def test_is_nominal_target():
d = DTDA()
for vem in _vems:
is_target = d.is_nominal_drug_target(vem, _braf)
assert is_target
is_target = d.is_nominal_drug_target(vem, _kras)
assert not is_target
def test_is_nominal_target():
d = DTDA()
for vem in _vems:
is_target = d.is_nominal_drug_target(vem, _braf)
assert is_target
is_target = d.is_nominal_drug_target(vem, _kras)
assert not is_target
def test_all_disease_list():
d = DTDA()
assert d.all_diseases
assert d.all_diseases == list(cbio_efo_map.keys())
assert all(isinstance(e, str) for e in d.all_diseases)
def test_all_target_list():
d = DTDA()
all_targets = d.get_all_targets()
assert len(all_targets) > 1000
assert all('HGNC' in a.db_refs for a in all_targets)
def test_all_drug_list():
d = DTDA()
all_drugs = d.get_all_drugs()
assert len(all_drugs) > 2300, len(all_drugs)
def test_find_drug_targets2():
d = DTDA()
targets = d.find_drug_targets(_alk_drug)
assert len(targets) == 1
assert any(target.name == 'TGFBR1' for target in targets), targets
def test_find_drug_targets1():
d = DTDA()
for vem in _vems:
targets = d.find_drug_targets(vem)
assert len(targets) >= 1, targets
assert any(target.name == 'BRAF' for target in targets), targets
def test_is_nominal_target_dash():
d = DTDA()
is_target = d.is_nominal_drug_target(_alk_drug, _tgfbr1)
assert is_target
def test_mutation_statistics():
d = DTDA()
mutation_dict = \
d.get_mutation_statistics('pancreatic carcinoma', 'missense')
assert mutation_dict['KRAS']['count'] > 0
def test_all_target_list():
d = DTDA()
assert d.all_targets
assert all('HGNC' in Agent._from_json(e).db_refs.keys()
for e in d.all_targets)
def test_all_drug_list():
d = DTDA()
assert d.all_drugs
assert all('HMS-LINCS' in Agent._from_json(e).db_refs.keys()
for e in d.all_drugs)
def test_find_drug_targets2():
d = DTDA()
targets = d.find_drug_targets(_alk_drug)
assert len(targets) == 1
assert any(target == 'TGFBR1' for target in targets), targets
def test_find_drug_targets1():
d = DTDA()
for vem in _vems:
targets = d.find_drug_targets(vem)
assert len(targets) >= 1, targets
assert any(target == 'BRAF' for target in targets), targets
def test_is_nominal_target_dash():
d = DTDA()
is_target = d.is_nominal_drug_target(_alk_drug, _tgfbr1)
assert is_target
def test_mutation_statistics():
d = DTDA()
mutation_dict = \
d.get_mutation_statistics('pancreatic carcinoma', 'missense')
assert mutation_dict['KRAS']['count'] > 0
