Пример #1
0
def test_create_eddy_correct_pipeline():
    fsl_course_dir = os.path.abspath('fsl_course_data')

    dwi_file = os.path.join(fsl_course_dir, "fdt/subj1/data.nii.gz")

    nipype_eddycorrect = create_eddy_correct_pipeline("nipype_eddycorrect")
    nipype_eddycorrect.inputs.inputnode.in_file = dwi_file
    nipype_eddycorrect.inputs.inputnode.ref_num = 0

    with warnings.catch_warnings():
        warnings.simplefilter("ignore")
        original_eddycorrect = pe.Node(interface=fsl.EddyCorrect(), name="original_eddycorrect")
    original_eddycorrect.inputs.in_file = dwi_file
    original_eddycorrect.inputs.ref_num = 0

    test = pe.Node(util.AssertEqual(), name="eddy_corrected_dwi_test")

    pipeline = pe.Workflow(name="test_eddycorrect")
    pipeline.base_dir = tempfile.mkdtemp(prefix="nipype_test_eddycorrect_")

    pipeline.connect([(nipype_eddycorrect, test, [("outputnode.eddy_corrected", "volume1")]),
                      (original_eddycorrect, test, [("eddy_corrected", "volume2")]),
                      ])

    pipeline.run(plugin='Linear')
    shutil.rmtree(pipeline.base_dir)
Пример #2
0
def test_create_eddy_correct_pipeline():
    fsl_course_dir = os.path.abspath(os.environ['FSL_COURSE_DATA'])

    dwi_file = os.path.join(fsl_course_dir, "fdt1/subj1/data.nii.gz")

    trim_dwi = pe.Node(fsl.ExtractROI(t_min=0, t_size=2), name="trim_dwi")
    trim_dwi.inputs.in_file = dwi_file

    nipype_eddycorrect = create_eddy_correct_pipeline("nipype_eddycorrect")
    nipype_eddycorrect.inputs.inputnode.ref_num = 0

    with warnings.catch_warnings():
        warnings.simplefilter("ignore")
        original_eddycorrect = pe.Node(interface=fsl.EddyCorrect(),
                                       name="original_eddycorrect")
    original_eddycorrect.inputs.ref_num = 0

    test = pe.Node(util.AssertEqual(), name="eddy_corrected_dwi_test")

    pipeline = pe.Workflow(name="test_eddycorrect")
    pipeline.base_dir = tempfile.mkdtemp(prefix="nipype_test_eddycorrect_")

    pipeline.connect([
        (trim_dwi, original_eddycorrect, [("roi_file", "in_file")]),
        (trim_dwi, nipype_eddycorrect, [("roi_file", "inputnode.in_file")]),
        (nipype_eddycorrect, test, [("outputnode.eddy_corrected", "volume1")]),
        (original_eddycorrect, test, [("eddy_corrected", "volume2")]),
    ])

    pipeline.run(plugin='Linear')
    shutil.rmtree(pipeline.base_dir)
def eddyCorrect(inDwi, output):
    from nipype.interfaces import fsl

    eddyc = fsl.EddyCorrect()
    eddyc.inputs.in_file = inDwi
    eddyc.inputs.out_file = output
    eddyc.inputs.ref_num = 0
    eddyc.run()
Пример #4
0
    def create_workflow(self, flow, inputnode, outputnode):
        # print inputnode
        processing_input = pe.Node(interface=util.IdentityInterface(
            fields=['diffusion', 'aparc_aseg', 'aseg', 'bvecs', 'bvals', 'grad', 'acqp', 'index', 'T1', 'brain',
                    'brain_mask', 'wm_mask_file', 'roi_volumes']), name='processing_input')

        # For DSI acquisition: extract the hemisphere that contains the data
        # if self.config.start_vol > 0 or self.config.end_vol < self.config.max_vol:
        #
        #     split_vol = pe.Node(interface=splitDiffusion(),name='split_vol')
        #     split_vol.inputs.start = self.config.start_vol
        #     split_vol.inputs.end = self.config.end_vol
        #
        #     split_bvecbval = pe.Node(interface=splitBvecBval(),name='split_bvecsbvals')
        #     split_bvecbval.inputs.start = self.config.start_vol
        #     split_bvecbval.inputs.end = self.config.end_vol
        #     split_bvecbval.inputs.orientation = 'h'
        #     split_bvecbval.inputs.delimiter = ' '
        #
        #     flow.connect([
        #                 (inputnode,split_vol,[('diffusion','in_file')]),
        #                 (split_vol,processing_input,[('data','diffusion')]),
        #                 (inputnode,split_bvecbval,[('bvecs','bvecs'),('bvals','bvals')]),
        #                 (split_bvecbval,processing_input,[('bvecs_split','bvecs'),('bvals_split','bvals')])
        #                 ])
        #
        # else:

        flow.connect([
            (inputnode, processing_input, [
             ('diffusion', 'diffusion'), ('bvecs', 'bvecs'), ('bvals', 'bvals')]),
        ])

        flow.connect([
            (inputnode, processing_input,
             [('T1', 'T1'), ('aparc_aseg', 'aparc_aseg'), ('aseg', 'aseg'), ('brain', 'brain'),
              ('brain_mask', 'brain_mask'), ('wm_mask_file', 'wm_mask_file'), ('roi_volumes', 'roi_volumes')]),
            (processing_input, outputnode, [('bvals', 'bvals')])
        ])

        # Conversion to MRTrix image format ".mif", grad_fsl=(inputnode.inputs.bvecs,inputnode.inputs.bvals)
        mr_convert = pe.Node(interface=MRConvert(
            stride=[1, 2, +3, +4]), name='mr_convert')
        mr_convert.inputs.quiet = True
        mr_convert.inputs.force_writing = True

        concatnode = pe.Node(interface=util.Merge(2), name='concatnode')

        def convertList2Tuple(lists):
            # print "******************************************",tuple(lists)
            return tuple(lists)

        flow.connect([
            # (processing_input,concatnode,[('bvecs','in1'),('bvals','in2')]),
            (processing_input, concatnode, [('bvecs', 'in1')]),
            (processing_input, concatnode, [('bvals', 'in2')]),
            (concatnode, mr_convert, [
             (('out', convertList2Tuple), 'grad_fsl')])
        ])

        # Convert Freesurfer data
        mr_convert_brainmask = pe.Node(
            interface=MRConvert(out_filename='brainmaskfull.nii.gz', stride=[
                                1, 2, 3], output_datatype='float32'),
            name='mr_convert_brain_mask')
        mr_convert_brain = pe.Node(
            interface=MRConvert(out_filename='anat_masked.nii.gz', stride=[
                                1, 2, 3], output_datatype='float32'),
            name='mr_convert_brain')
        mr_convert_T1 = pe.Node(
            interface=MRConvert(out_filename='anat.nii.gz', stride=[
                                1, 2, 3], output_datatype='float32'),
            name='mr_convert_T1')
        mr_convert_roi_volumes = pe.Node(
            interface=ApplymultipleMRConvert(
                stride=[1, 2, 3], output_datatype='float32', extension='nii'),
            name='mr_convert_roi_volumes')
        mr_convert_wm_mask_file = pe.Node(
            interface=MRConvert(out_filename='wm_mask_file.nii.gz', stride=[
                                1, 2, 3], output_datatype='float32'),
            name='mr_convert_wm_mask_file')

        flow.connect([
            (processing_input, mr_convert_brainmask,
             [('brain_mask', 'in_file')]),
            (processing_input, mr_convert_brain, [('brain', 'in_file')]),
            (processing_input, mr_convert_T1, [('T1', 'in_file')]),
            (processing_input, mr_convert_roi_volumes,
             [('roi_volumes', 'in_files')]),
            (processing_input, mr_convert_wm_mask_file,
             [('wm_mask_file', 'in_file')])
        ])

        # if self.config.partial_volume_estimation:
        #     pve_extractor_from_5tt = pe.Node(interface=ExtractPVEsFrom5TT(),name='pve_extractor_from_5tt')
        #     pve_extractor.inputs.pve_csf_file = 'pve_0.nii.gz'
        #     pve_extractor.inputs.pve_csf_file = 'pve_1.nii.gz'
        #     pve_extractor.inputs.pve_csf_file = 'pve_2.nii.gz'
        #
        #     flow.connect([
        #                 (mrtrix_5tt,pve_extractor_from_5tt,[('out_file','in_5tt')]),
        #                 (processing_input,pve_extractor_from_5tt,[('T1','ref_image')]),
        #                 ])

        # from nipype.interfaces import fsl
        # # Run FAST for partial volume estimation (WM;GM;CSF)
        # fastr = pe.Node(interface=fsl.FAST(),name='fastr')
        # fastr.inputs.out_basename = 'fast_'
        # fastr.inputs.number_classes = 3
        #
        # if self.config.fast_use_priors:
        #     fsl_flirt = pe.Node(interface=fsl.FLIRT(out_file='Template2Input.nii.gz',out_matrix_file='template2input.mat'),name="linear_registration")
        #     #fsl_flirt.inputs.in_file = os.environ['FSLDIR']+'/data/standard/MNI152_T1_1mm.nii.gz'
        #     template_path = os.path.join('data', 'segmentation', 'ants_template_IXI')
        #     fsl_flirt.inputs.in_file = pkg_resources.resource_filename('cmtklib', os.path.join(template_path, 'T_template2.nii.gz'))
        #     #fsl_flirt.inputs.dof = self.config.dof
        #     #fsl_flirt.inputs.cost = self.config.fsl_cost
        #     #fsl_flirt.inputs.no_search = self.config.no_search
        #     fsl_flirt.inputs.verbose = True
        #
        #     flow.connect([
        #                 (mr_convert_T1, fsl_flirt, [('converted','reference')]),
        #                 ])
        #
        #     fastr.inputs.use_priors = True
        #     fastr.inputs.other_priors = [pkg_resources.resource_filename('cmtklib', os.path.join(template_path,'3Class-Priors','priors1.nii.gz')),
        #                                  pkg_resources.resource_filename('cmtklib', os.path.join(template_path,'3Class-Priors','priors2.nii.gz')),
        #                                  pkg_resources.resource_filename('cmtklib', os.path.join(template_path,'3Class-Priors','priors3.nii.gz'))
        #                                 ]
        #     flow.connect([
        #                 (fsl_flirt, fastr, [('out_matrix_file','init_transform')]),
        #                 ])
        #
        # flow.connect([
        #             (mr_convert_brain,fastr,[('converted','in_files')]),
        #             # (fastr,outputnode,[('partial_volume_files','partial_volume_files')])
        #             ])

        # Threshold converted Freesurfer brainmask into a binary mask
        mr_threshold_brainmask = pe.Node(interface=MRThreshold(abs_value=1, out_file='brain_mask.nii.gz'),
                                         name='mr_threshold_brainmask')

        flow.connect([
            (mr_convert_brainmask, mr_threshold_brainmask,
             [('converted', 'in_file')])
        ])

        # Extract b0 and create DWI mask
        flirt_dwimask_pre = pe.Node(interface=fsl.FLIRT(out_file='brain2b0.nii.gz', out_matrix_file='brain2b0aff'),
                                    name='flirt_dwimask_pre')
        costs = ['mutualinfo', 'corratio', 'normcorr',
                 'normmi', 'leastsq', 'labeldiff', 'bbr']
        flirt_dwimask_pre.inputs.cost = costs[3]
        flirt_dwimask_pre.inputs.cost_func = costs[3]
        flirt_dwimask_pre.inputs.dof = 6
        flirt_dwimask_pre.inputs.no_search = False

        flirt_dwimask = pe.Node(
            interface=fsl.FLIRT(out_file='dwi_brain_mask.nii.gz',
                                apply_xfm=True, interp='nearestneighbour'),
            name='flirt_dwimask')

        mr_convert_b0 = pe.Node(interface=MRConvert(out_filename='b0.nii.gz', stride=[+1, +2, +3]),
                                name='mr_convert_b0')
        mr_convert_b0.inputs.extract_at_axis = 3
        mr_convert_b0.inputs.extract_at_coordinate = [0]

        flow.connect([
            (processing_input, mr_convert_b0, [('diffusion', 'in_file')])
        ])

        flow.connect([
            (mr_convert_T1, flirt_dwimask_pre, [('converted', 'in_file')]),
            (mr_convert_b0, flirt_dwimask_pre, [('converted', 'reference')]),
            (mr_convert_b0, flirt_dwimask, [('converted', 'reference')]),
            (flirt_dwimask_pre, flirt_dwimask, [
             ('out_matrix_file', 'in_matrix_file')]),
            (mr_threshold_brainmask, flirt_dwimask,
             [('thresholded', 'in_file')])
        ])

        # Diffusion data denoising
        if self.config.denoising:

            mr_convert_noise = pe.Node(interface=MRConvert(out_filename='diffusion_noisemap.nii.gz', stride=[+1, +2, +3, +4]),
                                       name='mr_convert_noise')

            if self.config.denoising_algo == "MRtrix (MP-PCA)":
                mr_convert.inputs.out_filename = 'diffusion.mif'
                dwi_denoise = pe.Node(
                    interface=DWIDenoise(
                        out_file='diffusion_denoised.mif', out_noisemap='diffusion_noisemap.mif'),
                    name='dwi_denoise')
                dwi_denoise.inputs.force_writing = True
                dwi_denoise.inputs.debug = True
                dwi_denoise.ignore_exception = True

                flow.connect([
                    # (processing_input,mr_convert,[('diffusion','in_file')]),
                    (processing_input, mr_convert, [('diffusion', 'in_file')]),
                    (mr_convert, dwi_denoise, [('converted', 'in_file')]),
                    (flirt_dwimask, dwi_denoise, [('out_file', 'mask')]),
                ])

            elif self.config.denoising_algo == "Dipy (NLM)":
                mr_convert.inputs.out_filename = 'diffusion_denoised.mif'
                dwi_denoise = pe.Node(
                    interface=dipy.Denoise(), name='dwi_denoise')
                if self.config.dipy_noise_model == "Gaussian":
                    dwi_denoise.inputs.noise_model = "gaussian"
                elif self.config.dipy_noise_model == "Rician":
                    dwi_denoise.inputs.noise_model = "rician"

                flow.connect([
                    (processing_input, dwi_denoise,
                     [('diffusion', 'in_file')]),
                    (flirt_dwimask, dwi_denoise, [('out_file', 'in_mask')]),
                    (dwi_denoise, mr_convert, [('out_file', 'in_file')])
                ])

            flow.connect([
                (dwi_denoise, mr_convert_noise, [('out_file', 'in_file')]),
                (mr_convert_noise, outputnode, [('converted', 'diffusion_noisemap')])
            ])
        else:
            mr_convert.inputs.out_filename = 'diffusion.mif'
            flow.connect([
                (processing_input, mr_convert, [('diffusion', 'in_file')])
            ])

        mr_convert_b = pe.Node(interface=MRConvert(out_filename='diffusion_corrected.nii.gz', stride=[+1, +2, +3, +4]),
                               name='mr_convert_b')

        if self.config.bias_field_correction:

            mr_convert_bias = pe.Node(interface=MRConvert(out_filename='diffusion_biasfield.nii.gz', stride=[+1, +2, +3, +4]),
                                      name='mr_convert_bias')

            if self.config.bias_field_algo == "ANTS N4":
                dwi_biascorrect = pe.Node(
                    interface=DWIBiasCorrect(
                        use_ants=True, out_bias='diffusion_denoised_biasfield.mif'),
                    name='dwi_biascorrect')
            elif self.config.bias_field_algo == "FSL FAST":
                dwi_biascorrect = pe.Node(
                    interface=DWIBiasCorrect(
                        use_fsl=True, out_bias='diffusion_denoised_biasfield.mif'),
                    name='dwi_biascorrect')

            dwi_biascorrect.inputs.debug = True

            if self.config.denoising:
                if self.config.denoising_algo == "MRtrix (MP-PCA)":
                    flow.connect([
                        (dwi_denoise, dwi_biascorrect,
                         [('out_file', 'in_file')]),
                        (flirt_dwimask, dwi_biascorrect,
                         [('out_file', 'mask')]),
                        (dwi_biascorrect, mr_convert_b,
                         [('out_file', 'in_file')])
                    ])
                elif self.config.denoising_algo == "Dipy (NLM)":
                    flow.connect([
                        (mr_convert, dwi_biascorrect,
                         [('converted', 'in_file')]),
                        (flirt_dwimask, dwi_biascorrect,
                         [('out_file', 'mask')]),
                        (dwi_biascorrect, mr_convert_b,
                         [('out_file', 'in_file')])
                    ])
            else:
                flow.connect([
                    (mr_convert, dwi_biascorrect, [('converted', 'in_file')]),
                    (flirt_dwimask, dwi_biascorrect, [('out_file', 'mask')])
                ])

            flow.connect([
                (dwi_biascorrect, mr_convert_bias, [('out_file', 'in_file')]),
                (mr_convert_bias, outputnode, [('converted', 'diffusion_biasfield')])
            ])
        else:
            if self.config.denoising:
                if self.config.denoising_algo == "MRtrix (MP-PCA)":
                    flow.connect([
                        (dwi_denoise, mr_convert_b, [('out_file', 'in_file')])
                    ])
                elif self.config.denoising_algo == "Dipy (NLM)":
                    flow.connect([
                        (mr_convert, mr_convert_b, [('converted', 'in_file')])
                    ])
            else:
                flow.connect([
                    (mr_convert, mr_convert_b, [('converted', 'in_file')])
                ])

        extract_grad_mrtrix = pe.Node(interface=ExtractMRTrixGrad(out_grad_mrtrix='grad.txt'),
                                      name='extract_grad_mrtrix')
        flow.connect([
            (mr_convert, extract_grad_mrtrix, [("converted", "in_file")])
        ])
        # extract_grad_fsl = pe.Node(interface=mrt.MRTrixInfo(out_grad_mrtrix=('diffusion_denoised.bvec','diffusion_denoised.bval')),name='extract_grad_fsl')

        # TODO extract the total readout directly from the BIDS json file
        acqpnode = pe.Node(interface=CreateAcqpFile(
            total_readout=self.config.total_readout), name='acqpnode')

        indexnode = pe.Node(interface=CreateIndexFile(), name='indexnode')
        flow.connect([
            (extract_grad_mrtrix, indexnode, [
             ("out_grad_mrtrix", "in_grad_mrtrix")])
        ])

        fs_mriconvert = pe.Node(
            interface=fs.MRIConvert(
                out_type='niigz', out_file='diffusion_preproc_resampled.nii.gz'),
            name="diffusion_resample")
        fs_mriconvert.inputs.vox_size = self.config.resampling
        fs_mriconvert.inputs.resample_type = self.config.interpolation

        mr_convert_b0_resample = pe.Node(interface=MRConvert(out_filename='b0_resampled.nii.gz', stride=[+1, +2, +3]),
                                         name='mr_convert_b0_resample')
        mr_convert_b0_resample.inputs.extract_at_axis = 3
        mr_convert_b0_resample.inputs.extract_at_coordinate = [0]

        # fs_mriconvert_b0 = pe.Node(interface=fs.MRIConvert(out_type='niigz',out_file='b0_resampled.nii.gz'),name="b0_resample")
        # fs_mriconvert_b0.inputs.vox_size = self.config.resampling
        # fs_mriconvert_b0.inputs.resample_type = self.config.interpolation

        flow.connect([
            (fs_mriconvert, mr_convert_b0_resample, [('out_file', 'in_file')]),
        ])

        # resampling Freesurfer data and setting output type to short
        fs_mriconvert_T1 = pe.Node(interface=fs.MRIConvert(out_type='niigz', out_file='anat_resampled.nii.gz'),
                                   name="anat_resample")
        fs_mriconvert_T1.inputs.vox_size = self.config.resampling
        fs_mriconvert_T1.inputs.resample_type = self.config.interpolation

        flow.connect([
            (mr_convert_T1, fs_mriconvert_T1, [('converted', 'in_file')]),
            # (mr_convert_b0_resample,fs_mriconvert_T1,[('converted','reslice_like')]),
            (fs_mriconvert_T1, outputnode, [('out_file', 'T1')])
        ])

        fs_mriconvert_brain = pe.Node(
            interface=fs.MRIConvert(
                out_type='niigz', out_file='anat_masked_resampled.nii.gz'),
            name="anat_masked_resample")
        fs_mriconvert_brain.inputs.vox_size = self.config.resampling
        fs_mriconvert_brain.inputs.resample_type = self.config.interpolation

        flow.connect([
            (mr_convert_brain, fs_mriconvert_brain,
             [('converted', 'in_file')]),
            # (mr_convert_b0_resample,fs_mriconvert_brain,[('converted','reslice_like')]),
            (fs_mriconvert_brain, outputnode, [('out_file', 'brain')])
        ])

        fs_mriconvert_brainmask = pe.Node(
            interface=fs.MRIConvert(
                out_type='niigz', resample_type='nearest', out_file='brain_mask_resampled.nii.gz'),
            name="brain_mask_resample")
        fs_mriconvert_brainmask.inputs.vox_size = self.config.resampling
        flow.connect([
            (mr_threshold_brainmask, fs_mriconvert_brainmask,
             [('thresholded', 'in_file')]),
            # (mr_convert_b0_resample,fs_mriconvert_brainmask,[('converted','reslice_like')]),
            (fs_mriconvert_brainmask, outputnode, [('out_file', 'brain_mask')])
        ])

        fs_mriconvert_brainmaskfull = pe.Node(
            interface=fs.MRIConvert(
                out_type='niigz', out_file='brain_mask_full_resampled.nii.gz'),
            name="brain_mask_full_resample")
        fs_mriconvert_brainmaskfull.inputs.vox_size = self.config.resampling
        fs_mriconvert_brainmaskfull.inputs.resample_type = self.config.interpolation
        flow.connect([
            (mr_convert_brainmask, fs_mriconvert_brainmaskfull,
             [('converted', 'in_file')]),
            # (mr_convert_b0_resample,fs_mriconvert_brainmaskfull,[('converted','reslice_like')]),
            (fs_mriconvert_brainmaskfull, outputnode,
             [('out_file', 'brain_mask_full')])
        ])

        fs_mriconvert_wm_mask = pe.Node(
            interface=fs.MRIConvert(
                out_type='niigz', resample_type='nearest', out_file='wm_mask_resampled.nii.gz'),
            name="wm_mask_resample")
        fs_mriconvert_wm_mask.inputs.vox_size = self.config.resampling
        flow.connect([
            (mr_convert_wm_mask_file, fs_mriconvert_wm_mask,
             [('converted', 'in_file')]),
            # (mr_convert_b0_resample,fs_mriconvert_wm_mask,[('converted','reslice_like')]),
            (fs_mriconvert_wm_mask, outputnode, [('out_file', 'wm_mask_file')])
        ])

        fs_mriconvert_ROIs = pe.MapNode(interface=fs.MRIConvert(out_type='niigz', resample_type='nearest'),
                                        iterfield=['in_file'], name="ROIs_resample")
        fs_mriconvert_ROIs.inputs.vox_size = self.config.resampling
        flow.connect([
            (mr_convert_roi_volumes, fs_mriconvert_ROIs,
             [('converted_files', 'in_file')]),
            # (mr_convert_b0_resample,fs_mriconvert_ROIs,[('converted','reslice_like')]),
            (fs_mriconvert_ROIs, outputnode, [("out_file", "roi_volumes")])
        ])

        # fs_mriconvert_PVEs = pe.MapNode(interface=fs.MRIConvert(out_type='niigz'),name="PVEs_resample",iterfield=['in_file'])
        # fs_mriconvert_PVEs.inputs.vox_size = self.config.resampling
        # fs_mriconvert_PVEs.inputs.resample_type = self.config.interpolation
        # flow.connect([
        #             (fastr,fs_mriconvert_PVEs,[('partial_volume_files','in_file')]),
        #             #(mr_convert_b0_resample,fs_mriconvert_ROIs,[('converted','reslice_like')]),
        #             (fs_mriconvert_PVEs,outputnode,[("out_file","partial_volume_files")])
        #             ])

        fs_mriconvert_dwimask = pe.Node(interface=fs.MRIConvert(out_type='niigz', resample_type='nearest',
                                                                out_file='dwi_brain_mask_resampled.nii.gz'),
                                        name="dwi_brainmask_resample")
        # fs_mriconvert_dwimask.inputs.vox_size = self.config.resampling
        flow.connect([
            (flirt_dwimask, fs_mriconvert_dwimask, [('out_file', 'in_file')]),
            (mr_convert_b0_resample, fs_mriconvert_dwimask,
             [('converted', 'reslice_like')]),
            (fs_mriconvert_dwimask, outputnode,
             [('out_file', 'dwi_brain_mask')])
        ])

        # TODO Implementation of FSL Topup

        if self.config.eddy_current_and_motion_correction:

            if self.config.eddy_correction_algo == 'FSL eddy_correct':

                eddy_correct = pe.Node(interface=fsl.EddyCorrect(ref_num=0, out_file='eddy_corrected.nii.gz'),
                                       name='eddy_correct')

                flow.connect([
                    (processing_input, outputnode, [("bvecs", "bvecs_rot")])
                ])

                if self.config.eddy_correct_motion_correction:

                    mc_flirt = pe.Node(
                        interface=fsl.MCFLIRT(
                            out_file='motion_corrected.nii.gz', ref_vol=0, save_mats=True),
                        name='motion_correction')
                    flow.connect([
                        (mr_convert_b, mc_flirt, [("converted", "in_file")])
                    ])

                    # FIXME rotate b vectors after motion correction (mcflirt)

                    flow.connect([
                        (mc_flirt, eddy_correct, [("out_file", "in_file")])
                    ])
                else:

                    flow.connect([
                        (mr_convert_b, eddy_correct,
                         [("converted", "in_file")])
                    ])

                # # DTK needs fixed number of directions (512)
                # if self.config.start_vol > 0 and self.config.end_vol == self.config.max_vol:
                #     merge_filenames = pe.Node(interface=util.Merge(2),name='merge_files')
                #     flow.connect([
                #                 (split_vol,merge_filenames,[("padding1","in1")]),
                #                 (eddy_correct,merge_filenames,[("eddy_corrected","in2")]),
                #                 ])
                #     merge = pe.Node(interface=fsl.Merge(dimension='t'),name="merge")
                #     flow.connect([
                #                 (merge_filenames,merge,[("out","in_files")]),
                #                 ])
                #     flow.connect([
                #                 (merge,fs_mriconvert,[('merged_file','in_file')]),
                #                 (fs_mriconvert,outputnode,[("out_file","diffusion_preproc")])
                #                 ])
                # elif self.config.start_vol > 0 and self.config.end_vol < self.config.max_vol:
                #     merge_filenames = pe.Node(interface=util.Merge(3),name='merge_files')
                #     flow.connect([
                #                 (split_vol,merge_filenames,[("padding1","in1")]),
                #                 (eddy_correct,merge_filenames,[("eddy_corrected","in2")]),
                #                 (split_vol,merge_filenames,[("padding2","in3")]),
                #                 ])
                #     merge = pe.Node(interface=fsl.Merge(dimension='t'),name="merge")
                #     flow.connect([
                #                 (merge_filenames,merge,[("out","in_files")])
                #                 ])
                #     flow.connect([
                #                 (merge,fs_mriconvert,[('merged_file','in_file')]),
                #                 (fs_mriconvert,outputnode,[("out_file","diffusion_preproc")])
                #                 ])
                # elif self.config.start_vol == 0 and self.config.end_vol < self.config.max_vol:
                #     merge_filenames = pe.Node(interface=util.Merge(2),name='merge_files')
                #     flow.connect([
                #                 (eddy_correct,merge_filenames,[("eddy_corrected","in1")]),
                #                 (split_vol,merge_filenames,[("padding2","in2")]),
                #                 ])
                #     merge = pe.Node(interface=fsl.Merge(dimension='t'),name="merge")
                #     flow.connect([
                #                 (merge_filenames,merge,[("out","in_files")])
                #                 ])
                #     flow.connect([
                #                 (merge,fs_mriconvert,[('merged_file','in_file')]),
                #                 (fs_mriconvert,outputnode,[("out_file","diffusion_preproc")])
                #                 ])
                # else:
                flow.connect([
                    (eddy_correct, fs_mriconvert, [
                     ('eddy_corrected', 'in_file')]),
                    (fs_mriconvert, outputnode, [
                     ("out_file", "diffusion_preproc")])
                ])

            else:
                eddy_correct = pe.Node(interface=cmp_fsl.EddyOpenMP(out_file="eddy_corrected.nii.gz", verbose=True),
                                       name='eddy')
                flow.connect([
                    (mr_convert_b, eddy_correct, [("converted", "in_file")]),
                    (processing_input, eddy_correct, [("bvecs", "bvecs")]),
                    (processing_input, eddy_correct, [("bvals", "bvals")]),
                    (flirt_dwimask, eddy_correct, [("out_file", "mask")]),
                    (indexnode, eddy_correct, [("index", "index")]),
                    (acqpnode, eddy_correct, [("acqp", "acqp")])
                ])

                flow.connect([
                    (eddy_correct, outputnode, [
                     ("bvecs_rotated", "bvecs_rot")])
                ])

                # # DTK needs fixed number of directions (512)
                # if self.config.start_vol > 0 and self.config.end_vol == self.config.max_vol:
                #     merge_filenames = pe.Node(interface=util.Merge(2),name='merge_files')
                #     flow.connect([
                #                 (split_vol,merge_filenames,[("padding1","in1")]),
                #                 (eddy_correct,merge_filenames,[("eddy_corrected","in1")])
                #                 ])
                #     merge = pe.Node(interface=fsl.Merge(dimension='t'),name="merge")
                #     flow.connect([
                #                 (merge_filenames,merge,[("out","in_files")]),
                #                 ])
                #     # resampling diffusion image and setting output type to short
                #     flow.connect([
                #                 (merge,fs_mriconvert,[('merged_file','in_file')]),
                #                 (fs_mriconvert,outputnode,[("out_file","diffusion_preproc")])
                #                 ])
                #
                # elif self.config.start_vol > 0 and self.config.end_vol < self.config.max_vol:
                #     merge_filenames = pe.Node(interface=util.Merge(3),name='merge_files')
                #     flow.connect([
                #                 (split_vol,merge_filenames,[("padding1","in1")]),
                #                 (eddy_correct,merge_filenames,[("eddy_corrected","in1")]),
                #                 (split_vol,merge_filenames,[("padding2","in3")])
                #                 ])
                #     merge = pe.Node(interface=fsl.Merge(dimension='t'),name="merge")
                #     flow.connect([
                #                 (merge_filenames,merge,[("out","in_files")]),
                #                 ])
                #     # resampling diffusion image and setting output type to short
                #     flow.connect([
                #                 (merge,fs_mriconvert,[('merged_file','in_file')]),
                #                 (fs_mriconvert,outputnode,[("out_file","diffusion_preproc")])
                #                 ])
                # elif self.config.start_vol == 0 and self.config.end_vol < self.config.max_vol:
                #     merge_filenames = pe.Node(interface=util.Merge(2),name='merge_files')
                #     flow.connect([
                #                 (eddy_correct,merge_filenames,[("eddy_corrected","in1")]),
                #                 (split_vol,merge_filenames,[("padding2","in2")])
                #                 ])
                #     merge = pe.Node(interface=fsl.Merge(dimension='t'),name="merge")
                #     flow.connect([
                #                 (merge_filenames,merge,[("out","in_files")]),
                #                 ])
                #     # resampling diffusion image and setting output type to short
                #     flow.connect([
                #                 (merge,fs_mriconvert,[('merged_file','in_file')]),
                #                 (fs_mriconvert,outputnode,[("out_file","diffusion_preproc")])
                #                 ])
                # else:
                # resampling diffusion image and setting output type to short
                flow.connect([
                    (eddy_correct, fs_mriconvert, [
                     ('eddy_corrected', 'in_file')]),
                    (fs_mriconvert, outputnode, [
                     ("out_file", "diffusion_preproc")])
                ])
        else:
            # resampling diffusion image and setting output type to short
            flow.connect([
                (mr_convert_b, fs_mriconvert, [("converted", "in_file")]),
                (fs_mriconvert, outputnode, [
                 ("out_file", "diffusion_preproc")]),
                (inputnode, outputnode, [("bvecs", "bvecs_rot")])
            ])

        # #mr_convertB.inputs.grad_fsl = ('bvecs', 'bvals')
        # flow.connect([
        #             (mr_convertF,mr_convertB,[("converted","in_file")])
        #             ])

        # else:
        #     if self.config.start_vol > 0 and self.config.end_vol == self.config.max_vol:
        #         merge_filenames = pe.Node(interface=util.Merge(2),name='merge_files')
        #         flow.connect([
        #                     (split_vol,merge_filenames,[("padding1","in1")]),
        #                     (mc_flirt,merge_filenames,[("out_file","in2")]),
        #                     ])
        #         merge = pe.Node(interface=fsl.Merge(dimension='t'),name="merge")
        #         flow.connect([
        #                     (merge_filenames,merge,[("out","in_files")]),
        #                     (merge,outputnode,[("merged_file","diffusion_preproc")])
        #                     ])
        #     elif self.config.start_vol > 0 and self.config.end_vol < self.config.max_vol:
        #         merge_filenames = pe.Node(interface=util.Merge(3),name='merge_files')
        #         flow.connect([
        #                     (split_vol,merge_filenames,[("padding1","in1")]),
        #                     (mc_flirt,merge_filenames,[("out_file","in2")]),
        #                     (split_vol,merge_filenames,[("padding2","in3")]),
        #                     ])
        #         merge = pe.Node(interface=fsl.Merge(dimension='t'),name="merge")
        #         flow.connect([
        #                     (merge_filenames,merge,[("out","in_files")]),
        #                     (merge,outputnode,[("merged_file","diffusion_preproc")])
        #                     ])
        #     elif self.config.start_vol == 0 and self.config.end_vol < self.config.max_vol:
        #         merge_filenames = pe.Node(interface=util.Merge(2),name='merge_files')
        #         flow.connect([
        #                     (mc_flirt,merge_filenames,[("out_file","in1")]),
        #                     (split_vol,merge_filenames,[("padding2","in2")]),
        #                     ])
        #         merge = pe.Node(interface=fsl.Merge(dimension='t'),name="merge")
        #         flow.connect([
        #                     (merge_filenames,merge,[("out","in_files")]),
        #                     (merge,outputnode,[("merged_file","diffusion_preproc")])
        #                     ])
        #     else:
        #         flow.connect([
        #                     (mc_flirt,outputnode,[("out_file","diffusion_preproc")])
        #                     ])

        fs_mriconvert_5tt = pe.Node(interface=fs.MRIConvert(out_type='niigz', out_file='act_5tt_resampled.nii.gz'),
                                    name="5tt_resample")
        fs_mriconvert_5tt.inputs.vox_size = self.config.resampling
        fs_mriconvert_5tt.inputs.resample_type = self.config.interpolation

        mrtrix_5tt = pe.Node(interface=Generate5tt(
            out_file='mrtrix_5tt.nii.gz'), name='mrtrix_5tt')
        mrtrix_5tt.inputs.algorithm = 'freesurfer'
        # mrtrix_5tt.inputs.algorithm = 'hsvs'

        flow.connect([
            (processing_input, mrtrix_5tt, [('aparc_aseg', 'in_file')]),
            (mrtrix_5tt, fs_mriconvert_5tt, [('out_file', 'in_file')]),
            (fs_mriconvert_5tt, outputnode, [('out_file', 'act_5TT')]),
        ])

        # if self.config.partial_volume_estimation:
        pve_extractor_from_5tt = pe.Node(
            interface=ExtractPVEsFrom5TT(), name='pve_extractor_from_5tt')
        pve_extractor_from_5tt.inputs.pve_csf_file = 'pve_0.nii.gz'
        pve_extractor_from_5tt.inputs.pve_gm_file = 'pve_1.nii.gz'
        pve_extractor_from_5tt.inputs.pve_wm_file = 'pve_2.nii.gz'

        flow.connect([
            (mrtrix_5tt, pve_extractor_from_5tt, [('out_file', 'in_5tt')]),
            (processing_input, pve_extractor_from_5tt, [('T1', 'ref_image')]),
        ])

        fs_mriconvert_PVEs = pe.MapNode(interface=fs.MRIConvert(out_type='niigz'), iterfield=['in_file'],
                                        name="PVEs_resample")
        fs_mriconvert_PVEs.inputs.vox_size = self.config.resampling
        fs_mriconvert_PVEs.inputs.resample_type = self.config.interpolation
        flow.connect([
            (pve_extractor_from_5tt, fs_mriconvert_PVEs,
             [('partial_volume_files', 'in_file')]),
            # (mr_convert_b0_resample,fs_mriconvert_ROIs,[('converted','reslice_like')]),
            (fs_mriconvert_PVEs, outputnode, [
             ("out_file", "partial_volume_files")])
        ])

        fs_mriconvert_gmwmi = pe.Node(interface=fs.MRIConvert(out_type='niigz', out_file='gmwmi_resampled.nii.gz'),
                                      name="gmwmi_resample")
        fs_mriconvert_gmwmi.inputs.vox_size = self.config.resampling
        fs_mriconvert_gmwmi.inputs.resample_type = self.config.interpolation

        mrtrix_gmwmi = pe.Node(interface=GenerateGMWMInterface(
            out_file='gmwmi.nii.gz'), name='mrtrix_gmwmi')

        update_gmwmi = pe.Node(
            interface=UpdateGMWMInterfaceSeeding(), name='update_gmwmi')
        update_gmwmi.inputs.out_gmwmi_file = 'gmwmi_proc.nii.gz'

        flow.connect([
            (mrtrix_5tt, mrtrix_gmwmi, [('out_file', 'in_file')]),
            (mrtrix_gmwmi, update_gmwmi, [('out_file', 'in_gmwmi_file')]),
            (processing_input, update_gmwmi, [
             ('roi_volumes', 'in_roi_volumes')]),
            (update_gmwmi, fs_mriconvert_gmwmi,
             [('out_gmwmi_file', 'in_file')]),
            (fs_mriconvert_gmwmi, outputnode, [('out_file', 'gmwmi')]),
        ])
#You need the output to be nifti, otherwise NODDI cannot read it
# eddy = Node (fsl.Eddy(), name = 'eddy')
# eddy.inputs.in_acqp  = acqparams
# eddy.inputs.in_bval  = bval
# eddy.inputs.in_bvec  = bvec
# eddy.inputs.in_index = index
# eddy.inputs.use_cuda = True
# eddy.inputs.is_shelled = True
# eddy.inputs.num_threads = 8
# eddy.inputs.niter = 2
# eddy.inputs.output_type = 'NIFTI' #This will be passed to NODDI and charmed

#I tried new Eddy function, it did not work very well, So, I am regressing to good old eddy_correct that perfroms only affine
#I compared new eddy vs mcflirt vs eddy_correct and the later really did perform much better

eddy = Node(fsl.EddyCorrect(), name='eddy')
eddy.inputs.ref_num = 0


#-----------------------------------------------------------------------------------------------------
# In[8]
# I decided to use RESTORE (non-linear algorithm) to fit the kurtosis tensor here instead of the default (WLS, linear)
# You will find: /media/amr/Amr_4TB/Work/October_Acquistion/Diffusion_TBSS_Stat/Study_Based_Template/Kurtosis_WLS
# as well as   : /media/amr/Amr_4TB/Work/October_Acquistion/Diffusion_TBSS_Stat/DTI_TBSS_workingdir_Study_Based_Template/DTI_TBSS_Study/_map_id_Kurtosis_FA_WLS
#for all map_list
# in the processing workingdir, there is only one copy, the RESTORE
# the folders without _WLS suffix are done using RESTORE
def Kurtosis(dwi, mask):
    import numpy as np
    import dipy.reconst.dki as dki
    import dipy.reconst.dti as dti
    def create_workflow(self, flow, inputnode, outputnode):
        """Create the stage worflow.

        Parameters
        ----------
        flow : nipype.pipeline.engine.Workflow
            The nipype.pipeline.engine.Workflow instance of the Diffusion pipeline

        inputnode : nipype.interfaces.utility.IdentityInterface
            Identity interface describing the inputs of the stage

        outputnode : nipype.interfaces.utility.IdentityInterface
            Identity interface describing the outputs of the stage
        """
        # print inputnode
        processing_input = pe.Node(
            interface=util.IdentityInterface(
                fields=[
                    "diffusion",
                    "aparc_aseg",
                    "aseg",
                    "bvecs",
                    "bvals",
                    "grad",
                    "acqp",
                    "index",
                    "T1",
                    "brain",
                    "brain_mask",
                    "wm_mask_file",
                    "roi_volumes",
                ]
            ),
            name="processing_input",
        )

        # fmt: off
        flow.connect(
            [
                (inputnode, processing_input, [("diffusion", "diffusion"),
                                               ("bvecs", "bvecs"),
                                               ("bvals", "bvals"),
                                               ("T1", "T1"),
                                               ("aparc_aseg", "aparc_aseg"),
                                               ("aseg", "aseg"),
                                               ("brain", "brain"),
                                               ("brain_mask", "brain_mask"),
                                               ("wm_mask_file", "wm_mask_file"),
                                               ("roi_volumes", "roi_volumes")]),
                (processing_input, outputnode, [("bvals", "bvals")]),
            ]
        )
        # fmt: on

        # Conversion to MRTrix image format ".mif", grad_fsl=(inputnode.inputs.bvecs,inputnode.inputs.bvals)
        mr_convert = pe.Node(
            interface=MRConvert(stride=[1, 2, +3, +4]),
            name="mr_convert"
        )
        mr_convert.inputs.quiet = True
        mr_convert.inputs.force_writing = True

        concatnode = pe.Node(interface=util.Merge(2), name="concatnode")

        # fmt: off
        flow.connect(
            [
                (processing_input, concatnode, [("bvecs", "in1")]),
                (processing_input, concatnode, [("bvals", "in2")]),
                (concatnode, mr_convert, [(("out", convert_list_to_tuple), "grad_fsl")]),
            ]
        )
        # fmt: on

        # Convert Freesurfer data
        mr_convert_brainmask = pe.Node(
            interface=MRConvert(
                out_filename="brainmaskfull.nii.gz",
                stride=[1, 2, 3],
                output_datatype="float32",
            ),
            name="mr_convert_brain_mask",
        )
        mr_convert_brain = pe.Node(
            interface=MRConvert(
                out_filename="anat_masked.nii.gz",
                stride=[1, 2, 3],
                output_datatype="float32",
            ),
            name="mr_convert_brain",
        )
        mr_convert_T1 = pe.Node(
            interface=MRConvert(
                out_filename="anat.nii.gz", stride=[1, 2, 3], output_datatype="float32"
            ),
            name="mr_convert_T1",
        )
        mr_convert_roi_volumes = pe.Node(
            interface=ApplymultipleMRConvert(
                stride=[1, 2, 3], output_datatype="float32", extension="nii"
            ),
            name="mr_convert_roi_volumes",
        )
        mr_convert_wm_mask_file = pe.Node(
            interface=MRConvert(
                out_filename="wm_mask_file.nii.gz",
                stride=[1, 2, 3],
                output_datatype="float32",
            ),
            name="mr_convert_wm_mask_file",
        )

        # fmt: off
        flow.connect(
            [
                (processing_input, mr_convert_brainmask, [("brain_mask", "in_file")]),
                (processing_input, mr_convert_brain, [("brain", "in_file")]),
                (processing_input, mr_convert_T1, [("T1", "in_file")]),
                (processing_input, mr_convert_roi_volumes, [("roi_volumes", "in_files")]),
                (processing_input, mr_convert_wm_mask_file, [("wm_mask_file", "in_file")]),
            ]
        )
        # fmt: on

        # if self.config.partial_volume_estimation:
        #     pve_extractor_from_5tt = pe.Node(interface=ExtractPVEsFrom5TT(),name='pve_extractor_from_5tt')
        #     pve_extractor.inputs.pve_csf_file = 'pve_0.nii.gz'
        #     pve_extractor.inputs.pve_csf_file = 'pve_1.nii.gz'
        #     pve_extractor.inputs.pve_csf_file = 'pve_2.nii.gz'
        #
        #     flow.connect([
        #                 (mrtrix_5tt,pve_extractor_from_5tt,[('out_file','in_5tt')]),
        #                 (processing_input,pve_extractor_from_5tt,[('T1','ref_image')]),
        #                 ])

        # from nipype.interfaces import fsl
        # # Run FAST for partial volume estimation (WM;GM;CSF)
        # fastr = pe.Node(interface=fsl.FAST(),name='fastr')
        # fastr.inputs.out_basename = 'fast_'
        # fastr.inputs.number_classes = 3
        #
        # if self.config.fast_use_priors:
        #     fsl_flirt = pe.Node(interface=fsl.FLIRT(out_file='Template2Input.nii.gz',out_matrix_file='template2input.mat'),name="linear_registration")
        #     #fsl_flirt.inputs.in_file = os.environ['FSLDIR']+'/data/standard/MNI152_T1_1mm.nii.gz'
        #     template_path = os.path.join('data', 'segmentation', 'ants_template_IXI')
        #     fsl_flirt.inputs.in_file = pkg_resources.resource_filename('cmtklib', os.path.join(template_path, 'T_template2.nii.gz'))
        #     #fsl_flirt.inputs.dof = self.config.dof
        #     #fsl_flirt.inputs.cost = self.config.fsl_cost
        #     #fsl_flirt.inputs.no_search = self.config.no_search
        #     fsl_flirt.inputs.verbose = True
        #
        #     flow.connect([
        #                 (mr_convert_T1, fsl_flirt, [('converted','reference')]),
        #                 ])
        #
        #     fastr.inputs.use_priors = True
        #     fastr.inputs.other_priors = [pkg_resources.resource_filename('cmtklib', os.path.join(template_path,'3Class-Priors','priors1.nii.gz')),
        #                                  pkg_resources.resource_filename('cmtklib', os.path.join(template_path,'3Class-Priors','priors2.nii.gz')),
        #                                  pkg_resources.resource_filename('cmtklib', os.path.join(template_path,'3Class-Priors','priors3.nii.gz'))
        #                                 ]
        #     flow.connect([
        #                 (fsl_flirt, fastr, [('out_matrix_file','init_transform')]),
        #                 ])
        #
        # flow.connect([
        #             (mr_convert_brain,fastr,[('converted','in_files')]),
        #             # (fastr,outputnode,[('partial_volume_files','partial_volume_files')])
        #             ])

        # Threshold converted Freesurfer brainmask into a binary mask
        mr_threshold_brainmask = pe.Node(
            interface=MRThreshold(abs_value=1, out_file="brain_mask.nii.gz"),
            name="mr_threshold_brainmask",
        )

        # fmt: off
        flow.connect(
            [(mr_convert_brainmask, mr_threshold_brainmask, [("converted", "in_file")])]
        )
        # fmt: on

        # Extract b0 and create DWI mask
        flirt_dwimask_pre = pe.Node(
            interface=fsl.FLIRT(
                out_file="brain2b0.nii.gz", out_matrix_file="brain2b0aff"
            ),
            name="flirt_dwimask_pre",
        )
        costs = [
            "mutualinfo",
            "corratio",
            "normcorr",
            "normmi",
            "leastsq",
            "labeldiff",
            "bbr",
        ]
        flirt_dwimask_pre.inputs.cost = costs[3]
        flirt_dwimask_pre.inputs.cost_func = costs[3]
        flirt_dwimask_pre.inputs.dof = 6
        flirt_dwimask_pre.inputs.no_search = False

        flirt_dwimask = pe.Node(
            interface=fsl.FLIRT(
                out_file="dwi_brain_mask.nii.gz",
                apply_xfm=True,
                interp="nearestneighbour",
            ),
            name="flirt_dwimask",
        )

        mr_convert_b0 = pe.Node(
            interface=MRConvert(out_filename="b0.nii.gz", stride=[+1, +2, +3]),
            name="mr_convert_b0",
        )
        mr_convert_b0.inputs.extract_at_axis = 3
        mr_convert_b0.inputs.extract_at_coordinate = [0]

        # fmt: off
        flow.connect(
            [
                (processing_input, mr_convert_b0, [("diffusion", "in_file")]),
                (mr_convert_T1, flirt_dwimask_pre, [("converted", "in_file")]),
                (mr_convert_b0, flirt_dwimask_pre, [("converted", "reference")]),
                (mr_convert_b0, flirt_dwimask, [("converted", "reference")]),
                (flirt_dwimask_pre, flirt_dwimask, [("out_matrix_file", "in_matrix_file")]),
                (mr_threshold_brainmask, flirt_dwimask, [("thresholded", "in_file")]),
            ]
        )
        # fmt: on

        # Diffusion data denoising
        if self.config.denoising:

            mr_convert_noise = pe.Node(
                interface=MRConvert(
                    out_filename="diffusion_noisemap.nii.gz", stride=[+1, +2, +3, +4]
                ),
                name="mr_convert_noise",
            )

            if self.config.denoising_algo == "MRtrix (MP-PCA)":
                mr_convert.inputs.out_filename = "diffusion.mif"
                dwi_denoise = pe.Node(
                    interface=DWIDenoise(
                        out_file="diffusion_denoised.mif",
                        out_noisemap="diffusion_noisemap.mif",
                    ),
                    name="dwi_denoise",
                )
                dwi_denoise.inputs.force_writing = True
                dwi_denoise.inputs.debug = True
                dwi_denoise.ignore_exception = True

                # fmt: off
                flow.connect(
                    [
                        # (processing_input,mr_convert,[('diffusion','in_file')]),
                        (processing_input, mr_convert, [("diffusion", "in_file")]),
                        (mr_convert, dwi_denoise, [("converted", "in_file")]),
                        (flirt_dwimask, dwi_denoise, [("out_file", "mask")]),
                    ]
                )
                # fmt: on

            elif self.config.denoising_algo == "Dipy (NLM)":
                mr_convert.inputs.out_filename = "diffusion_denoised.mif"
                dwi_denoise = pe.Node(interface=dipy.Denoise(), name="dwi_denoise")
                if self.config.dipy_noise_model == "Gaussian":
                    dwi_denoise.inputs.noise_model = "gaussian"
                elif self.config.dipy_noise_model == "Rician":
                    dwi_denoise.inputs.noise_model = "rician"

                # fmt: off
                flow.connect(
                    [
                        (processing_input, dwi_denoise, [("diffusion", "in_file")]),
                        (flirt_dwimask, dwi_denoise, [("out_file", "in_mask")]),
                        (dwi_denoise, mr_convert, [("out_file", "in_file")]),
                    ]
                )
                # fmt: on

            # fmt: off
            flow.connect(
                [
                    (dwi_denoise, mr_convert_noise, [("out_file", "in_file")]),
                    (mr_convert_noise, outputnode, [("converted", "diffusion_noisemap")]),
                ]
            )
            # fmt: on
        else:
            mr_convert.inputs.out_filename = "diffusion.mif"
            flow.connect([(processing_input, mr_convert, [("diffusion", "in_file")])])

        mr_convert_b = pe.Node(
            interface=MRConvert(
                out_filename="diffusion_corrected.nii.gz", stride=[+1, +2, +3, +4]
            ),
            name="mr_convert_b",
        )

        if self.config.bias_field_correction:

            mr_convert_bias = pe.Node(
                interface=MRConvert(
                    out_filename="diffusion_biasfield.nii.gz", stride=[+1, +2, +3, +4]
                ),
                name="mr_convert_bias",
            )

            if self.config.bias_field_algo == "ANTS N4":
                dwi_biascorrect = pe.Node(
                    interface=DWIBiasCorrect(
                        use_ants=True, out_bias="diffusion_denoised_biasfield.mif"
                    ),
                    name="dwi_biascorrect",
                )
            elif self.config.bias_field_algo == "FSL FAST":
                dwi_biascorrect = pe.Node(
                    interface=DWIBiasCorrect(
                        use_fsl=True, out_bias="diffusion_denoised_biasfield.mif"
                    ),
                    name="dwi_biascorrect",
                )

            dwi_biascorrect.inputs.debug = False

            if self.config.denoising:
                if self.config.denoising_algo == "MRtrix (MP-PCA)":
                    # fmt: off
                    flow.connect(
                        [
                            (dwi_denoise, dwi_biascorrect, [("out_file", "in_file")]),
                            (flirt_dwimask, dwi_biascorrect, [("out_file", "mask")]),
                            # (dwi_biascorrect, mr_convert_b,
                            #  [('out_file', 'in_file')])
                        ]
                    )
                    # fmt: on
                elif self.config.denoising_algo == "Dipy (NLM)":
                    # fmt: off
                    flow.connect(
                        [
                            (mr_convert, dwi_biascorrect, [("converted", "in_file")]),
                            (flirt_dwimask, dwi_biascorrect, [("out_file", "mask")]),
                            # (dwi_biascorrect, mr_convert_b,
                            #  [('out_file', 'in_file')])
                        ]
                    )
                    # fmt: on
            else:
                # fmt: off
                flow.connect(
                    [
                        (mr_convert, dwi_biascorrect, [("converted", "in_file")]),
                        (flirt_dwimask, dwi_biascorrect, [("out_file", "mask")]),
                    ]
                )
                # fmt: on

            # fmt: off
            flow.connect(
                [
                    (dwi_biascorrect, mr_convert_b, [("out_file", "in_file")]),
                    (dwi_biascorrect, mr_convert_bias, [("out_file", "in_file")]),
                    (mr_convert_bias, outputnode, [("converted", "diffusion_biasfield")]),
                ]
            )
            # fmt: on
        else:
            if self.config.denoising:
                if self.config.denoising_algo == "MRtrix (MP-PCA)":
                    # fmt: off
                    flow.connect(
                        [(dwi_denoise, mr_convert_b, [("out_file", "in_file")])]
                    )
                    # fmt: on
                elif self.config.denoising_algo == "Dipy (NLM)":
                    # fmt: off
                    flow.connect(
                        [(mr_convert, mr_convert_b, [("converted", "in_file")])]
                    )
                    # fmt: on
            else:
                # fmt: off
                flow.connect(
                    [(mr_convert, mr_convert_b, [("converted", "in_file")])]
                )
                # fmt: on

        extract_grad_mrtrix = pe.Node(
            interface=ExtractMRTrixGrad(out_grad_mrtrix="grad.txt"),
            name="extract_grad_mrtrix",
        )
        # fmt: off
        flow.connect(
            [(mr_convert, extract_grad_mrtrix, [("converted", "in_file")])]
        )
        # fmt: on
        # extract_grad_fsl = pe.Node(interface=mrt.MRTrixInfo(out_grad_mrtrix=('diffusion_denoised.bvec','diffusion_denoised.bval')),name='extract_grad_fsl')

        # TODO extract the total readout directly from the BIDS json file
        acqpnode = pe.Node(
            interface=CreateAcqpFile(total_readout=self.config.total_readout),
            name="acqpnode",
        )

        indexnode = pe.Node(interface=CreateIndexFile(), name="indexnode")
        # fmt: off
        flow.connect(
            [(extract_grad_mrtrix, indexnode, [("out_grad_mrtrix", "in_grad_mrtrix")])]
        )
        # fmt: on

        fs_mriconvert = pe.Node(
            interface=fs.MRIConvert(
                out_type="niigz", out_file="diffusion_preproc_resampled.nii.gz"
            ),
            name="diffusion_resample",
        )
        fs_mriconvert.inputs.vox_size = self.config.resampling
        fs_mriconvert.inputs.resample_type = self.config.interpolation

        mr_convert_b0_resample = pe.Node(
            interface=MRConvert(
                out_filename="b0_resampled.nii.gz", stride=[+1, +2, +3]
            ),
            name="mr_convert_b0_resample",
        )
        mr_convert_b0_resample.inputs.extract_at_axis = 3
        mr_convert_b0_resample.inputs.extract_at_coordinate = [0]

        # fs_mriconvert_b0 = pe.Node(interface=fs.MRIConvert(out_type='niigz',out_file='b0_resampled.nii.gz'),name="b0_resample")
        # fs_mriconvert_b0.inputs.vox_size = self.config.resampling
        # fs_mriconvert_b0.inputs.resample_type = self.config.interpolation

        # fmt: off
        flow.connect(
            [
                (fs_mriconvert, mr_convert_b0_resample, [("out_file", "in_file")]),
            ]
        )
        # fmt: on

        # resampling Freesurfer data and setting output type to short
        fs_mriconvert_T1 = pe.Node(
            interface=fs.MRIConvert(out_type="niigz", out_file="anat_resampled.nii.gz"),
            name="anat_resample",
        )
        fs_mriconvert_T1.inputs.vox_size = self.config.resampling
        fs_mriconvert_T1.inputs.resample_type = self.config.interpolation

        # fmt: off
        flow.connect(
            [
                (mr_convert_T1, fs_mriconvert_T1, [("converted", "in_file")]),
                # (mr_convert_b0_resample,fs_mriconvert_T1,[('converted','reslice_like')]),
                (fs_mriconvert_T1, outputnode, [("out_file", "T1")]),
            ]
        )
        # fmt: on

        fs_mriconvert_brain = pe.Node(
            interface=fs.MRIConvert(
                out_type="niigz", out_file="anat_masked_resampled.nii.gz"
            ),
            name="anat_masked_resample",
        )
        fs_mriconvert_brain.inputs.vox_size = self.config.resampling
        fs_mriconvert_brain.inputs.resample_type = self.config.interpolation

        # fmt: off
        flow.connect(
            [
                (mr_convert_brain, fs_mriconvert_brain, [("converted", "in_file")]),
                # (mr_convert_b0_resample,fs_mriconvert_brain,[('converted','reslice_like')]),
                (fs_mriconvert_brain, outputnode, [("out_file", "brain")]),
            ]
        )
        # fmt: on

        fs_mriconvert_brainmask = pe.Node(
            interface=fs.MRIConvert(
                out_type="niigz",
                resample_type="nearest",
                out_file="brain_mask_resampled.nii.gz",
            ),
            name="brain_mask_resample",
        )
        fs_mriconvert_brainmask.inputs.vox_size = self.config.resampling
        # fmt: off
        flow.connect(
            [
                (mr_threshold_brainmask, fs_mriconvert_brainmask, [("thresholded", "in_file")],),
                # (mr_convert_b0_resample,fs_mriconvert_brainmask,[('converted','reslice_like')]),
                (fs_mriconvert_brainmask, outputnode, [("out_file", "brain_mask")]),
            ]
        )
        # fmt: on

        fs_mriconvert_brainmaskfull = pe.Node(
            interface=fs.MRIConvert(
                out_type="niigz", out_file="brain_mask_full_resampled.nii.gz"
            ),
            name="brain_mask_full_resample",
        )
        fs_mriconvert_brainmaskfull.inputs.vox_size = self.config.resampling
        fs_mriconvert_brainmaskfull.inputs.resample_type = self.config.interpolation
        # fmt: off
        flow.connect(
            [
                (mr_convert_brainmask, fs_mriconvert_brainmaskfull, [("converted", "in_file")]),
                # (mr_convert_b0_resample,fs_mriconvert_brainmaskfull,[('converted','reslice_like')]),
                (fs_mriconvert_brainmaskfull, outputnode, [("out_file", "brain_mask_full")]),
            ]
        )
        # fmt: on

        fs_mriconvert_wm_mask = pe.Node(
            interface=fs.MRIConvert(
                out_type="niigz",
                resample_type="nearest",
                out_file="wm_mask_resampled.nii.gz",
            ),
            name="wm_mask_resample",
        )
        fs_mriconvert_wm_mask.inputs.vox_size = self.config.resampling
        # fmt: off
        flow.connect(
            [
                (mr_convert_wm_mask_file, fs_mriconvert_wm_mask, [("converted", "in_file")],),
                # (mr_convert_b0_resample,fs_mriconvert_wm_mask,[('converted','reslice_like')]),
                (fs_mriconvert_wm_mask, outputnode, [("out_file", "wm_mask_file")]),
            ]
        )
        # fmt: on

        fs_mriconvert_ROIs = pe.MapNode(
            interface=fs.MRIConvert(out_type="niigz", resample_type="nearest"),
            iterfield=["in_file"],
            synchronize=True,
            name="ROIs_resample"
        )
        fs_mriconvert_ROIs.inputs.vox_size = self.config.resampling
        # fmt: off
        flow.connect(
            [
                (mr_convert_roi_volumes, fs_mriconvert_ROIs, [("converted_files", "in_file")],),
                # (mr_convert_b0_resample,fs_mriconvert_ROIs,[('converted','reslice_like')]),
                (fs_mriconvert_ROIs, outputnode, [("out_file", "roi_volumes")]),
            ]
        )
        # fmt: on

        # fs_mriconvert_PVEs = pe.MapNode(interface=fs.MRIConvert(out_type='niigz'),name="PVEs_resample",iterfield=['in_file'])
        # fs_mriconvert_PVEs.inputs.vox_size = self.config.resampling
        # fs_mriconvert_PVEs.inputs.resample_type = self.config.interpolation
        # flow.connect([
        #             (fastr,fs_mriconvert_PVEs,[('partial_volume_files','in_file')]),
        #             #(mr_convert_b0_resample,fs_mriconvert_ROIs,[('converted','reslice_like')]),
        #             (fs_mriconvert_PVEs,outputnode,[("out_file","partial_volume_files")])
        #             ])

        fs_mriconvert_dwimask = pe.Node(
            interface=fs.MRIConvert(
                out_type="niigz",
                resample_type="nearest",
                out_file="dwi_brain_mask_resampled.nii.gz",
            ),
            name="dwi_brainmask_resample",
        )
        # fs_mriconvert_dwimask.inputs.vox_size = self.config.resampling

        # fmt: off
        flow.connect(
            [
                (flirt_dwimask, fs_mriconvert_dwimask, [("out_file", "in_file")]),
                (mr_convert_b0_resample, fs_mriconvert_dwimask, [("converted", "reslice_like")],),
                (fs_mriconvert_dwimask, outputnode, [("out_file", "dwi_brain_mask")]),
            ]
        )
        # fmt: on

        # TODO Implementation of FSL Topup

        if self.config.eddy_current_and_motion_correction:

            if self.config.eddy_correction_algo == "FSL eddy_correct":

                eddy_correct = pe.Node(
                    interface=fsl.EddyCorrect(
                        ref_num=0, out_file="eddy_corrected.nii.gz"
                    ),
                    name="eddy_correct",
                )

                # fmt: off
                flow.connect([(processing_input, outputnode, [("bvecs", "bvecs_rot")])])
                # fmt: on

                if self.config.eddy_correct_motion_correction:

                    mc_flirt = pe.Node(
                        interface=fsl.MCFLIRT(
                            out_file="motion_corrected.nii.gz",
                            ref_vol=0,
                            save_mats=True,
                        ),
                        name="motion_correction",
                    )
                    # fmt: off
                    flow.connect(
                        [
                            (mr_convert_b, mc_flirt, [("converted", "in_file")]),
                            (mc_flirt, eddy_correct, [("out_file", "in_file")])
                        ]
                    )
                    # fmt: on
                else:
                    # fmt: off
                    flow.connect(
                        [(mr_convert_b, eddy_correct, [("converted", "in_file")])]
                    )
                    # fmt: on

                # # DTK needs fixed number of directions (512)
                # if self.config.start_vol > 0 and self.config.end_vol == self.config.max_vol:
                #     merge_filenames = pe.Node(interface=util.Merge(2),name='merge_files')
                #     flow.connect([
                #                 (split_vol,merge_filenames,[("padding1","in1")]),
                #                 (eddy_correct,merge_filenames,[("eddy_corrected","in2")]),
                #                 ])
                #     merge = pe.Node(interface=fsl.Merge(dimension='t'),name="merge")
                #     flow.connect([
                #                 (merge_filenames,merge,[("out","in_files")]),
                #                 ])
                #     flow.connect([
                #                 (merge,fs_mriconvert,[('merged_file','in_file')]),
                #                 (fs_mriconvert,outputnode,[("out_file","diffusion_preproc")])
                #                 ])
                # elif self.config.start_vol > 0 and self.config.end_vol < self.config.max_vol:
                #     merge_filenames = pe.Node(interface=util.Merge(3),name='merge_files')
                #     flow.connect([
                #                 (split_vol,merge_filenames,[("padding1","in1")]),
                #                 (eddy_correct,merge_filenames,[("eddy_corrected","in2")]),
                #                 (split_vol,merge_filenames,[("padding2","in3")]),
                #                 ])
                #     merge = pe.Node(interface=fsl.Merge(dimension='t'),name="merge")
                #     flow.connect([
                #                 (merge_filenames,merge,[("out","in_files")])
                #                 ])
                #     flow.connect([
                #                 (merge,fs_mriconvert,[('merged_file','in_file')]),
                #                 (fs_mriconvert,outputnode,[("out_file","diffusion_preproc")])
                #                 ])
                # elif self.config.start_vol == 0 and self.config.end_vol < self.config.max_vol:
                #     merge_filenames = pe.Node(interface=util.Merge(2),name='merge_files')
                #     flow.connect([
                #                 (eddy_correct,merge_filenames,[("eddy_corrected","in1")]),
                #                 (split_vol,merge_filenames,[("padding2","in2")]),
                #                 ])
                #     merge = pe.Node(interface=fsl.Merge(dimension='t'),name="merge")
                #     flow.connect([
                #                 (merge_filenames,merge,[("out","in_files")])
                #                 ])
                #     flow.connect([
                #                 (merge,fs_mriconvert,[('merged_file','in_file')]),
                #                 (fs_mriconvert,outputnode,[("out_file","diffusion_preproc")])
                #                 ])
                # else:

                # fmt: off
                flow.connect(
                    [
                        (eddy_correct, fs_mriconvert, [("eddy_corrected", "in_file")]),
                        (fs_mriconvert, outputnode, [("out_file", "diffusion_preproc")],),
                    ]
                )
                # fmt: on

            else:
                eddy_correct = pe.Node(
                    interface=cmp_fsl.EddyOpenMP(
                        out_file="eddy_corrected.nii.gz", verbose=True
                    ),
                    name="eddy",
                )
                # fmt: off
                flow.connect(
                    [
                        (mr_convert_b, eddy_correct, [("converted", "in_file")]),
                        (processing_input, eddy_correct, [("bvecs", "bvecs")]),
                        (processing_input, eddy_correct, [("bvals", "bvals")]),
                        (flirt_dwimask, eddy_correct, [("out_file", "mask")]),
                        (indexnode, eddy_correct, [("index", "index")]),
                        (acqpnode, eddy_correct, [("acqp", "acqp")]),
                    ]
                )
                # fmt: on

                # resampling diffusion image and setting output type to short
                # fmt: off
                flow.connect(
                    [
                        (eddy_correct, outputnode, [("bvecs_rotated", "bvecs_rot")]),
                        (eddy_correct, fs_mriconvert, [("eddy_corrected", "in_file")]),
                        (fs_mriconvert,outputnode, [("out_file", "diffusion_preproc")])
                    ]
                )
                # fmt: on
        else:
            # resampling diffusion image and setting output type to short
            # fmt: off
            flow.connect(
                [
                    (mr_convert_b, fs_mriconvert, [("converted", "in_file")]),
                    (fs_mriconvert, outputnode, [("out_file", "diffusion_preproc")]),
                    (inputnode, outputnode, [("bvecs", "bvecs_rot")]),
                ]
            )
            # fmt: on

        # #mr_convertB.inputs.grad_fsl = ('bvecs', 'bvals')
        # flow.connect([
        #             (mr_convertF,mr_convertB,[("converted","in_file")])
        #             ])

        # else:
        #     if self.config.start_vol > 0 and self.config.end_vol == self.config.max_vol:
        #         merge_filenames = pe.Node(interface=util.Merge(2),name='merge_files')
        #         flow.connect([
        #                     (split_vol,merge_filenames,[("padding1","in1")]),
        #                     (mc_flirt,merge_filenames,[("out_file","in2")]),
        #                     ])
        #         merge = pe.Node(interface=fsl.Merge(dimension='t'),name="merge")
        #         flow.connect([
        #                     (merge_filenames,merge,[("out","in_files")]),
        #                     (merge,outputnode,[("merged_file","diffusion_preproc")])
        #                     ])
        #     elif self.config.start_vol > 0 and self.config.end_vol < self.config.max_vol:
        #         merge_filenames = pe.Node(interface=util.Merge(3),name='merge_files')
        #         flow.connect([
        #                     (split_vol,merge_filenames,[("padding1","in1")]),
        #                     (mc_flirt,merge_filenames,[("out_file","in2")]),
        #                     (split_vol,merge_filenames,[("padding2","in3")]),
        #                     ])
        #         merge = pe.Node(interface=fsl.Merge(dimension='t'),name="merge")
        #         flow.connect([
        #                     (merge_filenames,merge,[("out","in_files")]),
        #                     (merge,outputnode,[("merged_file","diffusion_preproc")])
        #                     ])
        #     elif self.config.start_vol == 0 and self.config.end_vol < self.config.max_vol:
        #         merge_filenames = pe.Node(interface=util.Merge(2),name='merge_files')
        #         flow.connect([
        #                     (mc_flirt,merge_filenames,[("out_file","in1")]),
        #                     (split_vol,merge_filenames,[("padding2","in2")]),
        #                     ])
        #         merge = pe.Node(interface=fsl.Merge(dimension='t'),name="merge")
        #         flow.connect([
        #                     (merge_filenames,merge,[("out","in_files")]),
        #                     (merge,outputnode,[("merged_file","diffusion_preproc")])
        #                     ])
        #     else:
        #         flow.connect([
        #                     (mc_flirt,outputnode,[("out_file","diffusion_preproc")])
        #                     ])

        if self.config.act_tracking:
            fs_mriconvert_5tt = pe.Node(
                interface=fs.MRIConvert(
                    out_type="niigz", out_file="act_5tt_resampled.nii.gz"
                ),
                name="5tt_resample",
            )
            fs_mriconvert_5tt.inputs.vox_size = self.config.resampling
            fs_mriconvert_5tt.inputs.resample_type = self.config.interpolation

            mrtrix_5tt = pe.Node(
                interface=Generate5tt(out_file="mrtrix_5tt.nii.gz"), name="mrtrix_5tt"
            )
            mrtrix_5tt.inputs.algorithm = "freesurfer"
            # mrtrix_5tt.inputs.algorithm = 'hsvs'

            # fmt: off
            flow.connect(
                [
                    (processing_input, mrtrix_5tt, [("aparc_aseg", "in_file")]),
                    (mrtrix_5tt, fs_mriconvert_5tt, [("out_file", "in_file")]),
                    (fs_mriconvert_5tt, outputnode, [("out_file", "act_5TT")]),
                ]
            )
            # fmt: on

            if self.config.tracking_tool == 'Dipy':
                pve_extractor_from_5tt = pe.Node(
                    interface=ExtractPVEsFrom5TT(), name="pve_extractor_from_5tt"
                )
                pve_extractor_from_5tt.inputs.pve_csf_file = "pve_0.nii.gz"
                pve_extractor_from_5tt.inputs.pve_gm_file = "pve_1.nii.gz"
                pve_extractor_from_5tt.inputs.pve_wm_file = "pve_2.nii.gz"

                # fmt: off
                flow.connect(
                    [
                        (mrtrix_5tt, pve_extractor_from_5tt, [("out_file", "in_5tt")]),
                        (processing_input, pve_extractor_from_5tt, [("T1", "ref_image")]),
                    ]
                )
                # fmt: on

                fs_mriconvert_PVEs = pe.MapNode(
                    interface=fs.MRIConvert(out_type="niigz"),
                    iterfield=["in_file"],
                    synchronize=True,
                    name="PVEs_resample"
                )
                fs_mriconvert_PVEs.inputs.vox_size = self.config.resampling
                fs_mriconvert_PVEs.inputs.resample_type = self.config.interpolation
                # fmt: off
                flow.connect(
                    [
                        (pve_extractor_from_5tt, fs_mriconvert_PVEs, [("partial_volume_files", "in_file")],),
                        # (mr_convert_b0_resample,fs_mriconvert_ROIs,[('converted','reslice_like')]),
                        (fs_mriconvert_PVEs, outputnode, [("out_file", "partial_volume_files")],),
                    ]
                )
                # fmt: on

        if self.config.gmwmi_seeding:
            fs_mriconvert_gmwmi = pe.Node(
                interface=fs.MRIConvert(
                    out_type="niigz", out_file="gmwmi_resampled.nii.gz"
                ),
                name="gmwmi_resample",
            )
            fs_mriconvert_gmwmi.inputs.vox_size = self.config.resampling
            fs_mriconvert_gmwmi.inputs.resample_type = self.config.interpolation

            mrtrix_gmwmi = pe.Node(
                interface=GenerateGMWMInterface(out_file="gmwmi.nii.gz"),
                name="mrtrix_gmwmi",
            )

            update_gmwmi = pe.Node(
                interface=UpdateGMWMInterfaceSeeding(), name="update_gmwmi"
            )
            update_gmwmi.inputs.out_gmwmi_file = "gmwmi_proc.nii.gz"
            # fmt: off
            flow.connect(
                [
                    (mrtrix_5tt, mrtrix_gmwmi, [("out_file", "in_file")]),
                    (mrtrix_gmwmi, update_gmwmi, [("out_file", "in_gmwmi_file")]),
                    (processing_input, update_gmwmi, [("roi_volumes", "in_roi_volumes")]),
                    (update_gmwmi, fs_mriconvert_gmwmi, [("out_gmwmi_file", "in_file")]),
                    (fs_mriconvert_gmwmi, outputnode, [("out_file", "gmwmi")]),
                ]
            )
Пример #7
0
 def create_workflow(self, flow, inputnode, outputnode):
     processing_input = pe.Node(
         interface=util.IdentityInterface(fields=['diffusion']),
         name='processing_input')
     # For DSI acquisition: extract the hemisphere that contains the data
     if self.config.start_vol > 0 or self.config.end_vol < self.config.max_vol:
         split_vol = pe.Node(interface=splitDiffusion(), name='split_vol')
         split_vol.inputs.start = self.config.start_vol
         split_vol.inputs.end = self.config.end_vol
         flow.connect([(inputnode, split_vol, [("diffusion", "in_file")]),
                       (split_vol, processing_input, [("data", "diffusion")
                                                      ])])
     else:
         flow.connect([(inputnode, processing_input, [("diffusion",
                                                       "diffusion")])])
     if self.config.motion_correction:
         mc_flirt = pe.Node(interface=fsl.MCFLIRT(
             out_file='motion_corrected.nii.gz', ref_vol=0),
                            name='motion_correction')
         flow.connect([(processing_input, mc_flirt, [("diffusion",
                                                      "in_file")])])
         if self.config.eddy_current_correction:
             eddy_correct = pe.Node(interface=fsl.EddyCorrect(
                 ref_num=0, out_file='eddy_corrected.nii.gz'),
                                    name='eddy_correct')
             flow.connect([(mc_flirt, eddy_correct, [("out_file", "in_file")
                                                     ])])
             if self.config.start_vol > 0 and self.config.end_vol == self.config.max_vol:
                 merge_filenames = pe.Node(interface=util.Merge(2),
                                           name='merge_files')
                 flow.connect([
                     (split_vol, merge_filenames, [("padding1", "in1")]),
                     (eddy_correct, merge_filenames, [("eddy_corrected",
                                                       "in2")]),
                 ])
                 merge = pe.Node(interface=fsl.Merge(dimension='t'),
                                 name="merge")
                 flow.connect([(merge_filenames, merge, [("out", "in_files")
                                                         ]),
                               (merge, outputnode,
                                [("merged_file", "diffusion_preproc")])])
             elif self.config.start_vol > 0 and self.config.end_vol < self.config.max_vol:
                 merge_filenames = pe.Node(interface=util.Merge(3),
                                           name='merge_files')
                 flow.connect([
                     (split_vol, merge_filenames, [("padding1", "in1")]),
                     (eddy_correct, merge_filenames, [("eddy_corrected",
                                                       "in2")]),
                     (split_vol, merge_filenames, [("padding2", "in3")]),
                 ])
                 merge = pe.Node(interface=fsl.Merge(dimension='t'),
                                 name="merge")
                 flow.connect([(merge_filenames, merge, [("out", "in_files")
                                                         ]),
                               (merge, outputnode,
                                [("merged_file", "diffusion_preproc")])])
             elif self.config.start_vol == 0 and self.config.end_vol < self.config.max_vol:
                 merge_filenames = pe.Node(interface=util.Merge(2),
                                           name='merge_files')
                 flow.connect([
                     (eddy_correct, merge_filenames, [("eddy_corrected",
                                                       "in1")]),
                     (split_vol, merge_filenames, [("padding2", "in2")]),
                 ])
                 merge = pe.Node(interface=fsl.Merge(dimension='t'),
                                 name="merge")
                 flow.connect([(merge_filenames, merge, [("out", "in_files")
                                                         ]),
                               (merge, outputnode,
                                [("merged_file", "diffusion_preproc")])])
             else:
                 flow.connect([(eddy_correct, outputnode,
                                [("eddy_corrected", "diffusion_preproc")])])
         else:
             if self.config.start_vol > 0 and self.config.end_vol == self.config.max_vol:
                 merge_filenames = pe.Node(interface=util.Merge(2),
                                           name='merge_files')
                 flow.connect([
                     (split_vol, merge_filenames, [("padding1", "in1")]),
                     (mc_flirt, merge_filenames, [("out_file", "in2")]),
                 ])
                 merge = pe.Node(interface=fsl.Merge(dimension='t'),
                                 name="merge")
                 flow.connect([(merge_filenames, merge, [("out", "in_files")
                                                         ]),
                               (merge, outputnode,
                                [("merged_file", "diffusion_preproc")])])
             elif self.config.start_vol > 0 and self.config.end_vol < self.config.max_vol:
                 merge_filenames = pe.Node(interface=util.Merge(3),
                                           name='merge_files')
                 flow.connect([
                     (split_vol, merge_filenames, [("padding1", "in1")]),
                     (mc_flirt, merge_filenames, [("out_file", "in2")]),
                     (split_vol, merge_filenames, [("padding2", "in3")]),
                 ])
                 merge = pe.Node(interface=fsl.Merge(dimension='t'),
                                 name="merge")
                 flow.connect([(merge_filenames, merge, [("out", "in_files")
                                                         ]),
                               (merge, outputnode,
                                [("merged_file", "diffusion_preproc")])])
             elif self.config.start_vol == 0 and self.config.end_vol < self.config.max_vol:
                 merge_filenames = pe.Node(interface=util.Merge(2),
                                           name='merge_files')
                 flow.connect([
                     (mc_flirt, merge_filenames, [("out_file", "in1")]),
                     (split_vol, merge_filenames, [("padding2", "in2")]),
                 ])
                 merge = pe.Node(interface=fsl.Merge(dimension='t'),
                                 name="merge")
                 flow.connect([(merge_filenames, merge, [("out", "in_files")
                                                         ]),
                               (merge, outputnode,
                                [("merged_file", "diffusion_preproc")])])
             else:
                 flow.connect([(mc_flirt, outputnode,
                                [("out_file", "diffusion_preproc")])])
     else:
         if self.config.eddy_current_correction:
             eddy_correct = pe.Node(interface=fsl.EddyCorrect(
                 ref_num=0, out_file="eddy_corrected.nii.gz"),
                                    name='eddy_correct')
             flow.connect([(processing_input, eddy_correct, [("diffusion",
                                                              "in_file")])])
             if self.config.start_vol > 0 and self.config.end_vol == self.config.max_vol:
                 merge_filenames = pe.Node(interface=util.Merge(2),
                                           name='merge_files')
                 flow.connect([
                     (split_vol, merge_filenames, [("padding1", "in1")]),
                     (eddy_correct, merge_filenames, [("eddy_corrected",
                                                       "in1")]),
                 ])
                 merge = pe.Node(interface=fsl.Merge(dimension='t'),
                                 name="merge")
                 flow.connect([(merge_filenames, merge, [("out", "in_files")
                                                         ]),
                               (merge, outputnode,
                                [("merged_file", "diffusion_preproc")])])
             elif self.config.start_vol > 0 and self.config.end_vol < self.config.max_vol:
                 merge_filenames = pe.Node(interface=util.Merge(3),
                                           name='merge_files')
                 flow.connect([
                     (split_vol, merge_filenames, [("padding1", "in1")]),
                     (eddy_correct, merge_filenames, [("eddy_corrected",
                                                       "in1")]),
                     (split_vol, merge_filenames, [("padding2", "in3")]),
                 ])
                 merge = pe.Node(interface=fsl.Merge(dimension='t'),
                                 name="merge")
                 flow.connect([(merge_filenames, merge, [("out", "in_files")
                                                         ]),
                               (merge, outputnode,
                                [("merged_file", "diffusion_preproc")])])
             elif self.config.start_vol == 0 and self.config.end_vol < self.config.max_vol:
                 merge_filenames = pe.Node(interface=util.Merge(2),
                                           name='merge_files')
                 flow.connect([
                     (eddy_correct, merge_filenames, [("eddy_corrected",
                                                       "in1")]),
                     (split_vol, merge_filenames, [("padding2", "in2")]),
                 ])
                 merge = pe.Node(interface=fsl.Merge(dimension='t'),
                                 name="merge")
                 flow.connect([(merge_filenames, merge, [("out", "in_files")
                                                         ]),
                               (merge, outputnode,
                                [("merged_file", "diffusion_preproc")])])
             else:
                 flow.connect([(eddy_correct, outputnode,
                                [("eddy_corrected", "diffusion_preproc")])])
         else:
             flow.connect([
                 (inputnode, outputnode, [("diffusion", "diffusion_preproc")
                                          ]),
             ])