def load_model(model_file, data, clinical, surv_time, edge_index):
"""The function for loading a pytorch model
"""
#############
m = MyNet(edge_index).to(device)
model = CoxPH(m, tt.optim.Adam(0.0001))
#_, features = m(data)
#print(features)
model.load_net(model_file)
prediction = model.predict_surv_df(data)
#print(prediction)
fs = features(model.net, torch.from_numpy(data).to(device))
#print(fs)
#ev = EvalSurv(prediction, clinical, surv_time)
#prediction = ev.concordance_td()
return prediction, fs
# Training ======================================================================
epochs = args.epochs
callbacks = [tt.callbacks.EarlyStopping()]
verbose = True
log = model.fit(x_train,
y_train,
batch_size,
epochs,
callbacks,
verbose,
val_data=val,
val_batch_size=batch_size)
# log = model.fit(x_train, y_train_transformed, batch_size, epochs, callbacks, verbose, val_data = val_transformed, val_batch_size = batch_size)
# Evaluation ===================================================================
_ = model.compute_baseline_hazards()
surv = model.predict_surv_df(x_test)
ev = EvalSurv(surv, durations_test, events_test, censor_surv='km')
# ctd = ev.concordance_td()
ctd = ev.concordance_td()
time_grid = np.linspace(durations_test.min(), durations_test.max(), 100)
ibs = ev.integrated_brier_score(time_grid)
nbll = ev.integrated_nbll(time_grid)
val_loss = min(log.monitors['val_'].scores['loss']['score'])
wandb.log({'val_loss': val_loss, 'ctd': ctd, 'ibs': ibs, 'nbll': nbll})
wandb.finish()
def pycox_deep(filename, Y_train, Y_test, opt, choice):
# choice = {'lr_rate': l, 'batch': b, 'decay': 0, 'weighted_decay': wd, 'net': net, 'index': index}
X_train, X_test = enc_using_trained_ae(filename, TARGET=opt, ALPHA=0.01, N_ITER=100, L1R=-9999)
path = './models/analysis/'
check = 0
savename = 'model_check_autoen_m5_test_batch+dropout+wd.csv'
# r=root, d=directories, f = files
for r, d, f in os.walk(path):
for file in f:
if savename in file:
check = 1
# X_train = X_train.drop('UR_SG3', axis=1)
# X_test = X_test.drop('UR_SG3', axis=1)
x_train = X_train
x_test = X_test
x_train['SVDTEPC_G'] = Y_train['SVDTEPC_G']
x_train['PC_YN'] = Y_train['PC_YN']
x_test['SVDTEPC_G'] = Y_test['SVDTEPC_G']
x_test['PC_YN'] = Y_test['PC_YN']
## DataFrameMapper ##
cols_standardize = list(X_train.columns)
cols_standardize.remove('SVDTEPC_G')
cols_standardize.remove('PC_YN')
standardize = [(col, None) for col in cols_standardize]
x_mapper = DataFrameMapper(standardize)
_ = x_mapper.fit_transform(X_train).astype('float32')
X_train = x_mapper.transform(X_train).astype('float32')
X_test = x_mapper.transform(X_test).astype('float32')
get_target = lambda df: (df['SVDTEPC_G'].values, df['PC_YN'].values)
y_train = get_target(x_train)
durations_test, events_test = get_target(x_test)
in_features = X_train.shape[1]
print(in_features)
num_nodes = choice['nodes']
out_features = 1
batch_norm = True # False for batch_normalization
dropout = 0.01
output_bias = False
# net = choice['net']
net = tt.practical.MLPVanilla(in_features, num_nodes, out_features, batch_norm, dropout, output_bias=output_bias)
print("training")
model = CoxPH(net, tt.optim.Adam)
# lrfinder = model.lr_finder(X_train, y_train, batch_size)
# lr_best = lrfinder.get_best_lr()
lr_best = 0.0001
model.optimizer.set_lr(choice['lr_rate'])
weighted_decay = choice['weighted_decay']
verbose = True
batch_size = choice['batch']
epochs = 100
if weighted_decay == 0:
callbacks = [tt.callbacks.EarlyStopping(patience=epochs)]
# model.fit(X_train, y_train, batch_size, epochs, callbacks, verbose=verbose)
else:
callbacks = [tt.callbacks.DecoupledWeightDecay(weight_decay=choice['decay'])]
# model.fit(X_train, y_train, batch_size, epochs, callbacks, verbose)
''''''
# dataloader = model.make_dataloader(tt.tuplefy(X_train, y_train),batch_size,True)
datas = tt.tuplefy(X_train, y_train).to_tensor()
print(datas)
make_dataset = tt.data.DatasetTuple;
DataLoader = tt.data.DataLoaderBatch
dataset = make_dataset(*datas)
dataloader = DataLoader(dataset, batch_size, False, sampler=StratifiedSampler(datas, batch_size))
# dataloader = DataLoader(dataset,batch_size, True)
model.fit_dataloader(dataloader, epochs, callbacks, verbose)
# model.fit(X_train, y_train, batch_size, epochs, callbacks, verbose)
# model.partial_log_likelihood(*val).mean()
print("predicting")
baseline_hazards = model.compute_baseline_hazards(datas[0], datas[1])
baseline_hazards = df(baseline_hazards)
surv = model.predict_surv_df(X_test)
surv = 1 - surv
ev = EvalSurv(surv, durations_test, events_test, censor_surv='km')
print("scoring")
c_index = ev.concordance_td()
print("c-index(", opt, "): ", c_index)
if int(c_index * 10) == 0:
hazardname = 'pycox_model_hazard_m5_v2_' + opt + '_0'
netname = 'pycox_model_net_m5_v2_' + opt + '_0'
weightname = 'pycox_model_weight_m5_v2_' + opt + '_0'
else:
hazardname = 'pycox_model_hazard_m5_' + opt + '_'
netname = 'pycox_model_net_m5_' + opt + '_'
weightname = 'pycox_model_weight_m5_' + opt + '_'
baseline_hazards.to_csv('./test/'+hazardname + str(int(c_index * 100)) + '_' + str(index) + '.csv', index=False)
netname = netname + str(int(c_index * 100)) + '_' + str(index) + '.sav'
weightname = weightname + str(int(c_index * 100)) + '_' + str(index) + '.sav'
model.save_net('./test/' + netname)
model.save_model_weights('./test/' + weightname)
pred = df(surv)
pred = pred.transpose()
surv_final = []
pred_final = []
for i in range(len(pred)):
pred_final.append(float(1-pred[Y_test['SVDTEPC_G'][i]][i]))
surv_final.append(float(pred[Y_test['SVDTEPC_G'][i]][i]))
Y_test_cox = CoxformY(Y_test)
#print(surv_final)
c_cox, concordant, discordant,_,_ = concordance_index_censored(Y_test_cox['PC_YN'], Y_test_cox['SVDTEPC_G'], surv_final)
c_cox_pred = concordance_index_censored(Y_test_cox['PC_YN'], Y_test_cox['SVDTEPC_G'], pred_final)[0]
print("c-index(", opt, ") - sksurv: ", round(c_cox, 4))
print("cox-concordant(", opt, ") - sksurv: ", concordant)
print("cox-disconcordant(", opt, ") - sksurv: ", discordant)
print("c-index_pred(", opt, ") - sksurv: ", round(c_cox_pred, 4))
fpr, tpr, _ = metrics.roc_curve(Y_test['PC_YN'], pred_final)
auc = metrics.auc(fpr, tpr)
print("auc(", opt, "): ", round(auc, 4))
if check == 1:
model_check = pd.read_csv(path+savename)
else:
model_check = df(columns=['option', 'gender', 'c-td', 'c-index', 'auc'])
line_append = {'option':str(choice), 'gender':opt, 'c-td':round(c_index,4), 'c-index':round(c_cox_pred,4), 'auc':round(auc,4)}
model_check = model_check.append(line_append, ignore_index=True)
model_check.to_csv(path+savename, index=False)
del X_train
del X_test
return surv_final
def train_deepsurv(data_df, r_splits):
epochs = 100
verbose = True
num_nodes = [32]
out_features = 1
batch_norm = True
dropout = 0.6
output_bias = False
c_index_at = []
c_index_30 = []
time_auc_30 = []
time_auc_60 = []
time_auc_365 = []
for i in range(len(r_splits)):
print("\nIteration %s"%(i))
#DATA PREP
df_train, df_val, df_test, df_test_30 = prepare_datasets(data_df, r_splits[i][2], r_splits[i][1], r_splits[i][0])
xcols = list(df_train.columns)
for col_name in ["subject_id", "event", "duration"]:
if col_name in xcols:
xcols.remove(col_name)
cols_standardize = xcols
standardize = [([col], StandardScaler()) for col in cols_standardize]
x_mapper = DataFrameMapper(standardize)
x_train = x_mapper.fit_transform(df_train).astype('float32')
x_val = x_mapper.transform(df_val).astype('float32')
x_test = x_mapper.transform(df_test).astype('float32')
x_test_30 = x_mapper.transform(df_test_30).astype('float32')
labtrans = CoxTime.label_transform()
get_target = lambda df: (df['duration'].values, df['event'].values)
y_train = labtrans.fit_transform(*get_target(df_train))
y_val = labtrans.transform(*get_target(df_val))
durations_test, events_test = get_target(df_test)
durations_test_30, events_test_30 = get_target(df_test_30)
val = tt.tuplefy(x_val, y_val)
(train_x, train_y), (val_x, val_y), (test_x, test_y), _ = df2array(data_df, df_train, df_val, df_test, df_test_30)
#MODEL
in_features = x_train.shape[1]
callbacks = [tt.callbacks.EarlyStopping()]
net = tt.practical.MLPVanilla(in_features, num_nodes, out_features, batch_norm, dropout, output_bias=output_bias)
model = CoxPH(net, tt.optim.Adam)
model.optimizer.set_lr(0.0001)
if x_train.shape[0] % 2:
batch_size = 255
else:
batch_size = 256
log = model.fit(x_train, y_train, batch_size, epochs, callbacks, val_data=val, val_batch_size=batch_size)
model.compute_baseline_hazards()
surv = model.predict_surv_df(x_test)
ev = EvalSurv(surv, durations_test, events_test, censor_surv='km')
c_index_at.append(ev.concordance_td())
surv_30 = model.predict_surv_df(x_test_30)
ev_30 = EvalSurv(surv_30, durations_test_30, events_test_30, censor_surv='km')
c_index_30.append(ev_30.concordance_td())
for time_x in [30, 60, 365]:
va_auc, va_mean_auc = cumulative_dynamic_auc(train_y, test_y, model.predict(x_test).flatten(), time_x)
eval("time_auc_" + str(time_x)).append(va_auc[0])
print("C-index_30:", c_index_30[i])
print("C-index_AT:", c_index_at[i])
print("time_auc_30", time_auc_30[i])
print("time_auc_60", time_auc_60[i])
print("time_auc_365", time_auc_365[i])
return c_index_at, c_index_30, time_auc_30, time_auc_60, time_auc_365
def train_LSTMCox(data_df, r_splits):
epochs = 100
verbose = True
in_features = 768
out_features = 1
batch_norm = True
dropout = 0.6
output_bias = False
c_index_at = []
c_index_30 = []
time_auc_30 = []
time_auc_60 = []
time_auc_365 = []
for i in range(len(r_splits)):
print("\nIteration %s"%(i))
#DATA PREP
df_train, df_val, df_test, df_test_30 = prepare_datasets(data_df, r_splits[i][2], r_splits[i][1], r_splits[i][0])
x_train = np.array(df_train["x0"].tolist()).astype("float32")
x_val = np.array(df_val["x0"].tolist()).astype("float32")
x_test = np.array(df_test["x0"].tolist()).astype("float32")
x_test_30 = np.array(df_test_30["x0"].tolist()).astype("float32")
labtrans = CoxTime.label_transform()
get_target = lambda df: (df['duration'].values, df['event'].values)
y_train = labtrans.fit_transform(*get_target(df_train))
y_val = labtrans.transform(*get_target(df_val))
durations_test, events_test = get_target(df_test)
durations_test_30, events_test_30 = get_target(df_test_30)
val = tt.tuplefy(x_val, y_val)
(train_x, train_y), (val_x, val_y), (test_x, test_y), _ = df2array(data_df, df_train, df_val, df_test, df_test_30)
#MODEL
callbacks = [tt.callbacks.EarlyStopping()]
net = LSTMCox(768, 32, 1, 1)
model = CoxPH(net, tt.optim.Adam)
model.optimizer.set_lr(0.0001)
if x_train.shape[0] % 2:
batch_size = 255
else:
batch_size = 256
log = model.fit(x_train, y_train, batch_size, epochs, callbacks, val_data=val, val_batch_size=batch_size)
model.compute_baseline_hazards()
surv = model.predict_surv_df(x_test)
ev = EvalSurv(surv, durations_test, events_test, censor_surv='km')
c_index_at.append(ev.concordance_td())
surv_30 = model.predict_surv_df(x_test_30)
ev_30 = EvalSurv(surv_30, durations_test_30, events_test_30, censor_surv='km')
c_index_30.append(ev_30.concordance_td())
for time_x in [30, 60, 365]:
va_auc, va_mean_auc = cumulative_dynamic_auc(train_y, test_y, model.predict(x_test).flatten(), time_x)
eval("time_auc_" + str(time_x)).append(va_auc[0])
print("C-index_30:", c_index_30[i])
print("C-index_AT:", c_index_at[i])
print("time_auc_30", time_auc_30[i])
print("time_auc_60", time_auc_60[i])
print("time_auc_365", time_auc_365[i])
return c_index_at, c_index_30, time_auc_30, time_auc_60, time_auc_365
output_bias=output_bias)
optimizer = tt.optim.Adam(lr=lr)
surv_model = CoxPH(net, optimizer)
model_filename = \
os.path.join(output_dir, 'models',
'%s_%s_exp%d_%s_bs%d_nep%d_nla%d_nno%d_lr%f_test.pt'
% (survival_estimator_name, dataset, experiment_idx,
val_string, batch_size, n_epochs, n_layers, n_nodes, lr))
assert os.path.isfile(model_filename)
print('*** Loading ***', flush=True)
surv_model.load_net(model_filename)
surv_df = surv_model.predict_surv_df(X_test_std)
surv = surv_df.to_numpy().T
print()
print('[Test data statistics]')
sorted_y_test_times = np.sort(y_test[:, 0])
print('Quartiles:')
print('- Min observed time:', np.min(y_test[:, 0]))
print('- Q1 observed time:',
sorted_y_test_times[int(0.25 * len(sorted_y_test_times))])
print('- Median observed time:', np.median(y_test[:, 0]))
print('- Q3 observed time:',
sorted_y_test_times[int(0.75 * len(sorted_y_test_times))])
print('- Max observed time:', np.max(y_test[:, 0]))
print('Mean observed time:', np.mean(y_test[:, 0]))
print('Fraction censored:', 1. - np.mean(y_test[:, 1]))
n_epochs,
verbose=False)
surv_model.compute_baseline_hazards()
elapsed = time.time() - tic
print('Time elapsed: %f second(s)' % elapsed)
np.savetxt(time_elapsed_filename,
np.array(elapsed).reshape(1, -1))
surv_model.save_net(model_filename)
else:
# print('*** Loading ***', flush=True)
surv_model.load_net(model_filename)
elapsed = float(np.loadtxt(time_elapsed_filename))
print('Time elapsed (from previous fitting): ' +
'%f second(s)' % elapsed)
surv_df = surv_model.predict_surv_df(fold_X_val_std)
ev = EvalSurv(surv_df,
fold_y_val[:, 0],
fold_y_val[:, 1],
censor_surv='km')
sorted_fold_y_val = np.sort(np.unique(fold_y_val[:, 0]))
time_grid = np.linspace(sorted_fold_y_val[0],
sorted_fold_y_val[-1], 100)
surv = surv_df.to_numpy().T
cindex_scores.append(ev.concordance_td('antolini'))
integrated_brier_scores.append(
ev.integrated_brier_score(time_grid))
print(' c-index (td):', cindex_scores[-1])
def main():
parser = setup_parser()
args = parser.parse_args()
if args.which_gpu != 'none':
os.environ["CUDA_VISIBLE_DEVICES"] = args.which_gpu
# save setting
if not os.path.exists(os.path.join(args.save_path, args.model_name)):
os.mkdir(os.path.join(args.save_path, args.model_name))
# data reading seeting
singnal_data_path = args.signal_dataset_path
table_path = args.table_path
time_col = 'SurvivalDays'
event_col = 'Mortality'
# dataset
data_pathes, times, events = read_dataset(singnal_data_path, table_path,
time_col, event_col,
args.sample_ratio)
data_pathes_train, data_pathes_test, times_train, times_test, events_train, events_test = train_test_split(
data_pathes, times, events, test_size=0.3, random_state=369)
data_pathes_train, data_pathes_val, times_train, times_val, events_train, events_val = train_test_split(
data_pathes_train,
times_train,
events_train,
test_size=0.2,
random_state=369)
labels_train = label_transfer(times_train, events_train)
dataset_train = VsDatasetBatch(data_pathes_train, *labels_train)
dl_train = tt.data.DataLoaderBatch(dataset_train,
args.train_batch_size,
shuffle=True)
labels_val = label_transfer(times_val, events_val)
dataset_val = VsDatasetBatch(data_pathes_val, *labels_val)
dl_val = tt.data.DataLoaderBatch(dataset_val,
args.train_batch_size,
shuffle=True)
labels_test = label_transfer(times_test, events_test)
dataset_test_x = VsTestInput(data_pathes_test)
dl_test_x = DataLoader(dataset_test_x, args.test_batch_size, shuffle=False)
net = resnet18(args)
model = CoxPH(
net,
tt.optim.Adam(lr=args.lr,
betas=(0.9, 0.999),
eps=1e-08,
weight_decay=5e-4,
amsgrad=False))
# callbacks = [tt.cb.EarlyStopping(patience=15)]
callbacks = [
tt.cb.BestWeights(file_path=os.path.join(
args.save_path, args.model_name, args.model_name + '_bestWeight'),
rm_file=False)
]
verbose = True
model_log = model.fit_dataloader(dl_train,
args.epochs,
callbacks,
verbose,
val_dataloader=dl_val)
save_args(os.path.join(args.save_path, args.model_name), args)
model_log.to_pandas().to_csv(os.path.join(args.save_path, args.model_name,
'loss.csv'),
index=False)
_ = model.compute_baseline_hazards(
get_vs_data(dataset_train), (dataset_train.time, dataset_train.event))
model.save_net(
path=os.path.join(args.save_path, args.model_name, args.model_name +
'_final'))
surv = model.predict_surv_df(dl_test_x)
surv.to_csv(os.path.join(args.save_path, args.model_name,
'test_sur_df.csv'),
index=False)
ev = EvalSurv(surv, np.array(labels_test[0]), np.array(labels_test[1]),
'km')
print(ev.concordance_td())
save_cindex(os.path.join(args.save_path, args.model_name),
ev.concordance_td())
print('done')
class DeepSurv_pycox():
def __init__(self,
layers,
nodes_per_layer,
dropout,
weight_decay,
batch_size,
lr=0.01,
seed=47):
# set seed
np.random.seed(seed)
_ = torch.manual_seed(seed)
self.standardalizer = None
self.standardize_data = True
self._duration_col = "duration"
self._event_col = "event"
self.in_features = None
self.out_features = 1
self.batch_norm = True
self.output_bias = False
self.activation = torch.nn.ReLU
self.epochs = 512
self.num_workers = 2
self.callbacks = [tt.callbacks.EarlyStopping()]
# parameters tuned
self.num_nodes = [int(nodes_per_layer) for _ in range(int(layers))]
self.dropout = dropout
self.weight_decay = weight_decay
self.lr = lr
self.batch_size = int(batch_size)
def set_standardize(self, standardize_bool):
self.standardize_data = standardize_bool
def _format_to_pycox(self, X, Y, F):
# from numpy to pandas df
df = pd.DataFrame(data=X, columns=F)
if Y is not None:
df[self._duration_col] = Y[:, 0]
df[self._event_col] = Y[:, 1]
return df
def _standardize_df(self, df, flag):
# if flag = test, the df passed in does not contain Y labels
if self.standardize_data:
df_x = df if flag == 'test' else df.drop(
columns=[self._duration_col, self._event_col])
if flag == "train":
cols_leave = []
cols_standardize = []
for column in df_x.columns:
if set(pd.unique(df[column])) == set([0, 1]):
cols_leave.append(column)
else:
cols_standardize.append(column)
standardize = [([col], StandardScaler())
for col in cols_standardize]
leave = [(col, None) for col in cols_leave]
self.standardalizer = DataFrameMapper(standardize + leave)
x = self.standardalizer.fit_transform(df_x).astype('float32')
y = (df[self._duration_col].values.astype('float32'),
df[self._event_col].values.astype('float32'))
elif flag == "val":
x = self.standardalizer.transform(df_x).astype('float32')
y = (df[self._duration_col].values.astype('float32'),
df[self._event_col].values.astype('float32'))
elif flag == "test":
x = self.standardalizer.transform(df_x).astype('float32')
y = None
else:
raise NotImplementedError
return x, y
else:
raise NotImplementedError
def fit(self, X, y, column_names):
# format data
self.column_names = column_names
full_df = self._format_to_pycox(X, y, self.column_names)
val_df = full_df.sample(frac=0.2)
train_df = full_df.drop(val_df.index)
train_x, train_y = self._standardize_df(train_df, "train")
val_x, val_y = self._standardize_df(val_df, "val")
# configure model
self.in_features = train_x.shape[1]
net = tt.practical.MLPVanilla(in_features=self.in_features,
num_nodes=self.num_nodes,
out_features=self.out_features,
batch_norm=self.batch_norm,
dropout=self.dropout,
activation=self.activation,
output_bias=self.output_bias)
self.model = CoxPH(
net, tt.optim.Adam(lr=self.lr, weight_decay=self.weight_decay))
# self.model.optimizer.set_lr(self.lr)
n_train = train_x.shape[0]
while n_train % self.batch_size == 1: # this will cause issues in batch norm
self.batch_size += 1
self.model.fit(train_x,
train_y,
self.batch_size,
self.epochs,
self.callbacks,
verbose=True,
val_data=(val_x, val_y),
val_batch_size=self.batch_size,
num_workers=self.num_workers)
self.model.compute_baseline_hazards()
def predict(self, test_x, time_list):
# format data
test_df = self._format_to_pycox(test_x, None, self.column_names)
test_x, _ = self._standardize_df(test_df, "test")
proba_matrix_ = self.model.predict_surv_df(test_x)
proba_matrix = np.transpose(proba_matrix_.values)
pred_medians = []
median_time = max(time_list)
# if the predicted proba never goes below 0.5, predict the largest seen value
for test_idx, survival_proba in enumerate(proba_matrix):
# the survival_proba is in descending order
for col, proba in enumerate(survival_proba):
if proba > 0.5:
continue
if proba == 0.5 or col == 0:
median_time = time_list[col]
else:
median_time = (time_list[col - 1] + time_list[col]) / 2
break
pred_medians.append(median_time)
return np.array(pred_medians), proba_matrix_
def main(data_root, cancer_type, anatomical_location, fold):
# Import the RDF graph for PPI network
f = open('seen.pkl', 'rb')
seen = pickle.load(f)
f.close()
#####################
f = open('ei.pkl', 'rb')
ei = pickle.load(f)
f.close()
global device
device = torch.device('cuda' if torch.cuda.is_available() else 'cpu')
# device = torch.device('cpu')
cancer_type_vector = np.zeros((33, ), dtype=np.float32)
cancer_type_vector[cancer_type] = 1
cancer_subtype_vector = np.zeros((25, ), dtype=np.float32)
for i in CANCER_SUBTYPES[cancer_type]:
cancer_subtype_vector[i] = 1
anatomical_location_vector = np.zeros((52, ), dtype=np.float32)
anatomical_location_vector[anatomical_location] = 1
cell_type_vector = np.zeros((10, ), dtype=np.float32)
cell_type_vector[CELL_TYPES[cancer_type]] = 1
pt_tensor_cancer_type = torch.FloatTensor(cancer_type_vector).to(device)
pt_tensor_cancer_subtype = torch.FloatTensor(cancer_subtype_vector).to(
device)
pt_tensor_anatomical_location = torch.FloatTensor(
anatomical_location_vector).to(device)
pt_tensor_cell_type = torch.FloatTensor(cell_type_vector).to(device)
edge_index = torch.LongTensor(ei).to(device)
# Import a dictionary that maps protiens to their coresponding genes by Ensembl database
f = open('ens_dic.pkl', 'rb')
dicty = pickle.load(f)
f.close()
dic = {}
for d in dicty:
key = dicty[d]
if key not in dic:
dic[key] = {}
dic[key][d] = 1
# Build a dictionary from ENSG -- ENST
d = {}
with open('data1/prot_names1.txt') as f:
for line in f:
tok = line.split()
d[tok[1]] = tok[0]
clin = [
] # for clinical data (i.e. number of days to survive, days to death for dead patients and days to last followup for alive patients)
feat_vecs = [
] # list of lists ([[patient1],[patient2],.....[patientN]]) -- [patientX] = [gene_expression_value, diff_gene_expression_value, methylation_value, diff_methylation_value, VCF_value, CNV_value]
suv_time = [
] # list that include wheather a patient is alive or dead (i.e. 0 for dead and 1 for alive)
can_types = ["BRCA_v2"]
data_root = '/ibex/scratch/projects/c2014/sara/'
for i in range(len(can_types)):
# file that contain patients ID with their coressponding 6 differnt files names (i.e. files names for gene_expression, diff_gene_expression, methylation, diff_methylation, VCF and CNV)
f = open(data_root + can_types[i] + '.txt')
lines = f.read().splitlines()
f.close()
lines = lines[1:]
count = 0
feat_vecs = np.zeros((len(lines), 17186 * 6), dtype=np.float32)
i = 0
for l in tqdm(lines):
l = l.split('\t')
clinical_file = l[6]
surv_file = l[2]
myth_file = 'myth/' + l[3]
diff_myth_file = 'diff_myth/' + l[1]
exp_norm_file = 'exp_count/' + l[-1]
diff_exp_norm_file = 'diff_exp/' + l[0]
cnv_file = 'cnv/' + l[4] + '.txt'
vcf_file = 'vcf/' + 'OutputAnnoFile_' + l[
5] + '.hg38_multianno.txt.dat'
# Check if all 6 files are exist for a patient (that's because for some patients, their survival time not reported)
all_files = [
myth_file, diff_exp_norm_file, diff_myth_file, exp_norm_file,
cnv_file, vcf_file
]
for fname in all_files:
if not os.path.exists(fname):
print('File ' + fname + ' does not exist!')
sys.exit(1)
# f = open(clinical_file)
# content = f.read().strip()
# f.close()
clin.append(clinical_file)
# f = open(surv_file)
# content = f.read().strip()
# f.close()
suv_time.append(surv_file)
temp_myth = myth_data(myth_file, seen, d, dic)
vec = np.array(get_data(exp_norm_file, diff_exp_norm_file,
diff_myth_file, cnv_file, vcf_file,
temp_myth, seen, dic),
dtype=np.float32)
vec = vec.flatten()
# vec = np.concatenate([
# vec, cancer_type_vector, cancer_subtype_vector,
# anatomical_location_vector, cell_type_vector])
feat_vecs[i, :] = vec
i += 1
min_max_scaler = MinMaxScaler(clip=True)
labels_days = []
labels_surv = []
for days, surv in zip(clin, suv_time):
# if days.replace("-", "") != "":
# days = float(days)
# else:
# days = 0.0
labels_days.append(float(days))
labels_surv.append(float(surv))
# Train by batch
dataset = feat_vecs
#print(dataset.shape)
labels_days = np.array(labels_days)
labels_surv = np.array(labels_surv)
censored_index = []
uncensored_index = []
for i in range(len(dataset)):
if labels_surv[i] == 1:
censored_index.append(i)
else:
uncensored_index.append(i)
model = CoxPH(MyNet(edge_index).to(device), tt.optim.Adam(0.0001))
censored_index = np.array(censored_index)
uncensored_index = np.array(uncensored_index)
# Each time test on a specific cancer type
# total_cancers = ["TCGA-BRCA"]
# for i in range(len(total_cancers)):
# test_set = [d for t, d in zip(total_cancers, dataset) if t == total_cancers[i]]
# train_set = [d for t, d in zip(total_cancers, dataset) if t != total_cancers[i]]
# Censored split
n = len(censored_index)
index = np.arange(n)
i = n // 5
np.random.seed(seed=0)
np.random.shuffle(index)
if fold < 4:
ctest_idx = index[fold * i:fold * i + i]
ctrain_idx = index[:fold * i] + index[fold * i + i:]
else:
ctest_idx = index[fold * i:]
ctrain_idx = index[:fold * i]
ctrain_n = len(ctrain_idx)
cvalid_n = ctrain_n // 10
cvalid_idx = ctrain_idx[:cvalid_n]
ctrain_idx = ctrain_idx[cvalid_n:]
# Uncensored split
n = len(uncensored_index)
index = np.arange(n)
i = n // 5
np.random.seed(seed=0)
np.random.shuffle(index)
if fold < 4:
utest_idx = index[fold * i:fold * i + i]
utrain_idx = index[:fold * i] + index[fold * i + i:]
else:
utest_idx = index[fold * i:]
utrain_idx = index[:fold * i]
utrain_n = len(utrain_idx)
uvalid_n = utrain_n // 10
uvalid_idx = utrain_idx[:uvalid_n]
utrain_idx = utrain_idx[uvalid_n:]
train_idx = np.concatenate(censored_index[ctrain_idx],
uncensored_index[utrain_idx])
np.random.seed(seed=0)
np.random.shuffle(train_idx)
valid_idx = np.concatenate(censored_index[cvalid_idx],
uncensored_index[uvalid_idx])
np.random.seed(seed=0)
np.random.shuffle(valid_idx)
test_idx = np.concatenate(censored_index[ctest_idx],
uncensored_index[utest_idx])
np.random.seed(seed=0)
np.random.shuffle(test_idx)
train_data = dataset[train_idx]
train_data = min_max_scaler.fit_transform(train_data)
train_labels_days = labels_days[train_idx]
train_labels_surv = labels_surv[train_idx]
train_labels = (train_labels_days, train_labels_surv)
val_data = dataset[valid_idx]
val_data = min_max_scaler.transform(val_data)
val_labels_days = labels_days[valid_idx]
val_labels_surv = labels_surv[valid_idx]
test_data = dataset[test_idx]
test_data = min_max_scaler.transform(test_data)
test_labels_days = labels_days[test_idx]
test_labels_surv = labels_surv[test_idx]
val_labels = (val_labels_days, val_labels_surv)
print(val_labels)
callbacks = [tt.callbacks.EarlyStopping()]
batch_size = 16
epochs = 100
val = (val_data, val_labels)
log = model.fit(train_data,
train_labels,
batch_size,
epochs,
callbacks,
True,
val_data=val,
val_batch_size=batch_size)
log.plot()
plt.show()
# print(model.partial_log_likelihood(*val).mean())
train = train_data, train_labels
# Compute the evaluation measurements
model.compute_baseline_hazards(*train)
surv = model.predict_surv_df(test_data)
print(surv)
ev = EvalSurv(surv, test_labels_days, test_labels_surv)
print(ev.concordance_td())