def start_new_run(state_manager, backup_manager, safe_to_exit, run_succeeded, ssm_file, cnv_file, top_k_trees_file, clonal_freqs_file, num_samples, mh_itr, mh_std, write_backups_every, rand_seed):
state = {}
state['rand_seed'] = rand_seed
seed(state['rand_seed'])
state['ssm_file'] = ssm_file
state['cnv_file'] = cnv_file
state['top_k_trees_file'] = top_k_trees_file
state['clonal_freqs_file'] = clonal_freqs_file
state['write_backups_every'] = write_backups_every
codes, n_ssms, n_cnvs = load_data(state['ssm_file'], state['cnv_file'])
if len(codes) == 0:
logmsg('No SSMs or CNVs provided. Exiting.', sys.stderr)
return
NTPS = len(codes[0].a) # number of samples / time point
state['glist'] = [datum.name for datum in codes if len(datum.name)>0]
# MCMC settings
state['burnin'] = 1000
state['num_samples'] = num_samples
state['dp_alpha'] = 25.0
state['dp_gamma'] = 1.0
state['alpha_decay'] = 0.25
state['top_k'] = 5
# Metropolis-Hastings settings
state['mh_burnin'] = 0
state['mh_itr'] = mh_itr # No. of iterations in metropolis-hastings
state['mh_std'] = mh_std
state['cd_llh_traces'] = zeros((state['num_samples'], 1))
state['working_directory'] = os.getcwd()
root = alleles(conc=0.1, ntps=NTPS)
state['tssb'] = TSSB(dp_alpha=state['dp_alpha'], dp_gamma=state['dp_gamma'], alpha_decay=state['alpha_decay'], root_node=root, data=codes)
# hack...
if 1:
depth=0
state['tssb'].root['sticks'] = vstack([ state['tssb'].root['sticks'], boundbeta(1, state['tssb'].dp_gamma) if depth!=0 else .999])
state['tssb'].root['children'].append({ 'node': state['tssb'].root['node'].spawn(),
'main':boundbeta(1.0, (state['tssb'].alpha_decay**(depth+1))*state['tssb'].dp_alpha) if state['tssb'].min_depth <= (depth+1) else 0.0,
'sticks' : empty((0,1)),
'children' : [] })
new_node = state['tssb'].root['children'][0]['node']
for n in range(state['tssb'].num_data):
state['tssb'].assignments[n].remove_datum(n)
new_node.add_datum(n)
state['tssb'].assignments[n] = new_node
for datum in codes:
datum.tssb = state['tssb']
tree_writer = TreeWriter()
state_manager.write_initial_state(state)
logmsg("Starting MCMC run...")
state['last_iteration'] = -state['burnin'] - 1
do_mcmc(state_manager, backup_manager, safe_to_exit, run_succeeded, state, tree_writer, codes, n_ssms, n_cnvs, NTPS)
def start_new_run(state_manager, backup_manager, safe_to_exit, run_succeeded,
config, ssm_file, cnv_file, params_file, top_k_trees_file,
clonal_freqs_file, burnin_samples, num_samples, mh_itr,
mh_std, write_state_every, write_backups_every, rand_seed,
tmp_dir):
state = {}
try:
state['rand_seed'] = int(rand_seed)
except TypeError:
# If rand_seed is not provided as command-line arg, it will be None,
# meaning it will hit this code path.
#
# Use random seed in this order:
# 1. If a seed is given on the command line, use that.
# 2. Otherwise, if `random_seed.txt` exists, use the seed stored there.
# 3. Otherwise, choose a new random seed and write to random_seed.txt.
try:
with open('random_seed.txt') as seedf:
state['rand_seed'] = int(seedf.read().strip())
except (TypeError, IOError) as E:
# Can seed with [0, 2**32).
state['rand_seed'] = randint(2**32)
seed(state['rand_seed'])
with open('random_seed.txt', 'w') as seedf:
seedf.write('%s\n' % state['rand_seed'])
state['ssm_file'] = ssm_file
state['cnv_file'] = cnv_file
state['tmp_dir'] = tmp_dir
state['top_k_trees_file'] = top_k_trees_file
state['clonal_freqs_file'] = clonal_freqs_file
state['write_state_every'] = write_state_every
state['write_backups_every'] = write_backups_every
codes, n_ssms, n_cnvs, cnv_logical_physical_mapping = load_data(
state['ssm_file'], state['cnv_file'])
if len(codes) == 0:
logmsg('No SSMs or CNVs provided. Exiting.', sys.stderr)
return
NTPS = len(codes[0].a) # number of samples / time point
state['glist'] = [datum.name for datum in codes if len(datum.name) > 0]
# MCMC settings
state['burnin'] = burnin_samples
state['num_samples'] = num_samples
state['dp_alpha'] = 25.0
state['dp_gamma'] = 1.0
state['alpha_decay'] = 0.25
state['top_k'] = 5
# Metropolis-Hastings settings
state['mh_burnin'] = 0
state['mh_itr'] = mh_itr # No. of iterations in metropolis-hastings
state['mh_std'] = mh_std
state['cd_llh_traces'] = zeros((state['num_samples'], 1))
state['burnin_cd_llh_traces'] = zeros((state['burnin'], 1))
state['working_directory'] = os.getcwd()
root = alleles(conc=0.1, ntps=NTPS)
state['tssb'] = TSSB(dp_alpha=state['dp_alpha'],
dp_gamma=state['dp_gamma'],
alpha_decay=state['alpha_decay'],
root_node=root,
data=codes)
# hack...
if 1:
depth = 0
state['tssb'].root['sticks'] = vstack([
state['tssb'].root['sticks'],
boundbeta(1, state['tssb'].dp_gamma) if depth != 0 else .999999
])
state['tssb'].root['children'].append({
'node':
state['tssb'].root['node'].spawn(),
'main':
boundbeta(1.0, (state['tssb'].alpha_decay**(depth + 1)) *
state['tssb'].dp_alpha) if state['tssb'].min_depth <=
(depth + 1) else 0.0,
'sticks':
empty((0, 1)),
'children': []
})
new_node = state['tssb'].root['children'][0]['node']
for n in range(state['tssb'].num_data):
state['tssb'].assignments[n].remove_datum(n)
new_node.add_datum(n)
state['tssb'].assignments[n] = new_node
for datum in codes:
datum.tssb = state['tssb']
tree_writer = TreeWriter()
tree_writer.add_extra_file('cnv_logical_physical_mapping.json',
json.dumps(cnv_logical_physical_mapping))
if params_file is not None:
with open(params_file) as F:
params = json.load(F)
else:
params = {}
tree_writer.add_extra_file('params.json', json.dumps(params))
state_manager.write_initial_state(state)
logmsg("Starting MCMC run...")
state['last_iteration'] = -state['burnin'] - 1
# This will overwrite file if it already exists, which is the desired
# behaviour for a fresh run.
with open('mcmc_samples.txt', 'w') as mcmcf:
mcmcf.write('Iteration\tLLH\tTime\n')
do_mcmc(state_manager, backup_manager, safe_to_exit, run_succeeded, config,
state, tree_writer, codes, n_ssms, n_cnvs, NTPS, tmp_dir)
def run(fin='data.txt',fout='./best',out2='top_k_trees',out3='clonal_frequencies',out4='llh_trace',num_samples=2500,mh_itr=5000,rand_seed=1):
if not os.path.exists(fout):
os.makedirs(fout)
else:
call(['rm','-r',fout])
os.makedirs(fout)
seed(rand_seed)
codes = load_data(fin)
NTPS = len(codes[0].a) # number of samples / time points
glist = [datum.name for datum in codes]
root = alleles(conc=0.1,ntps=NTPS)
tssb = TSSB( dp_alpha=dp_alpha, dp_gamma=dp_gamma, alpha_decay=alpha_decay, root_node=root, data=codes )
dp_alpha_traces = zeros((num_samples, 1))
dp_gamma_traces = zeros((num_samples, 1))
alpha_decay_traces = zeros((num_samples, 1))
conc_traces = zeros((num_samples, 1))
cd_llh_traces = zeros((num_samples, 1))
intervals = zeros((7))
best_tssb = 0
# clonal frequencies
freq = dict([(g,[] )for g in glist])
print "Starting MCMC run..."
for iter in range(-burnin,num_samples):
times = [ time.time() ]
tssb.resample_assignments()
times.append(time.time())
tssb.cull_tree()
times.append(time.time())
# assign node ids
wts,nodes=tssb.get_mixture()
for i,node in enumerate(nodes): node.id=i
mh_acc = metropolis(tssb,mh_itr,mh_std,mh_burnin,NTPS,fin)
times.append(time.time())
#root.resample_hypers()
times.append(time.time())
tssb.resample_sticks()
times.append(time.time())
tssb.resample_stick_orders()
times.append(time.time())
if iter >= 0:
tssb.resample_hypers(dp_alpha=True, alpha_decay=True, dp_gamma=True)
times.append(time.time())
intervals = intervals + diff(array(times))
if iter>=0:
dp_alpha_traces[iter] = tssb.dp_alpha
dp_gamma_traces[iter] = tssb.dp_gamma
alpha_decay_traces[iter] = tssb.alpha_decay
conc_traces[iter] = root.conc()
cd_llh_traces[iter] = tssb.complete_data_log_likelihood()
if iter>=0:
if True or mod(iter, 10) == 0:
(weights, nodes) = tssb.get_mixture()
print iter, len(nodes), cd_llh_traces[iter], mh_acc, tssb.dp_alpha, tssb.dp_gamma, tssb.alpha_decay#, " ".join(map(lambda x: "%0.2f" % x, intervals.tolist()))
intervals = zeros((7))
if iter >= 0 and argmax(cd_llh_traces[:iter+1]) == iter:
print "\t%f is best per-data complete data likelihood so far." % (cd_llh_traces[iter])
# save all trees
if iter >= 0:
fh = open(fout+'/'+str((cd_llh_traces[iter])[0]), 'w')
cPickle.dump(tssb, fh)
fh.close()
wts, nodes = tssb.get_mixture()
#Save log likelihood:savetxt('loglike',cd_llh_traces)
savetxt(out4,cd_llh_traces)
#log clonal frequencies
if iter >= 0:
wts, nodes = tssb.get_mixture()
for node in nodes:
data = node.get_data()
for datum in data:
for tp in arange(NTPS): freq[datum.name].append(float(round(node.params[tp],5)))
#save the best tree
print_top_trees(fout,out2,top_k)
#save clonal frequencies
glist = array(freq.keys(),str);glist.shape=(1,len(glist))
savetxt(out3,vstack((glist, array([freq[g] for g in freq.keys()]).T)),fmt='%s',delimiter=', ')
def start_new_run(state_manager, backup_manager, safe_to_exit, run_succeeded, config, ssm_file, cnv_file, top_k_trees_file, clonal_freqs_file, burnin_samples, num_samples, mh_itr, mh_std, write_state_every, write_backups_every, rand_seed, tmp_dir):
state = {}
with open('random_seed.txt', 'w') as seedf:
seedf.write('%s\n' % rand_seed)
try:
rand_seed = int(rand_seed)
state['rand_seed'] = rand_seed
seed(state['rand_seed'])
except TypeError:
# If rand_seed is not provided as command-line arg, it will be None,
# meaning it will hit this code path. Explicitly avoid calling seed(None)
# -- though this is currently the equivalent of calling seed() in that it
# seeds the PRNG with /dev/urandom, the semantics of seed(None) might
# change in later NumPy versions to always seed to the same state.
state['rand_seed'] = rand_seed
seed()
state['ssm_file'] = ssm_file
state['cnv_file'] = cnv_file
state['tmp_dir'] = tmp_dir
state['top_k_trees_file'] = top_k_trees_file
state['clonal_freqs_file'] = clonal_freqs_file
state['write_state_every'] = write_state_every
state['write_backups_every'] = write_backups_every
codes, n_ssms, n_cnvs = load_data(state['ssm_file'], state['cnv_file'])
if len(codes) == 0:
logmsg('No SSMs or CNVs provided. Exiting.', sys.stderr)
return
NTPS = len(codes[0].a) # number of samples / time point
state['glist'] = [datum.name for datum in codes if len(datum.name)>0]
# MCMC settings
state['burnin'] = burnin_samples
state['num_samples'] = num_samples
state['dp_alpha'] = 25.0
state['dp_gamma'] = 1.0
state['alpha_decay'] = 0.25
state['top_k'] = 5
# Metropolis-Hastings settings
state['mh_burnin'] = 0
state['mh_itr'] = mh_itr # No. of iterations in metropolis-hastings
state['mh_std'] = mh_std
state['cd_llh_traces'] = zeros((state['num_samples'], 1))
state['burnin_cd_llh_traces'] = zeros((state['burnin'], 1))
state['working_directory'] = os.getcwd()
root = alleles(conc=0.1, ntps=NTPS)
state['tssb'] = TSSB(dp_alpha=state['dp_alpha'], dp_gamma=state['dp_gamma'], alpha_decay=state['alpha_decay'], root_node=root, data=codes)
# hack...
if 1:
depth=0
state['tssb'].root['sticks'] = vstack([ state['tssb'].root['sticks'], boundbeta(1, state['tssb'].dp_gamma) if depth!=0 else .999])
state['tssb'].root['children'].append({ 'node': state['tssb'].root['node'].spawn(),
'main':boundbeta(1.0, (state['tssb'].alpha_decay**(depth+1))*state['tssb'].dp_alpha) if state['tssb'].min_depth <= (depth+1) else 0.0,
'sticks' : empty((0,1)),
'children' : [] })
new_node = state['tssb'].root['children'][0]['node']
for n in range(state['tssb'].num_data):
state['tssb'].assignments[n].remove_datum(n)
new_node.add_datum(n)
state['tssb'].assignments[n] = new_node
for datum in codes:
datum.tssb = state['tssb']
tree_writer = TreeWriter()
state_manager.write_initial_state(state)
logmsg("Starting MCMC run...")
state['last_iteration'] = -state['burnin'] - 1
# This will overwrite file if it already exists, which is the desired
# behaviour for a fresh run.
with open('mcmc_samples.txt', 'w') as mcmcf:
mcmcf.write('Iteration\tLLH\tTime\n')
do_mcmc(state_manager, backup_manager, safe_to_exit, run_succeeded, config, state, tree_writer, codes, n_ssms, n_cnvs, NTPS, tmp_dir)
def run(fin1,fin2,fout='trees.zip',out2='top_k_trees',out3='clonal_frequencies',out4='llh_trace',num_samples=2500,mh_itr=5000,mh_std=100,rand_seed=1):
seed(rand_seed)
codes, n_ssms, n_cnvs = load_data(fin1,fin2)
NTPS = len(codes[0].a) # number of samples / time point
glist = [datum.name for datum in codes if len(datum.name)>0]
root = alleles(conc=0.1,ntps=NTPS)
tssb = TSSB( dp_alpha=dp_alpha, dp_gamma=dp_gamma, alpha_decay=alpha_decay, root_node=root, data=codes )
# hack...
if 1:
depth=0
tssb.root['sticks'] = vstack([ tssb.root['sticks'], boundbeta(1, tssb.dp_gamma) if depth!=0 else .999])
tssb.root['children'].append({ 'node': tssb.root['node'].spawn(),
'main':boundbeta(1.0, (tssb.alpha_decay**(depth+1))*tssb.dp_alpha) if tssb.min_depth <= (depth+1) else 0.0,
'sticks' : empty((0,1)),
'children' : [] })
new_node=tssb.root['children'][0]['node']
for n in range(tssb.num_data):
tssb.assignments[n].remove_datum(n)
new_node.add_datum(n)
tssb.assignments[n] = new_node
####
for datum in codes: datum.tssb=tssb
dp_alpha_traces = zeros((num_samples, 1))
dp_gamma_traces = zeros((num_samples, 1))
alpha_decay_traces = zeros((num_samples, 1))
conc_traces = zeros((num_samples, 1))
cd_llh_traces = zeros((num_samples, 1))
intervals = zeros((7))
best_tssb = 0
# clonal frequencies
freq = dict([(g,[] )for g in glist])
print "Starting MCMC run..."
tree_writer = TreeWriter(fout)
for iter in range(-burnin,num_samples):
if iter<0: print iter
times = [ time.time() ]
tssb.resample_assignments()
times.append(time.time())
tssb.cull_tree()
times.append(time.time())
# assign node ids
wts,nodes=tssb.get_mixture()
for i,node in enumerate(nodes): node.id=i
##################################################
## some useful info about the tree,
## used by CNV related computations,
## to be called only after resampling assignments
set_node_height(tssb)
set_path_from_root_to_node(tssb)
map_datum_to_node(tssb)
##################################################
mh_acc = metropolis(tssb,mh_itr,mh_std,mh_burnin,n_ssms,n_cnvs,fin1,fin2,rand_seed,NTPS)
if float(mh_acc) < 0.08 and mh_std < 10000:
mh_std = mh_std*2.0
print "Shrinking MH proposals. Now %f" % mh_std
if float(mh_acc) > 0.5 and float(mh_acc) < 0.99:
mh_std = mh_std/2.0
print "Growing MH proposals. Now %f" % mh_std
times.append(time.time())
#root.resample_hypers()
times.append(time.time())
tssb.resample_sticks()
times.append(time.time())
tssb.resample_stick_orders()
times.append(time.time())
tssb.resample_hypers(dp_alpha=True, alpha_decay=True, dp_gamma=True)
times.append(time.time())
intervals = intervals + diff(array(times))
if iter>=0:
dp_alpha_traces[iter] = tssb.dp_alpha
dp_gamma_traces[iter] = tssb.dp_gamma
alpha_decay_traces[iter] = tssb.alpha_decay
conc_traces[iter] = root.conc()
cd_llh_traces[iter] = tssb.complete_data_log_likelihood()
if iter>=0:
if True or mod(iter, 10) == 0:
(weights, nodes) = tssb.get_mixture()
print iter, len(nodes), cd_llh_traces[iter], mh_acc, tssb.dp_alpha, tssb.dp_gamma, tssb.alpha_decay#, " ".join(map(lambda x: "%0.2f" % x, intervals.tolist()))
intervals = zeros((7))
if iter >= 0 and argmax(cd_llh_traces[:iter+1]) == iter:
print "\t%f is best per-data complete data likelihood so far." % (cd_llh_traces[iter])
# save all trees
if iter >= 0:
tree_writer.write_tree(tssb, cd_llh_traces[iter][0])
wts, nodes = tssb.get_mixture()
#Save log likelihood:savetxt('loglike',cd_llh_traces)
savetxt(out4,cd_llh_traces)
#log clonal frequencies
'''
if iter >= 0:
wts, nodes = tssb.get_mixture()
for node in nodes:
data = node.get_data()
for datum in data:
if datum.name in freq:
freq[datum.name].append(float(round(node.params,5)))
'''
tree_writer.close()
#save the best tree
print_top_trees(fout,out2,top_k)
#save clonal frequencies
glist = array(freq.keys(),str);glist.shape=(1,len(glist))
savetxt(out3,vstack((glist, array([freq[g] for g in freq.keys()]).T)),fmt='%s',delimiter=', ')
def run(fin='data.txt',
fout='./best',
out2='top_k_trees',
out3='clonal_frequencies',
out4='llh_trace',
num_samples=2500,
mh_itr=5000,
rand_seed=1):
if not os.path.exists(fout):
os.makedirs(fout)
else:
call(['rm', '-r', fout])
os.makedirs(fout)
seed(rand_seed)
codes = load_data(fin)
NTPS = len(codes[0].a) # number of samples / time points
glist = [datum.name for datum in codes]
root = alleles(conc=0.1, ntps=NTPS)
tssb = TSSB(dp_alpha=dp_alpha,
dp_gamma=dp_gamma,
alpha_decay=alpha_decay,
root_node=root,
data=codes)
dp_alpha_traces = zeros((num_samples, 1))
dp_gamma_traces = zeros((num_samples, 1))
alpha_decay_traces = zeros((num_samples, 1))
conc_traces = zeros((num_samples, 1))
cd_llh_traces = zeros((num_samples, 1))
intervals = zeros((7))
best_tssb = 0
# clonal frequencies
freq = dict([(g, []) for g in glist])
print "Starting MCMC run..."
for iter in range(-burnin, num_samples):
times = [time.time()]
tssb.resample_assignments()
times.append(time.time())
tssb.cull_tree()
times.append(time.time())
# assign node ids
wts, nodes = tssb.get_mixture()
for i, node in enumerate(nodes):
node.id = i
mh_acc = metropolis(tssb, mh_itr, mh_std, mh_burnin, NTPS, fin)
times.append(time.time())
#root.resample_hypers()
times.append(time.time())
tssb.resample_sticks()
times.append(time.time())
tssb.resample_stick_orders()
times.append(time.time())
if iter >= 0:
tssb.resample_hypers(dp_alpha=True,
alpha_decay=True,
dp_gamma=True)
times.append(time.time())
intervals = intervals + diff(array(times))
if iter >= 0:
dp_alpha_traces[iter] = tssb.dp_alpha
dp_gamma_traces[iter] = tssb.dp_gamma
alpha_decay_traces[iter] = tssb.alpha_decay
conc_traces[iter] = root.conc()
cd_llh_traces[iter] = tssb.complete_data_log_likelihood()
if iter >= 0:
if True or mod(iter, 10) == 0:
(weights, nodes) = tssb.get_mixture()
print iter, len(nodes), cd_llh_traces[
iter], mh_acc, tssb.dp_alpha, tssb.dp_gamma, tssb.alpha_decay #, " ".join(map(lambda x: "%0.2f" % x, intervals.tolist()))
intervals = zeros((7))
if iter >= 0 and argmax(cd_llh_traces[:iter + 1]) == iter:
print "\t%f is best per-data complete data likelihood so far." % (
cd_llh_traces[iter])
# save all trees
if iter >= 0:
fh = open(fout + '/' + str((cd_llh_traces[iter])[0]), 'w')
cPickle.dump(tssb, fh)
fh.close()
wts, nodes = tssb.get_mixture()
#Save log likelihood:savetxt('loglike',cd_llh_traces)
savetxt(out4, cd_llh_traces)
#log clonal frequencies
if iter >= 0:
wts, nodes = tssb.get_mixture()
for node in nodes:
data = node.get_data()
for datum in data:
for tp in arange(NTPS):
freq[datum.name].append(
float(round(node.params[tp], 5)))
#save the best tree
print_top_trees(fout, out2, top_k)
#save clonal frequencies
glist = array(freq.keys(), str)
glist.shape = (1, len(glist))
savetxt(out3,
vstack((glist, array([freq[g] for g in freq.keys()]).T)),
fmt='%s',
delimiter=', ')
def start_new_run(state_manager, backup_manager, safe_to_exit, run_succeeded, ssm_file, cnv_file, top_k_trees_file, clonal_freqs_file, burnin_samples, num_samples, mh_itr, mh_std, write_backups_every, rand_seed):
state = {}
with open('random_seed.txt', 'w') as seedf:
seedf.write('%s\n' % rand_seed)
try:
rand_seed = int(rand_seed)
state['rand_seed'] = rand_seed
seed(state['rand_seed'])
except TypeError:
# If rand_seed is not provided as command-line arg, it will be None,
# meaning it will hit this code path. Explicitly avoid calling seed(None)
# -- though this is currently the equivalent of calling seed() in that it
# seeds the PRNG with /dev/urandom, the semantics of seed(None) might
# change in later NumPy versions to always seed to the same state.
state['rand_seed'] = rand_seed
seed()
state['ssm_file'] = ssm_file
state['cnv_file'] = cnv_file
state['top_k_trees_file'] = top_k_trees_file
state['clonal_freqs_file'] = clonal_freqs_file
state['write_backups_every'] = write_backups_every
codes, n_ssms, n_cnvs = load_data(state['ssm_file'], state['cnv_file'])
if len(codes) == 0:
logmsg('No SSMs or CNVs provided. Exiting.', sys.stderr)
return
NTPS = len(codes[0].a) # number of samples / time point
state['glist'] = [datum.name for datum in codes if len(datum.name)>0]
# MCMC settings
state['burnin'] = burnin_samples
state['num_samples'] = num_samples
state['dp_alpha'] = 25.0
state['dp_gamma'] = 1.0
state['alpha_decay'] = 0.25
state['top_k'] = 5
# Metropolis-Hastings settings
state['mh_burnin'] = 0
state['mh_itr'] = mh_itr # No. of iterations in metropolis-hastings
state['mh_std'] = mh_std
state['cd_llh_traces'] = zeros((state['num_samples'], 1))
state['burnin_cd_llh_traces'] = zeros((state['burnin'], 1))
state['working_directory'] = os.getcwd()
root = alleles(conc=0.1, ntps=NTPS)
state['tssb'] = TSSB(dp_alpha=state['dp_alpha'], dp_gamma=state['dp_gamma'], alpha_decay=state['alpha_decay'], root_node=root, data=codes)
# hack...
if 1:
depth=0
state['tssb'].root['sticks'] = vstack([ state['tssb'].root['sticks'], boundbeta(1, state['tssb'].dp_gamma) if depth!=0 else .999])
state['tssb'].root['children'].append({ 'node': state['tssb'].root['node'].spawn(),
'main':boundbeta(1.0, (state['tssb'].alpha_decay**(depth+1))*state['tssb'].dp_alpha) if state['tssb'].min_depth <= (depth+1) else 0.0,
'sticks' : empty((0,1)),
'children' : [] })
new_node = state['tssb'].root['children'][0]['node']
for n in range(state['tssb'].num_data):
state['tssb'].assignments[n].remove_datum(n)
new_node.add_datum(n)
state['tssb'].assignments[n] = new_node
for datum in codes:
datum.tssb = state['tssb']
tree_writer = TreeWriter()
state_manager.write_initial_state(state)
logmsg("Starting MCMC run...")
state['last_iteration'] = -state['burnin'] - 1
do_mcmc(state_manager, backup_manager, safe_to_exit, run_succeeded, state, tree_writer, codes, n_ssms, n_cnvs, NTPS)
