def wright_fisher_transitions(N, fitness_landscape=None, incentive=None, mutations=None, w=None):
"""Computes transition probabilities for the Markov process. Since the transition matrix is tri-diagonal (i.e. sparse), use a dictionary."""
if not mutations:
mutations = boundary_mutations()
if not w:
w = 1.
d = dict()
d = numpy.zeros((N+1, N+1))
mu, nu = mutations(N, 0)
d[0][1] = mu
d[0][0] = 1- mu
mu, nu = mutations(N, N)
d[N][N-1] = nu
d[N][N] = 1 - nu
for a in range(1, N):
b = N - a
if incentive:
i = normalize(incentive([a,b]))
else:
i = normalize(multiply_vectors([a, b], fitness_landscape([a,b])))
i[0] = 1. - w + w * i[0]
i[1] = 1. - w + w * i[1]
mu, nu = mutations(N, a)
up = ((i[0] * (1. - mu) + i[1]*nu))
down = ((i[0] * mu + i[1]*(1. - nu)))
for j in range(0, N+1):
if (j == 0) or (j == N):
d[a][j] = exp(j * log(up) + (N-j) * log(down))
else:
d[a][j] = comb(N,j, exact=True) * exp(j * log(up) + (N-j) * log(down))
return d
def moran_transitions(N, fitness_landscape=None, incentive=None, mutations=None, w=None):
"""Computes transition probabilities for the Markov process. Since the transition matrix is tri-diagonal (i.e. sparse), use a dictionary."""
if not mutations:
mutations = boundary_mutations()
if not w:
w = 1.
d = dict()
mu, nu = mutations(N, 0)
d[(0,1)] = mu
d[(0,0)] = 1. - mu
mu, nu = mutations(N, N)
d[(N, N-1)] = nu
d[(N, N)] = 1. - nu
for a in range(1, N):
b = N - a
if incentive:
i = normalize(incentive([a,b]))
else:
i = normalize(multiply_vectors([a, b], fitness_landscape([a,b])))
i[0] = 1. - w + w * i[0]
i[1] = 1. - w + w * i[1]
mu, nu = mutations(N, a)
up = ((i[0] * (1. - mu) + i[1]*nu)) * float(b) / (a + b)
down = ((i[0] * mu + i[1]*(1. - nu))) * float(a) / (a + b)
d[(a, a+1)] = up
d[(a, a-1)] = down
d[(a, a)] = 1. - up - down
return d
def moran_transitions(N,
fitness_landscape=None,
incentive=None,
mutations=None,
w=None):
"""Computes transition probabilities for the Markov process. Since the transition matrix is tri-diagonal (i.e. sparse), use a dictionary."""
if not mutations:
mutations = boundary_mutations()
if not w:
w = 1.
d = dict()
mu, nu = mutations(N, 0)
d[(0, 1)] = mu
d[(0, 0)] = 1. - mu
mu, nu = mutations(N, N)
d[(N, N - 1)] = nu
d[(N, N)] = 1. - nu
for a in range(1, N):
b = N - a
if incentive:
i = normalize(incentive([a, b]))
else:
i = normalize(multiply_vectors([a, b], fitness_landscape([a, b])))
i[0] = 1. - w + w * i[0]
i[1] = 1. - w + w * i[1]
mu, nu = mutations(N, a)
up = ((i[0] * (1. - mu) + i[1] * nu)) * float(b) / (a + b)
down = ((i[0] * mu + i[1] * (1. - nu))) * float(a) / (a + b)
d[(a, a + 1)] = up
d[(a, a - 1)] = down
d[(a, a)] = 1. - up - down
return d
def wright_fisher_transitions(N,
fitness_landscape=None,
incentive=None,
mutations=None,
w=None):
"""Computes transition probabilities for the Markov process. Since the transition matrix is tri-diagonal (i.e. sparse), use a dictionary."""
if not mutations:
mutations = boundary_mutations()
if not w:
w = 1.
d = dict()
d = numpy.zeros((N + 1, N + 1))
mu, nu = mutations(N, 0)
d[0][1] = mu
d[0][0] = 1 - mu
mu, nu = mutations(N, N)
d[N][N - 1] = nu
d[N][N] = 1 - nu
for a in range(1, N):
b = N - a
if incentive:
i = normalize(incentive([a, b]))
else:
i = normalize(multiply_vectors([a, b], fitness_landscape([a, b])))
i[0] = 1. - w + w * i[0]
i[1] = 1. - w + w * i[1]
mu, nu = mutations(N, a)
up = ((i[0] * (1. - mu) + i[1] * nu))
down = ((i[0] * mu + i[1] * (1. - nu)))
for j in range(0, N + 1):
if (j == 0) or (j == N):
d[a][j] = exp(j * log(up) + (N - j) * log(down))
else:
d[a][j] = comb(N, j, exact=True) * exp(j * log(up) +
(N - j) * log(down))
return d