def train(model_name, gpu_id):
model_dir = '../models/' + model_name
if not os.path.isdir(model_dir):
os.mkdir(model_dir)
gpu = '/gpu:' + str(gpu_id)
os.environ["CUDA_VISIBLE_DEVICES"] = str(gpu_id)
config = tf.ConfigProto()
config.gpu_options.allow_growth = True
config.allow_soft_placement = True
set_session(tf.Session(config=config))
with tf.device(gpu):
model = networks.unet(vol_size, nf_enc, nf_dec)
model.compile(optimizer=Adam(lr=lr), loss=[
losses.cc3D(), losses.gradientLoss('l2')], loss_weights=[1.0, reg_param])
# model.load_weights('../models/udrnet2/udrnet1_1/120000.h5')
train_example_gen = datagenerators.example_gen(train_vol_names)
zero_flow = np.zeros((1, vol_size[0], vol_size[1], vol_size[2], 3))
for step in xrange(0, n_iterations):
X = train_example_gen.next()[0]
train_loss = model.train_on_batch(
[X, atlas_vol], [atlas_vol, zero_flow])
if not isinstance(train_loss, list):
train_loss = [train_loss]
printLoss(step, 1, train_loss)
if(step % model_save_iter == 0):
model.save(model_dir + '/' + str(step) + '.h5')
def train(model, gpu_id, lr, n_iterations, reg_param, model_save_iter,
load_iter):
model_dir = '/home/ys895/MAS3_Models'
if not os.path.isdir(model_dir):
os.mkdir(model_dir)
gpu = '/gpu:' + str(gpu_id)
os.environ["CUDA_VISIBLE_DEVICES"] = str(gpu_id)
config = tf.ConfigProto()
config.gpu_options.allow_growth = True
config.allow_soft_placement = True
set_session(tf.Session(config=config))
# UNET filters
nf_enc = [16, 32, 32, 32]
if (model == 'vm1'):
nf_dec = [32, 32, 32, 32, 8, 8, 3]
else:
nf_dec = [32, 32, 32, 32, 32, 16, 16, 3]
with tf.device(gpu):
model = networks.unet(vol_size, nf_enc, nf_dec)
if (load_iter != 0):
model.load_weights('/home/ys895/MAS3_Models/' + str(load_iter) +
'.h5')
model.compile(optimizer=Adam(lr=lr),
loss=[losses.cc3D(),
losses.gradientLoss('l2')],
loss_weights=[1.0, reg_param])
# model.load_weights('../models/udrnet2/udrnet1_1/120000.h5')
# return the data, add one more dimension into the data
train_example_gen = datagenerators.example_gen(train_vol_names)
zero_flow = np.zeros((1, vol_size[0], vol_size[1], vol_size[2], 3))
# In this part, the code inputs the data into the model
# Before this part, the model was set
for step in range(1, n_iterations + 1):
# choose randomly one of the atlas from the atlas_list
rand_num = random.randint(0, list_num - 1)
atlas_vol = atlas_list[rand_num]
#Parameters for training : X(train_vol) ,atlas_vol(atlas) ,zero_flow
X = train_example_gen.__next__()[0]
train_loss = model.train_on_batch([atlas_vol, X], [X, zero_flow])
if not isinstance(train_loss, list):
train_loss = [train_loss]
printLoss(step, 1, train_loss)
if (step % model_save_iter == 0):
model.save(model_dir + '/' + str(load_iter + step) + '.h5')
def train(model,save_name, gpu_id, lr, n_iterations, reg_param, model_save_iter):
model_dir = '../models/' + save_name
if not os.path.isdir(model_dir):
os.mkdir(model_dir)
gpu = '/gpu:' + str(gpu_id)
os.environ["CUDA_VISIBLE_DEVICES"] = str(gpu_id)
config = tf.ConfigProto()
config.gpu_options.allow_growth = True
config.allow_soft_placement = True
set_session(tf.Session(config=config))
# UNET filters
nf_enc = [16,32,32,32]
if(model == 'vm1'):
nf_dec = [32,32,32,32,8,8,3]
else:
nf_dec = [32,32,32,32,32,16,16,3]
with tf.device(gpu):
model = networks.unet(vol_size, nf_enc, nf_dec)
model.compile(optimizer=Adam(lr=lr), loss=[losses.cc3D(), losses.gradientLoss('l2')], loss_weights=[1.0, reg_param])
# model.load_weights('../models/udrnet2/udrnet1_1/120000.h5')
zeroflow = np.zeros((1, vol_size[0], vol_size[1], vol_size[2], 3))
for step in range(0, n_iterations):
sub = np.load(train_pairs[step % (noftrain ** 2)][0])
sub = np.reshape(sub, (1,) + sub.shape + (1,))
tmp = np.load(train_pairs[step % (noftrain ** 2)][1])
tmp = np.reshape(tmp, (1,) + tmp.shape + (1,))
train_loss = model.train_on_batch([sub, tmp], [tmp, zeroflow])
printLoss(step, train_loss, keras.get_value(model.optimizer.lr))
if(step % model_save_iter == 0):
model.save(model_dir + '/' + str(step) + '.h5')
if(step % (2*(noftrain ** 2)) == 0 and step > 0):
keras.set_value(model.optimizer.lr, keras.get_value(model.optimizer.lr) / 2)
def train(model,save_name, gpu_id, lr, n_iterations, reg_param, model_save_iter):
model_dir = '../models/' + save_name
if not os.path.isdir(model_dir):
os.mkdir(model_dir)
gpu = '/gpu:' + str(gpu_id)
os.environ["CUDA_VISIBLE_DEVICES"] = str(gpu_id)
config = tf.ConfigProto()
config.gpu_options.allow_growth = True
config.allow_soft_placement = True
set_session(tf.Session(config=config))
# UNET filters
nf_enc = [16,32,32,32]
if(model == 'vm1'):
nf_dec = [32,32,32,32,8,8,3]
else:
nf_dec = [32,32,32,32,32,16,16,3]
with tf.device(gpu):
model = networks.unet(vol_size, nf_enc, nf_dec)
model.compile(optimizer=Adam(lr=lr), loss=[
losses.cc3D(), losses.gradientLoss('l2')], loss_weights=[1.0, reg_param])
# model.load_weights('../models/udrnet2/udrnet1_1/120000.h5')
train_example_gen = datagenerators.example_gen(train_vol_names)
zero_flow = np.zeros((1, vol_size[0], vol_size[1], vol_size[2], 3))
for step in range(0, n_iterations):
X = train_example_gen.__next__()[0]
train_loss = model.train_on_batch(
[X, atlas_vol], [atlas_vol, zero_flow])
if not isinstance(train_loss, list):
train_loss = [train_loss]
printLoss(step, 1, train_loss)
if(step % model_save_iter == 0):
model.save(model_dir + '/' + str(step) + '.h5')
def train(model,
pretrained_path,
model_name,
gpu_id,
lr,
n_iterations,
use_mi,
gamma,
num_bins,
patch_size,
max_clip,
reg_param,
model_save_iter,
local_mi,
sigma_ratio,
batch_size=1):
"""
model training function
:param model: either vm1 or vm2 (based on CVPR 2018 paper)
:param model_dir: the model directory to save to
:param gpu_id: integer specifying the gpu to use
:param lr: learning rate
:param n_iterations: number of training iterations
:param reg_param: the smoothness/reconstruction tradeoff parameter (lambda in CVPR paper)
:param model_save_iter: frequency with which to save models
:param batch_size: Optional, default of 1. can be larger, depends on GPU memory and volume size
"""
os.environ['TF_CPP_MIN_LOG_LEVEL'] = '3'
restrict_GPU_tf(str(gpu_id))
restrict_GPU_keras(str(gpu_id))
train_labels = sio.loadmat('../data/labels.mat')['labels'][0]
n_labels = train_labels.shape[0]
normalized_atlas_vol = atlas_vol / np.max(atlas_vol) * max_clip
atlas_seg = datagenerators.split_seg_into_channels(seg, train_labels)
atlas_seg = datagenerators.downsample(atlas_seg)
model_dir = "../models/" + model_name
# prepare model folder
if not os.path.isdir(model_dir):
os.mkdir(model_dir)
# GPU handling
os.environ["CUDA_VISIBLE_DEVICES"] = str(gpu_id)
config = tf.ConfigProto()
config.gpu_options.allow_growth = True
config.allow_soft_placement = True
set_session(tf.Session(config=config))
# UNET filters for voxelmorph-1 and voxelmorph-2,
# these are architectures presented in CVPR 2018
nf_enc = [16, 32, 32, 32]
if model == 'vm1':
nf_dec = [32, 32, 32, 32, 8, 8]
else:
nf_dec = [32, 32, 32, 32, 32, 16, 16]
# prepare the model
# in the CVPR layout, the model takes in [image_1, image_2] and outputs [warped_image_1, flow]
# in the experiments, we use image_2 as atlas
bin_centers = np.linspace(0, max_clip, num_bins * 2 + 1)[1::2]
loss_function = losses.mutualInformation(bin_centers,
max_clip=max_clip,
local_mi=local_mi,
patch_size=patch_size,
sigma_ratio=sigma_ratio)
model = networks.cvpr2018_net(vol_size,
nf_enc,
nf_dec,
use_seg=True,
n_seg=len(train_labels))
model.compile(optimizer=Adam(lr=lr),
loss=[
loss_function,
losses.gradientLoss('l2'),
sparse_categorical_crossentropy
],
loss_weights=[1 if use_mi else 0, reg_param, gamma])
# if you'd like to initialize the data, you can do it here:
if pretrained_path != None and pretrained_path != '':
model.load_weights(pretrained_path)
# prepare data for training
train_example_gen = datagenerators.example_gen(train_vol_names,
return_segs=True,
seg_dir=train_seg_dir)
zero_flow = np.zeros([batch_size, *vol_size, 3])
# train. Note: we use train_on_batch and design out own print function as this has enabled
# faster development and debugging, but one could also use fit_generator and Keras callbacks.
for step in range(0, n_iterations):
# get data
X = next(train_example_gen)
X_seg = X[1]
X_seg = datagenerators.split_seg_into_channels(X_seg, train_labels)
X_seg = datagenerators.downsample(X_seg)
# train
train_loss = model.train_on_batch(
[X[0], normalized_atlas_vol, X_seg],
[normalized_atlas_vol, zero_flow, atlas_seg])
if not isinstance(train_loss, list):
train_loss = [train_loss]
# print the loss.
print_loss(step, 1, train_loss)
# save model
if step % model_save_iter == 0:
model.save(os.path.join(model_dir, str(step) + '.h5'))
def train(model,
model_dir,
gpu_id,
lr,
n_iterations,
reg_param,
model_save_iter,
batch_size=1):
"""
model training function
:param model: either vm1 or vm2 (based on CVPR 2018 paper)
:param model_dir: the model directory to save to
:param gpu_id: integer specifying the gpu to use
:param lr: learning rate
:param n_iterations: number of training iterations
:param reg_param: the smoothness/reconstruction tradeoff parameter (lambda in CVPR paper)
:param model_save_iter: frequency with which to save models
:param batch_size: Optional, default of 1. can be larger, depends on GPU memory and volume size
"""
# prepare model folder
if not os.path.isdir(model_dir):
os.mkdir(model_dir)
# GPU handling
os.environ["CUDA_VISIBLE_DEVICES"] = str(gpu_id)
config = tf.ConfigProto()
config.gpu_options.allow_growth = True
config.allow_soft_placement = True
set_session(tf.Session(config=config))
# UNET filters for voxelmorph-1 and voxelmorph-2,
# these are architectures presented in CVPR 2018
nf_enc = [16, 32, 32, 32]
if model == 'vm1':
nf_dec = [32, 32, 32, 32, 8, 8]
else:
nf_dec = [32, 32, 32, 32, 32, 16, 16]
# prepare the model
# in the CVPR layout, the model takes in [image_1, image_2] and outputs [warped_image_1, flow]
# in the experiments, we use image_2 as atlas
model = networks.unet(vol_size, nf_enc, nf_dec)
model.compile(optimizer=Adam(lr=lr),
loss=[losses.cc3D(),
losses.gradientLoss('l2')],
loss_weights=[1.0, reg_param])
# if you'd like to initialize the data, you can do it here:
# model.load_weights(os.path.join(model_dir, '120000.h5'))
# prepare data for training
train_example_gen = datagenerators.example_gen(train_vol_names)
zero_flow = np.zeros([batch_size, *vol_size, 3])
# train. Note: we use train_on_batch and design out own print function as this has enabled
# faster development and debugging, but one could also use fit_generator and Keras callbacks.
for step in range(0, n_iterations):
# get data
X = next(train_example_gen)[0]
# train
train_loss = model.train_on_batch([X, atlas_vol],
[atlas_vol, zero_flow])
if not isinstance(train_loss, list):
train_loss = [train_loss]
# print the loss.
print_loss(step, 1, train_loss)
# save model
if step % model_save_iter == 0:
model.save(os.path.join(model_dir, str(step) + '.h5'))
validation_list.append(val_files[ind[0]][:3] + val_files[ind[1]][:3])
validation_list.append(val_files[ind[1]][:3] + val_files[ind[0]][:3])
gen_train = vol_generator2(datapath, train_list, batch_size)
gen_test = vol_generator2(datapath, validation_list, batch_size)
# training
#history = sdn_refine.fit_generator(gen_train, steps_per_epoch = len(train_list)/batch_size, epochs = epochs, use_multiprocessing = True, verbose=1, validation_data = gen_test, validation_steps = len(validation_list)/batch_size)
#loss = history.history['loss']
#val_loss = history.history['val_loss']
for i in range(3):
set_trainable(sdn, True)
print("Weights in sdn is trainable: {}".format(sdn.trainable))
sdn.compile(
loss=[losses.cc3D(), losses.gradientLoss('l2')],
loss_weights=par['loss_weights'],
# metrics = [rec_img_loss, reg_grad],
optimizer=Adam(lr=par['lr'], decay=1e-5))
sdn.fit_generator(gen_train,
steps_per_epoch=len(train_list) / batch_size,
epochs=3,
use_multiprocessing=True,
verbose=1,
validation_data=gen_test,
validation_steps=len(validation_list) / batch_size)
print('\n ith training in sdn done.\n')
set_trainable(sdn, False)
print("Weights in sdn is trainable: {}".format(sdn.trainable))
print("Weights in sdn model of sdn_refine is trainable: {}".format(
sdn_refine.layers[-3].trainable))
def train(model,save_name, gpu_id, lr, n_iterations, reg_param, model_save_iter, alpha):
model_dir = '../models/' + save_name
if not os.path.isdir(model_dir):
os.mkdir(model_dir)
gpu = '/gpu:' + str(gpu_id)
os.environ["CUDA_VISIBLE_DEVICES"] = str(gpu_id)
config = tf.ConfigProto()
config.gpu_options.allow_growth = True
config.allow_soft_placement = True
set_session(tf.Session(config=config))
# UNET filters
nf_enc = [16,32,32,32]
if(model == 'vm1'):
nf_dec = [32,32,32,32,8,8,3]
else:
nf_dec = [32,32,32,32,32,16,16,3]
nf = [0, 8, 16, 32, 64]
with tf.device(gpu):
deformer = networks.unet(vol_size, nf_enc, nf_dec)
#deformer.compile(optimizer=Adam(lr=lr), loss=[losses.cc3D(), losses.gradientLoss('l2')], loss_weights=[1.0, reg_param])
# model.load_weights('../models/udrnet2/udrnet1_1/120000.h5')
discriminator = networks.similarity_net(vol_size, nf)
discriminator.compile(optimizer=Adam(lr), loss='binary_crossentropy')
discriminator.trainable = False
# Build GAN model
src = Input(shape=vol_size + (1,))
tgt = Input(shape=vol_size + (1,))
[warp, df] = deformer([src,tgt])
#pdb.set_trace()
sim_p = discriminator([warp, tgt])
GAN = Model([src, tgt], [sim_p, df])
GAN.compile(optimizer=Adam(lr), loss=['binary_crossentropy',losses.gradientLoss('l2')], loss_weights=[1.0, reg_param])
GAN.summary()
sz = sim_p.shape.as_list()
sz[0] = 1
p_one = np.ones(sz)
p_zero = np.zeros(sz)
zeroflow = np.zeros((1, vol_size[0], vol_size[1], vol_size[2], 3))
for step in range(0, n_iterations):
print 'Epoch ' + str(step // (n_pairs)) + ', Total iterations ' + str(step) + ', lr= ' + str(keras.get_value(discriminator.optimizer.lr)) + ':'
sub = np.load(train_pairs[step % (n_pairs)][0])
sub = np.reshape(sub, (1,) + sub.shape + (1,))
tmp = np.load(train_pairs[step % (n_pairs)][1])
tmp = np.reshape(tmp, (1,) + tmp.shape + (1,))
ref_sub = np.load(ref_pairs[step % (n_ref)][0])
ref_sub = np.reshape(ref_sub, (1,) + ref_sub.shape + (1,))
ref_tmp = np.load(ref_pairs[step % (n_ref)][1])
ref_tmp = np.reshape(ref_tmp, (1,) + ref_tmp.shape + (1,))
## ---------------- Train deformer --------------------------------##
keras.set_value(GAN.optimizer.lr, lr)
g_loss = GAN.train_on_batch([sub, tmp],[p_one, zeroflow])
print ' Train deformer: ' + str(g_loss[1])
print ' Regularization: ' + str(g_loss[2])
## ---------------- Train discriminator for reference --------------##
fused = alpha * sub + (1-alpha) * tmp
d_loss1 = discriminator.test_on_batch([fused, tmp], p_one)
## --------------------Tricks of blancing Registor and Discriminator-------------#
if d_loss1 > 0.6:
keras.set_value(discriminator.optimizer.lr, lr)
elif d_loss1 > 0.4:
keras.set_value(discriminator.optimizer.lr, lr * 0.1)
elif d_loss1 > 0.2:
keras.set_value(discriminator.optimizer.lr, lr * 0.01)
else:
keras.set_value(discriminator.optimizer.lr, lr * 0)
d_loss1 = discriminator.train_on_batch([fused, tmp], p_one)
print ' Test discriminator for positive sample: ' + str(d_loss1)
## ---------------- Train discriminator for deformer --------------##
[warped, deform] = deformer.predict([sub, tmp])
d_loss0 = discriminator.test_on_batch([warped, tmp], p_zero)
if d_loss0 > 0.6:
keras.set_value(discriminator.optimizer.lr, lr)
elif d_loss0 > 0.4:
keras.set_value(discriminator.optimizer.lr, lr * 0.1)
elif d_loss0 > 0.2:
keras.set_value(discriminator.optimizer.lr, lr * 0.01)
else:
keras.set_value(discriminator.optimizer.lr, lr * 0)
d_loss0 = discriminator.train_on_batch([warped, tmp], p_zero)
print ' Test discriminator for negative sample: ' + str(d_loss0)
if(step % model_save_iter == 0):
deformer.save(model_dir + '/' + str(step) + '.h5')
#if(step % (20 * n_pairs) == 0 and step > 0):
#lr = lr / 2
#alpha = np.abs(alpha - 0.05)
sys.stdout.flush()
def Loss(yTrue, yPred):
return losses.gradientLoss('l2')(
yTrue, yPred) + losses.gradientLoss('l2')(0, backward_flow)
def reg_loss(y_true, y_pred):
return gradientLoss('l2')(
y_true, y_pred) + par['NJ loss'] * NJ_loss(y_true, y_pred)
