def testGetNumOfBins(self):
self.assertEqual(
0, CompBinManager.getNumOfBins(GenomeRegion('hg18', 'chr1', 0, 0)))
self.assertEqual(
1,
CompBinManager.getNumOfBins(GenomeRegion('hg18', 'chr1', 0, 100)))
self.assertEqual(
2,
CompBinManager.getNumOfBins(GenomeRegion('hg18', 'chr1', 200,
400)))
self.assertEqual(
4,
CompBinManager.getNumOfBins(GenomeRegion('hg18', 'chr1', 67, 314)))
def testGetNumOfBins(self):
self.assertEqual(0, CompBinManager.getNumOfBins(GenomeRegion('hg18', 'chr1', 0, 0)))
self.assertEqual(1, CompBinManager.getNumOfBins(GenomeRegion('hg18', 'chr1', 0, 100)))
self.assertEqual(2, CompBinManager.getNumOfBins(GenomeRegion('hg18', 'chr1', 200, 400)))
self.assertEqual(4, CompBinManager.getNumOfBins(GenomeRegion('hg18', 'chr1', 67, 314)))
def storeBoundingRegions(self, boundingRegionTuples, genomeElementChrList,
sparse):
assert sparse in [False, True]
tempContents = OrderedDict()
genomeElementChrs = set(genomeElementChrList)
lastRegion = None
chrStartIdxs = OrderedDict()
chrEndIdxs = OrderedDict()
totElCount = 0
totBinCount = 0
for br in boundingRegionTuples:
if lastRegion is None or br.region.chr != lastRegion.chr:
if br.region.chr in tempContents:
raise InvalidFormatError(
"Error: bounding region (%s) is not grouped with previous bounding regions of the same chromosome (sequence)."
% br.region)
lastRegion = None
tempContents[br.region.chr] = OrderedDict()
if sparse:
chrStartIdxs[br.region.chr] = totElCount
else:
if br.region < lastRegion:
raise InvalidFormatError(
"Error: bounding regions in the same chromosome (sequence) are unsorted: %s > %s."
% (lastRegion, br.region))
if lastRegion.overlaps(br.region):
raise InvalidFormatError(
"Error: bounding regions '%s' and '%s' overlap." %
(lastRegion, br.region))
if lastRegion.end == br.region.start:
raise InvalidFormatError(
"Error: bounding regions '%s' and '%s' are adjoining (there is no gap between them)."
% (lastRegion, br.region))
if len(br.region) < 1:
raise InvalidFormatError(
"Error: bounding region '%s' does not have positive length."
% br.region)
if not sparse and len(br.region) != br.elCount:
raise InvalidFormatError(
"Error: track type representation is dense, but the length of bounding region '%s' is not equal to the element count: %s != %s"
% (br.region, len(br.region), br.elCount))
startIdx, endIdx = (totElCount, totElCount +
br.elCount) if not sparse else (None, None)
totElCount += br.elCount
if sparse:
chrEndIdxs[br.region.chr] = totElCount
tempContents[br.region.chr][br.region.start] = BoundingRegionInfo(
br.region.start, br.region.end, startIdx, endIdx, 0, 0)
lastRegion = br.region
if sparse:
totBinCount = 0
for chr in tempContents:
chrLen = GenomeInfo.getChrLen(self._genome, chr)
numBinsInChr = CompBinManager.getNumOfBins(
GenomeRegion(start=0, end=chrLen))
for key in tempContents[chr].keys():
startBinIdx = totBinCount
endBinIdx = totBinCount + numBinsInChr
brInfo = tempContents[chr][key]
if chr in genomeElementChrs:
tempContents[chr][key] = BoundingRegionInfo(brInfo.start, brInfo.end, \
chrStartIdxs[chr], chrEndIdxs[chr], \
startBinIdx, endBinIdx)
else:
if chrEndIdxs[chr] - chrStartIdxs[chr] > 0:
raise InvalidFormatError(
"Error: bounding region '%s' has incorrect element count: %s > 0"
% (GenomeRegion(chr=chr,
start=brInfo.start,
end=brInfo.end),
chrEndIdxs[chr] - chrStartIdxs[chr]))
tempContents[chr][key] = BoundingRegionInfo(
brInfo.start, brInfo.end, 0, 0, 0, 0)
if chr in genomeElementChrs:
totBinCount += numBinsInChr
if len(genomeElementChrs - set(tempContents.keys())) > 0:
raise InvalidFormatError(
'Error: some chromosomes (sequences) contains data, but has no bounding regions: %s'
% ', '.join(genomeElementChrs - set(tempContents.keys())))
ensurePathExists(self._fn)
for chr in tempContents:
brInfoDict = tempContents[chr]
tempContents[chr] = BrInfoHolder(tuple(brInfoDict.keys()),
tuple(brInfoDict.values()))
brShelve = safeshelve.open(self._fn)
brShelve.update(tempContents)
brShelve.close()
while not self.fileExists():
from gtrackcore.application.LogSetup import logMessage
logMessage(
"Bounding region shelve file '%s' has yet to be created" %
self._fn)
import time
time.sleep(0.2)
def storeBoundingRegions(self, boundingRegionTuples, genomeElementChrList, sparse):
assert sparse in [False, True]
tempContents = OrderedDict()
genomeElementChrs = set(genomeElementChrList)
lastRegion = None
chrStartIdxs = OrderedDict()
chrEndIdxs = OrderedDict()
totElCount = 0
totBinCount = 0
for br in boundingRegionTuples:
if lastRegion is None or br.region.chr != lastRegion.chr:
if br.region.chr in tempContents:
raise InvalidFormatError("Error: bounding region (%s) is not grouped with previous bounding regions of the same chromosome (sequence)." % br.region)
lastRegion = None
tempContents[br.region.chr] = OrderedDict()
if sparse:
chrStartIdxs[br.region.chr] = totElCount
else:
if br.region < lastRegion:
raise InvalidFormatError("Error: bounding regions in the same chromosome (sequence) are unsorted: %s > %s." % (lastRegion, br.region))
if lastRegion.overlaps(br.region):
raise InvalidFormatError("Error: bounding regions '%s' and '%s' overlap." % (lastRegion, br.region))
if lastRegion.end == br.region.start:
raise InvalidFormatError("Error: bounding regions '%s' and '%s' are adjoining (there is no gap between them)." % (lastRegion, br.region))
if len(br.region) < 1:
raise InvalidFormatError("Error: bounding region '%s' does not have positive length." % br.region)
if not sparse and len(br.region) != br.elCount:
raise InvalidFormatError("Error: track type representation is dense, but the length of bounding region '%s' is not equal to the element count: %s != %s" % (br.region, len(br.region), br.elCount))
startIdx, endIdx = (totElCount, totElCount + br.elCount) if not sparse else (None, None)
totElCount += br.elCount
if sparse:
chrEndIdxs[br.region.chr] = totElCount
tempContents[br.region.chr][br.region.start] = BoundingRegionInfo(br.region.start, br.region.end, startIdx, endIdx, 0, 0)
lastRegion = br.region
if sparse:
totBinCount = 0
for chr in tempContents:
chrLen = GenomeInfo.getChrLen(self._genome, chr)
numBinsInChr = CompBinManager.getNumOfBins(GenomeRegion(start=0, end=chrLen))
for key in tempContents[chr].keys():
startBinIdx = totBinCount
endBinIdx = totBinCount + numBinsInChr
brInfo = tempContents[chr][key]
if chr in genomeElementChrs:
tempContents[chr][key] = BoundingRegionInfo(brInfo.start, brInfo.end, \
chrStartIdxs[chr], chrEndIdxs[chr], \
startBinIdx, endBinIdx)
else:
if chrEndIdxs[chr] - chrStartIdxs[chr] > 0:
raise InvalidFormatError("Error: bounding region '%s' has incorrect element count: %s > 0" % (GenomeRegion(chr=chr, start=brInfo.start, end=brInfo.end), chrEndIdxs[chr] - chrStartIdxs[chr]))
tempContents[chr][key] = BoundingRegionInfo(brInfo.start, brInfo.end, 0, 0, 0, 0)
if chr in genomeElementChrs:
totBinCount += numBinsInChr
if len(genomeElementChrs - set(tempContents.keys())) > 0:
raise InvalidFormatError('Error: some chromosomes (sequences) contains data, but has no bounding regions: %s' % ', '.join(genomeElementChrs - set(tempContents.keys())))
ensurePathExists(self._fn)
for chr in tempContents:
brInfoDict = tempContents[chr]
tempContents[chr] = BrInfoHolder(tuple(brInfoDict.keys()), tuple(brInfoDict.values()))
brShelve = safeshelve.open(self._fn)
brShelve.update(tempContents)
brShelve.close()
while not self.fileExists():
from gtrackcore.application.LogSetup import logMessage
logMessage("Bounding region shelve file '%s' has yet to be created" % self._fn)
import time
time.sleep(0.2)
