def test_saveWork_single_timeout(self, testInstance, mocker):
testInstance.work = mocker.MagicMock()
testInstance.work.save.side_effect = [ConnectionTimeout('test'), None]
testInstance.saveWork()
assert testInstance.work.save.call_count == 2
def perform_request(self, method, url, params=None, body=None, timeout=None, ignore=()):
url_path = url
if params:
url_path = '%s?%s' % (url, urlencode(params or {}))
url = self.base_url + url_path
start = self.loop.time()
response = None
try:
with aiohttp.Timeout(timeout or self.timeout):
response = yield from self.session.request(method, url, data=body)
raw_data = yield from response.text()
duration = self.loop.time() - start
except Exception as e:
self.log_request_fail(method, url, url_path, body, self.loop.time() - start, exception=e)
if isinstance(e, asyncio.TimeoutError):
raise ConnectionTimeout('TIMEOUT', str(e), e)
raise ConnectionError('N/A', str(e), e)
finally:
if response is not None:
yield from response.release()
# raise errors based on http status codes, let the client handle those if needed
if not (200 <= response.status < 300) and response.status not in ignore:
self.log_request_fail(method, url, url_path, body, duration, status_code=response.status, response=raw_data)
self._raise_error(response.status, raw_data)
self.log_request_success(method, url, url_path, body, response.status, raw_data, duration)
return response.status, response.headers, raw_data
def perform(self, timeout=0.1):
"""
Loop on waiting handles to process them until they are no more waiting one and all send are finished.
It's never finished until closed for end of all processing, don't wait for it on loop
:param timeout: the timeout for the loop
:return: Nothing
"""
while self.running:
if len(self.handles) == 0:
# no activity, just sleep, for new queries
yield from self._try_load_queries(True, timeout)
else:
yield from self._try_load_queries(False)
if len(self.handles) == 0:
continue
# wait for something to happen
selected = self.multi.select(timeout)
if selected < 0:
continue
# it was not a select time out, something to do
ret, num_handles = self._perform_loop()
if ret > 0:
raise ConnectionError("pycurl failed", ret)
if len(self.handles) == 0:
continue
else:
# some handles to process
(waiting, succeded, failed) = self.multi.info_read()
for handle in succeded:
self.handles.remove(handle)
status = handle.getinfo(pycurl.RESPONSE_CODE)
self.multi.remove_handle(handle)
content_type, decoded = decode_body(handle)
if not self.running:
# is stopped, just swallow content
continue
elif status >= 200 and status < 300:
handle.cb(status, handle.headers, decoded)
elif status >= 300:
handle.f_cb(
return_error(
status,
decoded,
content_type,
http_message=handle.headers.pop('__STATUS__'),
url=handle.getinfo(pycurl.EFFECTIVE_URL)))
for handle, code, message in failed:
self.handles.remove(handle)
self.multi.remove_handle(handle)
if code == pycurl.E_OPERATION_TIMEDOUT:
ex = ConnectionTimeout(
code, message,
handle.getinfo(pycurl.EFFECTIVE_URL),
handle.getinfo(pycurl.TOTAL_TIME))
else:
ex = PyCurlException(
code, handle.errstr(),
handle.getinfo(pycurl.EFFECTIVE_URL))
handle.f_cb(ex)
def perform_request(self,
method,
url,
params=None,
body=None,
timeout=None,
ignore=(),
headers=None):
url = self.base_url + url
if params:
url = '%s?%s' % (url, urlencode(params or {}))
start = time.time()
request = requests.Request(method=method,
headers=headers,
url=url,
data=body)
prepared_request = self.session.prepare_request(request)
settings = self.session.merge_environment_settings(
prepared_request.url, {}, None, None, None)
send_kwargs = {'timeout': timeout or self.timeout}
send_kwargs.update(settings)
try:
response = self.session.request(prepared_request.method,
prepared_request.url,
data=prepared_request.body,
headers=prepared_request.headers,
**send_kwargs)
duration = time.time() - start
raw_data = response.text
except Exception as e:
self.log_request_fail(method,
url,
prepared_request.path_url,
body,
time.time() - start,
exception=e)
if isinstance(e, requests.exceptions.SSLError):
raise SSLError('N/A', str(e), e)
if isinstance(e, requests.Timeout):
raise ConnectionTimeout('TIMEOUT', str(e), e)
raise ConnectionError('N/A', str(e), e)
# raise errors based on http status codes, let the client handle those if needed
if not (200 <= response.status_code <
300) and response.status_code not in ignore:
self.log_request_fail(method, url, response.request.path_url, body,
duration, response.status_code, raw_data)
self._raise_error(response.status_code, raw_data)
self.log_request_success(method, url, response.request.path_url, body,
response.status_code, raw_data, duration)
return response.status_code, response.headers, raw_data
def perform_request(self, method, url, params=None, body=None, timeout=None, ignore=(), headers=None):
url_path = url
if params:
query_string = urlencode(params)
else:
query_string = ""
# Provide correct URL object to avoid string parsing in low-level code
url = yarl.URL.build(scheme=self.scheme,
host=self.hostname,
port=self.port,
path=url,
query_string=query_string,
encoded=True)
start = self.loop.time()
response = None
try:
request_timeout = timeout or self.timeout.total
with async_timeout.timeout(request_timeout, loop=self.loop):
# override the default session timeout explicitly
response = yield from self.session.request(method, url, data=body, headers=headers, timeout=request_timeout)
raw_data = yield from response.text()
duration = self.loop.time() - start
except asyncio.CancelledError:
raise
except Exception as e:
self.log_request_fail(method, url, url_path, body, self.loop.time() - start, exception=e)
if isinstance(e, ServerFingerprintMismatch):
raise SSLError('N/A', str(e), e)
if isinstance(e, asyncio.TimeoutError):
raise ConnectionTimeout('TIMEOUT', str(e), e)
raise ConnectionError('N/A', str(e), e)
finally:
if response is not None:
yield from response.release()
# raise errors based on http status codes, let the client handle those if needed
if not (200 <= response.status < 300) and response.status not in ignore:
self.log_request_fail(method, url, url_path, body, duration, status_code=response.status, response=raw_data)
self._raise_error(response.status, raw_data)
self.log_request_success(method, url, url_path, body, response.status, raw_data, duration)
return response.status, response.headers, raw_data
def perform_request(self, method, url, params=None, body=None, timeout=None, ignore=()): # noqa
url_path = url
url = (self.base_url / url.lstrip('/')).with_query(params)
start = self.loop.time()
response = None
try:
with aiohttp.Timeout(timeout or self.timeout, loop=self.loop): # noqa
response = yield from self.session.request(method, url, data=body, headers=self.headers, timeout=None) # noqa
raw_data = yield from response.text()
duration = self.loop.time() - start
except asyncio.TimeoutError as exc:
self.log_request_fail(method, url, url_path, body, self.loop.time() - start, exception=exc) # noqa
raise ConnectionTimeout('TIMEOUT', str(exc), exc)
except FingerprintMismatch as exc:
self.log_request_fail(method, url, url_path, body, self.loop.time() - start, exception=exc) # noqa
raise SSLError('N/A', str(exc), exc)
except ClientError as exc:
self.log_request_fail(method, url, url_path, body, self.loop.time() - start, exception=exc) # noqa
raise ConnectionError('N/A', str(exc), exc)
finally:
if response is not None:
yield from response.release()
# raise errors based on http status codes, let the client handle those if needed # noqa
if not (200 <= response.status < 300) and response.status not in ignore: # noqa
self.log_request_fail(method, url, url_path, body, duration, response.status, raw_data) # noqa
self._raise_error(response.status, raw_data)
self.log_request_success(method, url, url_path, body, response.status, raw_data, duration) # noqa
return response.status, response.headers, raw_data
def perform_request(self, method, url, params=None, body=None, timeout=None, ignore=()):
url = self.base_url + url
if params:
url = '%s?%s' % (url, urlencode(params or {}))
start = time.time()
headers = self.headers.copy()
try:
response = urlfetch.Fetch(url,
payload=body,
method=method,
headers=headers,
allow_truncated=False,
follow_redirects=True,
deadline=timeout,
validate_certificate=self.verify_certs)
duration = time.time() - start
raw_data = response.content
except Exception as e:
self.log_request_fail(method, url, url, body, time.time() - start, exception=e)
if isinstance(e, urlfetch_errors.SSLCertificateError):
raise SSLError('N/A', str(e), e)
if isinstance(e, urlfetch_errors.DeadlineExceededError):
raise ConnectionTimeout('TIMEOUT', str(e), e)
raise ConnectionError('N/A', str(e), e)
# raise errors based on http status codes, let the client handle those if needed
if not (200 <= response.status_code < 300) and response.status_code not in ignore:
self.log_request_fail(method, url, url, body, duration)
self._raise_error(response.status_code, raw_data)
self.log_request_success(method, url, url, body, response.status_code, raw_data, duration)
return response.status_code, response.headers, raw_data
def test_query_variants(self, mock_get_variants, mock_get_gene_counts,
mock_error_logger, mock_analyst_group):
url = reverse(query_variants_handler, args=['abc'])
self.check_collaborator_login(
url, request_data={'projectFamilies': PROJECT_FAMILIES})
url = reverse(query_variants_handler, args=[SEARCH_HASH])
# add a locus list
LocusList.objects.get(guid=LOCUS_LIST_GUID).projects.add(
Project.objects.get(guid=PROJECT_GUID))
# Test invalid inputs
response = self.client.get(url)
self.assertEqual(response.status_code, 400)
self.assertEqual(response.reason_phrase,
'Invalid search hash: {}'.format(SEARCH_HASH))
mock_error_logger.assert_not_called()
response = self.client.post(url,
content_type='application/json',
data=json.dumps({'search': SEARCH}))
self.assertEqual(response.status_code, 400)
self.assertEqual(response.reason_phrase,
'Invalid search: no projects/ families specified')
mock_error_logger.assert_not_called()
mock_get_variants.side_effect = InvalidIndexException('Invalid index')
response = self.client.post(url,
content_type='application/json',
data=json.dumps({
'projectFamilies': PROJECT_FAMILIES,
'search': SEARCH
}))
self.assertEqual(response.status_code, 400)
self.assertEqual(response.json()['error'], 'Invalid index')
mock_error_logger.assert_called_with('Invalid index', extra=mock.ANY)
mock_get_variants.side_effect = InvalidSearchException(
'Invalid search')
mock_error_logger.reset_mock()
response = self.client.post(url,
content_type='application/json',
data=json.dumps({
'projectFamilies': PROJECT_FAMILIES,
'search': SEARCH
}))
self.assertEqual(response.status_code, 400)
self.assertEqual(response.json()['error'], 'Invalid search')
mock_error_logger.assert_not_called()
mock_get_variants.side_effect = ConnectionTimeout(
'', '', ValueError('Timeout'))
response = self.client.post(url,
content_type='application/json',
data=json.dumps({
'projectFamilies': PROJECT_FAMILIES,
'search': SEARCH
}))
self.assertEqual(response.status_code, 504)
self.assertEqual(response.json()['error'],
'ConnectionTimeout caused by - ValueError(Timeout)')
mock_error_logger.assert_not_called()
mock_get_variants.side_effect = TransportError(
'N/A', 'search_phase_execution_exception', {'error': 'Invalid'})
response = self.client.post(url,
content_type='application/json',
data=json.dumps({
'projectFamilies': PROJECT_FAMILIES,
'search': SEARCH
}))
self.assertEqual(response.status_code, 400)
self.assertEqual(
response.json()['error'],
"TransportError: N/A - 'search_phase_execution_exception' - 'Invalid'"
)
self.assertEqual(response.json()['detail'], {'error': 'Invalid'})
mock_error_logger.assert_not_called()
error_info_json = {
'error': {
'root_cause': [{
'type':
'response_handler_failure_transport_exception'
}]
}
}
mock_get_variants.side_effect = TransportError(
'401', 'search_phase_execution_exception', error_info_json)
response = self.client.post(url,
content_type='application/json',
data=json.dumps({
'projectFamilies': PROJECT_FAMILIES,
'search': SEARCH
}))
self.assertEqual(response.status_code, 401)
self.assertEqual(
response.json()['error'],
"TransportError: 401 - 'search_phase_execution_exception' - response_handler_failure_transport_exception"
)
self.assertEqual(response.json()['detail'], error_info_json)
mock_error_logger.assert_not_called()
mock_get_variants.side_effect = _get_es_variants
# Test new search
response = self.client.post(url,
content_type='application/json',
data=json.dumps({
'projectFamilies': PROJECT_FAMILIES,
'search': SEARCH
}))
self.assertEqual(response.status_code, 200)
response_json = response.json()
self.assertSetEqual(
set(response_json.keys()), {
'searchedVariants', 'savedVariantsByGuid', 'genesById',
'search', 'variantTagsByGuid', 'variantNotesByGuid',
'variantFunctionalDataByGuid', 'locusListsByGuid'
})
self.assertListEqual(response_json['searchedVariants'], VARIANTS)
self.assertDictEqual(
response_json['search'], {
'search':
SEARCH,
'projectFamilies': [{
'projectGuid': PROJECT_GUID,
'familyGuids': mock.ANY
}],
'totalResults':
3,
})
self.assertSetEqual(
set(response_json['search']['projectFamilies'][0]['familyGuids']),
{'F000001_1', 'F000002_2'})
self.assertSetEqual(set(response_json['savedVariantsByGuid'].keys()), {
'SV0000001_2103343353_r0390_100', 'SV0000002_1248367227_r0390_100'
})
self.assertSetEqual(
set(response_json['genesById'].keys()),
{'ENSG00000227232', 'ENSG00000268903', 'ENSG00000233653'})
gene_fields = {'locusListGuids'}
gene_fields.update(GENE_VARIANT_FIELDS)
self.assertSetEqual(
set(response_json['genesById']['ENSG00000227232'].keys()),
gene_fields)
self.assertListEqual(
response_json['genesById']['ENSG00000227232']['locusListGuids'],
[LOCUS_LIST_GUID])
self.assertSetEqual(set(response_json['locusListsByGuid'].keys()),
{LOCUS_LIST_GUID})
intervals = response_json['locusListsByGuid'][LOCUS_LIST_GUID][
'intervals']
self.assertEqual(len(intervals), 2)
self.assertSetEqual(
set(intervals[0].keys()), {
'locusListGuid', 'locusListIntervalGuid', 'genomeVersion',
'chrom', 'start', 'end'
})
results_model = VariantSearchResults.objects.get(
search_hash=SEARCH_HASH)
mock_get_variants.assert_called_with(results_model,
sort='xpos',
page=1,
num_results=100,
skip_genotype_filter=False)
mock_error_logger.assert_not_called()
# Test pagination
response = self.client.get('{}?page=3'.format(url))
self.assertEqual(response.status_code, 200)
mock_get_variants.assert_called_with(results_model,
sort='xpos',
page=3,
num_results=100,
skip_genotype_filter=False)
mock_error_logger.assert_not_called()
# Test sort
response = self.client.get('{}?sort=pathogenicity'.format(url))
self.assertEqual(response.status_code, 200)
mock_get_variants.assert_called_with(results_model,
sort='pathogenicity',
page=1,
num_results=100,
skip_genotype_filter=False)
mock_error_logger.assert_not_called()
# Test export
export_url = reverse(export_variants_handler, args=[SEARCH_HASH])
response = self.client.get(export_url)
self.assertEqual(response.status_code, 200)
expected_content = [
[
'chrom', 'pos', 'ref', 'alt', 'gene', 'worst_consequence',
'1kg_freq', 'exac_freq', 'gnomad_genomes_freq',
'gnomad_exomes_freq', 'topmed_freq', 'cadd', 'revel', 'eigen',
'polyphen', 'sift', 'muttaster', 'fathmm', 'rsid', 'hgvsc',
'hgvsp', 'clinvar_clinical_significance', 'clinvar_gold_stars',
'filter', 'family_id_1', 'tags_1', 'notes_1', 'family_id_2',
'tags_2', 'notes_2', 'sample_1', 'num_alt_alleles_1', 'gq_1',
'ab_1', 'sample_2', 'num_alt_alleles_2', 'gq_2', 'ab_2'
],
[
'21', '3343400', 'GAGA', 'G', 'WASH7P', 'missense_variant', '',
'', '', '', '', '', '', '', '', '', '', '', '',
'ENST00000623083.3:c.1075G>A', 'ENSP00000485442.1:p.Gly359Ser',
'', '', '', '1',
'Tier 1 - Novel gene and phenotype (None)|Review (None)', '',
'2', '', '', 'NA19675', '1', '46.0', '0.702127659574',
'NA19679', '0', '99.0', '0.0'
],
[
'3', '835', 'AAAG', 'A', '', '', '', '', '', '', '', '', '',
'', '', '', '', '', '', '', '', '', '', '', '1', '', '', '',
'', '', 'NA19679', '0', '99.0', '0.0', '', '', '', ''
],
[
'12', '48367227', 'TC', 'T', '', '', '', '', '', '', '', '',
'', '', '', '', '', '', '', '', '', '', '', '', '2',
'Known gene for phenotype (None)|Excluded (None)',
'test n\xf8te (None)', '', '', '', '', '', '', '', '', '', '',
''
]
]
self.assertEqual(
response.content,
('\n'.join(['\t'.join(line)
for line in expected_content]) + '\n').encode('utf-8'))
mock_get_variants.assert_called_with(results_model,
page=1,
load_all=True)
mock_error_logger.assert_not_called()
# Test gene breakdown
gene_counts = {
'ENSG00000227232': {
'total': 2,
'families': {
'F000001_1': 2,
'F000002_2': 1
}
},
'ENSG00000268903': {
'total': 1,
'families': {
'F000002_2': 1
}
}
}
mock_get_gene_counts.return_value = gene_counts
gene_breakdown_url = reverse(get_variant_gene_breakdown,
args=[SEARCH_HASH])
response = self.client.get(gene_breakdown_url)
self.assertEqual(response.status_code, 200)
response_json = response.json()
self.assertSetEqual(set(response_json.keys()),
{'searchGeneBreakdown', 'genesById'})
self.assertDictEqual(response_json['searchGeneBreakdown'],
{SEARCH_HASH: gene_counts})
self.assertSetEqual(set(response_json['genesById'].keys()),
{'ENSG00000227232', 'ENSG00000268903'})
gene_fields = {
'constraints', 'omimPhenotypes', 'mimNumber', 'cnSensitivity'
}
gene_fields.update(GENE_FIELDS)
self.assertSetEqual(
set(response_json['genesById']['ENSG00000227232'].keys()),
gene_fields)
# Test compound hets
mock_get_variants.side_effect = _get_compound_het_es_variants
response = self.client.post(url,
content_type='application/json',
data=json.dumps({
'projectFamilies': PROJECT_FAMILIES,
'search': SEARCH
}))
self.assertEqual(response.status_code, 200)
response_json = response.json()
self.assertSetEqual(
set(response_json.keys()), {
'searchedVariants', 'savedVariantsByGuid', 'genesById',
'search', 'variantTagsByGuid', 'variantNotesByGuid',
'variantFunctionalDataByGuid', 'locusListsByGuid'
})
self.assertListEqual(response_json['searchedVariants'],
COMP_HET_VARAINTS)
self.assertSetEqual(set(response_json['savedVariantsByGuid'].keys()),
{'SV0000002_1248367227_r0390_100'})
self.assertSetEqual(set(response_json['genesById'].keys()),
{'ENSG00000233653'})
mock_error_logger.assert_not_called()
# Test cross-project discovery for analyst users
self.login_analyst_user()
mock_get_variants.side_effect = _get_es_variants
response = self.client.get('{}?sort=pathogenicity'.format(url))
self.assertEqual(response.status_code, 403)
mock_analyst_group.__bool__.return_value = True
mock_analyst_group.resolve_expression.return_value = 'analysts'
response = self.client.get('{}?sort=pathogenicity'.format(url))
self.assertEqual(response.status_code, 200)
response_json = response.json()
self.assertSetEqual(
set(response_json.keys()), {
'searchedVariants', 'savedVariantsByGuid', 'genesById',
'search', 'variantTagsByGuid', 'variantNotesByGuid',
'variantFunctionalDataByGuid', 'familiesByGuid',
'locusListsByGuid'
})
self.assertListEqual(response_json['searchedVariants'],
VARIANTS_WITH_DISCOVERY_TAGS)
self.assertSetEqual(set(response_json['familiesByGuid'].keys()),
{'F000011_11'})
mock_get_variants.assert_called_with(results_model,
sort='pathogenicity_hgmd',
page=1,
num_results=100,
skip_genotype_filter=False)
mock_error_logger.assert_not_called()
# Test no results
mock_get_variants.side_effect = _get_empty_es_variants
response = self.client.post(url,
content_type='application/json',
data=json.dumps({
'projectFamilies': PROJECT_FAMILIES,
'search': SEARCH
}))
self.assertEqual(response.status_code, 200)
response_json = response.json()
self.assertDictEqual(
response_json, {
'searchedVariants': [],
'search': {
'search': SEARCH,
'projectFamilies': PROJECT_FAMILIES,
'totalResults': 0,
}
})
mock_error_logger.assert_not_called()
def test_saveWork_multi_timeout_raise(self, testInstance, mocker):
testInstance.work = mocker.MagicMock()
testInstance.work.save.side_effect = ConnectionTimeout('test')
with pytest.raises(ConnectionTimeout):
testInstance.saveWork()
