def __init__(self, *p):
State.__init__(self, *p)
self.hmm = None
self.factory = None
self.repeatGeneratorX = None
self.repeatGeneratorY = None
self.consensus = ""
self.memoizeX = defaultdict(dict)
self.memoizeY = defaultdict(dict)
self.memoizeXsimple = dict()
self.memoizeYsimple = dict()
#self.dgmemoize = dict()
#self.rdgmemoize = dict()
self.consensusSampler = None
self.durationSampler = None
self.backgroundProbability = None
self.time = None
self.transitionMatrix = None
self.consensusDistribution = None
self.repeatLengthDistribution = None
self.repProb = None
self.modelversion = None
self.trackEmissions = None
self.x_count = 0
self.y_count = 0
self.cons_set = set()
self.cons_list = list()
def load(self, dictionary):
State.load(self, dictionary)
if "durations" not in dictionary:
raise ParseException("durations were not found in GeneralizedState")
self.durations = list(dictionary["durations"])
for d in range(len(self.durations)):
self.durations[d] = tuple(self.durations[d])
def test_state_loading(self):
a = State()
a.load(self.inputY)
X = a.toJSON()
Y = self.Y
self.assertDictEqual(X, Y, "Loading and dumping to JSON does not " + \
" work: " + str(X) + " != " + str(Y))
def load(self, dictionary):
State.load(self, dictionary)
if "durations" not in dictionary:
raise ParseException(
"durations were not found in GeneralizedState")
self.durations = list(dictionary["durations"])
for d in range(len(self.durations)):
self.durations[d] = tuple(self.durations[d])
def load(self, dictionary):
State.load(self, dictionary)
if 'backgroundprob' not in dictionary:
raise ParseException("Backround probability was not found in state")
self.backgroundProbability = [tuple(x)
for x in dictionary['backgroundprob']]
if 'time' not in dictionary:
raise ParseException('Time was not found in state')
self.time = dictionary['time']
if 'transitionmatrix' not in dictionary:
raise ParseException('Transition matrix not found in state')
self.transitionMatrix = dictionary['transitionmatrix']
if 'consensusdistribution' in dictionary:
self.consensusDistribution = default_dist(normalize_dict(
dictionary['consensusdistribution'],
mathType=self.mathType
))
else:
self.consensusDistribution = defaultdict(lambda *x: self.mathType(1.0))
if 'repeatlengthdistribution' in dictionary:
tp = type(dictionary['repeatlengthdistribution'])
if tp in [dict, defaultdict]:
self.repeatLengthDistribution = \
default_dist(normalize_dict(
dictionary['repeatlengthdistribution'],
mathType=self.mathType
))
else:
self.repeatLengthDistribution = \
dictionary['repeatlengthdistribution']
self.repProb = self.repeatLengthDistribution.p
if 'trackemissions' in dictionary:
self.trackEmissions = dictionary['trackemissions']
if 'version' in dictionary:
self.version = dictionary['version']
else:
self.version = 'v1'
if 'repprob' in dictionary:
self.repProb = self.mathType(dictionary['repprob'])
if self.version == 'v2':
self.trackEmissions = defaultdict(lambda *_: self.mathType(1.0))
self.trackEmissions['MM'] = self.mathType(1.0)
self.repeatLengthDistribution = defaultdict(lambda *_:
self.mathType(1.0))
self.repeatLengthDistribution[10] = self.mathType(1.0)
self.factory = RepeatProfileFactory(self.mathType, self.version,
self.repProb)
self.factory.backgroudProbability = self.backgroundProbability
self.factory.time = self.time
self.factory.transitionMatrix = self.transitionMatrix
def toJSON(self):
ret = State.toJSON(self)
ret['backgroundprob'] = self.backgroundProbability
ret['time'] = self.time
ret['transitionmatrix'] = self.transitionMatrix
if self.consensusDistribution != None:
ret['consensusdistribution'] = \
dist_to_json(self.consensusDistribution)
if self.repeatLengthDistribution != None:
ret['repeatlengthdistribution'] = \
dist_to_json(self.repeatLengthDistribution)
ret['trackemissions'] = self.trackEmissions
if self.version != None:
ret['version'] = self.version
if self.repProb != None:
ret['repprob'] = float(self.repProb)
#TODO: save consensus distribution
return ret
def toJSON(self):
ret = State.toJSON(self)
ret["durations"] = self.durations
return ret
def setUp(self):
self.inputY = {
"__name__": "State",
"name": "name",
"startprob": 1.0,
"emission": [("A", 1.0), (["C", "D"], 0.5)],
"endprob": 0.5
}
Y = self.inputY
Y["emission"][1] = (tuple(Y["emission"][1][0]), Y["emission"][1][1])
self.Y = Y
self.inputHMMData = dict()
for mathType in self.mathTypes:
hmmInit = {
"__name__": "HMM",
"states": [],
"transitions": [
{"from": "Init", "to": "White", "prob": mathType(0.3)},
{"from": "Init", "to": "Black", "prob": mathType(0.7)},
{"from": "White", "to": "White", "prob": mathType(1.0)},
{"from": "Black", "to": "Black", "prob": mathType(1.0)}
]
}
Init = State(mathType)
Init.load({
"__name__": "State",
"name": "Init",
"startprob": 1.0,
"endprob": 1.0,
"emission": [("0", 0.5), ("1", 0.5)]
})
White = State(mathType)
White.load({
"__name__": "State",
"name": "White",
"startprob": 0.0,
"endprob": 1.0,
"emission": [("0", 0.05), ("1", 0.95)]
})
Black = State(mathType)
Black.load({
"__name__": "State",
"name": "Black",
"startprob": 0.0,
"endprob": 1.0,
"emission": [("0", 0.9), ("1", 0.1)]
})
hmmInit["states"] = [White, Init, Black]
self.inputHMMData[mathType] = hmmInit
def load(self, dictionary):
State.load(self, dictionary)
if 'order' not in dictionary:
raise ParseException('order was not found in state')
self.order = dictionary['order']
def __init__(self, *p):
State.__init__(self, *p)
self.order = 0
def toJSON(self):
ret = State.toJSON(self)
ret['order'] = self.order
return ret
def createProfileHMMv1(mathType, consensus, time, backgroundProb, trans):
length = len(consensus)
states = []
transitions = []
for i in range(length):
char = consensus[i]
matchState = State(mathType)
insertState = State(mathType)
deleteState1 = GeneralizedState(mathType)
deleteState2 = GeneralizedState(mathType)
matchState.load({
"__name__": "State",
"name": "m" + str(i),
"startprob": 0.0,
"emission": JCModel(char, time, "ACGT"),
"endprob": 1.0
})
insertState.load({
"__name__": "State",
"name": "i" + str(i),
"startprob": 0.0,
"emission": backgroundProb,
"endprob": 1.0
})
deleteState1.load({
"__name__": "GeneralizedState",
"name": "1d" + str(i),
"startprob": 0.0,
"emission": [("", 1.0)],
"endprob": 0.0,
"durations": [(0, 1.0)]
})
deleteState2.load({
"__name__": "GeneralizedState",
"name": "2d" + str(i),
"startprob": 0.0,
"emission": [("", 1.0)],
"endprob": 0.0,
"durations": [(0, 1.0)]
})
states.extend([matchState, insertState, deleteState1, deleteState2])
if i < length - 1:
transitions.extend([
{
"from": "m" + str(i),
"to": "m" + str(i + 1),
"prob": trans['MM']
},
{
"from": "m" + str(i),
"to": "i" + str(i + 1),
"prob": trans['MI']
},
{
"from": "m" + str(i),
"to": "1d" + str(i + 1),
"prob": trans['MD']
},
{
"from": "1d" + str(i),
"to": "1d" + str(i + 1),
"prob": trans['DD']
},
{
"from": "1d" + str(i),
"to": "m" + str(i + 1),
"prob": trans['DM']
},
{
"from": "1d" + str(i),
"to": "i" + str(i + 1),
"prob": trans['DI']
},
{
"from": "2d" + str(i),
"to": "2d" + str(i + 1),
"prob": trans['DD']
},
{
"from": "2d" + str(i),
"to": "m" + str(i + 1),
"prob": trans['DM']
},
{
"from": "2d" + str(i),
"to": "i" + str(i + 1),
"prob": trans['DI']
},
])
transitions.extend([
{
"from": "i" + str(i),
"to": "i" + str(i),
"prob": trans['II']
},
{
"from": "i" + str(i),
"to": "m" + str(i),
"prob": trans['IM']
},
{
"from": "i" + str(i),
"to": "1d" + str(i),
"prob": trans['ID']
},
])
transitions.extend([
{
"from": "Init",
"to": "m0",
"prob": trans['_M']
},
{
"from": "Init",
"to": "i0",
"prob": trans['_I']
},
{
"from": "Init",
"to": "1d0",
"prob": trans['_D']
},
{
"from": "1d" + str(length - 1),
"to": "m0",
"prob": trans['_M']
},
{
"from": "1d" + str(length - 1),
"to": "i0",
"prob": trans['_I']
},
{
"from": "1d" + str(length - 1),
"to": "2d0",
"prob": trans['_D']
},
{
"from": "m" + str(length - 1),
"to": "Init",
"prob": 1.0 - trans['MI']
},
{
"from": "m" + str(length - 1),
"to": "i" + str(length),
"prob": trans['MI']
},
{
"from": "i" + str(length),
"to": "i" + str(length),
"prob": trans['II']
},
{
"from": "i" + str(length),
"to": "Init",
"prob": 1.0 - trans['II']
},
{
"from": "2d" + str(length - 1),
"to": "m0",
"prob": trans['_M'] / (trans['_M'] + trans['_I'])
},
{
"from": "2d" + str(length - 1),
"to": "i0",
"prob": trans['_I'] / (trans['_M'] + trans['_I'])
},
])
insertState = State(mathType)
insertState.load({
"__name__": "State",
"name": "i" + str(length),
"startprob": 0.0,
"emission": backgroundProb,
"endprob": 1.0
})
states.append(insertState)
initState = GeneralizedState(mathType)
initState.load({
"__name__": "GeneralizedState",
"name": "Init",
"startprob": 1.0,
"emission": [("", 1.0)],
"endprob": 1.0,
"durations": [(0, 1.0)]
})
states.append(initState)
hmm = GeneralizedHMM(mathType)
hmm.load({
"__name__": "GeneralizedHMM",
"states": states,
"transitions": transitions,
})
hmm.reorderStatesTopologically()
nm = consensus
if len(nm) > 20:
nm = hashlib.md5(consensus).hexdigest()
return hmm
def computeHints(self, realigner):
State.computeHints(self, realigner)
self.precomputeRepeatGenerators(realigner)
self.precomputeEmissionCache(realigner)
def test_state(self):
for numType in self.mathTypes:
state = State(numType)
state.load(self.inputY)
#test duration
X = list(state.durationGenerator())
Y = [(1, numType(1.0))]
self.assertEqual(X, Y, "HMM.durationGenerator() does not work: " + \
str(X) + " != " + str(Y))
#test emission
Y = numType(1.0)
X = state.emission("AC", 0)
self.assertAlmostEqual(X, Y, delta=1e-7,
msg="HMM.emission(\"AC\", 0) does not " + \
"work: " + str(X) + " != " + str(Y))
#test stateID
for Y in range(4):
state.setStateID(Y)
X = state.getStateID()
self.assertEqual(X, Y, "HMM.set/getStateID({0}) is broken." \
.format(Y))
#test transitions & remap
transitions = [(1, 1.0), (2, 0.4), (3, 0.2), (4, 0.6)]
M = {1: 2, 2: 3, 3: 4, 4: 5}
for (x, p) in transitions:
state.addTransition(x, p)
state.addReverseTransition(x, p)
X = state.followingIDs()
Y = transitions
self.assertEqual(X, Y, "HMM.?transitions are not working.")
X = state.previousIDs()
self.assertEqual(X, Y, "HMM.?reverse transitions are not working.")
state.remapIDs(M)
transitions = [(M[x[0]], x[1]) for x in transitions]
X = state.followingIDs()
Y = transitions
self.assertEqual(X, Y, "HMM.remapIDs() is not working.")
X = state.previousIDs()
self.assertEqual(X, Y, "HMM.remapIDs() is not working.")
state.clearTransitions()
Y = []
X = state.followingIDs()
X.extend(state.previousIDs())
self.assertEqual(X, Y, "HMM.clearTransitions() is not working.")
#test start & stop probability
X = state.getStartProbability()
Y = 1.0
self.assertAlmostEqual(X, Y, delta=1e-7,
msg="HMM.getStartProbability is broken.")
X = state.getEndProbability()
Y = 0.5
self.assertAlmostEqual(X, Y, delta=1e-7,
msg="HMM.getEndProbability is broken.")
def toJSON(self):
ret = State.toJSON(self)
ret['order'] = self.order
return ret
def __init__(self, *p):
State.__init__(self, *p)
self.durations = list()
def load(self, dictionary):
State.load(self, dictionary)
if 'order' not in dictionary:
raise ParseException('order was not found in state')
self.order = dictionary['order']
def __init__(self, *p):
State.__init__(self, *p)
self.order = 0
def __init__(self, *p):
State.__init__(self, *p)
self.durations = list()
def build_model(consensus, modelParam):
global model_cache
mathType = modelParam["mathType"]
model_factory = modelParam["modelFactory"]
if consensus in model_cache:
return model_cache[consensus]
model = model_factory.getHMM(consensus)
repProb = model_factory.repProb
repProb = 0.01
original_init_states = []
original_end_states = []
for i in range(len(model.states)):
if model.states[i].startProbability > 0: original_init_states.append(i)
if model.states[i].endProbability > 0: original_end_states.append(i)
background_state = State(mathType)
background_state.load({
"__name__": "State",
"name": "BackgroundState",
"startprob": 0.0,
"emission": model_factory.backgroundProbability,
"endprob": 1.0,
})
background_state_id = model.addState(background_state)
init_state = GeneralizedState(mathType)
init_state.load({
"__name__": "GeneralizedState",
"name": "FinderInit",
"startprob": 1.0,
"emission": [("", 1.0)],
"endprob": 0.0,
"durations": [(0, 1.0)]
})
init_state_id = model.addState(init_state)
model.addTransition(
init_state_id,
background_state_id,
mathType(1.0) - repProb
)
model.addTransition(
background_state_id,
background_state_id,
mathType(1.0) - repProb
)
for i in original_init_states:
prob = model.states[i].startProbability * repProb
model.addTransition(init_state_id, i, prob)
model.addTransition(background_state_id, i, prob)
model.states[i].startProbability = mathType(0.0)
for i in original_end_states:
model.addTransition(
i,
background_state_id,
model.states[i].endProbability
)
model.reorderStatesTopologically()
#for state in model.states:
# print state.stateName
#model_cache[consensus] = model
nm = consensus
if len(nm) > 20:
nm = hashlib.md5(consensus).hexdigest()
with open('submodels/{0}.js'.format(consensus), 'w') as f:
def LogNumToJson(obj):
if isinstance(obj, LogNum):
return '{0} {1}'.format(str(float(obj)),str(obj.value))
raise TypeError
json.dump(model.toJSON(), f, indent=4, sort_keys=True,
default=LogNumToJson)
return model
def toJSON(self):
ret = State.toJSON(self)
ret["durations"] = self.durations
return ret
def createProfileHMMv2(mathType, consensus, time, backgroundProb, trans):
if consensus == None or len(consensus) == 0:
raise "Wrong consensus: {}".format(consensus)
length = len(consensus)
states = []
transitions = []
for i in range(length):
char = consensus[i]
matchState = State(mathType)
insertState = State(mathType)
deleteState1 = GeneralizedState(mathType)
deleteState2 = GeneralizedState(mathType)
matchState.load({
"__name__": "State",
"name": "m" + str(i),
"startprob": 0.0,
"emission": JCModel(char, time, "ACGT"),
"endprob": 0.0
})
insertState.load({
"__name__": "State",
"name": "i" + str(i),
"startprob": 0.0,
"emission": backgroundProb,
"endprob": 0.0
})
deleteState1.load({
"__name__": "GeneralizedState",
"name": "1d" + str(i),
"startprob": 0.0,
"emission": [("", 1.0)],
"endprob": 0.0,
"durations": [(0, 1.0)]
})
deleteState2.load({
"__name__": "GeneralizedState",
"name": "2d" + str(i),
"startprob": 0.0,
"emission": [("", 1.0)],
"endprob": 0.0,
"durations": [(0, 1.0)]
})
states.extend([matchState, insertState, deleteState1, deleteState2])
if i < length - 1:
transitions.extend([
{
"from": "m" + str(i),
"to": "m" + str(i + 1),
"prob": trans['MM']
},
{
"from": "m" + str(i),
"to": "i" + str(i + 1),
"prob": trans['MI']
},
{
"from": "m" + str(i),
"to": "1d" + str(i + 1),
"prob": trans['MD']
},
{
"from": "1d" + str(i),
"to": "1d" + str(i + 1),
"prob": trans['DD']
},
{
"from": "1d" + str(i),
"to": "m" + str(i + 1),
"prob": trans['DM']
},
{
"from": "1d" + str(i),
"to": "i" + str(i + 1),
"prob": trans['DI']
},
{
"from": "2d" + str(i),
"to": "2d" + str(i + 1),
"prob": trans['DD']
},
{
"from": "2d" + str(i),
"to": "m" + str(i + 1),
"prob": trans['DM']
},
{
"from": "2d" + str(i),
"to": "i" + str(i + 1),
"prob": trans['DI']
},
])
transitions.extend([
{
"from": "i" + str(i),
"to": "i" + str(i),
"prob": trans['II']
},
{
"from": "i" + str(i),
"to": "m" + str(i),
"prob": trans['IM']
},
{
"from": "i" + str(i),
"to": "1d" + str(i),
"prob": trans['ID']
},
])
transitions.extend([
{
"from": "Init",
"to": "m0",
"prob": trans['_M']
},
{
"from": "Init",
"to": "i0",
"prob": trans['_I']
},
{
"from": "Init",
"to": "1d0",
"prob": trans['_D']
},
{
"from": "Init",
"to": "End",
"prob": trans['_E']
},
{
"from": "1d" + str(length - 1),
"to": "m0",
"prob": trans['DRM']
},
{
"from": "1d" + str(length - 1),
"to": "End",
"prob": trans['DRE']
},
{
"from": "1d" + str(length - 1),
"to": "i0",
"prob": trans['DRI']
},
{
"from": "1d" + str(length - 1),
"to": "2d0",
"prob": trans['DRD']
},
{
"from": "m" + str(length - 1),
"to": "Init",
"prob": trans['MR_']
},
{
"from": "m" + str(length - 1),
"to": "End",
"prob": trans['MRE']
},
{
"from": "m" + str(length - 1),
"to": "i" + str(length),
"prob": trans['MRI']
},
{
"from": "i" + str(length),
"to": "i" + str(length),
"prob": trans['IRI']
},
{
"from": "i" + str(length),
"to": "Init",
"prob": trans['IR_']
},
{
"from": "i" + str(length),
"to": "End",
"prob": trans['IRE']
},
])
insertState = State(mathType)
insertState.load({
"__name__": "State",
"name": "i" + str(length),
"startprob": 0.0,
"emission": backgroundProb,
"endprob": 0.0
})
states.append(insertState)
initState = GeneralizedState(mathType)
initState.load({
"__name__": "GeneralizedState",
"name": "Init",
"startprob": 1.0,
"emission": [("", 1.0)],
"endprob": 0.0,
"durations": [(0, 1.0)]
})
states.append(initState)
endState = GeneralizedState(mathType)
endState.load({
"__name__": "GeneralizedState",
"name": "End",
"startprob": 0.0,
"emission": [("", 1.0)],
"endprob": 1.0,
"durations": [(0, 1.0)],
})
states.append(endState)
remstate = '2d' + str(length - 1)
states = [state for state in states if state.stateName != remstate]
transitions = [
tran for tran in transitions
if tran['to'] != remstate and tran['from'] != remstate
]
hmm = GeneralizedHMM(mathType)
hmm.load({
"__name__": "GeneralizedHMM",
"states": states,
"transitions": transitions,
})
for i in range(len(hmm.states)):
hmm.states[i].normalizeTransitions()
hmm.reorderStatesTopologically()
nm = consensus
if len(nm) > 20:
nm = hashlib.md5(consensus).hexdigest()
#with Open('submodels/{0}.js'.format(nm), 'w') as f:
# def LogNumToJson(obj):
# if isinstance(obj, LogNum):
# return '{0} {1}'.format(str(float(obj)),str(obj.value))
# raise TypeError
# json.dump(hmm.toJSON(), f, indent=4, sort_keys=True,
# default=LogNumToJson)
return hmm
