in [HealthStats.HIV_DEATH, HealthStats.BACKGROUND_DEATH]:
# rate_matrix[s.value][HealthStats.BACKGROUND_DEATH.value] \
# = -np.log(1 - Data.ANNUAL_PROB_BACKGROUND_MORT)
# convert back to transition probability matrix
prob_matrix[:], p = MarkovCls.continuous_to_discrete(
rate_matrix, Data.DELTA_T)
# print('Upper bound on the probability of two transitions within delta_t:', p)
return prob_matrix
def calculate_prob_matrix_none():
""" :returns transition probability matrix for disease under no therapy """
# create an empty matrix populated with zeros
prob_matrix = []
for s in prob_matrix:
prob_matrix.append[0] * len(s)
# call the transition rate matrix
rate_matrix = Data.TRANS_MATRIX
# convert to transition probability matrix
prob_matrix[:], p = MarkovCls.continuous_to_discrete(
rate_matrix=rate_matrix, delta_t=Data.DELTA_T)
return prob_matrix
def __init__(self, therapy):
# selected therapy
self._therapy = therapy
# simulation time step
self._delta_t = Data.DELTA_T
# calculate the adjusted discount rate
self._adjDiscountRate = Data.DISCOUNT * Data.DELTA_T
# initial health state
self._initialHealthState = HealthStats.UNDETECTABLE
# annual treatment cost
if self._therapy == Therapies.NONE:
self._annualTreatmentCost = 0
else:
self._annualTreatmentCost = Data.Anticoagulant_COST
# transition rate matrix of the selected therapy
self._rate_matrix = []
self._prob_matrix = []
# treatment relative risk
self._treatmentRR = 0
# calculate transition probabilities depending of which therapy options is in use
if therapy == Therapies.NONE:
self._rate_matrix = Data.TRANS_MATRIX
# convert rate to probability
self._prob_matrix[:], p = MarkovCls.continuous_to_discrete(
self._rate_matrix, Data.DELTA_T)
# print('Upper bound on the probability of two transitions within delta_t:', p)
# else:
# self._rate_matrix = Data.TRANS_MATRIX_ANTICOAG
# self._prob_matrix[:], p = MarkovCls.continuous_to_discrete(self._rate_matrix, Data.DELTA_T)
# print('Upper bound on the probability of two transitions within delta_t:', p)
# annual state costs and utilities
self._annualStateCosts = Data.ANNUAL_STATE_COST
self._annualStateUtilities = Data.ANNUAL_STATE_UTILITY
from enum import Enum
import Question2 as matrixdatat
delta_t = 0.25
Discount_Rate = 0.03
rate_matrix_wotherapy = [[
None, matrixdata.lambda1, 0, matrixdata.lambda2,
matrixdata.non_stroke_deathrate
], [0, None, matrixdata.rate_stroke_post, 0, 0],
[
0, matrixdata.rate_poststr_stroke, None,
matrixdata.rate_poststr_strokedeath,
matrixdata.non_stroke_mortality
], [0, 0, 0, None, 0], [0, 0, 0, 0, None]]
prob_matrixwotherapy = MarkovCls.continuous_to_discrete(
rate_matrix_wotherapy, delta_t)
rate_matrix_wtherapy = [[
None, matrixdata.lambda1, 0, matrixdata.lambda2,
matrixdata.non_stroke_deathrate
], [0, None, matrixdata.rate_stroke_post, 0, 0],
[
0, matrixdatat.rate_poststr_stroke_withtherapy,
None, matrixdata.rate_poststr_strokedeath,
matrixdatat.therapy_non_stroke_deathrate
], [0, 0, 0, None, 0], [0, 0, 0, 0, None]]
prob_matrixwtherapy = MarkovCls.continuous_to_discrete(rate_matrix_wtherapy,
delta_t)
TRANS = [prob_matrixwotherapy[0], prob_matrixwtherapy[0]]
import scr.MarkovClasses as MarkovCls
POP_SIZE = 2000 # cohort population size
SIM_LENGTH = 15 # length of simulation (years)
ALPHA = 0.05 # significance level for calculating confidence intervals
DELTA_T = 0.25 # years (length of time step, how frequently you look at the patient)
DISCOUNT = 0.03 # annual discount rate
# transition matrix
TRANS_MATRIX=[[None,TM.srroke_afterfirst,0,TM.death_afterfirst,TM.non_stroke_deathrate],
[0,None,TM.rate_post_stroke,0,0],
[0,TM.rate_poststr_stroke,None,TM.rate_poststr_strokedeath,TM.non_stroke_mortality],
[0,0,0,None,0],
[0,0,0,0,None]]
Prob_TransMatrix_None=MarkovCls.continuous_to_discrete(TRANS_MATRIX,DELTA_T)
TRANS_MATRIX_COMBO=[[None,TM.srroke_afterfirst,0,TM.death_afterfirst,TM.non_stroke_deathrate],
[0,None,TM.rate_post_stroke,0,0],
[0,TM.rate_poststr_stroke_withtherapy,None,TM.rate_poststr_strokedeath,TM.therapy_non_stroke_deathrate],
[0,0,0,None,0],
[0,0,0,0,None]]
Prob_TransMatrix_Anti=MarkovCls.continuous_to_discrete(TRANS_MATRIX_COMBO,DELTA_T)
# annual health utility of each health state
ANNUAL_STATE_UTILITY = [
1.00, # Well
0.20, # Stroke
0.90, # Post-Stroke
[None,Stroke_Survive,0,Stroke_Death,Non_Stroke_Mort],
[0,None,Post_Stroke_Survive,0,0],
[0,Post_Stroke_Survive,None,Post_Stroke_Survive,Non_Stroke_Mort],
[0,0,0,None,0],
[0,0,0,0,None]
]
Drug_Matrix = [
[None,Stroke_Survive,0,Stroke_Death,Non_Stroke_Mort],
[0,None,Post_Stroke_Survive,0,0],
[0,Drug_Post_Stroke,None,Drug_Post_Stroke,Drug_Non_Stroke_Mort],
[0,0,0,None,0],
[0,0,0,0,None]
]
Prob_Non_Drug_Matrix = MarkovCls.continuous_to_discrete(No_Drug_Matrix,delta_t)
Prob_Drug_Martix = MarkovCls.continuous_to_discrete(Drug_Matrix,delta_t)
HEALTH_UTILITY = [
1, # well
0.2, # stroke
0.9, # post-stroke
0 # dead
]
HEALTH_COST = [
0,
5000, # stroke - one time cost
200, # post-stroke /year
750, # when anticoagulation is used
RATE_MATRIX = [
[0, lambda1, 0, lambda2, rate_non_stroke_mortality],
[0, 0, lambda5, 0, 0],
[0, lambda3, 0, lambda4, rate_non_stroke_mortality],
[0, 0, 0, 0, 0],
[0, 0, 0, 0, 0]
]
print("")
print("Rate matrix for anticoagulation therapy")
print(RATE_MATRIX[0])
print(RATE_MATRIX[1])
print(RATE_MATRIX[2])
print(RATE_MATRIX[3])
print(RATE_MATRIX[4])
DELTA_T = 0.25
print("")
print("DELTA_T =", DELTA_T)
print("")
print("Transform rate matrix to transition probability matrix")
TRANS_MATRIX_ANTICOAG = []
TRANS_MATRIX_ANTICOAG[:], T = MarkovCls.continuous_to_discrete(RATE_MATRIX, DELTA_T)
print(TRANS_MATRIX_ANTICOAG[0],",")
print(TRANS_MATRIX_ANTICOAG[1],",")
print(TRANS_MATRIX_ANTICOAG[2],",")
print(TRANS_MATRIX_ANTICOAG[3],",")
print(TRANS_MATRIX_ANTICOAG[4])
def get_discrete_prob_matrix(self):
# convert back to transition probability matrix
self._prob_matrix[:], p = MarkovCls.continuous_to_discrete(self._prob_matrix, Data.DELTA_T)
print('Upper bound on the probability of two transitions within delta_t:', p)
def simulate_fiveshort(self, sim_length_short):
""" simulate the patient over the specified simulation length """
# random number generator for this patient
self._rng = rndClasses.RNG(self._id)
if self.vaccine==0:
k=0
# while the patient is alive and simulation length is not yet reached
while (self.healthstat != 8) and k * ma.delta_t < sim_length_short:
# find the transition probabilities of the future states
trans_probs = ma.prob_matrix[0][self.healthstat]
# create an empirical distribution
empirical_dist = rndClasses.Empirical(trans_probs)
# sample from the empirical distribution to get a new state
# (returns an integer from {0, 1, 2, ...})
new_state_index = empirical_dist.sample(self._rng)
# caculate cost and utality
cost = ma.cost_matrix[self.healthstat] + ma.salary * ma.work_loss_day[self.healthstat]
utility = ma.utility_matrix[self.healthstat] * ma.delta_t
# update total discounted cost and utility (corrected for the half-cycle effect)
self.totalDiscountCost += \
EconCls.pv(cost, ma.discount_rate * ma.delta_t, k + 1)
self.totalDiscountUtility += \
EconCls.pv(utility, ma.discount_rate * ma.delta_t, k + 1)
# update diseases:
if self.healthstat==HealthStats.Pneumoniae.value:
self.pneumonaie+=1
if self.healthstat==HealthStats.Meningitis.value:
self.meningitis+=1
if self.healthstat==HealthStats.AOM_T.value or self.healthstat==HealthStats.AOM_NT.value:
self.aom+=1
# update disability number
if self.healthstat == HealthStats.Disability.value:
self._ndisability = 1
# update deafness number
if self.healthstat == HealthStats.Deaf.value :
self._ndeaf = 1
# update health state
self.healthstat = new_state_index[0]
#update number of deahts
if self.healthstat==HealthStats.DEATH.value:
self._ndeath=1
# increment time step
k += 1
if self.vaccine==1:
k=0
while (self.healthstat!=8) and k * ma.delta_t<sim_length_short:
new_rate_matrix=gen_vaccine_prob_matrix(self.shot)
prob_matrixm = MarkovCls.continuous_to_discrete(new_rate_matrix, ma.delta_t)
trans_probsm = prob_matrixm[0][self.healthstat]
empirical_dist = rndClasses.Empirical(trans_probsm)
new_state_index = empirical_dist.sample(self._rng)
cost = ma.cost_matrix[self.healthstat] + ma.salary * ma.work_loss_day[self.healthstat]
utility = ma.utility_matrix[self.healthstat] * ma.delta_t
self.totalDiscountCost += \
EconCls.pv(cost, ma.discount_rate * ma.delta_t, k + 1)
self.totalDiscountUtility += \
EconCls.pv(utility, ma.discount_rate * ma.delta_t, k + 1)
# update disability number
if self.healthstat == HealthStats.Disability.value:
self._ndisability = 1
# update deafness number
if self.healthstat == HealthStats.Deaf.value:
self._ndeaf = 1
# update diseases:
if self.healthstat==HealthStats.Pneumoniae.value:
self.pneumonaie+=1
if self.healthstat==HealthStats.Meningitis.value:
self.meningitis+=1
if self.healthstat==HealthStats.AOM_T.value or self.healthstat==HealthStats.AOM_NT.value:
self.aom+=1
print(self.healthstat)
self.healthstat = new_state_index[0]
#update number of deaths
if self.healthstat==HealthStats.DEATH.value:
self._ndeath=1
if k==3:
self.shot+=1
self.totalDiscountCost+= \
EconCls.pv(ma.vaccine_administration+ma.vaccine_cost, ma.discount_rate * ma.delta_t, k + 1)
if k==5:
self.shot+=1
self.totalDiscountCost+= \
EconCls.pv(ma.vaccine_administration+ma.vaccine_cost, ma.discount_rate * ma.delta_t, k + 1)
if k==11:
self.shot+=1
self.totalDiscountCost+= \
EconCls.pv(ma.vaccine_administration+ma.vaccine_cost, ma.discount_rate * ma.delta_t, k + 1)
# increment time step
k += 1
rate_pneumoniae_to_recovery, None, 0, 0, 0, 0, 0, 0,
rate_pneumoniae_to_death
],
[
rate_meningitis_to_recovery, 0, None,
rate_memingitis_to_disability, rate_memingitis_to_deafness,
0, 0, 0, rate_meningitis_to_death
], [0, 0, 0, None, 0, 0, 0, 0, 0],
[0, 0, 0, 0, None, 0, 0, 0, 0],
[
rate_bacteremia_to_recovery, 0, 0, 0, 0, None, 0, 0,
rate_bacteremia_to_death
], [rate_aom_to_recovery, 0, 0, 0, 0, 0, None, 0, 0],
[rate_aom_to_recovery, 0, 0, 0, 0, 0, 0, None, 0],
[0, 0, 0, 0, 0, 0, 0, 0, None]]
prob_matrix = MarkovCls.continuous_to_discrete(rate_matrix, delta_t)
print(prob_matrix)
cost_matrix = [0, 652, 3851, 0, 0, 2863, 119, 357, 0]
utility_matrix = [1, 0.9941, 0.9768, 0.7393, 0.8611, 0.9941, 0.995, 0.82, 0]
work_loss_day = [
0, worklossday_pneumoniae, worklossday_meningitis, 0, 0,
worklossday_bacteremia, worklossday_aom, worklossday_aom, 0
]
salary = 30
cohort_size = 200000
print("Annual rate of transition from stroke to post-stroke (lambda5):",
lambda5)
RATE_MATRIX = [[0, lambda1, 0, lambda2, rate_non_stroke_mortality],
[0, 0, lambda5, 0, 0],
[0, lambda3, 0, lambda4, rate_non_stroke_mortality],
[0, 0, 0, 0, 0], [0, 0, 0, 0, 0]]
print("")
print("Rate matrix for no therapy")
print(RATE_MATRIX[0])
print(RATE_MATRIX[1])
print(RATE_MATRIX[2])
print(RATE_MATRIX[3])
print(RATE_MATRIX[4])
DELTA_T = 0.25
print("")
print("DELTA_T =", DELTA_T)
print("")
print("Transform rate matrix to transition probability matrix")
TRANS_MATRIX = []
TRANS_MATRIX[:], S = MarkovCls.continuous_to_discrete(RATE_MATRIX, DELTA_T)
print(TRANS_MATRIX[0], ",")
print(TRANS_MATRIX[1], ",")
print(TRANS_MATRIX[2], ",")
print(TRANS_MATRIX[3], ",")
print(TRANS_MATRIX[4])