def print_comparative_outcomes(multi_cohort_outcomes_no, multi_cohort_outcomes_asp):
""" prints average increase in survival time, discounted cost, and discounted utility
under combination therapy compared to mono therapy
:param multi_cohort_outcomes_mono: outcomes of a multi-cohort simulated under mono therapy
:param multi_cohort_outcomes_combo: outcomes of a multi-cohort simulated under combination therapy
"""
# increase in mean survival time under combination therapy with respect to mono therapy
increase_mean_survival_time = Stat.DifferenceStatPaired(
name='Increase in mean survival time',
x=multi_cohort_outcomes_asp.meanSurvivalTimes,
y_ref=multi_cohort_outcomes_no.meanSurvivalTimes)
# estimate and PI
estimate_PI = increase_mean_survival_time.get_formatted_mean_and_interval(interval_type='p',
alpha=D.ALPHA,
deci=2)
print("Increase in mean survival time and {:.{prec}%} uncertainty interval:"
.format(1 - D.ALPHA, prec=0),
estimate_PI)
# increase in mean discounted cost under combination therapy with respect to mono therapy
increase_mean_discounted_cost = Stat.DifferenceStatPaired(
name='Increase in mean discounted cost',
x=multi_cohort_outcomes_asp.meanCosts,
y_ref=multi_cohort_outcomes_no.meanCosts)
# estimate and PI
estimate_PI = increase_mean_discounted_cost.get_formatted_mean_and_interval(interval_type='p',
alpha=D.ALPHA,
deci=2,
form=',')
print("Increase in mean discounted cost and {:.{prec}%} uncertainty interval:"
.format(1 - D.ALPHA, prec=0),
estimate_PI)
# increase in mean discounted QALY under combination therapy with respect to mono therapy
increase_mean_discounted_qaly = Stat.DifferenceStatPaired(
name='Increase in mean discounted QALY',
x=multi_cohort_outcomes_asp.meanQALYs,
y_ref=multi_cohort_outcomes_no.meanQALYs)
# estimate and PI
estimate_PI = increase_mean_discounted_qaly.get_formatted_mean_and_interval(interval_type='p',
alpha=D.ALPHA,
deci=2)
print("Increase in mean discounted utility and {:.{prec}%} uncertainty interval:"
.format(1 - D.ALPHA, prec=0),
estimate_PI)
def calculate_summary_stats(self):
"""
calculate the summary statistics
"""
# summary statistics of mean cost
self.statMeanPCost = Stat.SummaryStat(name='Average Palivizumab cost',
data=self.PCosts)
# summary statistics of mean QALY
self.statMeanPQALY = Stat.SummaryStat(name='Average Palivizumab QALY',
data=self.PQALYs)
self.statMeanNCost = Stat.SummaryStat(
name='Average no prophylaxis cost', data=self.NCosts)
# summary statistics of mean QALY
self.statMeanNQALY = Stat.SummaryStat(
name='Average no prophylaxis QALY', data=self.NQALYs)
def print_comparative_outcomes(sim_outcomes_amino, sim_outcomes_immuno):
""" prints average increase in survival time, discounted cost, and discounted utility
under immunosuppresive therapy compared to aminosalicylate therapy
:param sim_outcomes_amino: outcomes of a cohort simulated under mono therapy
:param sim_outcomes_immuno: outcomes of a cohort simulated under combination therapy
"""
# increase in mean survival time under immuno therapy with respect to amino therapy
increase_survival_time = Stat.DifferenceStatIndp(
name='Increase in mean survival time',
x=sim_outcomes_immuno.survivalTimes,
y_ref=sim_outcomes_amino.survivalTimes)
# estimate and CI
estimate_CI = increase_survival_time.get_formatted_mean_and_interval(
interval_type='c', alpha=D.ALPHA, deci=2)
print(
"Increase in mean survival time and {:.{prec}%} confidence interval:".
format(1 - D.ALPHA, prec=0), estimate_CI)
# increase in mean discounted cost under immuno therapy with respect to amino therapy
increase_discounted_cost = Stat.DifferenceStatIndp(
name='Increase in mean discounted cost',
x=sim_outcomes_immuno.costs,
y_ref=sim_outcomes_amino.costs)
# estimate and CI
estimate_CI = increase_discounted_cost.get_formatted_mean_and_interval(
interval_type='c', alpha=D.ALPHA, deci=2, form=',')
print(
"Increase in mean discounted cost and {:.{prec}%} confidence interval:"
.format(1 - D.ALPHA, prec=0), estimate_CI)
#
# increase in number of patients alive under immuno therapy with respect to amino therapy
increase_patients_alive = Stat.DifferenceStatIndp(
name='Increase in mean number of patients alive',
x=sim_outcomes_immuno.numPatientsAlive,
y_ref=sim_outcomes_amino.numPatientsAlive)
# estimate and CI
estimate_CI = increase_patients_alive.get_formatted_mean_and_interval(
interval_type='c', alpha=D.ALPHA, deci=2)
print(
"Increase in mean number of patients alive and {:.{prec}%} confidence interval:"
.format(1 - D.ALPHA, prec=0), estimate_CI)
def mytest_discrete_time(data):
# define a discrete-time statistics
discrete_stat = Stat.DiscreteTimeStat('Test discrete-time statistics')
# record data points
for point in data:
discrete_stat.record(point)
print('Testing discrete-time statistics:')
print_results(discrete_stat)
def print_comparative_outcomes(sim_outcomes_SOC, sim_outcomes_NSB):
"""
:param sim_outcomes_SOC: outcomes of a cohort simulated under SOC diagnostics
:param sim_outcomes_NSB: outcomes of a cohort simulated under NSB diagnostics
"""
# increase in mean survival time under combination therapy with respect to mono therapy
increase_survival_time = Stat.DifferenceStatIndp(
name='Increase in mean survival time',
x=sim_outcomes_combo.survivalTimes,
y_ref=sim_outcomes_mono.survivalTimes)
# estimate and CI
estimate_CI = increase_survival_time.get_formatted_mean_and_interval(
interval_type='c', alpha=D.ALPHA, deci=2)
print(
"Increase in mean survival time and {:.{prec}%} confidence interval:".
format(1 - D.ALPHA, prec=0), estimate_CI)
# increase in mean discounted cost under combination therapy with respect to mono therapy
increase_discounted_cost = Stat.DifferenceStatIndp(
name='Increase in mean discounted cost',
x=sim_outcomes_combo.costs,
y_ref=sim_outcomes_mono.costs)
# estimate and CI
estimate_CI = increase_discounted_cost.get_formatted_mean_and_interval(
interval_type='c', alpha=D.ALPHA, deci=2, form=',')
print(
"Increase in mean discounted cost and {:.{prec}%} confidence interval:"
.format(1 - D.ALPHA, prec=0), estimate_CI)
# increase in mean discounted utility under combination therapy with respect to mono therapy
increase_discounted_utility = Stat.DifferenceStatIndp(
name='Increase in mean discounted utility',
x=sim_outcomes_combo.utilities,
y_ref=sim_outcomes_mono.utilities)
# estimate and CI
estimate_CI = increase_discounted_utility.get_formatted_mean_and_interval(
interval_type='c', alpha=D.ALPHA, deci=2)
print(
"Increase in mean discounted utility and {:.{prec}%} confidence interval:"
.format(1 - D.ALPHA, prec=0), estimate_CI)
def extract_outcomes(self, simulated_patients):
for patient in simulated_patients:
if not (patient.stateMonitor.survivalTime is None):
self.survivalTimes.append(patient.stateMonitor.survivalTime)
self.costs.append(
patient.stateMonitor.costUtilityMonitor.totalDiscountedCost)
self.utilities.append(
patient.stateMonitor.costUtilityMonitor.totalDiscountedUtility)
self.statSurvivalTime = Stat.SummaryStat('Survival time',
self.survivalTimes)
self.statCost = Stat.SummaryStat('Discounted cost', self.costs)
self.statUtility = Stat.SummaryStat('Discounted utility',
self.utilities)
self.nLivingPatients = Path.PrevalencePathBatchUpdate(
name='# of living patients',
initial_size=len(simulated_patients),
times_of_changes=self.survivalTimes,
increments=[-1] * len(self.survivalTimes))
def print_comparative_outcomes(sim_outcomes_NO, sim_outcomes_ASP):
# increase in mean survival time under therapy with respect to no therapy
decrease_survival_time = Stat.DifferenceStatIndp(
name='Increase in mean survival time',
x=sim_outcomes_ASP.survivalTimes,
y_ref=sim_outcomes_NO.survivalTimes)
# estimate and CI
estimate_CI = decrease_survival_time.get_formatted_mean_and_interval(
interval_type='c', alpha=D.ALPHA, deci=2)
print(
"Increase in mean survival time and {:.{prec}%} confidence interval:".
format(1 - D.ALPHA, prec=0), estimate_CI)
# increase in mean discounted cost under therapy with respect to no therapy
increase_discounted_cost = Stat.DifferenceStatIndp(
name='Increase in mean discounted cost',
x=sim_outcomes_ASP.costs,
y_ref=sim_outcomes_NO.costs)
# estimate and CI
estimate_CI = increase_discounted_cost.get_formatted_mean_and_interval(
interval_type='c', alpha=D.ALPHA, deci=2, form=',')
print(
"Increase in mean discounted cost and {:.{prec}%} confidence interval:"
.format(1 - D.ALPHA, prec=0), estimate_CI)
# increase in mean discounted utility under combination therapy with respect to no therapy
increase_discounted_utility = Stat.DifferenceStatIndp(
name='Increase in mean discounted utility',
x=sim_outcomes_ASP.utilities,
y_ref=sim_outcomes_NO.utilities)
# estimate and CI
estimate_CI = increase_discounted_utility.get_formatted_mean_and_interval(
interval_type='c', alpha=D.ALPHA, deci=2)
print(
"Increase in mean discounted utility and {:.{prec}%} confidence interval:"
.format(1 - D.ALPHA, prec=0), estimate_CI)
def get_mortality_estimate_credible_interval(self, alpha):
"""
:param n_samples: number of resamples from parameter values
:param alpha: the significance level
:returns tuple (mean, [lower, upper]) of the posterior distribution"""
# calculate the credible interval
sum_stat = Stat.SummaryStat(name='Posterior samples',
data=self.mortalityResamples)
estimate = sum_stat.get_mean() # estimated mortality probability
credible_interval = sum_stat.get_PI(alpha=alpha) # credible interval
return estimate, credible_interval
def mytest_continuous_time(times, observations):
# define a continuous-time statistics
continuous_stat = Stat.ContinuousTimeStat(
'Test continuous-time statistics', 0)
for obs in range(0, len(times)):
# find the increment
inc = 0
if obs == 0:
inc = observations[obs]
else:
inc = observations[obs] - observations[obs - 1]
continuous_stat.record(times[obs], inc)
print('Testing continuous-time statistics:')
print_results(continuous_stat)
def __init__(self, name, initial_size, sim_rep=0, collect_stat=True):
"""
:param name: name of this sample path
:param initial_size: (int) value of the sample path at simulation time 0
:param sim_rep: (int) simulation replication of this sample path
:param collect_stat: set to True to collect statistics on average, max, min, stDev, etc for this sample path
"""
self.name = name
self.simRep = sim_rep
self.currentSize = initial_size # current size of the sample path
self._times = [0] # times at which changes occur
self._values = [initial_size] # size of this sample path over time
# statistics on this prevalence sample path
self.ifCollectStat = collect_stat
if collect_stat:
self.stat = Stat.ContinuousTimeStat(name=name, initial_time=0)
def mytest_ratio_stat_paied(x, y):
# define
stat = Stat.RatioStatPaired('Test RatioStatPaired', x, y)
print('Testing RatioStatPaired:')
print_results(stat)
def mytest_ratio_stat_indp(x, y):
# define
stat = Stat.RatioStatIndp('Test RatioStatIndp', x, y)
print('Testing RatioStatIndp:')
print_results(stat)
def mytest_diff_stat_paired(x, y):
# define
stat = Stat.DifferenceStatPaired('Test DifferenceStatPaired', x, y)
print('Testing DifferenceStatPaired:')
print_results(stat)
def mytest_diff_stat_indp(x, y):
# define
stat = Stat.DifferenceStatIndp('Test DifferenceStatIndp', x, y)
print('Testing DifferenceStatIndp:')
print_results(stat)
def mytest_summary_stat(data):
# define a summary statistics
sum_stat = Stat.SummaryStat('Test summary statistics', data)
print('Testing summary statistics:')
print_results(sum_stat)
def mytest_relativeDiff_stat_paied(x, y):
# define
stat = Stat.RelativeDifferencePaired('Test RelativeDifferencePaired', x, y)
print('Testing RelativeDifferencePaired:')
print_results(stat)
def extract_outcomes(self, simulated_patients):
""" extracts outcomes of a simulated cohort
:param simulated_patients: a list of simulated patients"""
# record survival time
for patient in simulated_patients:
# survival time
if not (patient.stateMonitor.survivalTime is None):
self.survivalTimes.append(patient.stateMonitor.survivalTime)
# USE THIS SECTION IF NO INFORMATION ABOUT TIMES; USE THE BELOW SECTION IF WANT INFO ON TIMES
if patient.stateMonitor.ifHOSP_TBD:
self.nHOSP_TBD += 1
if patient.stateMonitor.ifHOSP_TBM:
self.nHOSP_TBM += 1
if patient.stateMonitor.ifDX_TBD:
self.nDX_TBD += 1
if patient.stateMonitor.ifDX_TBM:
self.nDX_TBM += 1
if patient.stateMonitor.ifCLEARED:
self.nCLEARED += 1
if patient.stateMonitor.ifDEAD:
self.nDEAD += 1
# USE THIS SECTION IF WANT INFORMATION ABOUT TIME FOR EACH TRANSITION; USE ABOVE IF DON'T WANT
# if patient.stateMonitor.ifHOSP_TBM:
# self.timesINFECTEDtoHOSP_TBM.append(patient.stateMonitor.timeINFECTEDtoHOSP_TBM)
# self.nHOSP_TBM += 1
# if patient.stateMonitor.ifHOSP_TBD:
# self.timesINFECTEDtoHOSP_TBD.append(patient.stateMonitor.timeINFECTEDtoHOSP_TBD)
# self.nHOSP_TBD += 1
# if patient.stateMonitor.ifDX_TBM:
# self.timesHOSP_TBMtoDX_TBM.append(patient.stateMonitor.timeHOSP_TBMtoDX_TBM)
# self.nDX_TBM += 1
# if patient.stateMonitor.ifDX_TBD and patient.stateMonitor.ifHOSP_TBD:
# self.timesHOSP_TBDtoDX_TBD.append(patient.stateMonitor.timeHOSP_TBDtoDX_TBD)
# self.nDX_TBD += 1
# if patient.stateMonitor.ifDX_TBD and (patient.stateMonitor.ifHOSP_TBD is False): # and \
# # (patient.stateMonitor.ifHOSP_TBD is False) and (patient.stateMonitor.ifDEAD is False):
# self.timesINFECTEDtoDX_TBD.append(patient.stateMonitor.timeINFECTEDtoDX_TBD)
# self.nDX_TBD += 1
# if patient.stateMonitor.ifCLEARED and patient.stateMonitor.ifDX_TBD:
# self.timesDX_TBDtoCLEARED.append(patient.stateMonitor.timeDX_TBDtoCLEARED)
# self.nCLEARED += 1
# if patient.stateMonitor.ifCLEARED and patient.stateMonitor.ifDX_TBM:
# self.timesDX_TBMtoCLEARED.append(patient.stateMonitor.timeDX_TBMtoCLEARED)
# self.nCLEARED += 1
# if patient.stateMonitor.ifCLEARED and (patient.stateMonitor.ifDX_TBD is False) and \
# (patient.stateMonitor.ifDX_TBM is False):
# self.timesINFECTEDtoCLEARED.append(patient.stateMonitor.timeINFECTEDtoCLEARED)
# self.nCLEARED += 1
# # times from HOSP_TBM to DEAD
# if patient.stateMonitor.ifDEAD and patient.stateMonitor.ifHOSP_TBM and \
# (patient.stateMonitor.ifCLEARED is False) and (patient.stateMonitor.ifHOSP_TBD is False) and \
# (patient.stateMonitor.ifDX_TBD is False) and (patient.stateMonitor.ifDX_TBM is False):
# self.timesHOSP_TBMtoDEAD.append(patient.stateMonitor.timeHOSP_TBMtoDEAD)
# self.nDEAD += 1
# # times from HOSP_TBD to DEAD
# if patient.stateMonitor.ifDEAD and patient.stateMonitor.ifHOSP_TBD and \
# (patient.stateMonitor.ifCLEARED is False) and (patient.stateMonitor.ifHOSP_TBM is False) and \
# (patient.stateMonitor.ifDX_TBM is False) and (patient.stateMonitor.ifDX_TBD is False):
# self.timesHOSP_TBDtoDEAD.append(patient.stateMonitor.timeHOSP_TBDtoDEAD)
# self.nDEAD += 1
# # get rid of cleared and the two hosps
# if patient.stateMonitor.ifDEAD and patient.stateMonitor.ifDX_TBM and \
# (patient.stateMonitor.ifCLEARED is False) and (patient.stateMonitor.timeHOSP_TBMtoDEAD is None) and\
# (patient.stateMonitor.ifHOSP_TBD is False) and (patient.stateMonitor.ifDX_TBD is False):
# self.timesDX_TBMtoDEAD.append(patient.stateMonitor.timeDX_TBMtoDEAD)
# self.nDEAD += 1
# if patient.stateMonitor.ifDEAD and patient.stateMonitor.ifDX_TBD and \
# (patient.stateMonitor.ifCLEARED is False) and (patient.stateMonitor.timeHOSP_TBDtoDEAD is None) and\
# (patient.stateMonitor.ifHOSP_TBM is False) and (patient.stateMonitor.ifDX_TBM is False):
# self.timesDX_TBDtoDEAD.append(patient.stateMonitor.timeDX_TBDtoDEAD)
# self.nDEAD += 1
# if patient.stateMonitor.ifDEAD and patient.stateMonitor.ifCLEARED and \
# (patient.stateMonitor.timeHOSP_TBMtoDEAD is None) and (patient.stateMonitor.timeHOSP_TBDtoDEAD is None) and \
# (patient.stateMonitor.timeDX_TBMtoDEAD is None) and (patient.stateMonitor.timeDX_TBDtoDEAD is None):
# self.timesCLEAREDtoDEAD.append(patient.stateMonitor.timeCLEAREDtoDEAD)
# self.nDEAD += 1
# discounted cost and discounted utility
self.costs.append(
patient.stateMonitor.costUtilityMonitor.totalDiscountedCost)
# self.utilities.append(patient.stateMonitor.costUtilityMonitor.totalDiscountedUtility)
# discounted cost of all the patients who present to healthcare
if not patient.stateMonitor.ifINFECTEDtoCLEARED:
self.costsPresenting.append(
patient.stateMonitor.costUtilityMonitor.totalDiscountedCost
)
if patient.stateMonitor.survivalTime is None:
self.listYLLPresenting.append(0)
else:
self.listYLLPresenting.append(
62.77 - (patient.stateMonitor.survivalTime / 52))
if patient.stateMonitor.mortality56Day:
self.nMortality56Day += 1
# total YLL due to TB infection
if not patient.stateMonitor.ifCLEARED:
if not (patient.stateMonitor.survivalTime is None):
self.totalYLL += 62.77 - (
patient.stateMonitor.survivalTime / 52)
self.listYLL.append(62.77 -
(patient.stateMonitor.survivalTime /
52))
else:
self.listYLL.append(0)
if patient.stateMonitor.mortality2Months:
self.nMortality2Months += 1
if patient.stateMonitor.mortality2Years:
self.nMortality2Years += 1
if patient.stateMonitor.mortality5Years:
self.nMortality5Years += 1
if patient.stateMonitor.mortality1Year:
self.nMortality1Year += 1
# Gather Data
self.nHospitalized = self.nHOSP_TBD + self.nHOSP_TBM
self.mortality56Day = self.nMortality56Day / D.POP_SIZE
self.mortality2Months = self.nMortality2Months / D.POP_SIZE
self.mortality1Year = self.nMortality1Year / D.POP_SIZE
self.mortality2Years = self.nMortality2Years / D.POP_SIZE
self.mortality5Years = self.nMortality5Years / D.POP_SIZE
# self.timesINFECTED = self.timesINFECTEDtoCLEARED + self.timesINFECTEDtoDX_TBD + self.timesINFECTEDtoHOSP_TBM + \
# self.timesINFECTEDtoHOSP_TBD
# self.timesHOSP_TBD = self.timesHOSP_TBDtoDEAD + self.timesHOSP_TBDtoDX_TBD
# self.timesHOSP_TBM = self.timesHOSP_TBMtoDEAD + self.timesHOSP_TBMtoDX_TBM
# self.timesDX_TBM = self.timesDX_TBMtoCLEARED + self.timesDX_TBMtoDEAD
# self.timesDX_TBD = self.timesDX_TBDtoCLEARED + self.timesDX_TBDtoDEAD
# self.timesCLEARED = self.timesCLEAREDtoDEAD
# Summary Statistics
self.statSurvivalTime = Stat.SummaryStat('Survival time',
self.survivalTimes)
# self.statTimeINFECTEDtoHOSP_TBD = Stat.SummaryStat('Infected to HOSP_TBD', self.timesINFECTEDtoHOSP_TBD)
# self.statTimeINFECTEDtoHOSP_TBM = Stat.SummaryStat('Infected to HOSP_TBM', self.timesINFECTEDtoHOSP_TBM)
# self.statTimeINFECTEDtoDX_TBD = Stat.SummaryStat('Infected to DX_TBD', self.timesINFECTEDtoDX_TBD)
# self.statTimeINFECTEDtoCLEARED = Stat.SummaryStat('Infected to Cleared', self.timesINFECTEDtoCLEARED)
# self.statTimeCLEAREDtoDEAD = Stat.SummaryStat('Cleared to Dead', self.timesCLEAREDtoDEAD)
# self.statTimeHOSP_TBDtoDEAD = Stat.SummaryStat('HOSP_TBD to Dead', self.timesHOSP_TBDtoDEAD)
# self.statTimeHOSP_TBDtoDX_TBD = Stat.SummaryStat('HOSP_TBD to DX_TBD', self.timesHOSP_TBDtoDX_TBD)
# self.statTimeHOSP_TBMtoDEAD = Stat.SummaryStat('HOSP_TBM to DEAD', self.timesHOSP_TBMtoDEAD)
# self.statTimeHOSP_TBMtoDX_TBM = Stat.SummaryStat('HOSP_TBM to DX_TBM', self.timesHOSP_TBMtoDX_TBM)
# self.statTimeDX_TBDtoDEAD = Stat.SummaryStat('DX_TBD to Dead', self.timesDX_TBDtoDEAD)
# self.statTimeDX_TBDtoCLEARED = Stat.SummaryStat('DX_TBD to Cleared', self.timesDX_TBDtoCLEARED)
# self.statTimeDX_TBMtoDEAD = Stat.SummaryStat('DX_TBM to Dead', self.timesDX_TBMtoDEAD)
# self.statTimeDX_TBMtoCLEARED = Stat.SummaryStat('DX_TBM to Cleared', self.timesDX_TBMtoCLEARED)
#
# self.statTimesINFECTED = Stat.SummaryStat('Infected', self.timesINFECTED)
# self.statTimesHOSP_TBM = Stat.SummaryStat('HOSP_TBM', self.timesHOSP_TBM)
# self.statTimesHOSP_TBD = Stat.SummaryStat('HOSP_TBD', self.timesHOSP_TBD)
# self.statTimesDX_TBD = Stat.SummaryStat('DX_TBD', self.timesDX_TBD)
# self.statTimesDX_TBM = Stat.SummaryStat('DX_TBM', self.timesDX_TBM)
# self.statTimesCLEARED = Stat.SummaryStat('Cleared', self.timesCLEARED)
self.statCost = Stat.SummaryStat('Discounted cost', self.costs)
# self.statCostPresenting = Stat.SummaryStat('Discounted cost (Presenting)', self.costsPresenting)
# self.statUtility = Stat.SummaryStat('Discounted utility', self.utilities)
# survival curve
self.nLivingPatients = Path.PrevalencePathBatchUpdate(
name='# of living patients',
initial_size=len(simulated_patients),
times_of_changes=self.survivalTimes,
increments=[-1] * len(self.survivalTimes))
def mytest_relativeDiff_stat_indp(x, y):
# define
stat = Stat.RelativeDifferenceIndp('Test RelativeDifferenceIndp', x, y)
print('Testing RelativeDifferenceIndp:')
print_results(stat)
def print_comparative_outcomes(multi_cohort_outcomes_SOC, multi_cohort_outcomes_NSB):
""" prints average increase in survival time, discounted cost, and discounted utility
under combination therapy compared to mono therapy
:param multi_cohort_outcomes_mono: outcomes of a multi-cohort simulated under mono therapy
:param multi_cohort_outcomes_combo: outcomes of a multi-cohort simulated under combination therapy
"""
# increase in mean survival time under combination therapy with respect to mono therapy
increase_mean_survival_time = Stat.DifferenceStatPaired(
name='Increase in mean survival time',
x=multi_cohort_outcomes_NSB.meanSurvivalTimes,
y_ref=multi_cohort_outcomes_SOC.meanSurvivalTimes)
# estimate and PI
estimate_PI = increase_mean_survival_time.get_formatted_mean_and_interval(interval_type='p',
alpha=D.ALPHA,
deci=2)
print("Increase in mean survival time and {:.{prec}%} uncertainty interval:"
.format(1 - D.ALPHA, prec=0),
estimate_PI)
# increase in mean number of hospitalizations
increase_mean_nHosp = Stat.DifferenceStatPaired(
name='Increase in mean number of kids hospitalized',
x=multi_cohort_outcomes_NSB.nHospitalized,
y_ref=multi_cohort_outcomes_SOC.nHospitalized)
# estimate and PI
estimate_PI = increase_mean_nHosp.get_formatted_mean_and_interval(interval_type='p',
alpha=D.ALPHA,
deci=2)
print("Increase in mean number of hospitalizations and {:.{prec}%} uncertainty interval:"
.format(1 - D.ALPHA, prec=0),
estimate_PI)
# increase in mean number of YLLs
increase_mean_YLLs = Stat.DifferenceStatPaired(
name='Increase in mean number of Years of Life Lost',
x=multi_cohort_outcomes_NSB.totalYLL,
y_ref=multi_cohort_outcomes_SOC.totalYLL)
# estimate and PI
estimate_PI = increase_mean_YLLs.get_formatted_mean_and_interval(interval_type='p',
alpha=D.ALPHA,
deci=2)
print("Increase in mean number of Years of Life Lost and {:.{prec}%} uncertainty interval:"
.format(1 - D.ALPHA, prec=0),
estimate_PI)
# increase in mean number of patients w/ TBM
increase_mean_TBM = Stat.DifferenceStatPaired(
name='Increase in mean number of cases of TB meningitis',
x=multi_cohort_outcomes_NSB.nTBM,
y_ref=multi_cohort_outcomes_SOC.nTBM)
# estimate and PI
estimate_PI = increase_mean_TBM.get_formatted_mean_and_interval(interval_type='p',
alpha=D.ALPHA,
deci=2)
print("Increase in mean number of cases of TB meningitis and {:.{prec}%} uncertainty interval:"
.format(1 - D.ALPHA, prec=0),
estimate_PI)
# increase in mean 2-month mortality
increase_mean_mortality2Month = Stat.DifferenceStatPaired(
name='Increase in mean 2-month mortality',
x=multi_cohort_outcomes_NSB.mortality2Month,
y_ref=multi_cohort_outcomes_SOC.mortality2Month)
# estimate and PI
estimate_PI = increase_mean_mortality2Month.get_formatted_mean_and_interval(interval_type='p',
alpha=D.ALPHA,
deci=2)
print("Increase in mean 2-month mortality and {:.{prec}%} uncertainty interval:"
.format(1 - D.ALPHA, prec=0),
estimate_PI)
# increase in mean 2-year mortality
increase_mean_mortality2Year = Stat.DifferenceStatPaired(
name='Increase in mean 2-year mortality',
x=multi_cohort_outcomes_NSB.mortality2Years,
y_ref=multi_cohort_outcomes_SOC.mortality2Years)
# estimate and PI
estimate_PI = increase_mean_mortality2Year.get_formatted_mean_and_interval(interval_type='p',
alpha=D.ALPHA,
deci=2)
print("Increase in mean 2-year mortality and {:.{prec}%} uncertainty interval:"
.format(1 - D.ALPHA, prec=0),
estimate_PI)
# increase in mean 5-year mortality
increase_mean_mortality5Year = Stat.DifferenceStatPaired(
name='Increase in mean 5-year mortality',
x=multi_cohort_outcomes_NSB.mortality5Years,
y_ref=multi_cohort_outcomes_SOC.mortality5Years)
# estimate and PI
estimate_PI = increase_mean_mortality5Year.get_formatted_mean_and_interval(interval_type='p',
alpha=D.ALPHA,
deci=2)
print("Increase in mean 5-year mortality and {:.{prec}%} uncertainty interval:"
.format(1 - D.ALPHA, prec=0),
estimate_PI)
# increase in mean discounted cost under combination therapy with respect to mono therapy
increase_mean_discounted_cost = Stat.DifferenceStatPaired(
name='Increase in mean discounted cost',
x=multi_cohort_outcomes_NSB.meanCosts,
y_ref=multi_cohort_outcomes_SOC.meanCosts)
# estimate and PI
estimate_PI = increase_mean_discounted_cost.get_formatted_mean_and_interval(interval_type='p',
alpha=D.ALPHA,
deci=2,
form=',')
print("Increase in mean discounted cost and {:.{prec}%} uncertainty interval:"
.format(1 - D.ALPHA, prec=0),
estimate_PI)
