Exemplo n.º 1
0
def extend_front(front, seed, constellation):
    # new_pos =front.xyz + np.array([L_NORM,0,2.0])
    # new_front = prepare_next_front(front,new_pos,set_radius=1.0)
    # return [new_front]

    # repelled by a different neuron, get information
    other_entities = get_entity("cell_type_1", constellation)
    target = np.array([200, 30, 200])

    if not len(other_entities) == 0:
        dir_to_entity = gradient_to(front,
                                    other_entities,
                                    strength=10.0,
                                    decay_factor=0.15,
                                    cutoff=2.5,
                                    what="nearest")
        if np.allclose(dir_to_entity, np.array([0.0, 0.0, 0.0])):
            new_pos = front.xyz + \
              normalize_length(target-front.xyz,L_NORM ) + \
              normalize_length(unit_sample_on_sphere(),L_NORM/1.0 ) # was 10
            new_front = prepare_next_front(front, new_pos, set_radius=1.0)
            print("[debug] To_left.py:: still far")
        else:
            new_pos = front.xyz + normalize_length(
                -1 * dir_to_entity + unit_sample_on_sphere(), L_NORM)
            new_front = prepare_next_front(front, new_pos, set_radius=1.0)
            print("[debug] To_left.py:: potential intercept avoided")
    else:  # during the first extension cycle, no distal info is known locally
        new_pos = front.xyz + normalize_length(target - front.xyz, L_NORM)
        new_front = prepare_next_front(front, new_pos, set_radius=1.0)
    return [new_front]
Exemplo n.º 2
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def extend_front(front, seed, constellation):
    if front.order == 0:  # soma
        new_fronts = []
        for i in range(2):
            rnd_dir = unit_sample_on_sphere()
            rnd_dir[2] = np.abs(rnd_dir[2])
            new_pos = normalize_length(rnd_dir, 25)
            new_pos = front.xyz + new_pos
            new_front = prepare_next_front(front,
                                           new_pos,
                                           set_radius=3.0,
                                           add_order=1)
            new_fronts.append(new_front)
        return new_fronts
    else:
        rnd_dir = unit_sample_on_sphere()
        other_entities = get_entity("pia", constellation)
        #print ("pia entities: ", other_entities)
        dir_to_pia = direction_to(front, other_entities, what="nearest")
        new_pos = front.xyz + normalize_length(dir_to_pia, 10)
        new_front = prepare_next_front(front,
                                       new_pos,
                                       radius_factor=0.5,
                                       add_order=False)
        return [new_front]
Exemplo n.º 3
0
def extend_front(front,seed,constellation) :
    # new_pos =front.xyz + np.array([L_NORM,0,2.0])
    # new_front = prepare_next_front(front,new_pos,set_radius=1.0)
    # return [new_front]

    # repelled by a different neuron, get information
    other_entities = get_entity("cell_type_1",constellation)
    target = np.array([200,30,200])
    
    if not len(other_entities) == 0:
        dir_to_entity = gradient_to(front,other_entities,strength=10.0,decay_factor=0.15,cutoff=2.5,what="nearest")
        if np.allclose(dir_to_entity,np.array([0.0,0.0,0.0])):
            new_pos = front.xyz + \
              normalize_length(target-front.xyz,L_NORM ) + \
              normalize_length(unit_sample_on_sphere(),L_NORM/1.0 ) # was 10
            new_front = prepare_next_front(front,new_pos,set_radius=1.0)
            print "[debug] To_left.py:: still far"
        else:
            new_pos = front.xyz + normalize_length(-1*dir_to_entity + unit_sample_on_sphere(),L_NORM)
            new_front = prepare_next_front(front,new_pos,set_radius=1.0)
            print "[debug] To_left.py:: potential intercept avoided"
    else: # during the first extension cycle, no distal info is known locally
        new_pos =front.xyz + normalize_length(target-front.xyz,L_NORM )
        new_front = prepare_next_front(front,new_pos,set_radius=1.0)        
    return [new_front]
Exemplo n.º 4
0
def extend_front(front, seed, constellation):
    if front.order == 0:  # this is the soma
        new_fronts = []
        for i in range(np.random.randint(8, 17)):
            rnd_dir = unit_sample_on_sphere()
            new_pos = front.xyz + normalize_length(rnd_dir, L_NORM)
            new_front = prepare_next_front(front,
                                           new_pos,
                                           set_radius=8.0,
                                           add_order=True)
            new_front.swc_type = 2
            new_fronts.append(new_front)
        return new_fronts
    else:
        # follow a simple branching rule in all other cases
        bif_prob = 0.6 / (front.order * 2.5)
        if front.order > 5:
            bif_prob = 0.03

        if np.random.random() > bif_prob:  # continue a front
            # random component
            rnd_dir = unit_sample_on_sphere()
            # unit vector of current heading
            heading = front.xyz - front.parent.xyz
            # soma-tropism, sample direction away from the soma
            soma_dir = -1.0 * normalize_length(
                direction_to(front, [front.soma_pos], what="nearest"), 0.4)
            # combine all infliences on the new direction of growth
            new_dir = normalize_length(heading, 1.0) + soma_dir + rnd_dir
            new_pos = front.xyz + normalize_length(new_dir, L_NORM)
            if front.radius <= 0.3:
                new_front = prepare_next_front(front,
                                               new_pos,
                                               set_radius=0.3,
                                               add_order=False)
            else:
                new_front = prepare_next_front(front,
                                               new_pos,
                                               radius_factor=0.9,
                                               add_order=False)
            # stop growth
            if np.random.random() < 0.06 and front.path_length >= 600:
                return []
            return [new_front]
        else:  # branch a front, generate two child fronts
            new_fronts = []
            for i in range(2):
                rnd_dir = unit_sample_on_sphere()
                heading = front.xyz - front.parent.xyz
                new_dir = normalize_length(heading, 1.5) + rnd_dir
                new_pos = front.xyz + normalize_length(new_dir, L_NORM)
                new_front = prepare_next_front(front,
                                               new_pos,
                                               radius_factor=0.7,
                                               add_order=True)
                new_fronts.append(new_front)
            return new_fronts
Exemplo n.º 5
0
def extend_front(front,seed,constellation) :
    if front.order == 0 : # soma
        new_fronts = []
        for i in range(3):
            rnd_dir = unit_sample_on_sphere()
            rnd_dir[2] = np.abs(rnd_dir[2])
            new_pos = normalize_length(rnd_dir,15)
            new_pos = front.xyz + new_pos
            new_front = prepare_next_front(front,new_pos,set_radius=3.0,add_order=1)
            new_fronts.append(new_front)
        return new_fronts
    else :
        if np.random.random() < 0.1 :
            new_fronts = []
            other_entities = get_entity("pia",constellation)
            for i in range(2):
                rnd_dir = unit_sample_on_sphere()

                if len(other_entities) == 0:
                    rnd_dir = unit_sample_on_sphere()
                    rnd_dir[2] = np.abs(rnd_dir[2])
                    new_pos = normalize_length(rnd_dir,15)
                    new_pos = front.xyz + new_pos
                    new_front = prepare_next_front(front,new_pos,set_radius=3.0,add_order=1)
                    new_fronts.append(new_front)
                else:
                    dir_to_pia = direction_to(front,other_entities,what="nearest")
                    dir_to_pia = normalize_length(dir_to_pia,2.0) + rnd_dir 

                    new_pos = front.xyz + normalize_length(dir_to_pia,10)

                    new_front = prepare_next_front(front,new_pos,radius_factor=0.5,add_order=True)
                    new_fronts.append(new_front)
            return new_fronts
        else :
            rnd_dir = unit_sample_on_sphere()

            other_entities = get_entity("pia",constellation)

            gradient_to_pia = gradient_to(front,other_entities,1.0,0.0001,what='nearest')
            # or go directly to the pia
            # gradient_to_pia = direction_to(front,other_entities,what='nearest')
            
            pia_interaction = gradient_to_pia + rnd_dir

            new_dir = normalize_length(pia_interaction,1.5) #+ rnd_dir 
            new_pos = front.xyz + normalize_length(new_dir,10)
            new_front = prepare_next_front(front,new_pos,radius_factor=0.95)
            if new_pos[2] > 190 :
                return None
            else:
                return [new_front]
Exemplo n.º 6
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def extend_basal_front(front, constellation):
    bif_prob = 0.78 / (2.0 * front.order + 1.0)  # was2.5 and  0.8
    bif_prob = bif_prob if front.order < 6 else bif_prob / 1.8
    bif_prob = 0.0 if front.order >= 6 else bif_prob

    if front.order >= 2 and np.random.random() < 0.07:  # wa 00.6
        front.no_branch = True

    if np.random.random() > bif_prob or \
            front.no_branch:
        rnd_dir = unit_sample_on_sphere()
        heading = front.xyz - front.parent.xyz
        soma_dir = -1.0 * normalize_length(
            direction_to(front, [front.soma_pos], what="nearest"), 0.8)

        eigen_entities = get_eigen_entity(front, constellation)
        eigen_dir = np.array([0, 0, 0])
        eigen_dir = -1.0 * gradient_to(front,
                                       eigen_entities,
                                       5.0 / (front.order),
                                       0.05,
                                       what="nearest",
                                       cutoff=0.2)

        new_dir = normalize_length(heading, 1.0) + soma_dir + normalize_length(
            rnd_dir, 1.2) + eigen_dir
        new_pos = front.xyz + normalize_length(new_dir, L_NORM)
        new_front = prepare_next_front(front,
                                       new_pos,
                                       radius_factor=0.98,
                                       add_order=False)

        term_prob = 0.015 * front.order if front.order <= 6 else 0.3
        if np.random.random() < term_prob:
            return []
        return [new_front]
    else:
        new_fronts = []
        for i in range(2):
            rnd_dir = unit_sample_on_sphere()
            heading = front.xyz - front.parent.xyz
            new_dir = normalize_length(heading, 1.5) + rnd_dir
            new_pos = front.xyz + normalize_length(new_dir, L_NORM)
            new_front = prepare_next_front(front,
                                           new_pos,
                                           radius_factor=0.98,
                                           add_order=True)
            new_fronts.append(new_front)
        return new_fronts
Exemplo n.º 7
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def extend_front(front,seed,constellation) :
    if front.order == 0:
        new_fronts = []
        for i in range(5):
            rnd_dir = unit_sample_on_sphere()
            new_pos = normalize_length(rnd_dir,L_NORM*5)
            new_pos = front.xyz + new_pos
            new_front = prepare_next_front(front,new_pos,set_radius=1.0,add_order=True)
            new_fronts.append(new_front)
        return new_fronts
            
    else:
        rnd_dir = unit_sample_on_sphere()
        new_pos = normalize_length(rnd_dir,L_NORM)
        new_pos = front.xyz + new_pos
        new_front = prepare_next_front(front,new_pos,set_radius=1.0)
        return [new_front]
Exemplo n.º 8
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def extend_front(front, seed, constellation):
    """ Grow away from self-contained stretches of neurites.
    """
    eigen_entities = get_eigen_entity(front, constellation)
    if len(eigen_entities) == 0:
        if front.order == 0:
            rnd_dir = unit_sample_on_sphere()
            new_pos = front.xyz + np.array([26, 0, 0])
            new_front = prepare_next_front(front,
                                           new_pos,
                                           set_radius=1.0,
                                           add_order=True)
            return [new_front]
        else:
            new_pos1 = front.xyz + np.array([5, 5, 0])
            new_front1 = prepare_next_front(front,
                                            new_pos1,
                                            set_radius=1.0,
                                            add_order=True)
            new_pos2 = front.xyz + np.array([5, -5, 0])
            new_front2 = prepare_next_front(front,
                                            new_pos2,
                                            set_radius=1.0,
                                            add_order=True)
            return [new_front1, new_front2]
    else:
        if np.random.random() > 0.2:
            rnd_dir = unit_sample_on_sphere()
            dir_away = -1.0 * direction_to(
                front, eigen_entities, what="nearest")
            dir_away = normalize_length(dir_away, 4) + rnd_dir
            new_pos = front.xyz + normalize_length(dir_away, L_NORM)
            new_front = prepare_next_front(front, new_pos, set_radius=1.0)
            return [new_front]
        else:
            daughters = []
            for i in range(2):
                rnd_dir = unit_sample_on_sphere()
                dir_away = -1.0 * direction_to(
                    front, eigen_entities, what="nearest")
                dir_away = normalize_length(dir_away, 4.0) + rnd_dir
                new_pos = front.xyz + normalize_length(dir_away, L_NORM)
                new_front = prepare_next_front(front, new_pos, set_radius=1.0)
                daughters.append(new_front)
            return daughters
Exemplo n.º 9
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def extend_front(front,seed,constellation) :
    if front.order == 0 : # soma
        new_fronts = []
        for i in range(2):
            rnd_dir = unit_sample_on_sphere()
            rnd_dir[2] = np.abs(rnd_dir[2])
            new_pos = normalize_length(rnd_dir,25)
            new_pos = front.xyz + new_pos
            new_front = prepare_next_front(front,new_pos,set_radius=3.0,add_order=1)
            new_fronts.append(new_front)
        return new_fronts
    else :
        rnd_dir = unit_sample_on_sphere()
        other_entities = get_entity("pia",constellation)
        #print "pia entities: ", other_entities
        dir_to_pia = direction_to(front,other_entities,what="nearest")
        new_pos = front.xyz + normalize_length(dir_to_pia,10)
        new_front = prepare_next_front(front,new_pos,radius_factor=0.5,add_order=False)
        return [new_front]
Exemplo n.º 10
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def extend_front(front, seed, constellation):
    if front.order == 0:
        new_fronts = []
        for i in range(5):
            rnd_dir = unit_sample_on_sphere()
            new_pos = normalize_length(rnd_dir, L_NORM * 5)
            new_pos = front.xyz + new_pos
            new_front = prepare_next_front(front,
                                           new_pos,
                                           set_radius=1.0,
                                           add_order=True)
            new_fronts.append(new_front)
        return new_fronts

    else:
        rnd_dir = unit_sample_on_sphere()
        new_pos = normalize_length(rnd_dir, L_NORM)
        new_pos = front.xyz + new_pos
        new_front = prepare_next_front(front, new_pos, set_radius=1.0)
        return [new_front]
Exemplo n.º 11
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def extend_front(front,seed,constellation) :
    """ follow gradient to a_point Attractor.
    The stronger the attraction becomes, the straighter the path
    to the attractor
    """
    other_entities = get_entity("a_point",constellation)
    rnd_dir = unit_sample_on_sphere()
    dir_to_entity = gradient_to(front,other_entities,1.7,0.01,what="nearest")
    dir_to_entity = dir_to_entity + 0.5*rnd_dir 
    new_pos = front.xyz + normalize_length(dir_to_entity,L_NORM)
    
    new_front = prepare_next_front(front,new_pos,set_radius=1.0)

    return [new_front]
Exemplo n.º 12
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def create_basal_branches(front, constellation):
    new_fronts = []
    for i in range(np.random.randint(5, 11)):
        rnd_dir = unit_sample_on_sphere()
        rnd_dir[2] = -1.0 * np.abs(
            rnd_dir[2])  # try to grow "downwards"/deeper
        new_pos = front.xyz + normalize_length(rnd_dir, L_NORM)
        new_front = prepare_next_front(front,
                                       new_pos,
                                       set_radius=0.3,
                                       add_order=True)
        new_front.swc_type = 3
        new_front.no_branch = False
        new_fronts.append(new_front)
    return new_fronts
Exemplo n.º 13
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def extend_front(front,seed,constellation) :
    # attract by a different neuron, get information
    other_entities = get_entity("substance_x",constellation)

    # fetch the case that no such entities exists    
    if len(other_entities) == 0 :
        new_pos =front.xyz + np.array([L_NORM,0,0])
    else :
        rnd_dir = unit_sample_on_sphere()
        dir_to_entity = direction_to(front,other_entities,what="nearest")
        dir_to_entity = normalize_length(dir_to_entity,1.0) + rnd_dir*0.3
        new_pos = front.xyz + normalize_length(dir_to_entity,L_NORM)
    new_front = prepare_next_front(front,new_pos,set_radius=1.5)

    return [new_front]
Exemplo n.º 14
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def extend_front(front, seed, constellation):
    # attract by a different neuron, get information
    other_entities = get_entity("substance_x", constellation)

    # fetch the case that no such entities exists
    if len(other_entities) == 0:
        new_pos = front.xyz + np.array([L_NORM, 0, 0])
    else:
        rnd_dir = unit_sample_on_sphere()
        dir_to_entity = direction_to(front, other_entities, what="nearest")
        dir_to_entity = normalize_length(dir_to_entity, 1.0) + rnd_dir * 0.3
        new_pos = front.xyz + normalize_length(dir_to_entity, L_NORM)
    new_front = prepare_next_front(front, new_pos, set_radius=1.5)

    return [new_front]
Exemplo n.º 15
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def extend_apical_front(front, constellation):
    pia = get_entity("pia", constellation)
    dir_to_pia = direction_to(front, pia, what="nearest")
    grad_to_pia = gradient_to(front,
                              pia,
                              5.0,
                              0.015,
                              cutoff=0.3,
                              what="nearest")
    if np.sqrt(sum((grad_to_pia)**2)) >= 3.0:
        print "too close to pia!!! +++++++++++++++++++"
        #time.sleep(1)
        return []

    if (front.layer == 4 or front.layer == 5) and not front.oblique:
        # make an oblique dendrite with some probability (and extend the main branch)
        oblique_prob = 0.3 if front.layer == 4 else 0.12  # maybe L5 -> 0.0
        if front.order >= 15:
            oblique_prob = 0.0

        if np.random.random() < oblique_prob:
            new_fronts = []
            # orthogonal direction to parent branch: HOWTO?
            rnd_dir = unit_sample_on_sphere()
            heading = front.xyz - front.parent.xyz
            new_dir = normalize_length(heading,0.5) + \
                      normalize_length(rnd_dir,1.0)
            new_pos = front.xyz + normalize_length(new_dir, APICAL_NORM)
            new_front = prepare_next_front(front,
                                           new_pos,
                                           radius_factor=0.98,
                                           add_order=True)
            new_front.oblique = True
            #new_front.swc_type=8
            new_front.oblique_start = front  # for directional information
            # if front.layer == 4 and np.random.random() < 0.005:
            #     new_front.oblique=False

            # and extend
            rnd_dir = unit_sample_on_sphere()
            heading = front.xyz - front.parent.xyz
            new_dir = normalize_length(dir_to_pia,1.5) + \
                      normalize_length(heading,0.) + \
                      normalize_length(rnd_dir,.5)
            new_pos = front.xyz + normalize_length(new_dir, APICAL_MAIN)
            new_front2 = prepare_next_front(front,
                                            new_pos,
                                            radius_factor=0.98,
                                            add_order=True)
            #new_front2.swc_type = 4 if front.layer == 5 else 5
            return [new_front, new_front2]
        else:
            # only extend
            rnd_dir = unit_sample_on_sphere()
            heading = front.xyz - front.parent.xyz
            new_dir = normalize_length(dir_to_pia,1.5) + \
                      normalize_length(heading,0.) + \
                      normalize_length(rnd_dir,.5)
            new_pos = front.xyz + normalize_length(new_dir, APICAL_MAIN)
            new_front = prepare_next_front(front,
                                           new_pos,
                                           radius_factor=0.98,
                                           add_order=False)
            #new_front.swc_type = 4 if front.layer == 5 else 5
            return [new_front]

    if front.oblique:
        # extend or terminate the oblique
        if front.path_length - front.oblique_start.path_length > 100 and np.random.random(
        ) < 0.1:
            return []
        else:
            rnd_dir = unit_sample_on_sphere()

            eigen_entities = get_eigen_entity(front, constellation)
            eigen_dir = np.array([0, 0, 0])
            # fairly strong self-repulsion, away from the main trunk...
            eigen_dir = -1.5 * gradient_to(
                front, eigen_entities, 5.0, 0.03, what="nearest", cutoff=0.2)

            # or away from the trunk, front.oblique_start
            dir_from_trunk = -1.0 * (front.oblique_start.xyz - front.xyz)
            dir_from_trunk = normalize_length(dir_from_trunk, 1.0)

            heading = front.xyz - front.parent.xyz
            new_dir = normalize_length(heading,1.0) + \
                      normalize_length(rnd_dir,0.5) + \
                      dir_from_trunk
            #normalize_length(dir_to_pia,0.1)
            #eigen_dir # + \
            # normalize_length(dir_to_pia,0.4)
            if front.layer == 3:
                new_dir = new_dir + -1.0 * normalize_length(dir_to_pia, 0.5)
            # if front.layer == 5 :
            #     new_dir = new_dir + normalize_length(dir_to_pia,0.5)

            new_pos = front.xyz + normalize_length(new_dir, APICAL_NORM)
            new_front = prepare_next_front(front,
                                           new_pos,
                                           radius_factor=0.98,
                                           add_order=False)
            #new_front.swc_type=8
            # make "normal, not oblique"
            return [new_front]

    if front.layer >= 3:  #== 3:
        # keep track of the order to limit the number of bifurcations in this layer
        if not hasattr(front, 'start_order_L3') and front.layer == 3:
            # this is the first time, store the current order
            front.start_order_L3 = front.order

        # bifurcate or extend
        bif_prob = 0.08
        if front.order - front.start_order_L3 >= 3:
            bif_prob = 0
        if np.random.random() < bif_prob:
            #bifurcate
            new_fronts = []
            first_vec = None
            attempts = 0
            for i in range(2):
                rnd_dir = unit_sample_on_sphere()
                heading = front.xyz - front.parent.xyz
                new_dir = normalize_length(dir_to_pia,0.5) + \
                                  normalize_length(heading,0.5) + \
                                  normalize_length(rnd_dir,1.0)
                new_pos = front.xyz + normalize_length(new_dir, APICAL_NORM)

                # make sure the bif amplitude reaches a minimum...
                if first_vec == None:
                    first_vec = normalize_length(new_dir, APICAL_NORM)
                else:
                    angle_amp = _amp_angle(
                        first_vec, normalize_length(new_dir, APICAL_NORM))
                    while angle_amp <= MIN_AMP_ANGLE and attempts <= MAX_ANGLE_ATTEMPTS:
                        attempts = attempts + 1
                        rnd_dir = unit_sample_on_sphere()
                        heading = front.xyz - front.parent.xyz
                        new_dir = normalize_length(dir_to_pia,0.5) + \
                                          normalize_length(heading,0.5) + \
                                          normalize_length(rnd_dir,1.0)
                        new_pos = front.xyz + normalize_length(
                            new_dir, APICAL_NORM)
                        angle_amp = _amp_angle(
                            first_vec, normalize_length(new_dir, APICAL_NORM))

                new_front = prepare_next_front(front,
                                               new_pos,
                                               radius_factor=0.98,
                                               add_order=True)
                new_front.tufted = True
                # new_front.swc_type = 5
                new_fronts.append(new_front)
            return new_fronts
        else:
            # simply extend
            rnd_dir = unit_sample_on_sphere()

            eigen_entities = get_eigen_entity(front, constellation)
            eigen_dir = np.array([0, 0, 0])
            eigen_dir = -1.0 * gradient_to(front,
                                           eigen_entities,
                                           front.repulsion_l3,
                                           0.015,
                                           what="nearest",
                                           cutoff=0.2)
            gradient_from_pia = -1.0 * gradient_to(
                front, pia, 5 * 0.7, 0.01, what="nearest", cutoff=0.2)

            heading = front.xyz - front.parent.xyz
            new_dir = normalize_length(heading,1.0) + \
                      normalize_length(rnd_dir,0.3) + \
                      eigen_dir + \
                      normalize_length(dir_to_pia,1.)+ \
                      gradient_from_pia

            new_pos = front.xyz + normalize_length(new_dir, APICAL_NORM)
            new_front = prepare_next_front(front,
                                           new_pos,
                                           radius_factor=0.98,
                                           add_order=False)
            # new_front.swc_type = 6

            # some probability to terminate
            if front.layer == 3 and np.random.random(
            ) < 0.01 and front.order - front.start_order_L3 >= 3:
                return []
            else:
                return [new_front]
            #return [new_front]

    if front.layer == 2:
        # keep track of the order to limit the number of bifurcations in this layer
        if not hasattr(front, 'start_order_L2'):
            # this is the first time, store the current order
            front.start_order_L2 = front.order

        # bifurcate or extend
        bif_prob = 0.1
        if front.order - front.start_order_L3 <= 2:
            bif_prob = 0.4

        rrr = np.random.random()
        if rrr <= 0.5:
            if front.order - front.start_order_L2 >= 3:
                bif_prob = 0
        else:
            if front.order - front.start_order_L2 >= 4:
                bif_prob = 0

        if np.random.random() < bif_prob:
            #bifurcate
            new_fronts = []
            first_vec = None
            attempts = 0
            for i in range(2):
                rnd_dir = unit_sample_on_sphere()
                heading = front.xyz - front.parent.xyz
                new_dir = normalize_length(dir_to_pia,0.5) + \
                                  normalize_length(heading,0.5) + \
                                  normalize_length(rnd_dir,1.0)
                new_pos = front.xyz + normalize_length(new_dir, APICAL_NORM)

                # make sure the bif amplitude reaches a minimum...
                if first_vec == None:
                    first_vec = normalize_length(new_dir, APICAL_NORM)
                else:
                    angle_amp = _amp_angle(
                        first_vec, normalize_length(new_dir, APICAL_NORM))
                    while angle_amp <= MIN_AMP_ANGLE and attempts <= MAX_ANGLE_ATTEMPTS:
                        attempts = attempts + 1
                        rnd_dir = unit_sample_on_sphere()
                        heading = front.xyz - front.parent.xyz
                        new_dir = normalize_length(dir_to_pia,0.5) + \
                                          normalize_length(heading,0.5) + \
                                          normalize_length(rnd_dir,1.0)
                        new_pos = front.xyz + normalize_length(
                            new_dir, APICAL_NORM)
                        angle_amp = _amp_angle(
                            first_vec, normalize_length(new_dir, APICAL_NORM))

                new_front = prepare_next_front(front,
                                               new_pos,
                                               radius_factor=0.98,
                                               add_order=True)
                new_front.tufted = True
                # new_front.swc_type = 7
                new_fronts.append(new_front)
            return new_fronts
        else:
            # simply extend
            rnd_dir = unit_sample_on_sphere()

            eigen_entities = get_eigen_entity(front, constellation)
            eigen_dir = np.array([0, 0, 0])
            eigen_dir = -1.0 * gradient_to(front,
                                           eigen_entities,
                                           front.repulsion_l2,
                                           0.015,
                                           what="nearest",
                                           cutoff=0.2)
            gradient_from_pia = -1.0 * gradient_to(
                front, pia, 4.0 * 0.7, 0.01, what="nearest", cutoff=0.2)

            heading = front.xyz - front.parent.xyz
            new_dir = normalize_length(heading,1.0) + \
                      normalize_length(rnd_dir,0.3) + \
                      eigen_dir + \
                      normalize_length(dir_to_pia,1.)+ \
                      gradient_from_pia

            new_pos = front.xyz + normalize_length(new_dir, APICAL_NORM)
            new_front = prepare_next_front(front,
                                           new_pos,
                                           radius_factor=0.98,
                                           add_order=False)
            # front.swc_type = 7

            # some probability to terminate
            if np.random.random(
            ) < 0.03:  #* (front.order - front.start_order_L2):
                return []
            else:
                return [new_front]

    if front.layer == 1:
        # keep track of the order to limit the number of bifurcations in this layer
        if not hasattr(front, 'start_order_L1'):
            # this is the first time, store the current order
            front.start_order_L1 = front.order

        # bifurcate or extend
        bif_prob = 0.08
        if front.order - front.start_order_L3 <= 4:
            bif_prob = 0.3
        if front.order - front.start_order_L1 >= 1:
            bif_prob = 0

        if np.random.random() < bif_prob:
            #bifurcate
            new_fronts = []
            first_vec = None
            attempts = 0
            for i in range(2):
                rnd_dir = unit_sample_on_sphere()
                heading = front.xyz - front.parent.xyz
                new_dir = normalize_length(dir_to_pia,0.5) + \
                                  normalize_length(heading,0.5) + \
                                  normalize_length(rnd_dir,1.0)
                new_pos = front.xyz + normalize_length(new_dir, APICAL_NORM)

                # make sure the bif amplitude reaches a minimum...
                if first_vec == None:
                    print "first_vec == None, new_dir: ", new_dir
                    first_vec = normalize_length(new_dir, APICAL_NORM)
                else:
                    print "first_vec: ", first_vec, " , other: ", normalize_length(
                        new_dir, APICAL_NORM)
                    angle_amp = _amp_angle(
                        first_vec, normalize_length(new_dir, APICAL_NORM))
                    while angle_amp <= MIN_AMP_ANGLE and attempts <= MAX_ANGLE_ATTEMPTS:
                        attempts = attempts + 1
                        rnd_dir = unit_sample_on_sphere()
                        heading = front.xyz - front.parent.xyz
                        new_dir = normalize_length(dir_to_pia,0.5) + \
                                          normalize_length(heading,0.5) + \
                                          normalize_length(rnd_dir,1.0)
                        new_pos = front.xyz + normalize_length(
                            new_dir, APICAL_NORM)
                        angle_amp = _amp_angle(
                            first_vec, normalize_length(new_dir, APICAL_NORM))
                        print "angle_amp=", angle_amp, ", attemps: ", attempts

                new_front = prepare_next_front(front,
                                               new_pos,
                                               radius_factor=0.98,
                                               add_order=True)
                new_front.tufted = True
                #new_front.swc_type = 8
                new_fronts.append(new_front)
            return new_fronts
        else:
            # simply extend
            rnd_dir = unit_sample_on_sphere()

            eigen_entities = get_eigen_entity(front, constellation)
            eigen_dir = np.array([0, 0, 0])
            eigen_dir = -1.0 * gradient_to(front,
                                           eigen_entities,
                                           front.repulsion_l1,
                                           0.015,
                                           what="nearest",
                                           cutoff=0.2)
            gradient_from_pia = 0 * gradient_to(
                front, pia, 3.0 * 0.7, 0.01, what="nearest",
                cutoff=0.2)  # 2014-05-12

            heading = front.xyz - front.parent.xyz
            new_dir = normalize_length(heading,1.0) + \
                      normalize_length(rnd_dir,0.3) + \
                      eigen_dir + \
                      normalize_length(dir_to_pia,1.)+ \
                      gradient_from_pia

            new_pos = front.xyz + normalize_length(new_dir, APICAL_NORM)
            new_front = prepare_next_front(front,
                                           new_pos,
                                           radius_factor=0.98,
                                           add_order=False)
            #new_front.swc_type = 8

            if np.random.random() < 0.06:
                return []
            else:
                return [new_front]
            return [new_front]
Exemplo n.º 16
0
def extend_front(front, seed, constellation):
    if front.order == 0:  # soma
        new_fronts = []
        for i in range(3):
            rnd_dir = unit_sample_on_sphere()
            rnd_dir[2] = np.abs(rnd_dir[2])
            new_pos = normalize_length(rnd_dir, 15)
            new_pos = front.xyz + new_pos
            new_front = prepare_next_front(front,
                                           new_pos,
                                           set_radius=3.0,
                                           add_order=1)
            new_fronts.append(new_front)
        return new_fronts
    else:
        if np.random.random() < 0.1:
            new_fronts = []
            other_entities = get_entity("pia", constellation)
            for i in range(2):
                rnd_dir = unit_sample_on_sphere()

                if len(other_entities) == 0:
                    rnd_dir = unit_sample_on_sphere()
                    rnd_dir[2] = np.abs(rnd_dir[2])
                    new_pos = normalize_length(rnd_dir, 15)
                    new_pos = front.xyz + new_pos
                    new_front = prepare_next_front(front,
                                                   new_pos,
                                                   set_radius=3.0,
                                                   add_order=1)
                    new_fronts.append(new_front)
                else:
                    dir_to_pia = direction_to(front,
                                              other_entities,
                                              what="nearest")
                    dir_to_pia = normalize_length(dir_to_pia, 2.0) + rnd_dir

                    new_pos = front.xyz + normalize_length(dir_to_pia, 10)

                    new_front = prepare_next_front(front,
                                                   new_pos,
                                                   radius_factor=0.5,
                                                   add_order=True)
                    new_fronts.append(new_front)
            return new_fronts
        else:
            rnd_dir = unit_sample_on_sphere()

            other_entities = get_entity("pia", constellation)

            gradient_to_pia = gradient_to(front,
                                          other_entities,
                                          1.0,
                                          0.0001,
                                          what='nearest')
            # or go directly to the pia
            # gradient_to_pia = direction_to(front,other_entities,what='nearest')

            pia_interaction = gradient_to_pia + rnd_dir

            new_dir = normalize_length(pia_interaction, 1.5)  #+ rnd_dir
            new_pos = front.xyz + normalize_length(new_dir, 10)
            new_front = prepare_next_front(front, new_pos, radius_factor=0.95)
            if new_pos[2] > 190:
                return None
            else:
                return [new_front]